the biology of cancer and its relationship to disparities in cancer occurrence and outcomes
Báo cáo y học: "The biology of genomes: sequence gives way to function" ppsx
... a panel of recombinant inbred (RI) strains derived from the Brown Norway and the spontaneously hypertensive rat, a model system for insulin resistance, and presented the results of linkage analyses ... complex traits and understanding the history of the human species as represented in our DNA, Chakravarti ended on a philosophical note, pointing out that we have a responsibility to demonstrate the ... progress towards characterizing the genetic architectures of complex traits, using Q-T interval and Hirschsprung’s disease as examples Drawing connections between elucidating the genetic basis of complex...
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CAN THE EFFECT OF GRAMMATICAL CLASS BE REDUCED TO DIFFERENCES IN IMAGEABILITY
... analysis of the performance of the participants in the various tasks can reveal how one effect manifests itself in the face of the other and whether or not the two effects are independent These ... to their lemmas These lemmas then become competitors of the lemma of defend Competition is what mainly determines selection latency According to Roelofs (1992), the probability of selecting the ... 1997) An investigation of the influence of these two effects at word form retrieval will increase our understanding of spoken word production In their study of the role of semantic and syntactic...
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Báo cáo khoa học: Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins pot
... Domain Database of NCBI was screened with the protein coding sequence of clone of CLAP and the Fas I domains in the protein compared with 10 other fasciclin I-containing proteins The most highly ... Processing of the pro-CLAP C-terminus is essential to lower the molecular mass and pI of the protein to values observed by SDS/ PAGE and IEF Interestingly, pool sequencing of the mixture of CNBr ... represent the pI values of the major bands in e and f, while the numbers at the left are the pI values of standard proteins The arrow at the right represents the pI value of 6.84 calculated for the...
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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot
... maintaining the integrity of the endothelium through both direct and indirect mechanisms APC can potentially limit the elaboration of proinflammatory cytokines, such as tumor necrosis factor-α ... permeability to protein (unpublished data) The reason for the conflicting results of endothelial barrier protection in the in vivo studies is not clear, but these findings reinforce the need to cautiously ... attributed to inhibition of the proapoptotic transcription factor p53, normalization of the proapoptotic Bax/Bcl-2 ratio, and reduction of caspase-3 signaling, all of which decreased apoptosis Using...
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Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs
... doi:10.1038/cddis.2011.12 The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling, Hui-Min Lin, Kuan-Boone Tan and Gigi N.C Chiu International ... presenting author) Podium Presentation The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells Leong-Uung Ling*, Hui-Min Lin, Kuan-Boone Tan and ... a protein kinase C (PKC) and sphingosine kinase (SK) inhibitor, and is currently evaluated in Phase I clinical trials Yet, the underlying mechanisms of its action remain largely unknown The research...
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Functional study of zebrafish udu and its relationship to the notch signaling pathway
... Thus the PAH domain of Udu may be involved in these processes in maintaining genome intergrity, while the SANT-L domain of Udu protein could function as a chromatin-remodeling molecule during ... splicing of intron or by alternative initiation of translation The presence of an alternative promoter in intron of p53 leads to the expression of an amino-terminally truncated p53 protein initiated ... domain The PAH-L domain of Udu contains four α-helix motifs, which are similar to the PAH repeats found in yeast SIN3 (Wang et al., 1990) SIN3 protein has no intrinsic DNA binding abilities and...
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The Savings and Loan Crisis and Its Relationship to Banking pptx
... 79 In its audit of the Resolution Trust Corporations 1994 and 1995 financial statements, the U.S General Accounting Office estimated the total direct and indirect cost of resolving the savings ... However, field examiners reported to the FHLBB in Washington rather than to the regional PSA, and the regional PSA effectively reported to no one In fact, according to one insider, the regional Federal ... were designed to alleviate disintermediation, or the flow of deposits out of financial institutions into money market mutual funds and other investments However, the increase in insured liabilities...
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Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
... interest [8,9] Apart from some equilibrium and kinetic constants related to the binding of l-Arg [10–14] and NOHA [10], nothing is known about the thermodynamics and kinetics of the binding of ... guanidine to lead to NO formation in the presence of iNOS could be the ability of the corresponding N-hydroxyguanidine to bind to the active site without being released before being further oxidized ... used to completely convert iNOSoxy into a LS state iNOSoxy–Fe(III)–ImH complex allowing one to more easily follow the binding of guanidines or N-hydroxyguanidines to the iNOSoxy substrate binding...
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The Fraction of Cancer Attributable to Lifestyle and Environmental Factors in the UK in 2010 docx
... exposure in the UK DM Parkin and SC Darby Tobacco-attributable cancer burden in the UK in 2010 DM Parkin S14 11 Cancers attributable to infection in the UK in 2010 DM Parkin S77 S6 10 Cancers ... attributable to exposure to hormones in the UK in 2010 DM Parkin S73 The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010: Introduction DM Parkin S42 S70 S2 Cancers ... Journal of Cancer Multidisciplinary Journal of Cancer Research S34 Cancers attributable to dietary factors in the UK in 2010: IV Salt DM Parkin 16 The fraction of cancer attributable to lifestyle and...
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báo cáo hóa học:" The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities" doc
... four-point response scale The instrument also contains an item assessing the perceived financial impact of the disease and treatment and two seven-point response scales pertaining to global health and ... Before testing the ability of the instruments to discriminate across disease-severity measures, the psychometric properties of the cancer- specific instruments in terms of internal consistency and construct ... cancer patients, especially considering the fact that members of the general public not often include aspects of adaptation into their valuations The responsiveness of the instruments needs to...
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Báo cáo lâm nghiệp: "Litter production in a Quercus suber forest of Montseny (NE Spain) and its relationship to meteorological conditions" pptx
... humidity in order to carry out the maximum photosynthesis, and this tends to be during the spring and part of the autumn During and after the appearance of shoots, the plant discards the old leaves, ... quite erratic and depends significantly on wind and storms The fall period takes place mostly at the beginning of springtime and the end of the autumn and varies a lot depending on the year as observed ... limiting factor and the density of the crown is found to be balanced with the level of rainfall and soil reserves [14] This is clearly reflected in the positive correlation between rainfall and the...
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báo cáo khoa học:" The ability of cancer-specific and generic preference-based instruments to discriminate across clinical and self-reported measures of cancer severities" pot
... four-point response scale The instrument also contains an item assessing the perceived financial impact of the disease and treatment and two seven-point response scales pertaining to global health and ... Before testing the ability of the instruments to discriminate across disease-severity measures, the psychometric properties of the cancer- specific instruments in terms of internal consistency and construct ... cancer patients, especially considering the fact that members of the general public not often include aspects of adaptation into their valuations The responsiveness of the instruments needs to...
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Báo cáo khoa học: "Bench-to-bedside review: Oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and posttraumatic shock" pptx
... [29] Indeed, the substantial differences in the proportion of trauma patients with severe head injury in the studies shown in Fig may account for the variation in the LD25 and LD50 points seen in ... equivalent to 120% of their SBV Alternatively, they were randomly assigned to initial resuscitation (R1) with a predetermined percentage of their SBV (again by infusing 5% colloid) equivalent to 8.4%, ... 120% of their SBV Then, after a hour delay period in which no further volume resuscitation was given, the animals were given the remaining portion of the calculated 120% of the SBV lost during...
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Báo cáo y học: "Bench-to-bedside review: The MET syndrome – the challenges of researching and adopting medical emergency teams"
... how the roles of ICU and hospital doctors and nursing staff are being viewed Nevertheless, allegiance to the traditional approach of initially calling the parent medical unit doctors when there ... accounting for 86.1% of these [45] Interestingly, in that study, 17.8% of all recordings of early signs and 9% of late signs were judged by nurses to be ‘usual for the patient’ These commonly included ... tracking effects over time, integrating detailed process knowledge into the work of interpretation, using small samples and short experimental cycles of change, and using multifactorial designs in...
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An investigation into the reality of teaching and learning speaking skills to the 2nd year non-major english students at pre-intermediate level of proficiency at hanoi university of industry
... made The thesis consists of three main parts: the introduction, the development, and the conclusion The introduction - gives rationale for the study and sets up the aims, scopes and methods of the ... Teachers’ and students’ attitudes towards speaking skill and the role of teaching and learning speaking skills 20 Table 2: Students’ purposes of learning English and their participation in learning to ... Language Teaching, speaking skills, three main stages of speaking and motivation in a speaking lesson Chapter investigates the current teaching and learning English speaking to the 2nd year non-major...
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Music cover, the effects of it and The attitudes of NEU’s students to Music cover in Vietnam
... made the song newer, brings the song back to the listener with the whole new style and the performance is completely like remaining the life for the song The cover music in Vietnam is the kind of ... many different opinions about that In the world, the covering music is very normal, but the singers or bands have to have permission of the artist Covering music is an art and the lyric writer ... meanings When audience can understand the lyrics of the original song and they make comparison, they mainly recognize that major of covered songs are not as good as the original ones Hence, they...
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A computational study to investigate the effects of insulation and EGR in a diesel engine
... reduce the extent of burning of last portions of fuel injected into the prechamber The unburned fuel in the prechamber may therefore increase with load, but its burning rate in the main chamber ... the brake-specific fuel consumption (BSFC) of the IDI engine to increase and the total engine efficiency to decrease compared to that of a DI diesel engine Because of these disadvantages of the ... operation, the momentum of fuel spray increases because of the increase of injection pressure and the increase of the injected fuel mass due to the increased effective flow area with increased...
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TEACHING PRONUNCIATION TO THE FIRST YEAR STUDENTS AT THE UNIVERSITY OF TRANSPORT AND COMMUNICATIONS a CASE STUDY
... pronunciation teaching in the context, specifying the shortcomings and then making suggestions to improve the teaching of pronunciation Aims of the study The aim of the study was to investigate how the teachers ... beyond the control of educators’ They qualified their findings by stating that variables of formal training and the quality of the training in pronunciation could affect the results, as would the ... stress) were taught at the beginning of the elementary course, and then they were integrated into the teaching of other areas during the courses The suprasegmental elements (intonation, rhythm, thought...
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HOW TO IMPROVE LISTENING SKILLS IN TOEIC THE CASE OF questions and responses short conversations
... objects of the study are: To study the theory of Listening comprehension, focusing on listening part and in TOEIC test, structure of each part and some tips to it To get know about the reality of ... and instructions 29 Thanking people and responding to thanks 30 Making, accepting and declining invitation 32 Making and responding request 33 10 Apologizing and responding ... as listening skills in TOEIC test Scope of the study In fact, there are lots of various methods to improve listening skills in TOEIC test, the case of part and It requires much of time and effort...
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Tài liệu The Game of Life and How to Play It pdf
... and she often made mental pictures of herself living in the house In the course of time, the man died and she moved into the house Several years afterwards, coming into the knowledge of Spiritual ... clothes and “rings and things,” but without envying others She lived in the world of the wondrous, and only riches seemed real to her Before long she married a rich man, and the rings and things ... disease) The student continued, “How long must one remain in the dark” and I replied, “until one can see in the dark,” and “casting the burden enables one to see in the dark.” In order to impress the...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25