the balanced growth path
The ubiquitin-proteasome pathway in cell cycle control
Ngày tải lên :
25/10/2013, 21:20
... and then effects the processive attachment of ubiqui-
tin monomers first to lysines on the targeted protein and then to lysines of
previously attached ubiquitins. The activation of ubiquitin by the ... down-regulated. The primary
mechanism whereby this requirement is met is via the APC/C-dependent
The ubiquitin-proteasome pathway in cell cycle control 157
minal to the F-box. In addition, some members of the ... domain
properly with respect to the catalytic site of the SCF core. The essentiality
of dimerization in the function of other Cdc4/Fbw7 homologs remains to be
determined.
The second class of SCF cofactor...
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Tài liệu Management by objectives and the Balanced Scorecard: will Rome fall again? doc
Ngày tải lên :
26/01/2014, 12:20
... remain as the focus (Bartol and Mar-
tin, 1991; Odiorne, 1987; Reddin and Kehoe,
1974).
The Balanced Scorecard
This section details the development of the
Balanced Scorecard, and defines the charac-
teristics ... has
been detailed as the failure of management to
shift their thinking to the human relations
model. It is worthwhile considering the impli-
cations of this with respect to the Balanced
Scorecard. ... is likely that the business envi-
ronment of the 1990s is more conducive to the
use of the human relations model than was
the case with MBO implementation. This is
associated with the widespread...
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Effective Performance Management with the Balanced Scorecard
Ngày tải lên :
09/02/2014, 21:12
... strategy.
Thus, the balanced scorecard design
process is founded on the premise of
strategy as a set of hypotheses about
cause and effect. These hypotheses
form the strategy for moving the
organisation ... intake).
Interestingly, users of the scorecard
noted that:
the more you understand the
scorecard and the more you get used
to reading it, the more you see these
connections and the more you
understand ... developed.
The report should outline:
The balanced scorecard objectives
and measures that the project has
an impact on;
The actions required to implement
the project;
– Desired project outcomes;
–The...
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- 4
A Practitioner’s Guide to the Balanced Scorecard
Ngày tải lên :
09/02/2014, 21:12
... teams developing the strategy and then grappling
with the issues of communicating and aligning the rest of the
organisation to the strategy. There were some notable
exceptions, with the case studies ... the architect
and the design team need to co-ordinate a series of meetings
with the sub–groups to refine the strategic objectives and
ensure they reflect the decisions made at the workshop. They
need ... essential that the architect and the team keep a clear
overview of the relationships between the various Scorecards,
the measures in each quadrant and the relationship of the
measures to each other. In...
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Tài liệu Báo cáo khoa học: Isoprenoid biosynthesis via the methylerythritol phosphate pathway Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase ppt
Ngày tải lên :
21/02/2014, 03:20
... wasincubatedwithH-DXRinthe
presence of NADPH, consumption of the cofactor was
shown by the decrease in the absorption at 340 nm,
suggesting that the enzyme reduced the aldehyde 4.Forthe
identification of MEP, the ... triterpenoids of the
hopane series from Methylobacterium fujisawaense demon-
strated for the first time the presence of a rearrangement in
the MEP pathway [48]. By analogy with the biosynthesis of
the amino ... NADPH-dependent reduction of the oxo
group to give the final product. In the reactions catalyzed by
the two enzymes, the ketol-acid and the DXP isomero-
reductase, the formation of the expected intermediates,
3-hydroxy-3-methyl-2-oxo-butyrate...
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Your Guide to the Breast Cancer Pathology Report pptx
Ngày tải lên :
06/03/2014, 02:21
... is
removed from the body to check for
cancer. These are called pathology
reports. Each report has the results
of the studies done on the removed
tissue. The information in these
reports will ... Your Pathology Report
• The pathology report answers
questions about a breast abnormality 6
• Is the breast abnormality a cancer? 6
• Is the breast cancer invasive? 7
• How different are the ...
Your Guide
to the
Breast Cancer
Pathology Report
TABLE OF CONTENTS
Wait for the Whole Picture
• Waiting for test results 2
• Get all the information you need 3
• Parts of your pathology report...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
Ngày tải lên :
06/03/2014, 09:22
... that the R645–R657 peptide competes
to disrupt the interaction of the JM region with
another non-identified region in the receptor [67]. The
non-identified region of the receptor to which the JM
region ... contributing to their pathogenesis [16–19].
The Ca
2+
signal generated by the EGFR
The activation of the EGFR generates a Ca
2+
signal,
broadly defined as the transient rise of the intracellular
concentration ... result
of the interaction of the distal segment of the JM, par-
ticularly the E663–S671 residues, with the C-terminal
lobe of the kinase domain of the apposed monomer
[48,69], as well as the stabilizing...
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Báo cáo khoa học: Prediction of missing enzyme genes in a bacterial metabolic network Reconstruction of the lysine-degradation pathway ofPseudomonas aeruginosa doc
Ngày tải lên :
07/03/2014, 09:20
... in metabolic pathways are found visually
by looking at the connectivity between the enzyme genes on
the pathway map reflecting current pathway knowledge.
Suppose that there is a pathway hole between ... In this study the param-
eter h is set to 10
5
. This means that, the larger the distance
between two genes along the chromosome, the smaller the
value of the similarity score. The resulting ... by the number of nucleotides between the end of
the i-th gene and the start of the j-th gene along the chro-
mosomes. We then derived a distance kernel using the for-
mula K
position
(x
i
,x
j
)...
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Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx
Ngày tải lên :
07/03/2014, 17:20
... increase of synthesis of pyr-
idine nucleotide cofactors, as the total pool of these
increased. Whether the synthesis is regulated by the
NADPH concentration remains speculation. The
G6PDH overproducing ... 6-phosphate is a branching point to several
pathways. It leads to the pentose phosphate pathway,
glycolysis and the pathways for biosynthesis of cell
wall components. The Aspergillus niger gene encoding
G6PDH ... Figure 4B shows the X-loading weights of the
X-variables (measured variables other than NADPH)
and the Y-loading of NADPH on the two PCs. As
NADPH is in the first quadrant of Fig. 4B (the four
quadrants...
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Báo cáo khoa học: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin⁄26S proteasome-mediated proteolysis potx
Ngày tải lên :
15/03/2014, 09:20
... interaction with the DSK2 homolog
from the respective species, we decided to test the
hydrophobic patches within the UBLs of the DSK2
homologs for their involvement in the interaction with
RPN13. The potential ... abolished the
association with RPN10 (Fig. 2B). These results indi-
cate that the UBLs of the human RAD23 and DSK2
homologs and yeast DSK2 play a role in the associa-
tion with the RPN10 homolog. Furthermore, ... critical for the interaction. S5a in parentheses is the
designated name for the human RPN10 homolog.
d
IF, the interface regions on the UBL–UBA factors that are involved in binding with the docking...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
Ngày tải lên :
15/03/2014, 21:20
... focuses on whether the terms of bank lending ease or tighten
over the course of the relationship as the relationship strengthens and the bank gains access to more
information. The extant theory offers ... in their life spans. During the early years of the fund, the senior managers search for and
screen new deals, and structure the contracts with the selected companies. During the middle years, the
venture ... of the relationship (whether it extends to deposits and other services),
3) the size of the borrowing firm and its outside finance options, 4) the structure of the banking industry, and
5) the...
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Báo cáo khoa học: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway potx
Ngày tải lên :
16/03/2014, 12:20
... epidermal growth factor receptor; IP, immunoprecipitation by the antibody to the protein indicated at the
right; WB, western immunoblot with the antibody to the compound indicated at the right. ... whether the SLe
x
level of InR on insulin-responsive cells in diabetic
patients was changed. This may reveal the role of the
sugar chains on InR in the pathogenesis of diabetes.
In summary, the ... epidermal growth factor receptor (EGFR) on the cell surface and in
cells, as well as the sialyl Lewis X (SLe
x
, the product of a1,3-FucT-VII)
content of the EGFR were unchanged. However the level...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
Ngày tải lên :
17/03/2014, 11:20
... serum-starved
andstimulatedwithEGForTGFa before the cells were
washed and Hrs was immunoprecipitated from the lysate.
We chose to stimulate the cells with the growth factors
for 8 min, as the growth factor-stimulated ... While EGF remains bound to the
receptor at the acidic endosomal pH, thus activating the
receptor kinase, transforming growth factor a (TGFa)
rapidly dissociates and leaves the EGF receptor inactive
after ... of the epidermal
growth factor receptor signaling pathway. J. Biol. Chem. 277,
1031–1039.
37. Willingham, M.C., Jay, G. & Pastan, I. (1979) Localization of the
ASV src gene product to the...
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Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc
Ngày tải lên :
23/03/2014, 15:21
... expected, the
largest differences are found for the PPP split-ratio and
the fluxes of the nonoxidative branch of the PPP.
The minimized covariance-weighted sum of
squared residuals (SS
res
) in these ... normalized for the glucose-uptake rate.
Values outside parentheses denote the net
fluxes, while values inside parentheses
represent the exchange fluxes. Solid arrow-
heads denote the direction of the net ... of the traditional
model. The similarity of the flux estimates indicates
that the presence of isoenzymes reduces the difference
in
13
C-label distribution between the two models and
impedes their...
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The Next Growth Opportunity for Banks: How the Post-Crisis Financial Needs of Younger Consumers Will Transform Retail Banking Services pdf
Ngày tải lên :
29/03/2014, 08:20
... to address their needs using the
tools they and their peers have adopted, including mobile devices, video, and
social networking—and they are willing to switch to banks that embrace these
technologies. ... Younger customers trust banks to help them. Despite challenges caused by the
economic crisis, Gen Y and Gen X customers still trust their banks and want them
to be their primary providers of advice. ...
This finding does not predict the demise of the branch channel, but rather the advent of a
much more prominent virtual one. In fact, when asked about where these customers would
like to finalize...
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