the atrophy hypertrophy complex in liver disease
Báo cáo y học: "Combined left hepatectomy with fenestration and using a harmonic scalpel, fibrin glue and closed suction drainage to prevent bile leakage and ascites in the management of symptomatic polycystic liver disease: a case report" pps
... desirable The aim of our study was to prove the suitability of the ultrasound scissors, closed suction drain and fibrin glue in surgery for PLD In our clinic, this cutting device is mainly used in laparoscopic ... Ethicon Endosurgery, Cincinnati, Ohio, USA) The diameter of the removed lobe was 17 cm (Figure 3) Cysts located on the surface of the right hepatic lobe, including the three dominant cysts, were ... symptoms The optimal treatment for symptomatic PLD is uncertain There is no clear consensus regarding the optimum timing of intervention and the surgical approach is based in part on the number,...
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Báo cáo khoa học: The chloroplast ClpP complex in Chlamydomonas reinhardtii contains an unusual high molecular mass subunit with a large apical domain doc
... ClpP1L in denaturing gel Both of them originated from the last 90 C-terminal residues of the protein, one of them from the very C terminus In the MS analysis, no peptides were found corresponding ... protein elements called inteins [27–29] Inteins are autonomously folding protein domains capable of selfexcision, and are present in many essential proteins throughout the three kingdoms of life In ... extension has been hypothesized to in uence access to the substrate binding pocket [18] Another interesting feature of these proteins is the mutation into a bulkier residue of the second of two G...
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Báo cáo khoa học: The role of DYRK1A in neurodegenerative diseases docx
... hyperphosphorylated in the DS brain Gene dosage-related increases in DYRK1A levels in DS appear to be the major factor distinguishing the pattern and consequences of tau protein hyperphosphorylation in DS and in ... [20,22,43]; the DYRK1A-stimulated, several-fold increase in the rate of tau protein phosphorylation by GSK-3b [20,43]; the several-fold increase in the number of DYRK1A-positive NFTs in the brains of ... immunoreactivity in the nucleus, cytoplasm and synapses in the CA4 sector (D) Immunoreactivity in the cortex is weaker than in the hippocampus and is more prominent in pyramidal than granule neurons (E, F) In...
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Báo cáo khoa học: Analysis of the RNA degradosome complex in Vibrio angustum S14 potx
... results Incubations were at 25 °C The horizontal axis indicates the protein fused with the T18 domain and the vertical axis indicates the protein fused with the T25 domain Empty cells indicate ... comigrating with the RNA degradosome in the native gels Together with ribosomal proteins, we identified enolase and PNPase in these high-molecular-mass complexes, confirming the results obtained in ... bands containing RhlB may have been reduced as the proteins were in their native rather than denatured state, making the epitopes more difficult to recognize by the antiserum It is interesting to...
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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... probiotics in allergic disorders The interest in probiotic therapeutic potential in allergic disorders stemmed from the fact that they have been shown to reduce inflammatory cytokines and improve intestinal ... and the others The type of probiotic product was different as well as the timing of the introduction of the probiotic, Taylor et al administered the probiotic supplement postnatally, while other ... Bjorksten B: The gastrointestinal flora and the skin Is there a link? Pediatr Allergy Immunol 2001, 12(Suppi 14):51-5 Sepp E, et al.: Intestinal microbiota and immunoglobulin E responses in 5-year-old...
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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
... the result of a single SNP in Ncf1, resulting in the shift from threonine to the disease- promoting methionine at position 153 in the p47phox protein [21] The consequences of the amino acid shift ... coincide with any critical binding sites It is most likely that the shift affects the three-dimensional structure of the protein, impairing the binding capabilities to the other proteins in the ... samples as the initial analysis and can therefore not be considered to be independent from each other Nonetheless, in order to obtain an indication of the validity of the P values obtained in these...
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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
... understanding of the role of this cytokine in human diseases Conclusions The cytokine field is constantly growing as novel moieties are described The principal challenges facing us now are to define the ... receptor chain with high affinity (1011/M) and slow off-rate, rendering it a useful and specific inhibitor in biologic systems Common γ-chain signalling cytokines – interleukin-15 and interleukin-21 ... blockade (p40) in psoriasis suggest that singlecytokine targeting can reap rich rewards in complex polygenic diseases In the future, rational targeting using pharmacogenomic or protein biomarker-based...
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Báo cáo y học: "The role of stress in rheumatic diseases" ppsx
... depression, anxiety) and pain are processed somewhat independently in the central nervous system [7] Supporting this conclusion are the clinical data indicating that drugs acting as both antidepressants ... or serotonin–norepinephrine reuptake inhibitors) are equally effective analgesics in chronic pain conditions in patients with and without depression [8] The lack of direct overlap in the central ... between these systems Observable changes in the ANS or HPA axis tone in some individuals may represent a baseline diathesis or risk factor for the subsequent development of chronic pain, or the changes...
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Báo cáo khoa học: "Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease" potx
... et al proteins such as fibronectin and laminin, and it plays a role in wound healing [26] Decorin is the smallest dermatan sulphate containing PG The presence of decorin alters the kinetics of ... endostatin The binding of endostatin by heparan sulphate is important for its antiangiogenic function [52] The interaction between heparan sulphate and laminin could be important in determining the integrity ... sulphate binds FGF, storing it in an inactive form until needed, thereby allowing rapid response to stimuli [44] Another well studied example of protein-GAG interaction involves the binding of antithrombin...
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Báo cáo y học: "The dosage-compensation complex in flies and humans" ppt
... high-affinity binding sites for the DCC, which the complex can bind even when it is missing certain subunits In addition, there could be many binding sites of lower affinity throughout the remainder ... ISWI-containing remodeling factor is involved in the assembly of H1-containing chromatin He proposed that the reason only the X chromosome lacks H1 is that the small maternal contribution of ISWI in these ... on the chromatin composition of the male X chromosome in iswi mutants: immunostaining has revealed that the chromatin of the X chromosome, but not the autosomes, lacks histone H1, suggesting...
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Ascites and Renal Dysfunction in Liver Disease Pathogenesis, Diagnosis, and Treatment docx
... drain into mucosal venules, which in turn drain into collecting venules which join to form main venules and finally drain into the portal vein except the distal rectum, which drains into the internal ... for Pt (in the mucosa of the rat small intestine) that increases during intestinal absorption and decreases during cholera toxin-induced intestinal secretion Pt increases in response to intra-arterial ... degraded by kininases (I and II) The kidney is rich in tissular kallikrein and all the different components of this system (kallikrein, kininogen, kinin binding sites, and kininases), although they are...
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Biochemical characterization of the bi lobe complex in trypanosoma brucei
... forms during its alternating life cycle between and within the insect and mammalian hosts (Fig 1-1) Procyclic form found in the midgut of the fly vector and the bloodstream form living in the mammalian ... during the cell cycle in a dynamic pattern Starting with the MtQ at the time of its assembly, TbPLK then localizes to the basal bodies as they duplicate, passing through the FPC and bilobe to the ... are among the symptoms of the first stage of the disease Following penetration through the blood-brain barrier, the parasite invades the central nervous system (CNS) and patients enter the second...
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Trinucleotide (CAG) repeat polymorphism of the androgen receptor gene in human disease
... amino acids at the base of the first zinc finger (glycine 577, serine 578 and valine 581) which are essential for the interaction of the AR protein with the hormone response elements (HRE) in the ... huntingtin, the poly-glutamine expansion are located within the amino terminal region, while for the atrophin is near in the Cterminus (Choong et al, 1998) An interesting observation is that there ... mediate or modulate proteinprotein interactions, raising the possibility that changes in their length during evolution could result in changes in the strength of protein-protein interactions As a number...
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Analysis of the multisubunit exocyst complex in schizosaccharomyces pombe
... that in the actomyosin ring, bipolar myosin filaments connect to each other by actin filaments The ‘walking’ of myosins along the actin filaments then results in the contraction of the actomyosin ... filaments and finally tightening into a ring structure, suggesting that the spot may represents the progenitor of the actomyosin ring Interestingly, the Myo2p ring constricts into two spots at ... formation of the actomyosin ring in the subsequent round of mitosis, indicating that the Myo2p spot is important for the assembly of the actomyosin ring 1.2.2.3 A SIN pathway regulating septation In S...
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Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... in pink, and the hinge region of the ISP is shown in white the integration or stability of the ISP within the bc1 complex In order to investigate its effect on the bc1 complex, we introduced this ... glutamate could interfere with the movement of the ISP, which would, in turn, alter the catalytic activity of the complex The mutation could also affect the binding of the ISP to the bc1 complex and ... enzyme with their ISP in different conformations The mutation G167E could distort the hinge region of the ISP and hinder the movement of the headgroup Mutations in the hinge region of the ISP, which...
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Nonalcoholic fatty liver disease in children living in the obeseogenic society doc
... seem to depend on continuing therapy as rebound increase of liver enzymes and worsening of histological features happen following cessation of therapy Other concerns include increased body weight ... not to a liver biopsy is commonly raised Arguments against liver biopsy include cost, sampling error, variability of pathological interpretation, the benign nature of the disorder in the majority ... clinical background and imaging studies On the other hand, performing liver biopsy will establish the diagnosis, provide prognostic information, assess severity, and motivate the patient and the...
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The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years pptx
... patients including ANA in 15.4%, and SMA in 10% of patients Liver histology The main liver biopsy features are summarised in table Some degree of fibrosis was present in 59% of children including ... requiring liver transplantation in paediatric NAFLD remains uncertain, and further studies in this area are needed It is also intriguing that both cases undergoing liver transplantation in our ... conditions inducing cellular stress and insulin resistance; both insulin resistance and oxidative stress are key components in the development of NAFLD.42 The main strengths of our study are the inclusion...
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Báo cáo hóa học: " Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice" ppt
... are indicated in bold/underlined) from the template of a pUC19 plasmid DNA containing GH1 (Xinxiang Medical University, Xinxiang, Henan Province, China) The 677-bp GH1 DNA fragment (including the ... recombinant protein administration and thus avoid the inconvenience of repetitive subcutaneous injections Therefore, we used GH gene delivery technology rather than recombinant GH injection in this ... was gradually increased from 17% to 35% during the first week of feeding and then maintained at the same concentration for another weeks [25] Food intake was recorded daily in the control and...
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Báo cáo sinh học: " The association of complex liver disorders with HBV genotypes prevalent in Pakistan" doc
... remaining individuals become asymptomatic carriers In perinatal transmission, there is a strong chance for the child to become chronically infected compared to the infection acquired during adulthood,(about ... reflecting the geographical difference but instead are showing the most prevalent genotype as most virulent as in the case of Europe then why is genotype A more common in Acute infection in Japanese ... manifestations In the recent years, there has been an explosion of knowledge regarding clinical significance of HBV genotypes in terms of clinical outcomes and therapeutic response to antiviral therapy in...
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Báo cáo hóa học: " The association of complex liver disorders with HBV genotypes prevalent in Pakistan" pdf
... remaining individuals become asymptomatic carriers In perinatal transmission, there is a strong chance for the child to become chronically infected compared to the infection acquired during adulthood,(about ... reflecting the geographical difference but instead are showing the most prevalent genotype as most virulent as in the case of Europe then why is genotype A more common in Acute infection in Japanese ... manifestations In the recent years, there has been an explosion of knowledge regarding clinical significance of HBV genotypes in terms of clinical outcomes and therapeutic response to antiviral therapy in...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008