... last) the elements with a value equal to value & returns an iterator to the new end of the range, which now includes only the values not equal to value Removes from the range [first, last) the ... removed from the same end • The queue container adaptor is a “First In, First Out” (FIFO) data structure characterized by having elements inserted into one end & removed from the other end • The priority ... each element copied, the value is assigned & the iterator is incremented • Each copy requires the target container is of a sufficient size to hold the set of assigned elements • The argument passed...
... container from the end to the beginning Reverse iterators reverse the more usual behavior of ++ and – rp moves the reverse iterator rp towards the beginning of the container rp++ moves the reverse ... ordered pair in the map The STL provides a template class pair defined in the utility header file You may wish to read about the multiset and multimap See Josuttis, The C++ Standard Library Addison ... property of the items called the priority, so that the highest priority item is removed first The deque is the default container for both stack and queue A vector cannot be used for a queue as the queue...
... first line of the SUV constructor passes the make, model, and year up to the base class, so they can be initialized in the base class, thereby avoiding the need to duplicate them in the initialization ... use, then look at the value of the Class attribute in the web service’s asmx file (see the attribute at the start of the asmx file) and use that appended with the name of the ... Choose the first option because the Microsoft AJAX Library option contains just the client JavaScript components that are included in the full ASP.NET AJAX installation On the other hand, besides the...
... and the utilities that thelibrary uses Then, I describe all the components, each in one or more chapters The first component is the standard templatelibrary (STL) There is no doubt that the ... the name of the file containing the program as the first comment line You can find the files on the Internet at the Web site of the book: http://www.cppstdlib.com 1.5 State of the Art The C++11 standard ... presenting the contents of this book One was on the order of the C++ standard However, this is not the best way to explain the components of the C++ standard library from scratch Another approach...
... the inhibitors as well as to the packing constraints of the environment The larger and wider the features of the ligands that compete with the occluding loop for binding to theactive site, the ... N-terminus, theactive site C29 The C-terminal domain is based on a four-stranded b-barrel fold, contributing H199, the other active site residue Theactive site cleft is formed at the interface ... human [22] and rat procathepsins B [23] They revealed that, in the zymogen form, the propeptide rather than the occluding loop fills theactive site cleft It was shown that the single and double...
... the activity Given the 3D structure of the HtA active site, and the interactions between side chains, we propose that D40, H42, R95 and F126 also form part of it As in other ribotoxins, theactive ... the structure of the remaining part is the same in both proteins, including a short segment (N56, C57 and D58) forming a turn of 310 helix (D75, C76 and D77 in a-sarcin) Theactive site Theactive ... further than other ribotoxins to become smaller and more economical At the same time, theactive site of HtA, as revealed by the 3D structure, shows a different arrangement to that shown by the...
... conned to the substrate binding cleft (the 170 loop) in theactive site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and theactive ... in the vicinity of the S1 pocket [11,34], in the rst part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areas that are stabilized by TF [9,25,26] The ... substrate processing These bonds are two of the components of the invisible scaffold supporting theactive conformation One bond participates in stabilization of the 170 loop while the other connects...
... respectively, the amounts of protein (lg) in the TH and DO activity peaks Yields were calculated with the values in parentheses, which are the three most active fractions from the purification ... is at pH These preferred activities of the two PPOs of R solanacearum are opposite to the names assigned to them when the genome of this bacterium was sequenced and the function of these conceptual ... logical according to the mathematical algorithm used for the blast search Score and e values depend on several factors, but mostly the total length of the sequence used for the blast The shorter sequence...
... between the base G4 and the sidechain of Asn122 In the second model (Fig 1B) the structure of the hexanucelotide is, on the whole, unchanged and the majority of the interactions that were seen in the ... at the bottom left and the target adenine is at the top of each model The sidechains of RTA are shown in blue (A) Model has the tetraloop bound in theactive site of RTA with G4 stacked upon the ... 234 and 235 [9] Of theses residues, only Arg213 is in the vicinity of theactive site of RTA In order to establish the role of arginyl residues around theactive site of RTA in the binding of rRNA,...
... during the activation step of the ready enzyme increases the lag phase without preventing the activation [29] On the other hand, when added to theactive enzyme, O2 would react directly with theactive ... (probably the HupU subunit) interacts with the N-terminal domain of the histidine kinase HupT to transduce the signal of H2 availability [13] We therefore addressed the question of whether the mutation ... the deeply buried active site [23–25] As both molecular H2 and O2 are hydrophobic gases, they probably use the same access pathway to the hydrogenase active site The amino-acid sequences of the...
... properly as a lid for theactive site, thereby granting easier access for the cofactor ThDP to its binding site The lower thermal stability of the mutant E1s and the increased Vmax in the DCPIP assay, ... detected by the PDH assay The interaction of E1 (a2b2) with the PSBD was unaffected by any of the mutations in E1a (Fig 4) Therefore, any effects of the mutations on the catalytic activities of the PDH ... with the E1 crystal structures in that the arginine residues corresponding to E1aR282 of the B stearothermophilus E1 are not pointing towards theactive site, identified by the C2-carbon of the...
... located in the insert within the catalytic domain, close to the catalytic His264, and the proximity to theactive site may explain the effect of oligomerization on enzyme activity Even though the exact ... differences in the C-terminal part of the enzyme (Fig 2A) where 13 of 44 amino acids are different Therefore, chimeric enzymes with the N-terminal part from the human and the C-terminal part from the murine ... a chaperone or other factors influencing the formation of theactive complex For example, it is possible that a protein in the 293-cells sequesters the Arg-containing subunits, thereby preventing...
... simulations of the modelled binary GK–ATP complex revealed that the global rmsd of the structure converged at the end of the 2-ns simulation period (Fig S2A) The dynamic changes in theactive site ... 0.02 mM The data points and the solid line represent the difference between the WT and T228M hGK titrations (C) The same experiment as in (A), but performed on the GST fusion proteins The titration ... of these residues with the nucleotide at theactive site The catalytic mechanism of GK has been the subject of several detailed analyses, and is still a partly unresolved issue Although some theoretical...
... and the I2BS stereospecificities would be useful Interestingly, the lowest-energy orientation for each of the three ligands in the large active site of MAO-A put them in the middle of theactive ... these I2BS ligands might be expected to bind in theactive site in the same way as other reversible MAO-A inhibitors In the experiment in Fig 3, the extinction coefficient for guanabenz from the ... given in Table Evidence for the proximity of these ligands to the flavin in MAO-A comes from the influence of the ligand on the redox properties of the flavin Like other inhibitors of MAO-A [23,30],...
... more than 50% of them clustered together in front of the rectus (re)-face of the isoalloxazine ring of the FAD cofactor This substrate location is shown in Fig 2A, which includes the 10 molecules ... nidulans, and the activities of the site-directed variants (when active) could be directly detected in filtrates of 48 h cultures of the transformants harbouring the mutated aao sequences The first ... with the hydroxyl group in Ca, representative of the range of AAO substrates [9,19,33] Most of these alcohols docked in front of the re-side of the isoalloxazine ring of FAD [34], with the benzylic...
... that the carboxylic groups in the Asp140-Asp142-Glu144 triad contain two protons at the pH where the enzyme is most activeThe basic arm of the pH-activity profile must be determined by the loss ... in the preceding run Some of the pH profiles differed strongly from the wildtype profile, however, the profiles for the amide and corresponding alanine mutants were similar in all cases Together these ... the D140N, D142N, E144Q and D215N mutants, the pH-dependency of specific activity was recorded for these four mutants and the four corresponding alanine mutants The least active mutants (i.e the...
... parallel to the a-helices and the b-sheet of the protein As the 1HN-15N bond vectors in the a-helices are therefore almost parallel to the z-axis, their size is mainly determined by the positive ... addition, the C-terminus folds back onto the core of the protein thereby allowing the side chain of Leu86 to partly fill the hole created by the removal of Ile14 Due to these changes other alterations ... used for the calculations Therefore, we recalculated the structure of the wild-type protein on the basis of the restraints used previously [15] with the same protocol used here for the Incidence...