the action query family

Another Piece of the Action

Ngày tải lên : 06/11/2012, 16:13

... exact same moment of time. There was the smell of the perfume she had chosen that day, the quality of her voice, the people that were in the corridor at the same time, and the way she had looked ... have the power to destroy the turtle head, but instead you play games with him?” Duana asked. It was enough of a distraction that Worf ran him through the chest with the sword, all the way to the ... Fleet’s return. The first wave of intruders arrived on the deck of the Minnesota just prior to the Captain officially hailing the planet’s leader. The Iotian’s President appeared on the view screen...

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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis

Ngày tải lên : 25/10/2013, 21:20

... shaded areas). Within the pocket domain (pocket subdomains A and B and the spacer region) the highest homology between the pRb protein family is found in the A and B subdomains. The pocket-domain ... reflect the not yet fully understood specific functions of these proteins at these specific stages of the cell cycle. 4.4 pRb Family Mediated Regulation of E2F by Cellular Localization Another level ... phosphorylation of these sites are involved in the regulation of p130 specific functions and interactions. The difference in phosphorylation sites and kinases involved in the phosophorylation of these sites...

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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc

Ngày tải lên : 13/02/2014, 06:20

... within the time constraints of the family planning clinics. On the other hand, a client is potentially done a disservice if the information provided conceals or downplays information about the mechanism ... Demographic information was asked at the conclusion of the questionnaire. The Spanish and the English version of the questionnaire are available from the authors upon request. The questionnaire was distributed ... offering students courses in technical and other subjects after they have left school. ‡ Other: includes the other options in the questionnaire: "there is no exact time", "I am not...

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Tài liệu Produced jointly by the British HIV Association (BHIVA), the British Association for Sexual Health & HIV (BASHH) and the Faculty of Family Planning & Reproductive Health Care doc

Ngày tải lên : 13/02/2014, 10:20

... which there is no restriction for use of the method 2 A condition where the advantages of using the method generally outweigh the theoretical or proven risks 3 A condition where the theoretical ... based on a ‘welfare of the child’ assessment, as in any other couple 57 . The treating HIV physician should be asked to sign the Welfare of the Child form in preference to the GP as he/she is ... Page 6 of 62 There is limited and controversial data on the effect of HAART on the natural history of disease and so management of women should be the same whether receiving therapy or not....

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Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc

Ngày tải lên : 18/02/2014, 06:20

... indicating the direct suppression of Per1, 2 and 3 by these miRNAs (Fig. 3B–D). Together, these data indicate that the miR-192 ⁄ 194 cluster is a potent and direct regulator of the Per gene family. Endogenously ... in the absence of a functional SCN [27]. Therefore, it would be interesting to determine the exact role of miR-192 ⁄ 194 in these tissues. Together, the identiﬁcation of inhibitory miRNAs for the ... in an anti-phase fashion to that of the CCGs. When the other negative regulators of BMAL1, the Per and Cry proteins, are at their peak levels in the nucleus, they function in complexes to suppress...

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Tài liệu Báo cáo khoa học: Bioinformatics of the glycoside hydrolase family 57 and identiﬁcation of catalytic residues in amylopullulanase from Thermococcus hydrothermalis doc

Ngày tải lên : 19/02/2014, 12:20

... and, in the case of equal lengt hs, a lphabe tically. The division is based on the evolutionary tree s (Fig. 4). For the amylopullulanase from Thermococcus hydrothermalis (Q9Y8I8_THEHY), the numbering ... by the fact that the reactivation of the enzymes could be achieved by the addition of an external nucleophile to the reaction medium. Gratifyingly, in T. hydrothermalis amylopullulanase, the ... data). Therefore, in attempt to provide the ﬁrst elements towards the understanding of the functionality of the potentially valuable, heat stable GH-57 enzymes, especially that of the T. hydrothermalis...

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Tài liệu Báo cáo khoa học: Evolutionary relationships of the prolyl oligopeptidase family enzymes docx

Ngày tải lên : 19/02/2014, 13:20

... respect to the studied enzymes of the POP family, POP seems to be the most conserved enzyme. Ten conserved amino acids were found at the active site of the enzyme of each of the studied POP family ... were used as the outgroup in this analysis, as this enzyme is a close neighbor to the POP family and a member of the serine protease family S28. The NJPLOT program was used to display the constructed phylogenetic ... proposed that the b-propeller of P. furiosus POP does not perform the same function as the mammalian enzyme, i.e. the exclusion of large peptides from the active site [25]. Clearly the role of the b-propeller has...

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Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx

Ngày tải lên : 22/02/2014, 07:20

... Thus, the proteins of the CYP11B subfamily catalysing the last biosynthetic steps are the key enzymes for the synthesis of both mineralocorticoids and glucocorticoids. From molecular cloning of the ... evolution and function of the hormonal system. We ﬁrst cloned the genes of the CYP11B family of the guinea pig. The 11b- hydroxylase of the guinea pig showed higher substrate speciﬁcity than the aldosterone ... sequences of the CYP11B family. These analyses showed that CYP11B2 proteins are more closely related to each other than CYP11B1 proteins across species. Furthermore, the 3¢ UTR of the guinea pig...

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Báo cáo khoa học: Structure analysis of the ﬂavoredoxin from Desulfovibrio vulgaris Miyazaki F reveals key residues that discriminate the functions and properties of the ﬂavin reductase family pdf

Ngày tải lên : 07/03/2014, 02:20

... sheet with the b12 of the other monomer, and towards the C-terminus, the subsequent residues, Phe182–Lys186, pass through the a2 vicinity of the other monomer. For the FeR dimer, the N-terminal ... oxygen for the oxygenase reaction [8]. In this family, neither component of the enzyme binds ﬂavin tightly as a cofactor, but rather utilizes it as another substrate [8]. Considering the amino ... enzymes; these reactions depend on the redox ability of the ﬂavin species. Although the basic redox reactions are identical or similar, it is of interest to understand the molecular bases for the...

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Báo cáo khoa học: Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family pot

Ngày tải lên : 07/03/2014, 09:20

... enzymes. The most signiﬁcant difference between the amphioxus and the other retinal reductases was, nevertheless, their preference for the NADH cofactor. To our knowledge, these are the ﬁrst ... Reactions were started by the addition of cofactor and carried out for 15 min at 37 °Cin 0.5 mL. The amount of protein used in the reaction mixture was 15 lg. The reaction was terminated by the ... charged amino acids at the N-terminus of the signaling sequence, but rather contained the L24ERGR motif at the C-terminus of the hydrophobic sequence, thereby resembling the R19ERQV, R19ERKV,...

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Báo cáo khoa học: Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family pdf

Ngày tải lên : 07/03/2014, 12:20

... however, there is no report showing the presence of PQRFamide peptides in other vertebrates. On the other hand, we recently identiﬁed a new member of the RFamide peptide family that has either ... neuropeptide action. We therefore characterized the regions in the brain showing the expression of lamprey PQRFamide peptide mRNA using in situ hybridization. The expression was localized mainly in the ... were then compared with those of other RFamide peptides. Consistent with the result of the phylogenetic analysis, lamprey PQRFamide peptides displayed the highest sequence similarity to the group...

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Báo cáo khoa học: Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins pot

Ngày tải lên : 07/03/2014, 16:20

... major bands in e and f, while the numbers at the left are the pI values of standard proteins. The arrow at the right represents the pI value of 6.84 calculated for the unmodified CLAP p rotein based ... the proteins reached their equilibrium positions, the gels containing the CLAP e, f, pI standards, and buffer only were removed from their glass tubes, soaked in distilled water for 5–10 min then ... member o f the fas ciclin family of proteins, w e w ere i nterested t o know whether the protein – like many o ther fasci clins – has been modified C-terminally with a GPI moiety [36]. The presence...

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Báo cáo khoa học: Relation between domain evolution, speciﬁcity, and taxonomy of the a-amylase family members containing a C-terminal starch-binding domain pot

Ngày tải lên : 08/03/2014, 08:20

... separates the amylase group from the CGTase group, while the thin dotted line indicates the change of the border between the two parts in the C domain tree and the SBD tree. Ó FEBS 2003 a-Amylase family ... the ﬁve-domain members of the GH 13, can be taken as an approximation of the ﬁrst three domains in the four-domain members. It also shows the typical Table 1. The enzymes from the a-amylase family ... performing the searches in the molecular biology databases (using the default parameters) to retrieve for comparison all the relevant enzymes from the a-amylase family having a C-terminal SBD. As query, the...

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Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot

Ngày tải lên : 15/03/2014, 10:20

... neuron-speciﬁc [8]. The APP family of proteins is believed to play important roles in both the peripheral and central nervous systems [6]. In the former, they are involved in the formation and ... is the b-site APP-cleaving enzyme 1 (BACE1). Here, we investigated the effects of genetic manipulation of BACE1 on the processing of the APP family of proteins. BACE1 expression regulated the ... relevance of these complexes has yet to be demonstrated. As we found that BACE1 activity regulates the maturation and the processing of the three APP family members, we were interested determining whether...

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Báo cáo Y học: Cloning of the manganese lipoxygenase gene reveals homology with the lipoxygenase gene family doc

Ngày tải lên : 18/03/2014, 01:20

... Mn-LOX-Gga gene, Northern and Southern blot analyses. (A) The Mn-LOX-Gga gene. The open box indicates the protein coding region. The solid lines show the 5¢-and3¢-UTR and the intron. An arrow ... has identiﬁed the Fe(II) ligands. These are one water molecule and ﬁve amino acids [12]. The iron ligands are the carboxyl oxygen of the C-terminal isoleucine (or valine) residue, the nitrogen ... (5¢-UTR) (up to the vector sequence) and  0.6-kb of the 3¢-UTR. The GC content averaged 60.5%. The 5¢-UTR did not contain TATA or CAAT-like boxes. The transcription start point for the Mn-LOX-Gga...