targeting the antioxidative capacity of regulatory t cells

Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx

Ngày tải lên : 08/08/2014, 21:20

... et al, Regulatory T Cells in the Context of Allergic Disease thus preventing the activation of mast cells and basophils IgG4 has been shown to reduce the IgE-mediated degranulation of these cells ... required to elucidate the in vivo role of these cells and their subsets Effects of SIT on Dendritic Cells To understand the mechanisms of action of SIT, some cardinal steps should be explained The ... mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated oral LCs expressed...

5
503
0

Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot

Ngày tải lên : 09/08/2014, 01:24

... Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, ... suggested that the TR responses are specific for selfantigens It is thought that TR cells in mice represent those thymocytes with the highest affinity for self-peptide but that are below the threshold ... decreases the ability of these dendritic cells to activate T cells [20,21] IL-10 can also have direct effects on CD4+ T cells Constant antigen stimulation of T cells in the presence of IL-10, either...

8
478
0

Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

Ngày tải lên : 09/08/2014, 06:22

... the rest of the body was determined using a γ-counter Thereafter, the total radioactivity recovered per animal was calculated by adding the counts of the organs and the rest of the body (a) The ... depletion ameliorates the acute stage of the model [15] On the other hand, it could be possible that the suppressive function of regulatory T cells is switched off under the inflammatory conditions ... If these hypotheses are correct, then they could explain why the transfer of Treg cells after arthritis induction is not effective On the one hand, transfer of Treg cells 24 hours after intra-articular...

11
440
0

Báo cáo y học: "Japanese Encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells" doc

Ngày tải lên : 11/08/2014, 21:21

... replication DCs infected with P3 attenuated allostimulatory activities to T cells To test whether P3 infection will impair the ability of DCs to activate allogeneic naïve T cells, the direct effect ... UV-P3-stimulated DCs did not alter the expansion of the Treg, as well as the mock-treated DCs Discussion Most studies conducted to evaluate the pathogenesis of JEV infection have noted the interaction ... present antigen to and activate T lymphocytes through up-regulating the expression of costimulatory and antigen presentation-associtated molecules at the mature stage [17] To examine whether the characteristics...

11
252
0

Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx

Ngày tải lên : 14/08/2014, 19:22

... onto the Ficoll Paque so that they form two separate layers After the centrifugation at 1800 rpm for 20 min, the leukocytes can now be collected at the interphase between the Ficoll Paque and the ... directly to DCs may a new alternative of therapies for patients with allergic asthma These findings suggest that spleen DCs and Foxp3+Tregs prevents the generation and activation of Th2 effector cells ... novel pathway of regulation of type immunity in asthma Competing interests The authors declare that they have no competing interests Authors' contributions YL performed all analyses and wrote the...

8
258
0

Báo cáo Y học: Repression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells pptx

Ngày tải lên : 24/03/2014, 03:21

... respectively The NFAT-Luc reporter was constructed by inserting an oligonucleotide encoding the NFAT binding site of the FasL promoter (5¢-ATTGTGGGCGGAAACTTCCAG-3¢) with additional GATC motifs at the ... line that was stably transfected with the NFATZH reporter construct (Oum, J.-H & Park, J., unpublished results) The reporter construct contained three copies of the distal NFAT binding site in the ... the FasL promoter Therefore, it is possible that the activities of RA are mediated through transcriptional modulation by other nuclear transcriptional factors, such as NFAT and SP-1 To test this...

9
481
0

báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot

Ngày tải lên : 18/06/2014, 15:20

... concluded that hTERT p540 is not expressed or is cryptic on the surface of tumour cells and that immunization of cancer patients with hTERT p540 leads to the production of T cells that not recognize tumour ... with hTERT-pulsed DCs homing of the tumour-specific T cell populations to tumour sites contributes to the effectiveness of the antitumour immunity generated [85] Unfortunately, due to the limited ... substantial generation of tetramer+, CD8+, T cells In fact, the responses generated to the two DC preparations were atypical only in this particular patient The remaining patients showed the pattern...

23
439
0

Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx

Ngày tải lên : 09/08/2014, 06:23

... treatment decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint inflammation and the reinstatement of ... all these studies CD4+CD25+ Treg were detected in the joints or synovial fluid of the patients In these reports it was also shown that the identified CD4+CD25+ Treg had a suppressive function ... autoimmune inflammation These results therefore further indicate, in keeping with the paper by Frey and colleagues, that therapeutic use of CD4+CD25 Treg might not be a feasible option treatment...

3
336
0

Báo cáo y học: "haracterization of regulatory T cells in urban newborns" pptx

Ngày tải lên : 13/08/2014, 13:22

... and the R system for statistical computing [27] Results Subject characteristics The subjects in this study consisted of a subset of newborns and mothers enrolled in URECA at the Boston study site ... phytohemagglutinin (PHA) The median is represented by the horizontal bar within the box The upper and lower boundaries of the box represent the 25th to 75th percentiles of the data, respectively Observations ... no statistical differences in baseline characteristics of newborns with and without proliferation data (Table 1) Although of the infants were admitted to the ICU, none of them were intubated...

10
233
0

Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps

Ngày tải lên : 09/08/2014, 01:23

... characterisation of the surface profile of TR cells has revealed them to be quite distinct from conventional naïve effector T cells Aside from the constitutive expression of CD25, TR cells show elevated ... (b) TR cells outcompete TE cells for stimulatory ligands on the APC surface by virtue of their high expression of adhesion molecules (c) TR cells modulate the behaviour of the APC so that they ... confirmation of whether such peripherally generated regulatory cells are contiguous with naturally occurring TR cells or are simply another T cell activation state will have to await the assessment of...

7
576
0

Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot

Ngày tải lên : 09/08/2014, 03:24

... death of some T cells [48,49], while others observed that this cytokine protected T cells from apoptosis [50,51] We favor the hypothesis that TGF-β promotes the death of mature Th1 and Th2 cells ... Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes Characterization of the CD4+ T cell subset that inhibits this autoimmune potential J Exp ... activation of CD4+ CD25+ cells is antigen specific, once these cells are activated they not only suppress T cells stimulated by the same antigen, but they also inhibit T cells stimulated by other...

6
408
0

Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt

Ngày tải lên : 09/08/2014, 10:22

... slight edema and erythema from the ankle to the tarsal bone, = moderate edema and erythema from the ankle to the tarsal bone, and = edema and erythema from the ankle to the entire leg The sum of the ... immunity or immune tolerance; this determination is based on the maturation or activation state and the subset of DCs, and cytokine profiles in the microenvironment at the time of antigen uptake ... addition of 1-MT, an IDO inhibitor These findings suggest that the functional activities of IDO from tolerized mice could affect the T- cell response In the resting state, autoreactive T cells...

10
473
0

báo cáo hóa học:" In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells" docx

Ngày tải lên : 18/06/2014, 15:20

... soluble factors in the supernatant inhibit the maturation of fusion cells and have a negative impact in the stimulation of T cells To determine the induction of WT1-specitic CD8+ T cells, a pentameric ... [25] Therefore, we investigated whether supernatants derived from the HCC cells affect the function and maturation of DCs The data show that exposure of immature DCs to the supernatants results ... capacities in vitro Treg may contribute to the attenuated CTL responses in the presence of the supernatants A major obstacle to the development of any active immunotherapeutic approach to cancer...

19
459
0

Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease" potx

Ngày tải lên : 09/08/2014, 01:23

... in the joint These features were apparent in the vast majority of the patients despite the different treatments they received, indicating that the anti-rheumatic drugs that patients receive not ... enrichment of regulatory T cells was seen Thus, the simple extrapolation of the animal data into future therapeutic strategies that aim at reconstituting this population does not seem to hold true ... influence the function of the regulatory T cells [32] Further studies are therefore needed to understand why the regulatory T cells not efficiently halt the chronic inflammation in the rheumatic joint...

12
425
0

Báo cáo y học: "Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells" pps

Ngày tải lên : 09/08/2014, 07:20

... T cells to the joint in inflammatory arthritis and suggests that in the microenvironment of the joint, dysregulation of functional patterns of expression may occur Competing interests The authors ... Acknowledgements We thank the patients and their families for contributing to this study and the clinical staff for help with collection of samples We thank members of the Information Systems Unit and Statistics ... released without new protein synthesis on stimulation We have also demonstrated that several of the features of this inflammatory T cell population within the joint, such as the continued high...

11
508
0

Báo cáo y học: " CD39+ Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism" pps

Ngày tải lên : 12/08/2014, 13:22

... suggesting that these proinflammatory cytokines might affect the generation and differentiation of Tregs or/and Th17 cells in MPE To evaluate the contribution of cytokines to the numbers of pleural ... promote the generation and differentiation and of Th17 cells; in contrast, TGF-b could reduce the increased percentage of Th17 cells stimulated by the above cytokines On the other hand, TGF-b ... generation and differentiation of Th17 cells It was quite well documented that various cytokines contribute to the generation and differentiation of Tregs or Th17 cells In the present study,...

10
440
0

Báo cáo y học: " Generation of H9 T-cells stably expressing a membrane-bound form of the cytoplasmic tail of the " pps

Ngày tải lên : 13/08/2014, 09:21

... confirmed the authenticity of the membrane/cytosol separation In summary, these results point to functional membrane insertion of the Env-TMD-CT protein There were no obvious cytotoxic effects on the ... ultracentrifuged particles) of the respective virions released into the media (right) The top portions of the filters have been probed with anti-gp120 serum and the bottom portion with anti-CT antibodies ... C-terminally truncated Env proteins Although other reasons may account for this lack of transcomplementation, the most likely explanation is that the Env-TMD-CT has to be part of the full-length Env protein...

5
362
0

Báo cáo y học: "Signatures of human regulatory T cells: an encounter with old friends and new" pdf

Ngày tải lên : 14/08/2014, 16:21

... 5'-CGA AGG GTC TCC GCG GGG TCA CAT-3' TNFRSF1B 5'-GTA GCC TTG CCC GGA TTC TGG-3' 5'-ACC CTG CCC CTG CTC TGC TA-3' TRAF1 5'-GGG GCA TAA ACT TTC CTC TTC C-3' 5'-TTT GGG GTT ATA CAT TGC TCA GTG-3' LGALS3 ... on the TCR with N-glycans, thereby limiting the lateral mobility of the TCR and resulting in restricted TCR-mediated signaling on T cells [42] We therefore suggest that upregulation of both galectins ... downregulation of FHIT also contributes to the inactive status of TP53 Based on our data, we suggest that destabilization and thereby inactivation of TP53 provokes a shift in TReg cells from apoptotic sensitivity...

18
389
0

The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses

Ngày tải lên : 09/09/2015, 18:58

... lymphocytes T cells provide important cell mediated immunity by participating in the cytolysis of infected cells through the recognition of antigen presented on MHC class I They so through the T cell ... uninfected cells in a bystander manner (Mitrovic et al., 1994) 1.7.2 Bystander activation of T- cells Bystander activation of T cells, i.e the stimulation of unrelated, heterologous T- cells by cytokines ... that acts upstream of GATA-3 (Hou et al., 1994) In contrast, STAT3, ROR-α and ROR-γ mediates the development of Th17 cells (Dong, 2008) Fig 1.3 illustrates the development of the four main T helper...

279
365
0

Transcriptional regulation of the inducible costimulator (ICOS) in t cells

Ngày tải lên : 13/09/2015, 19:52

... promiscuously the icos promoter in developing Th0, Th1 and vi Th2 cells but became selectively associated with T- bet at the promoter and with GATA-3 at the 3′UTR in fully differentiated Th1 and Th2 cells, ... respectively The binding dynamics of these transcription factors coincided with the chromatin accessibility of these regulatory regions in the different Th cells as assessed by histone trimethylation ... although this observation was later attributed to the profound decrease of immunoregulatory CD4+CD25+ T cells in CD28-deficient NOD mice Another study found that the production of effector cytokines...

151
307
0