t cells and systemic lupus erythematosus
Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... lupus erythematosus Regulatory T cells (Tregs) (red) and effector T cells, shown as potentially pathogenic anti-self T cells (blue), can affect the maturation of immature dendritic cells (DCs) to ... Toll-like receptor (TLR) and TLR9 stimulation by apoptotic bodies in systemic lupus erythematosus (SLE) results in type interferon production, which promotes immunogenic DCs that activate potentially ... the balance between immunogenic and tolerogenic DCs, and thereby to correct Treg numbers and function In active lupus, the products of the apoptotic cells that bind to Toll-like receptor 7, Toll-like...
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Báo cáo y học: "Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus" ppsx
... untreated patients with rheumatoid arthritis and expression patients treated with corticoid and/ or non-steroidal anti-inflammatory drugs or treatment with anti-tumor necrosis factor-α therapy The ... sedimentation rate; i.v., intravenous; nd, not determined; NSAID, non-steroidal anti-inflammatory drugs; OA, osteoarthritis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus aTreatment ... results in vitro are not R1010 OA RA SLE CXCL10 concentrations in sera Sera of healthy controls and of sera patients with rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis...
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Báo cáo y học: " Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus" doc
... both cell subsets without an alteration in the Th17/Th1 ratio The ratio of Th17 to Th1 cells was higher in patients with SLE than in healthy controls (Figure 2b) Taken together, these observations ... patients with nephritis SLE, systemic lupus erythematosus 12 Shah et al Arthritis Research & Therapy 2010, 12:R53 http://arthritis-research.com/content/12/2/R53 APC-conjugated anti-IFN-g antibodies ... concentrations in patients with systemic lupus erythematosus Lupus 2000, 9:589-593 Wong CK, Lit LC, Tam LS, Li EK, Wong PT, Lam CW: Hyperproduction of IL23 and IL-17 in patients with systemic lupus...
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Báo cáo y học: "Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus" pot
... populations were used as stimulators (Ss) Mitomycin C is an antitumoral antibiotic that has the ability to inhibit proliferation without affecting the viability of the feeder cells in long-term ... interleukin To study the phenotypic and functional characteristics of BMDCs at different stages of differentiation, various agents were used to stimulate the maturation of these cells For immature BM ... majority of these patients had active lupus disease- Page 10 of 12 related cytopenia or fever despite drug treatment; it is therefore tempting to suggest that our findings reflect the true role...
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Báo cáo y học: " Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus" potx
... that potentially contribute to its mechanism of action in SLE Materials and methods Subjects After informed consent was obtained for the protocol approved by the Institutional Review Board at the ... Epratuzumab increases the motility of the B -cells To evaluate the functionality of b1 integrin on the B -cells, we checked the capacity of B -cells to transmigrate through fibronectin independently ... was found to bind to the highest extent on CD27negative B -cells followed by CD27positive cells The competition experiments demonstrated that this binding is specific via targeting CD22 and a role...
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Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf
... found that at least two of the anti-mouse CD22 monoclonal antibodies not deplete B cells in vivo The failure to find evidence for an immune response by the treated patients to the administered ... is quite modest and inconsistent (Figure in [1]), there is at present no obvious way to follow patients for physiological effects of the treatment or for the need for retreatment, which will ... is that the binding of CD22 changes little in the organism, and thus the current randomized controlled trial may fail to find evidence for therapeutic efficacy Assuming, however, that epratuzumab...
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Báo cáo y học: "Identity of mysterious CD4+CD25–Foxp3+ cells in systemic lupus erythematosus" pps
... Foxp3+ T cells in patients with systemic lupus erythematosus J Immunol 2009, 182:1689-1695 Horwitz DA: Regulatory T cells in systemic lupus erythematosus: past, present and future Arthritis Res Ther ... Horwitz Arthritis Research & Therapy 2010, 12:101 http://arthritis-research.com/content/12/1/101 CD4+CD25–Foxp3+ in untreated new-onset lupus patients lacked the phenotype and functional activity ... isolated CD4+CD25–CD127– cells by fluorescence-activated cell sorting and found that the cells contained up to 53% Foxp3+ T cells Functional studies revealed that these cells suppressed T- cell...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... independent subset because their differentiation was independent of the Th1 and Th2 promoting transcription factors T- bet, STAT1, STAT4 and STAT6 ROR- t, RORα and STAT3 appear to be critical for the ... lupus T cells [39] There is a direct interaction between HRES-1/Rab4, CD4 and TCRζ Rapamycin treatment of lupus patients reversed the TCRζ deficiency of lupus T cells, and normalized T- cell-activation-induced ... via cGMP Together, these data indicate that NO has a crucial role in the regulation of Th1/Th2 polarization Nitric oxide regulates T lymphocyte activation in systemic lupus erythematosus Considerable...
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Báo cáo y học: "Defective response of CD4+ T cells to retinoic acid and TGFb in systemic lupus erythematosus" ppt
... albeit incomplete, and have concluded that these cells represent an attempt to control active autoimmune activation [14] The size of the Treg compartment results from the combined contribution ... suggested that CD25- Tregs correspond to activated T cells without suppressive activity [13] The other group working with treated patients has shown that the CD25- Tregs retain a suppressive function, ... these results show in HCs the expected positive correlation between CD25-Tregs and memory T cells and negative correlation between CD25 + Tregs and memory T cells The fact that these correlations...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... error rate, demonstrating somatic hypermutation in vivo The difference in mutation rates between the two GCs may indicate that they are in different states of maturity or that GC B might have ... abnormalities in the pattern of somatic hypermutation and antigen selection To our knowledge, this is the first detailed study of the repertoire of the splenic GC response in SLE Materials and methods ... numbers in the FRs, this can be attributed to the fact that these segments are longer and there is therefore increased likelihood of random mutations occurring In order to correct for this, the number...
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Báo cáo y học: "Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus" pot
... 5'-aagcaaacctcggggatact-3' and anti-sense 5'-ggggcttgatctcaaaat ga-3'; and beta microglobulin, sense 5'-gggttt catccatccgac-3' and anti-sense 5'-acggacggcatactcatc-3' For protein detection of caspase ... Smit AJ, Bootsma H, Kallenberg CG, Bijl M: Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus ... Whether this indicates the existence of subsets of CPCs that intrinsically differ with respect to apoptotic responsiveness or that CPCs can adapt to culture conditions remains to be investigated...
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Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells" pdf
... localization and its tetratricopeptide repeat motifs provide some clues that emphasize the role played by IFIT4 in the interaction between proteins via its tetratricopeptide repeat domain That no translocation ... activity and lupus nephritis in patients with systemic lupus erythematosus Arthritis Rheum 2006, 54:2951-2962 Crow MK: Interferon pathway activation in systemic lupus erythematosus Curr Rheumatol ... leading to the activation of autoreactive T cells that 'help' to drive autoantibody production in B cells [58] 10 11 12 Conclusion Our results indicate that IFIT4 might contribute to the pathogenesis...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf
... online http://arthritis-research.com/content/10/5/R114 Table Demographic and clinical characteristics of systemic lupus erythematosus patients Characteristic Systemic lupus erythematosus patients ... correlation test Results SLE dendritic cells exhibit diminished FITC-dextran uptake We first demonstrated that moDCs from SLE patients have impaired endocytic capacity Healthy control moDCs exhibited ... receptor expression correlates with circulating IFNγ We next investigated potential factors contributing to the observed aberrant phenotype in DCs from SLE patients To Available online http://arthritis-research.com/content/10/5/R114...
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Báo cáo y học: "Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus" potx
... performed the statistical analysis and contributed to the interpretation of the data JW and BDvdM contributed to the aquisition and interpretation of RTPCR experiments PCL contributed to concept and ... receptor; SLE, systemic lupus erythematosus; SLEDAI, systemic lupus erythematosus disease activity index; Competing interests The authors declare that they have no competing interests Authors’ ... design, interpretation of data CGMK contributed to concept and design, interpretation of data and revising the article MB contributed to concept and design, inclusion SLE patients, interpretation...
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Báo cáo y học: "Systemic lupus erythematosus and the type I interferon system" docx
... dendritic cells (DCs) and activation of T cells The IFN-α produced induces the maturation of PDCs and the differentiation of monocytes to type DCs; both cell types express the co-stimulatory molecules ... response and prevent apoptosis in activated T cells IL-12R, IL-12 receptor; TCR, T cell antigen receptor (d) Production of autoantibodies by B cells Activated Th cells provide help to B cells with ... on type DCs [76] These events are facilitated by the fact that antigen presentation and the production of cytokines such as type I IFNs occur in similar, if not identical, DCs Activated T cells...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... cluster of the Toll-like receptor (TLR) family (that is, TLR1, TLR2, TLR4, and TLR5) and another cluster of Fc receptors (FcRs) were identified in this network The two clusters were indirectly ... network was mainly attributed to TNF (Figure 2c) We found that two IFI molecules were included in the second network, and that seven out of the 14 upregulated molecules that constructed the third ... erythematosus patients systemic TNF stimulation on gene expression in healthy individuals Effect of TNF stimulation on gene expression in healthy individuals and and systemic lupus erythematosus patients...
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Báo cáo y học: "Practical and theoretical barriers to the prevention of accelerated atherosclerosis in systemic lupus erythematosus" docx
... Available online http://arthritis-research.com/content/5/4/178 Second, studies from Toronto and Baltimore show that risk factor identification and, by implication, treatment fall short of what one would ... find it difficult to change their lifestyles and take additional medications on top of complicated regimens or little reinforcement from their providers In recruiting patients with SLE and hyperlipidemia ... hyperlipidemia for a statin dosing study, our experience has been that the patients who are the most willing to participate are relatively young and healthy, with very mild SLE, and few other health problems...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... in patients with SLE with and without CNS engagement, as well as in cerebrally healthy control subjects (c) CSF content of tau in patients with SLE stratified with respect to brain magnetic resonance ... interleukin-6, prostaglandin E2 and autoantibodies in patients with neuropsychiatric systemic lupus erythematosus and central nervous system infections Scand J Rheumatol 1994, 23:57-63 18 Yeh TS, ... treatment In this group such a treatment resulted in significantly decreased Aβ42 levels This finding indicates that treatment with alkylating agents such as cyclophosphamide might affect either...
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Báo cáo y học: "Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility" pptx
... interpretation GS and LT were both responsible for the planning of the work and contributed to data analysis, interpretation, and write-up Acknowledgements We thank Mrs Birgitta Gullstrand and ... patients with systemic lupus erythematosus: association with clinical symptoms Arthritis Rheum 1998, 41:1181-1189 25 Sturfelt G, Hellmer G, Truedsson L: TNF microsatellites in systemic lupus erythematosus- a ... et al.: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus Arthritis...
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Báo cáo y học: "Commentary on “Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al" pdf
... haplotypes of markers and demonstration that families with these haplotypes are largely responsible for the evidence of linkage support the hypothesis that true susceptibility genes may map to the ... spanning the five markers Even though the results presented in the study provide consistent and compelling evidence to support association to the region using a number of tests, it must be remembered ... D’Angelo WA, Christian CL: Studies of twins with systemic lupus erythematosus: A review of the literature and presentation of 12 additional sets Am J Med 1975, 59:533-552 Deapen D, Escalante A, Weinrib...
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