... SystemicTreatmentof Malignant Melanoma IX SystemicTreatmentof Renal Cell Carcinoma X SystemicTreatmentof Lung Cancer XI SystemicTreatmentof Gastric Cancer XI1 SystemicTreatment ... XVI SystemicTreatmentof Brain Tumors XVII SystemicTreatmentof Neuroblastoma XVIII SystemicTreatmentof Prostate Carcinoma XIX SystemicTreatmentof Carcinoma of the Uterine ... TreatmentofMyelomatosisSystemicTreatmentof Kaposi's Sarcoma SystemicTreatmentof Soft Tissue Sarcomas 119 134 141 146 149 152 vi i CONTENTS VII SystemicTreatmentof Osteosarcomas...
... evidence III Studies with level of evidence IV DS, diagnostic studies Levels of evidence for studies of the accuracy of diagnostic tests Levels of evidence Ia Type of evidence • Ib II • • III • ... professionals and patients is essential It should be supported by the provision of evidence-based information, offered in a form that is tailored to the needs of the individual patient The treatment, ... radiotherapy should be offered sequential chemoradiotherapy A 1.8 Treatmentof small-cell lung cancer 1.8.1 Patients with SCLC should be offered an assessment that includes evaluation of the major prognostic...
... prescribed, to encompass at least 95% of the PTV, ranged from 45 to 50.4 Gy, delivered in 25 to 28 daily fractions in the phase of elective pelvic lymph node treatmentTreatment plannings were generated ... 0.01) (Table 5) Crude incidence of acute GU toxicity was similar in both groups among patients with rectal cancer (Table 6) Discussion Use of IMRT in the treatmentof pelvic tumors has been increasing ... comparing conventional RT versus IMRT in the treatmentof cervical cancer Results of these two trials will contribute to assess the benefits and risks of IMRT in patients with gynecologic tumors...
... extent of contact and compression of critical neurological structures Details of the radiosurgical treatments are found in Table A median treatment dose of 2500 cGy was delivTable 3: Radiosurgery treatment ... fossa Parasellar Orbit Petroclival Goal of CyberKnife treatment Primary treatment for local disease (%) Secondary treatment (%) Previous treatment Previous craniofacial surgery Previous external beam ... responsibility for all aspects of the treatment planning and procedure, determined the minimal tumor margin dose of the target vol- ume, the treatment isodose and the number oftreatment sessions into...
... side of the equation is the rate of increase of φ while the second term on the left is the net rate of flow of φ out of fluid element The first term on the right side is the rate of change of φ ... Development of the ice front and the boundary of the complete ablation 77 Figure 5.16 Classification of profiles and equivalent ellipsoid: (a) classification of profile in terms of border ... Summary of the size of the frozen tissue in short-axis and long-axis 157 IX List of Figures Figure 2.1 Flow chart on the mechanism of tissue destruction 14 Figure 2.2 Description of...
... of both cephalic and distal pancreatic remnants [1] Moreover, the laparoscopic technique, one of the best examples of modern surgery, is now more widely used for the diagnosis and treatmentof ... resected [21] In a systemic review of 1.646 Table 1: Reports of pancreatoduodenectomy (PD) with simultaneous venous vessel resection (VR) Author (Year of publication) Number of PD with VR Mortality ... attempted because of locally unresectable disease [29] In an analysis by Shimada et al of 88 patients with extended DP, which Page of 10 (page number not for citation purposes) World Journal of Surgical...
... (range, 0.9 – 3.5 cm) Treatment characteristics Three equal fractions of 15 to 20 Gy were delivered in an average of days (Table 3) Treatment plans were composed of hundreds of pencil beams shaped ... stop smoking just prior to treatment; any deleterious effects of radiosurgery may be offset by the early beneficial effects of smoking cessation [25] Ninety-five percent of the patients in the current ... Follow-up was determined from the date of the last treatment Two-sided Wilcoxon signed-ranks tests were used to assess statistical significance (α = 0.05) of post -treatment changes in forced expiratory...
... to improve the effectiveness ofsystemic chemotherapy The novel strategy that I propose here to improve the effectiveness ofsystemic chemotherapy in the treatmentof malignant brain tumors is ... limit of pore size in the BBTB of the microvasculature of early, less mature and smaller malignant brain tumor colonies is to nanometers lower than that of the BBTB of the microvasculature of late, ... randomized trial of surgery in the treatmentof single metastases to the brain New England Journal of Medicine 1990, 322:494 Jellinger K, Volc D, Grisold W: Multimodality treatmentof malignant gliomas...
... subject of controversy One of the most important controversies is whether the degree of downstaging warrants this type of surgery [1] Results of the German (CAO/ARO/AIO 94) randomized trial of preoperative ... actuarial method of Kaplan and Meier [24] The calculation of OS, DFS and LC was performed from the date of diagnosis to the date of the event Survival was measured from the date of diagnosis to ... Results Neadjuvant treatmentOf the 101 patients treated, (6.9%) did not complete the prescribed dose of preoperative RT because of persistent neutropenia and/or diarrhea Of these, two died due...
... single measure of how well the treatment dose distribution of a specific radiation treatment plan conforms to the size and shape of the target volume In general, the conformity index of a given radiosurgical ... simultaneous irradiation of multiple lesions The lack of a requirement for the use of a head-frame allows for staged treatment Since the planning system has access to a large number of potential non-isocentric ... 1:46 appropriate treatment option for many patients [5] However, single-fraction radiosurgical treatment may be difficult because of the potentially large size and irregular shapes of these tumors...
... analysis of the number of attached cells in rabbits Full-thickness osteochondral defects (5 mm × mm wide, mm deep) were created in the trochlear groove of the femurs of adult rabbits The distal end of ... small portion of the cells adhered to the cartilage defect Injection of more cells would increase the number of cells that adhered to the defect; however, the injection of a large number of cells ... spur formation was observed on the edge of the trochlear groove of the femur in some samples of the control group, but there were no osteoarthritic changes of the femorotibial joint in any groups...
... cause of death and different treatment groups Our analysis reveals 27 of 60 patients with no attempt at local control, died of myeloma This ratio of progression to myeloma was similar in other treatment ... approximately 26% of the US population It is the only comprehensive source of population based data in the U.S that includes the stage of cancer at the time of diagnosis and follow-up of all patients ... oftreatment (occurring within months of diagnosis) [22-34] The SEER program is currently regarded as the standard of quality among cancer registries around the world with case completeness of...
... from the date of completion oftreatment to the last date of follow-up or the date of death Actuarial local control and overall survival were calculated using the Kaplan-Meier method Treatment Delivery ... the response to treatment in solid tumors European Organization for Research and Treatmentof Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl ... approaching the limit of 40 Gy A second Unger et al Journal of Hematology & Oncology 2010, 3:39 http://www.jhoonline.org/content/3/1/39 Page of Figure Right hilar metastasis treatment planning PET/CT...
... tight dose fall-off in the area of vertebral body invasion Figure demonstrates the sharp fall-off from the treatment dose of 74 Gy (red) to the approximate spinal cord tolerance dose of 50 Gy (purple) ... accuracy of fiducial markers with the use of other forms of IGRT Watchman et al [10] compared KV X-ray imaging and fiducial marker matching for the set-up of 18 treatment fractions of stereotactic ... weeks after treatment was completed A CT scan of the chest and abdomen obtained 10 months after radiation treatment showed stable soft-tissue asymmetry in the mediastinum, with no evidence of recurrent...
... Function efficacy of small molecules on stiffness of ASM at the level of a single living cell Figure S2: Modulation of pCofilin-14-3-3 protein interactions A potential mechanism of action of small molecules ... Phosphorylated cofilin is bound to 14-3-3 proteins [20-22] and, in human ASM, PKA-activated phosphorylation of HSP20 is associated with dephosphorylation of cofilin and subsequent loss of actin stress ... analogs of HSP20 (pHSP20) co-precipitate with a class of 143-3 proteins and, moreover, competitively inhibit the binding of phosphorylated cofilin to 14-3-3 proteins Using SPR-based evaluation of...
... control of physiological variables as well as therapeutic modalities is of the outmost importance [9] The use oftreatment bundles’ could be a further necessary step in the direction of optimal ... phases of ALI, how can it be assessed in order to initiate heparin administration as rapidly as necessary? How can dosage of the drug be titrated to achieve maximal local effects without the risk of ... achieve maximal local effects without the risk ofsystemic complications? What is the adequate duration of this therapy? Does the underlying cause of ALI make any difference with regard to this...
... I is Professor of Clinical Psychology in the Department of Psychology at the University of Montreal Fearing Others The Nature and Treatmentof Social Phobia Ariel Stravynski University of Montreal ... disruptive social anxiety are features of the lives of many thousands of people But exactly what is social phobia? What causes it? What is its nature and what kinds of treatments can improve it? Using ... and ways of testing them 81 5.3 Reliability: agreeing about the entity of social phobia 86 5.4 Predictors of response to treatment 95 5.5 Social phobia in the family 99 5.6 Association of social...
... avoiding Page of 10 (page number not for citation purposes) proarrhythmic drugs Reduction of the systemic inflammatory state is tempting but is of course always the purpose of ICU treatment The ... by insufficient treatmentof AF or, on the contrary, is caused by adverse effects of the treatment, however, is too realistic to be ignored All we have stated about the treatmentof AF in MICU ... disease and other nosocomial complications Can treatmentof atrial fibrillation improve survival? There are few data on the effect oftreatmentof AF on mortality in ICU patients A meta-analysis...
... Antipsychotics [29] Initiation ofTreatment First Year ofTreatment Duration ofTreatment • Baseline fasting glucose level • Fasting glucose level every 3–4 months • Observe for signs of hyperglycemia • ... of our patients develop renal disease, psychiatrists must be aware of the effects of psychotropics on the kidneys, as well the effects of decreased renal functioning on the pharmacokinetics of ... bioavailability of free, active highly protein-bound drugs Accumulation of active hydroxylated metabolites of carbamazepine may lead to symptoms of drug toxicity despite therapeutic drug levels [70] Of all...
... mind, in the presence of adherent scars, after having infiltrated the whole area with a solution of Lidocaine 0.5% and Epinephrine 1:200,000 very close to one of the two edges of the scar, a small ... that brings great improvement to the treatmentof depressed scars AUTHORS' CONTRIBUTIONS FI: participated in the surgical treatment and in the follow-up of this patient MT: drafted the manuscript ... literature FMA: participated in the surgical treatment and in the follow-up of this patient MM: participated in the design of this case study and in the follow-up of this patient ADI: revised the literature...