systemic therapy of indignant disease
advances in cancer research
... Systemic Treatment of Leukemias Systemic Treatment of Lymphomas., Systemic Treatment of Myelomatosis Systemic Treatment of Kaposi's Sarcoma Systemic Treatment of Soft Tissue ... Treatment of Bladder Tumors Intraarterial IFN Therapy 108 109 112 112 113 115 116 117 118 Chapter 10 Systemic Therapy of Indignant Disease I I1 I11 IV V VI Systemic IFN Therapy of Tumors-Screening ... VII Systemic Treatment of Osteosarcomas VIII Systemic Treatment of Malignant Melanoma IX Systemic Treatment of Renal Cell Carcinoma X Systemic Treatment of Lung Cancer XI Systemic...
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Lung cancer - The diagnosis and treatment of lung cancer pdf
... be offered chemotherapy and radiotherapy according to the stage of disease and performance status A 1.9.12 Stent insertion should be considered for the immediate relief of severe symptoms of ... radical radiotherapy should be offered sequential chemoradiotherapy A 1.8 Treatment of small-cell lung cancer 1.8.1 Patients with SCLC should be offered an assessment that includes evaluation of the ... or a Karnofsky score of 80–100), to improve survival, disease control and quality of life A NICE Guideline – lung cancer 15 1.6.2 Chemotherapy for advanced NSCLC should be a combination of a single...
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Báo cáo khoa học: "Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity" pdf
... Elective radiotherapy with intensity modulated radiation therapy (IMRT) technique in the treatment of pelvic lymph nodes and primary tumor region Analysis of acute toxicity Procedings of the 49th ... consider that the low number of events could have limited the statistical power of this analysis Another advantage of IMRT is the possibility to deliver a different level of daily dose to the distinct ... tumor sites must be irradiated List of abbreviation ASTRO: Americal Society of Therapeutic Radiation Oncology; CRT: Conformal Radiation Therapy; CT: Chemotherapy; CTV: Clinical Target Volume;...
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báo cáo khoa học: "Treatment of malignant tumors of the skull base with multi-session radiosurgery" pdf
... consisted of 21 men and 10 women, with a median age of 57 (range: 11 – 81) (Table 1) The histopathology of all tumors was Page of 11 (page number not for citation purposes) Journal of Hematology ... (%) Time to Death Min Max Mean Median Local disease outcome Disease regression (%) Stable disease (%) Disease progression (%) Death due to treated disease (%) Time to local progression (weeks) ... period of 22 months, a tumor control rate of 68% was recorded The other study by Iwai and Yamanaka of 18 similar patients showed a tumor control rate of 67% during a median follow up of 10 months...
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Effective treatment of solid tumors via cryosurgery
... side of the equation is the rate of increase of φ while the second term on the left is the net rate of flow of φ out of fluid element The first term on the right side is the rate of change of φ ... Development of the ice front and the boundary of the complete ablation 77 Figure 5.16 Classification of profiles and equivalent ellipsoid: (a) classification of profile in terms of border ... 16 2.3.4 Repetition of freeze-thaw cycles 17 2.4. Shape factor of tumor profile 18 2.5. Heating of large blood flows and metabolism 20 2.6. Radiofrequency ablation ...
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Báo cáo khoa học: "Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery?" potx
... resected [21] In a systemic review of 1.646 Table 1: Reports of pancreatoduodenectomy (PD) with simultaneous venous vessel resection (VR) Author (Year of publication) Number of PD with VR Mortality ... attempted because of locally unresectable disease [29] In an analysis by Shimada et al of 88 patients with extended DP, which Page of 10 (page number not for citation purposes) World Journal of Surgical ... of both cephalic and distal pancreatic remnants [1] Moreover, the laparoscopic technique, one of the best examples of modern surgery, is now more widely used for the diagnosis and treatment of...
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Báo cáo khoa học: " Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors" docx
... sites and received salvage systemic therapy Despite treatment one patient died of progressive metastatic disease at months A second single lung metastasis patient died of a myocardial infarction ... at 11 months without evidence of local or systemic disease No stage I lung cancer patient developed metastatic disease However, stage I lung cancer patients died of comorbid illnesses (1 secondary ... consisting of mild brief fatigue was reported in the majority of patients Transient chest wall discomfort, typically lasting several weeks, developed in of 11 patients with lesions within mm of the...
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báo cáo hóa học:" Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors" docx
... to improve the effectiveness of systemic chemotherapy The novel strategy that I propose here to improve the effectiveness of systemic chemotherapy in the treatment of malignant brain tumors is ... chemotherapy[9,10,28-31] Systemic chemotherapy consists of small molecule chemotherapy drugs[8,32] that are drugs of molecular weights (MW) less than kDa and diameters less than to nm These small molecule chemotherapy ... Journal of Translational Medicine 2009, 7:77 otherapy[8,15,20-27]; and in the treatment of metastatic brain tumors, it remains unclear as to if there is any additional benefit of systemic chemotherapy[9,10,28-31]...
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Báo cáo khoa học: " Neoadjuvant radiochemotherapy in the treatment of fixed and semi-fixed rectal tumors. Analysis of results and prognostic factors" pptx
... the time of this analysis, 46 patients (45.5%) were alive with no evidence of disease, (4.9%) were alive with evidence of disease, 42 (41.6%) died due to the rectal cancer, (4%) died of second ... subject of controversy One of the most important controversies is whether the degree of downstaging warrants this type of surgery [1] Results of the German (CAO/ARO/AIO 94) randomized trial of preoperative ... actuarial method of Kaplan and Meier [24] The calculation of OS, DFS and LC was performed from the date of diagnosis to the date of the event Survival was measured from the date of diagnosis to...
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Báo cáo khoa học: " CyberKnife® radiosurgery in the treatment of complex skull base tumors: analysis of treatment planning parameters" potx
... simultaneous irradiation of multiple lesions The lack of a requirement for the use of a head-frame allows for staged treatment Since the planning system has access to a large number of potential non-isocentric ... single measure of how well the treatment dose distribution of a specific radiation treatment plan conforms to the size and shape of the target volume In general, the conformity index of a given radiosurgical ... 29 88 55 53 Number of Patients Number of Lesions Male Female Age Min Max Mean Median A second control group used for comparison consisted of 43 patients with metastatic tumors of the cerebral and...
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Báo cáo y học: "Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect" pdf
... analysis of the number of attached cells in rabbits Full-thickness osteochondral defects (5 mm × mm wide, mm deep) were created in the trochlear groove of the femurs of adult rabbits The distal end of ... small portion of the cells adhered to the cartilage defect Injection of more cells would increase the number of cells that adhered to the defect; however, the injection of a large number of cells ... defect bAverage thickness of the reparative cartilage compared with that of the surrounding cartilage Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol 10 No Koga...
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báo cáo khoa học: "Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database" ppt
... of both modalities of local control did not further improve survival Limitations of the current study include lack of any information on specific chemotherapy regimens or any other adjuvant therapy ... nature of data, lack of information about chemotherapy or serological or radiological investigations; the current study addresses some of the controversies in disease progression and impact of local ... administration of radiation therapy was associated with an improvement in survival (5 year survival of 60% among patients with radiation therapy as compared to 46% without any radiation therapy, p...
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báo cáo khoa học: "CyberKnife for hilar lung tumors: report of clinical response and toxicity" potx
... The follow-up duration was defined as the time from the date of completion of treatment to the last date of follow-up or the date of death Actuarial local control and overall survival were calculated ... compare favorably to a large RTOG trial of conventionally fractionated radiation therapy for palliation of inoperable NSCLC, which demonstrated palliation of symptoms in 60% and local control in ... mainstem endobronchial disease, who had received 48 Gy in fractions, died of complication related to radiosurgery without evidence of tumor recurrence Despite the short survival of treated patients...
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báo cáo khoa học: "Successful treatment of a T4 lung tumor with vertebral body invasion using fiducial markers in the thoracic spine for image-guided radiation therapy: A case report" pps
... tight dose fall-off in the area of vertebral body invasion Figure demonstrates the sharp fall-off from the treatment dose of 74 Gy (red) to the approximate spinal cord tolerance dose of 50 Gy (purple) ... accuracy of fiducial markers with the use of other forms of IGRT Watchman et al [10] compared KV X-ray imaging and fiducial marker matching for the set-up of 18 treatment fractions of stereotactic ... consented He was randomized to receive 74 Gy of radiation therapy using conventional daily fractions of Gy with Figure Pre-treatment computed tomographic scan Page of concurrent carboplatin and paclitaxel,...
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Báo cáo y học: " A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged highthroughput biophysical screening" pps
... Function efficacy of small molecules on stiffness of ASM at the level of a single living cell Figure S2: Modulation of pCofilin-14-3-3 protein interactions A potential mechanism of action of small molecules ... Phosphorylated cofilin is bound to 14-3-3 proteins [20-22] and, in human ASM, PKA-activated phosphorylation of HSP20 is associated with dephosphorylation of cofilin and subsequent loss of actin stress ... analogs of HSP20 (pHSP20) co-precipitate with a class of 143-3 proteins and, moreover, competitively inhibit the binding of phosphorylated cofilin to 14-3-3 proteins Using SPR-based evaluation of...
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Báo cáo y học: "Nebulised heparin: a new approach to the treatment of acute lung injury" pdf
... achieve maximal local effects without the risk of systemic complications? What is the adequate duration of this therapy? Does the underlying cause of ALI make any difference with regard to this ... control of physiological variables as well as therapeutic modalities is of the outmost importance [9] The use of ‘treatment bundles’ could be a further necessary step in the direction of optimal ... Critical Care Vol 12 No Suter The translation of a potentially beneficial effect of inhaled heparin in experimental models of ALI to clinical practice has not yet been achieved; important...
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Cambridge.University.Press.Fearing.Others.The.Nature.and.Treatment.of.Social.Phobia.Mar.2007.pdf
... symptoms of heart disease and hyperventilation a disease of the lungs (1999, p 84) While the process of medicalization reached its peak in the first half of the nineteenth century, a process of psychologization ... I is Professor of Clinical Psychology in the Department of Psychology at the University of Montreal Fearing Others The Nature and Treatment of Social Phobia Ariel Stravynski University of Montreal ... criteria of social phobia in the International Classification of Diseases (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) page 76 5.2 A conceptual outline of validity...
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Báo cáo y học: "Clinical review: Treatment of new-onset atrial fibrillation in medical intensive care patients – a clinical framework"
... 80% of patients with AF convert to SR within 24 hours The use of β-blockers before the start of AF and the absence of diabetes and left ventricular hypertrophy were independent predictors of conversion ... and avoiding Page of 10 (page number not for citation purposes) proarrhythmic drugs Reduction of the systemic inflammatory state is tempting but is of course always the purpose of ICU treatment ... adverse effect of a specific drug is hard to detect in ICU patients because of the polypharmacy and because of the difficulty to distinguish between adverse effects, underlying disease and other...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... from renal disease are on the rise [65] As more of our patients develop renal disease, psychiatrists must be aware of the effects of psychotropics on the kidneys, as well the effects of decreased ... first year of therapy Page of 10 (page number not for citation purposes) Annals of General Hospital Psychiatry 2004, http://www.general-hospital-psychiatry.com/content/3/1/7 The effects of anticonvulsants ... bioavailability of free, active highly protein-bound drugs Accumulation of active hydroxylated metabolites of carbamazepine may lead to symptoms of drug toxicity despite therapeutic drug levels [70] Of all...
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Báo cáo y học: "Surgical Treatment of Depressed Scar: A Simple Technique"
... mind, in the presence of adherent scars, after having infiltrated the whole area with a solution of Lidocaine 0.5% and Epinephrine 1:200,000 very close to one of the two edges of the scar, a small ... the mobility of the recuperated tissue 378 Fig.2: A small incision with an undermining scissor inside it Fig.3: The scar is completely undermined Fig.1: An example of a depressed scar of the abdomen ... below Infact, the use of the stitches in depth is performed in order to prevent that the adhesion can recreate again: this relapse could promote the formation of a layer of reactive collagen in...
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