systemic ifn therapy of tumors—screening trials

advances in cancer research

Ngày tải lên : 20/01/2016, 03:47

... Treatment of Bladder Tumors Intraarterial IFN Therapy 108 109 112 112 113 115 116 117 118 Chapter 10 Systemic Therapy of Indignant Disease I I1 I11 IV V VI Systemic IFN Therapy of Tumors-Screening ... Tumors-Screening Trials Systemic Treatment of Leukemias Systemic Treatment of Lymphomas., Systemic Treatment of Myelomatosis Systemic Treatment of Kaposi's Sarcoma Systemic ... Carcinoma X Systemic Treatment of Lung Cancer XI Systemic Treatment of Gastric Cancer XI1 Systemic Treatment of Colorectal Carcinoma XI11 Systemic and Intraarterial IFN Treatment of Liver...

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Lung cancer - The diagnosis and treatment of lung cancer pdf

Ngày tải lên : 15/03/2014, 00:20

... radical radiotherapy should be offered sequential chemoradiotherapy A 1.8 Treatment of small-cell lung cancer 1.8.1 Patients with SCLC should be offered an assessment that includes evaluation of the ... be offered chemotherapy and radiotherapy according to the stage of disease and performance status A 1.9.12 Stent insertion should be considered for the immediate relief of severe symptoms of ... evidence III Studies with level of evidence IV DS, diagnostic studies Levels of evidence for studies of the accuracy of diagnostic tests Levels of evidence Ia Type of evidence • Ib II • • III •...

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Báo cáo khoa học: "Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors. Analysis of acute toxicity" pdf

Ngày tải lên : 09/08/2014, 09:20

... Elective radiotherapy with intensity modulated radiation therapy (IMRT) technique in the treatment of pelvic lymph nodes and primary tumor region Analysis of acute toxicity Procedings of the 49th ... medicine, multi-institutional prospective clinical trials are important to corroborate the real benefit of IMRT in the treatment of Table Crude incidence of acute GU toxicity in both groups according ... comparing conventional RT versus IMRT in the treatment of cervical cancer Results of these two trials will contribute to assess the benefits and risks of IMRT in patients with gynecologic tumors The...

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báo cáo khoa học: "Treatment of malignant tumors of the skull base with multi-session radiosurgery" pdf

Ngày tải lên : 10/08/2014, 22:20

... consisted of 21 men and 10 women, with a median age of 57 (range: 11 – 81) (Table 1) The histopathology of all tumors was Page of 11 (page number not for citation purposes) Journal of Hematology ... period of 22 months, a tumor control rate of 68% was recorded The other study by Iwai and Yamanaka of 18 similar patients showed a tumor control rate of 67% during a median follow up of 10 months ... recently, "hypofractionated" or staged radiosurgery has provided an attractive alternative This therapy has been successfully utilized in the treatment of tumors in which preservation of surrounding...

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Effective treatment of solid tumors via cryosurgery

Ngày tải lên : 10/09/2015, 09:09

... side of the equation is the rate of increase of φ while the second term on the left is the net rate of flow of φ out of fluid element The first term on the right side is the rate of change of φ ... Development of the ice front and the boundary of the complete ablation 77 Figure 5.16 Classification of profiles and equivalent ellipsoid: (a) classification of profile in terms of border ... 16 2.3.4 Repetition of freeze-thaw cycles 17 2.4. Shape factor of tumor profile 18 2.5. Heating of large blood flows and metabolism 20 2.6. Radiofrequency ablation ...

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Báo cáo khoa học: "Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery?" potx

Ngày tải lên : 09/08/2014, 07:22

... resected [21] In a systemic review of 1.646 Table 1: Reports of pancreatoduodenectomy (PD) with simultaneous venous vessel resection (VR) Author (Year of publication) Number of PD with VR Mortality ... of both cephalic and distal pancreatic remnants [1] Moreover, the laparoscopic technique, one of the best examples of modern surgery, is now more widely used for the diagnosis and treatment of ... attempted because of locally unresectable disease [29] In an analysis by Shimada et al of 88 patients with extended DP, which Page of 10 (page number not for citation purposes) World Journal of Surgical...

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Báo cáo khoa học: " Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors" docx

Ngày tải lên : 09/08/2014, 10:21

... conventionally fractionated radiotherapy approaches prompted researchers in the last decade to explore ways of delivering high doses of radiation in shorter periods of time [1] Utilizing a body frame ... Treatment characteristics Three equal fractions of 15 to 20 Gy were delivered in an average of days (Table 3) Treatment plans were composed of hundreds of pencil beams shaped using a single 20, 25 ... consisting of mild brief fatigue was reported in the majority of patients Transient chest wall discomfort, typically lasting several weeks, developed in of 11 patients with lesions within mm of the...

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báo cáo hóa học:" Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors" docx

Ngày tải lên : 18/06/2014, 15:20

... to improve the effectiveness of systemic chemotherapy The novel strategy that I propose here to improve the effectiveness of systemic chemotherapy in the treatment of malignant brain tumors is ... chemotherapy[9,10,28-31] Systemic chemotherapy consists of small molecule chemotherapy drugs[8,32] that are drugs of molecular weights (MW) less than kDa and diameters less than to nm These small molecule chemotherapy ... Journal of Translational Medicine 2009, 7:77 otherapy[8,15,20-27]; and in the treatment of metastatic brain tumors, it remains unclear as to if there is any additional benefit of systemic chemotherapy[9,10,28-31]...

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Báo cáo khoa học: " Neoadjuvant radiochemotherapy in the treatment of fixed and semi-fixed rectal tumors. Analysis of results and prognostic factors" pptx

Ngày tải lên : 09/08/2014, 10:20

... subject of controversy One of the most important controversies is whether the degree of downstaging warrants this type of surgery [1] Results of the German (CAO/ARO/AIO 94) randomized trial of preoperative ... actuarial method of Kaplan and Meier [24] The calculation of OS, DFS and LC was performed from the date of diagnosis to the date of the event Survival was measured from the date of diagnosis to ... radiotherapy for rectal cancer: a systemic overview of 8507 patients from 22 randomised trials The Lancet 2001, 358:1291-1304 Lindmark GE, Kraaz WG, Elvin PAB: Rectal cancer: evaluation of staging...

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Báo cáo khoa học: " CyberKnife® radiosurgery in the treatment of complex skull base tumors: analysis of treatment planning parameters" potx

Ngày tải lên : 09/08/2014, 10:21

... simultaneous irradiation of multiple lesions The lack of a requirement for the use of a head-frame allows for staged treatment Since the planning system has access to a large number of potential non-isocentric ... single measure of how well the treatment dose distribution of a specific radiation treatment plan conforms to the size and shape of the target volume In general, the conformity index of a given radiosurgical ... 29 88 55 53 Number of Patients Number of Lesions Male Female Age Min Max Mean Median A second control group used for comparison consisted of 43 patients with metastatic tumors of the cerebral and...

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Báo cáo y học: "Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect" pdf

Ngày tải lên : 09/08/2014, 10:23

... analysis of the number of attached cells in rabbits Full-thickness osteochondral defects (5 mm × mm wide, mm deep) were created in the trochlear groove of the femurs of adult rabbits The distal end of ... small portion of the cells adhered to the cartilage defect Injection of more cells would increase the number of cells that adhered to the defect; however, the injection of a large number of cells ... defect bAverage thickness of the reparative cartilage compared with that of the surrounding cartilage Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol 10 No Koga...

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báo cáo khoa học: "Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database" ppt

Ngày tải lên : 10/08/2014, 22:20

... of both modalities of local control did not further improve survival Limitations of the current study include lack of any information on specific chemotherapy regimens or any other adjuvant therapy ... administration of radiation therapy was associated with an improvement in survival (5 year survival of 60% among patients with radiation therapy as compared to 46% without any radiation therapy, p ... approximately 26% of the US population It is the only comprehensive source of population based data in the U.S that includes the stage of cancer at the time of diagnosis and follow-up of all patients...

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báo cáo khoa học: "CyberKnife for hilar lung tumors: report of clinical response and toxicity" potx

Ngày tải lên : 10/08/2014, 22:21

... The follow-up duration was defined as the time from the date of completion of treatment to the last date of follow-up or the date of death Actuarial local control and overall survival were calculated ... compare favorably to a large RTOG trial of conventionally fractionated radiation therapy for palliation of inoperable NSCLC, which demonstrated palliation of symptoms in 60% and local control in ... Page of 16 17 Received: 29 May 2010 Accepted: 22 October 2010 Published: 22 October 2010 18 References Qiao X, Tullgren O, Lax I, Sirzen F, Lewensohn R: The role of radiotherapy in treatment of...

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báo cáo khoa học: "Successful treatment of a T4 lung tumor with vertebral body invasion using fiducial markers in the thoracic spine for image-guided radiation therapy: A case report" pps

Ngày tải lên : 10/08/2014, 23:20

... tight dose fall-off in the area of vertebral body invasion Figure demonstrates the sharp fall-off from the treatment dose of 74 Gy (red) to the approximate spinal cord tolerance dose of 50 Gy (purple) ... accuracy of fiducial markers with the use of other forms of IGRT Watchman et al [10] compared KV X-ray imaging and fiducial marker matching for the set-up of 18 treatment fractions of stereotactic ... use of fiducial markers for accurate treatment set-up Shirato et al [9] reported marker migration in one of three patients who underwent transcutaneous insertion of spinal markers for radiotherapy...

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Báo cáo y học: " A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged highthroughput biophysical screening" pps

Ngày tải lên : 12/08/2014, 13:22

... Function efficacy of small molecules on stiffness of ASM at the level of a single living cell Figure S2: Modulation of pCofilin-14-3-3 protein interactions A potential mechanism of action of small molecules ... Phosphorylated cofilin is bound to 14-3-3 proteins [20-22] and, in human ASM, PKA-activated phosphorylation of HSP20 is associated with dephosphorylation of cofilin and subsequent loss of actin stress ... analogs of HSP20 (pHSP20) co-precipitate with a class of 143-3 proteins and, moreover, competitively inhibit the binding of phosphorylated cofilin to 14-3-3 proteins Using SPR-based evaluation of...

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Báo cáo y học: "Nebulised heparin: a new approach to the treatment of acute lung injury" pdf

Ngày tải lên : 13/08/2014, 11:22

... of systemic complications? What is the adequate duration of this therapy? Does the underlying cause of ALI make any difference with regard to this approach? Ultimately, randomized controlled trials ... control of physiological variables as well as therapeutic modalities is of the outmost importance [9] The use of ‘treatment bundles’ could be a further necessary step in the direction of optimal ... Critical Care Vol 12 No Suter The translation of a potentially beneficial effect of inhaled heparin in experimental models of ALI to clinical practice has not yet been achieved; important...

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Cambridge.University.Press.Fearing.Others.The.Nature.and.Treatment.of.Social.Phobia.Mar.2007.pdf

Ngày tải lên : 21/09/2012, 10:54

... I is Professor of Clinical Psychology in the Department of Psychology at the University of Montreal Fearing Others The Nature and Treatment of Social Phobia Ariel Stravynski University of Montreal ... (attendant and son of Ares À the god of war) denoting fear, terror, panic Its source is the worship of Phobos, who had the power to instill terror in enemies of ancient Greeks The deity was often depicted ... symptoms of heart disease and hyperventilation a disease of the lungs (1999, p 84) While the process of medicalization reached its peak in the first half of the nineteenth century, a process of psychologization...

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Báo cáo y học: "Clinical review: Treatment of new-onset atrial fibrillation in medical intensive care patients – a clinical framework"

Ngày tải lên : 25/10/2012, 10:35

... 80% of patients with AF convert to SR within 24 hours The use of β-blockers before the start of AF and the absence of diabetes and left ventricular hypertrophy were independent predictors of conversion ... and avoiding Page of 10 (page number not for citation purposes) proarrhythmic drugs Reduction of the systemic inflammatory state is tempting but is of course always the purpose of ICU treatment ... SN, Powe NR, Bass EB: Efficacy of agents for pharmacologic conversion of atrial fibrillation and subsequent maintenance of sinus rhythm: a meta-analysis of clinical trials J Fam Pract 2000, 49:1033-1046...

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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

Ngày tải lên : 25/10/2012, 10:51

... first year of therapy Page of 10 (page number not for citation purposes) Annals of General Hospital Psychiatry 2004, http://www.general-hospital-psychiatry.com/content/3/1/7 The effects of anticonvulsants ... of our patients develop renal disease, psychiatrists must be aware of the effects of psychotropics on the kidneys, as well the effects of decreased renal functioning on the pharmacokinetics of ... bioavailability of free, active highly protein-bound drugs Accumulation of active hydroxylated metabolites of carbamazepine may lead to symptoms of drug toxicity despite therapeutic drug levels [70] Of all...

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Báo cáo y học: "Surgical Treatment of Depressed Scar: A Simple Technique"

Ngày tải lên : 25/10/2012, 11:00

... mind, in the presence of adherent scars, after having infiltrated the whole area with a solution of Lidocaine 0.5% and Epinephrine 1:200,000 very close to one of the two edges of the scar, a small ... the mobility of the recuperated tissue 378 Fig.2: A small incision with an undermining scissor inside it Fig.3: The scar is completely undermined Fig.1: An example of a depressed scar of the abdomen ... below Infact, the use of the stitches in depth is performed in order to prevent that the adhesion can recreate again: this relapse could promote the formation of a layer of reactive collagen in...

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