synthetic zinc finger transcription factors
Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... identification of transcription factors is that FEBS Journal 277 (2010) 128–147 ª 2009 The Authors Journal compilation ª 2009 FEBS S Mitra et al Zebrafish T-cell transcription factors t-bet, stat6 ... IFN-c is released Zebrafish T-cell transcription factors t-bet, stat6 and foxp3 In conclusion, this investigation has identified three important transcription factors in zebrafish, t-bet, stat6 ... between the expression of these transcription factors and the cytokine genes known to be produced by different T-cell subtypes in mammals These transcription factors, together with many of the...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... post-transcriptional processing of the protein [41] Additionally, it is evident that AP-2 transcription factors can indirectly modulate genes by functional interactions with other transcription factors, ... molecular processes of chondrogenic and skeletal development, including transcription factors Essential transcription factors in chondrocyte differentiation are Sox9 and Runx2 Sox9 plays a key ... AP-2 transcription factors bind to the palindromic recognition sequence 5¢-GCCN3GGC-3¢ or variations of this GC-rich sequence within multiple gene promoters [45] AP-2s play a dual role as transcriptional...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt
... pathological roles in RA Other transcription factors Other transcription factors implicated in the pathogenesis of RA are the signal transducer and activator of transcription (STAT) family of ... respond to particular stimuli Such binding proteins are transcriptional factors In this review, we focus on the role of transcriptional factors on the pathology of rheumatoid arthritis (RA) Nuclear ... emphasizes the importance of the NF-jB, NFAT and AP-1 transcription factors in RA, and therefore signaling cascades of these transcription factors are feasible targets for a comprehensive anti-RA...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... )260 and )119 promote efficient transcription As several consensus binding sequences for known transcription factors such as GATA, Ets, and MyoD/ E-box binding factors were present within )260/)119, ... 4) The two transcription start sites were surrounded by GCrich sequences including the binding sites for transcription factor Sp1, as frequently found in promoters without a TATA box Transcription ... revealed the presence of consensus binding sequences for several transcription factors including Ets, GATA, and MyoD/E-box binding factors The introduction of mutation into one of the putative Etsbinding...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... promoter by the AP-1 and CREB transcription factors The AP-1 refers to the DNA binding activity specific for the palindromic sequence 5¢-TGAGTCAG-3¢ Transcription factors of the basic leucine zipper ... or heterodimer combinations of B-Zip transcription factors including CREB homodimers, CREB–ATF heterodimers and dimers consisting of other ATF transcription factors In addition, there are other ... with transcriptional adapter proteins like CREB-binding protein (CBP) or other transcription coactivators that interact with the basal transcriptional machinery and increase the rate of transcription...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
... of the Muc5b promoter by TTF-1 and GATA factors Using this approach, we aimed to show the transcriptional regulation of Muc5b by these two transcription factors, thereby providing a strong base ... GATA family of transcription factors is composed of several factors [25] In the lung, it has been shown that GATA-4 ⁄ GATA-5 ⁄ GATA-6 are expressed in a restricted manner These factors participate ... (2007) The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer...
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Báo cáo khoa học: Structure of FocB – a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli pdf
... these regulatory genes encodes the FocB protein, a member of the PapB family of fimbrial transcriptional factors The members of the PapB family identified so far exist in both the E coli and Salmonella ... which appears to be quite different from the canonical HTH motifs found in many bacterial transcription factors [30–32] In particular, the second helix of the HTH motif, the putative recognition ... right-handed helical bundle with a partly open configuration The HTH motif, as it is known from transcription factors in both prokaryotes and eukaryotes, recognizes a specific DNA-sequence and is mostly...
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Báo cáo khoa học: Hepatocyte-specific interplay of transcription factors at the far-upstream enhancer of the carbamoylphosphate synthetase gene upon glucocorticoid induction doc
... extent DNA accessibility to transcription factors and the sequence in which the transcription factors bind play a role Furthermore, it remains unclear whether accessory factors have to bind first ... ubiquitously expressed glucocorticoid receptor (GR) and three accessory factors These accessory factors are the liver-enriched transcription factors forkhead box A (FoxA) and CCAAT ⁄ enhancer-binding protein ... response units is the order and time at which the transcription factors bind to their response elements With only four response elements for transcription factors located within a stretch of 80 bp,...
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Báo cáo Y học: Molecular interactions between nuclear factor kB (NF-kB) transcription factors and a PNA– DNA chimera mimicking NF-kB binding sites doc
... and p50 NF-kB transcription factors In addition, Fig 4A shows that, unlike NF-kB PDP –PDP molecules, NF-kB PNA–PNA hybrids not affect the binding of p50 and p52 NF-kB transcription factors to 32P-labelled ... molecules for transcription factors In addition, we hope our results will have practical implications The finding that DNA –PNA chimeras stably interact with NF-kB transcription factors encourages ... or p50 NF-kB factors The double stranded PDP –PDP chimera mimicking the HIV-1 NF-kB binding sites does not inhibit the interactions between NFIL2, GATA-1 and STAT-1 transcription factors to the...
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Báo cáo khoa học: The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-DisplacementProtein (CUX1) repressor ppt
... differentiation [19] PLZF is a transcription factor composed of a repression domain ` BTB ⁄ POZ (bric-a-brac, tramtrack, brad complex ⁄ poxvirus zinc finger) and nine Kruppel zinc fingers [20] ¨ This ... gene transcription by forming a physical barrier in the PLZF genomic region that corresponds to the 5¢-UTR, causing a limitation of PLZF transcriptional initiation and gene processing via the transcriptional ... nature of the molecular pathways susceptible to direct influence by its transcriptional activity The Cux1 gene encodes for a transcriptional repressor that belongs to the homeodomain protein family...
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Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... archaeal transcription factors To allow more detailed insights into the molecular repression mechanism of nitrogen-regulated promoters, we studied the binding properties of NrpRII to the general transcription ... between an archaeal repressor and the general archaeal transcription factors TBP and TFB besides the recent documentation of interactions between the transcriptional activator GvpE and all five TBPs ... the nifH promoter by simultaneously contacting NrpRI and the general transcription factors, resulting in full repression of transcription External nitrogen limitation is perceived by sensing the...
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Báo cáo khoa học: Transcription factors Sp1 and C⁄EBP regulate NRAMP1 gene expression ppt
... nuclear factors [17] Sp1 is thus often associated with Ets-related transcription factors, e.g myeloid Elf-1-like factor (MEF) [18,19] Members of the C ⁄ EBP family are important nuclear factors ... The C ⁄ EBP+ plasmids upregulated transcription similarly to CDP ⁄ Cut p110, indicating that CCAAT-binding factors also bind to the NRAMP1 basal promoter NRAMP1 transcription is regulated by cooperation ... Such a dramatic effect proved that CCAAT-binding factors are crucial to control of NRAMP1 transcriptional activity Endogenous Sp1 and C ⁄ EBP factors bind the NRAMP1 promoter in maturing monocytic...
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Báo cáo khoa học: Nucleocytoplasmic shuttling of STAT transcription factors Thomas Meyer and Uwe Vinkemeier doc
... Ó FEBS 2004 Nucleocytoplasmic shuttling of STAT transcription factors (Eur J Biochem 271) 4607 Fig STATs at the cell membrane A schematic representation ... STATs through the nuclear pore remain to Ó FEBS 2004 Nucleocytoplasmic shuttling of STAT transcription factors (Eur J Biochem 271) 4609 FITC-BSA STAT1 Hoechst A Fig Nucleocytoplasmic shuttling ... cytokine receptors in the cell membrane Ó FEBS 2004 Nucleocytoplasmic shuttling of STAT transcription factors (Eur J Biochem 271) 4611 STAT nucleocytoplasmic transport in disease It is increasingly...
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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx
... measure and grade the response without compromising cell viability Msn2 and Msn4 are two zinc- finger transcription factors initially described as mediators of the yeast general stress response [53] ... conditions, YAP4 is not regulated by Msn4, further supports growing evidence that the two zinc- finger transcription factors are not entirely redundant in function [59] Yap4 and Yap6 are constitutively ... nuclear accumulation of Hog1 activates downstream transcription factors YAP4 is activated via Msn2 and subsequently the encoded factor elicits the transcription of its target genes between them...
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Báo cáo sinh học: "MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells" pptx
... such factors as snail, slug/snail2, zinc finger E-box binding homeobox (ZEB) and ZEB2 have been shown to directly bind to the Ecadherin promoter and repress its transcription [15] Several recent ... in this study [15,17] ZEB1 and ZEB2 are related homeodomain-containing transcriptional factors that repress E-cadherin transcription [17,38,39] E-cadherin is a central component of the adherens ... MicroRNA Reverse Transcription Kit (Applied Biosystems) Predesigned TaqMan MicroRNA Assays including the primer set and TaqMan probe were purchased from Applied Biosystems The reverse transcription...
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Báo cáo sinh học: "Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors" ppt
... acts to regulate the transcription of a number of target genes S6K Growth control by FOXO factors elF4E rpS6 Cell growth and division Figure The dFOXO protein mediates a transcriptional response ... reduced insulin signaling Daf16 was found to encode a transcriptional regulator of the Forkheadbox type O (FOXO) class of Forkhead-related factors, thus indicating that control of gene expression ... kinases, appears to be a critical step in cell-cycle arrest by FOXO The transcription of p27kip1 is directly induced by FOXO factors in response to low insulin levels, and cells lacking the kip1...
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Báo cáo y học: "The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis" pot
... conformational shift in the resonances of the first zinc finger in the peptide, while simultaneously permitting the demonstration of second zinc finger resonances that had been apparently unstructured ... the zinc finger protein TIS11 Biochem Biophys Res Commun 2002, 293:1242-1247 263 Arthritis Research & Therapy 264 Vol No Carrick et al 37 Blackshear P, Phillips RS, Lai WS: Tandem CCCH zinc finger ... Thorn JM, Kennington EA, Blackshear PJ: Interactions of CCCH zinc finger proteins with mRNA Binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA...
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Báo cáo y học: "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors" potx
... (Figure 2a) The majority of START domains are found in transcription factors of the HD family HDs are DNA-binding motifs involved in the transcriptional regulation of key developmental processes ... 5:R41 information The presence of the START domain in HD transcription factors suggests the possibility of lipid/sterol regulation of gene transcription for HD-START proteins, as previously hypothesized ... presence of the lipid/sterolbinding domain in a transcription factor has a parallel in the animal kingdom (Figure 5) In animals, steroid-binding transcription factors of the nuclear receptor superfamily...
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Báo cáo y học: " Regulatory interdependence of myeloid transcription factors revealed by Matrix RNAi analysis" docx
... deviation; siRNA: small interfering RNA; TF: transcription factor; TFBS: transcription factor binding site; TRN: transcriptional regulatory network; TSS: transcription start site Authors' contributions ... Identification of DNA regions and a set of transcriptional regulatory factors involved in transcriptional regulation of several human liver-enriched transcription factor genes Nucleic Acids Res ... Levine M, Tjian R: Transcription regulation and animal diversity Nature 2003, 424:147-151 Ernst P, Smale ST: Combinatorial regulation of transcription I: General aspects of transcriptional control...
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