synergistic co delivery of doxorubicin and paclitaxel using multi functionalized micelles for cancer treatment
Development of multi functionalized polymeric carriers for delivery of anticancer drug combinations
... PTX-TAT/FOL micelles and co- delivery of TAM- TAT/FOL micelles & PTX-TAT/FOL micelles_ 0.6/1 The synergistic effect of co- delivery of TAM- TAT/FOL micelles & PTX-TAT/FOL micelles_ 0.6/1 compared to ... Cytotoxicity of DOX- loaded micelles 61 3.3.8 Cellular uptake 67 3.4 Conclusions 68 CHAPTER Synergistic co- delivery of doxorubicin and paclitaxel using multifunctionalized ... delivery of single drug-loaded micelles, (2) co- delivery of two singe drug-loaded micelles at the ratio of CDDP/DOX at XII 20/1, and (3) delivery of dual drugs-loaded micelles at the ratio of CDDP/DOX...
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Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers
... Feng SS Novel powder formulations for controlled delivery of poorly soluble anticancer drug: application and investigation of PT TPGS and PEG in spray-dried particulate system J Control Release 2005;103:565- ... (ii) drying of spray into drying gas, (iii) formation of dry particles and (iv) separation and collection of the dry SC product from the drying gas [2-4] Figure shows a scheme of the conventional ... diagram of this device and the functional principle of mesh vibration and the NU electrostatic particle collector [10] Several authors used this spray-dryer for the production of NPs and MPs For...
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analysis and deformulation of polymeric materials paints, plastics, adhesives, and inks
... distinguish types of formulations and how to efficiently, economically, and, hopefully, painlessly deformulate it Formulations can be mixtures of materials of widely varying concentrations and forms To ... Scheme for preparation of solid ink specimen for deformulation Scheme for deformulation of a solid ink specimen SEM micrographs of washable black writing pen ink Scheme for preparation of liquid ... thermogram of polypropylene TGA thermogram of polystyrene TMA thermogram of poly (styrene -co- butadiene) copolymer film DMA thermograms of poly (styrene -co- butadiene) copolymer films of different compositions...
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design, synthesis, and characterization of polymeric materials for uses in energy storage applications
... adapted for publication in Chemistry of Materials and was coauthored by H.R Allcock and D.A Stone Chapter has been adapted for publication in Solid State Ionics and was coauthored by H.R Allcock and ... adapted for publication in Solid State Ionics and was coauthored by H.R Allcock and A.M Maher Chapter has been adapted for publication in Macromolecules and was coauthored by H.R Allcock and D.A ... Microform 3231914 Copyright 2006 by ProQuest Information and Learning Company All rights reserved This microform edition is protected against unauthorized copying under Title 17, United States Code...
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A mechanism based approach void growth and coalescence in polymeric adhesive joints
... fellow and mentor, for his invaluable guidance and insightful knowledge in continuum mechanics His passion and enthusiasm for research work was contagious and had been, and most surely will continue ... coalescence ahead of a crack in polymeric adhesive joints, and how these parameters contribute to the formation of extended damage zones 5 The major findings of this research and recommendations for future ... to a concentration of microvoids into bands of fibrils which are known to exhibit extension ratios of up to 500% before breakage The voids and fibrils make up about 50% each by volume, and constitute...
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Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery
... The scope of this thesis include the fabrication of multifunctional polymeric micelles, the selectivity of the micelles between cancer cells and tumor cells, the P-gp inhibition of the micelles, ... effects of traditional chemotherapy Cancer is responsible for 22.9% of annual deaths in the world and becomes the leading cause of deaths in recent years However, treatments of cancer are painful, often ... with cancer chemotherapy is the development of multidrug-resistant (MDR) tumor cells during the course of treatment To overcome MDR, a new drug formulation - PLGA-PEG-FOL formulated with d-α-tocopheryl...
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Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres
... dollars and 12-15 years needed for the development of a new drug, a drug can get a new life by developing a controlled delivery system with much less money and time consumed (20% of money and half of ... linear relationship between the copolymer composition and the mechanical and degradation properties of the materials For example, a copolymer of 50% glycolide and 50% dl-lactide degrades faster ... information obtained from a chromatographic experiment is contained in the chromatogram, a record of the concentration or mass profile of the sample components as a function of the movement of...
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Design of functional polymeric micelles as a carrier for anticancer drug delivery
... stability of acid -functionalized polycarbonate micelles with the introduction of urea -functionalized polycarbonate (PUC) and PEG diblock copolymer to form unique and coherent mixed micelles via ... bonding and hydrophobic interaction) between the core-forming hydrophobic blocks of the copolymers and between the micellar core and the encompassed drug molecules It is postulated that the micelles ... release and cytotoxicity of PEG-PAC/PEG-PUC2 mixed micelles 64 3.4 Conclusion 66 Chapter Micelles formed from block copolymers of PEG and polycarbonate bearing both acid and...
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Báo cáo y học: "Pravastatin Provides Antioxidant Activity and Protection of Erythrocytes Loaded Primaqe"
... 2.76 % and 2.28%) was observed at NaCl concentration of 0.9 % for control, pravastatin, primaquine and their combinations respectively On another side the maximum hemolysis of 94.8% for control ... acid was prepared 200 μL of RBCs lysate and 1.9 ml distilled water were added to complete the volume of ml After boiling for h, the mixture was cooled, and ml of n-butanol and pyridine (15:1) solution ... erythrocytes, 98.4% for pravastatin, 99.5% for primaquine and 95.2% for the combination between pravastatin and primaquine was occurred at NaCl concentration of 0.1% Typical micrographs of erythrocytes...
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Báo cáo khóa học: Conformational changes of b-lactoglobulin in sodium bis(2-ethylhexyl) sulfosuccinate reverse micelles A fluorescence and CD study docx
... resolution, a nm bandwidth and a sensitivity of 10 millidegrees (mdeg) An average of 5–10 scans was recorded and corrected by subtracting the baseline spectrum of unfilled RM of the same composition ... decrease in the local dielectric constant and consequent lowering of the average polarity of the Trp environment and/ or with conformational changes of the protein that are accompanied by Fig Fluorescence ... as a consequence of the loss of most of the helical and sheet secondary structure This apparent bfia transition cannot be interpreted only in terms of the decrease of the dielectric constant of...
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Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... bonds of D92 and H110 with carboxyl group of the OA molecule, specific for this particular ligand conformation Whether this form of OA binding is enhanced further by the more stable conformation of ... properties of its complexes with fatty acids path length cm) of 3.5 mL each: one for the assay and one for the control assay The contents of each cuvette were mixed 5–10 times by gentle inversion of ... in the molecule B in comparison with higher disorder of the ligand in the molecule A However, despite of the lack of strong lattice contacts that may affect the conformation of the lid, its high...
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inorganic polymeric nanocomposites and membranes (advances in polymer science) (advances in polymer science)
... – CH2 – CF2 – Copolymers were obtained by copolycondensation of hybrid bis-silanols and dichlorosilanes to give random copolymers or by copolycondensation of hybrid bis-silanols and diacetamidosilanes ... (AB)n random and alternated copolymers and (BAB)n alternated copolymers has been achieved and showed the influence of the structure of the polymer 16 F Guida-Pietrasanta · B Boutevin Random copolymers ... decided to consider the synthesis of polymers of the type of Fig 12: Fig 12 He recognized, then, that these types of compounds would be less flexible than classical silicones, at low temperature and...
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buchmeiser - polymeric materials in organic synthesis and catalysis (wiley, 2003)
... Therefore, I soon found myself contacting colleagues asking for contributions, tables of contents and manuscripts Quite surprising, I received hardly any negative replies This and the professional ... intense subject of research effort, in practice the specific combination of their physical characteristics coupled with the rather inconvenient method of synthesis, and resulting costs relative ... materials of very regular pore structure (e g zeolites), permanently porous organic polymers consist of a very complex network of pores of different sizes connected to each other Correction of these...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
... polymeric micelles are fabricated according to the physicochemical properties of drugs and the compatibility between the core of micelles and drug molecules [14,21] Unfavorably, propofol-loaded ... lower the CMC of micelle-forming material [27,28] In the case of our experiment, the hydrophobic segments forming the core of plain micelles and mixed micelles were PLA chains, and PLA and octadecyl ... that the content of mPEGPLA in the prepared mixed micelles was almost mg/mL Optimization of micelle composition and characterization of mixed micelles Drug-free plain and mixed micelles of mPEG-PLA/Solutol...
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Báo cáo hóa học: " Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules" ppt
... (CoQ10 and GTCC), and the amount of lipid (CoQ10 and GTCC) was kept at a fixed concentration of 12.5% (w/w) with regard to the total mass of 100 g Briefly, CoQ10 and GTCC were mixed at 60°C, and ... peaks of CoQ10 and of the comelting complex of GTCC/CoQ10 were absent, indicating a supercooled state due to the effect of nanosize particles From the above result, the crystallisation point of CoQ10LNCs ... Cryo-TEM of CoQ10-LNCs at a magnification of 15000 with different contents of CoQ10 in the inner lipid core, prepared at a pressure of 1000 bar A CoQ10-LNCs-100; B CoQ10-LNCs-75; C CoQ10-LNCs-50; D CoQ10-LNCs-25;...
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Báo cáo hóa học: " Facile Preparation of Crosslinked Polymeric Nanocapsules via Combination of Surface-Initiated Atom Transfer Radical Polymerization and Ultraviolet Irradiated " docx
... samples were dispersed in toluene (PS-SNs) and dimethylformamide (CPNs) in an ultrasonic bath for min, and then deposited on a copper grid covered with a perforated carbon film PS-SNs 100 80 CPNs 60 ... (DMF), tetrahydrofuran (THF), ethanol, hydrofluoric acid, and other solvents used were all of analytical reagent grade and obtained from Tianjin Chemical Co. , Tianjin, China, and were used without ... CaH2 and distilled under reduced pressure Triethylamine (TEA) and tetrahydrofuran (THF) were dried by CaH2 overnight, and then distilled under reduced pressure before use Toluene, dimethylformamide...
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Báo cáo hóa học: " Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap" ppt
... and fluorescence imaging for diagnosis; however, there are few studies on the multifunctional magnetic targeting drug delivery system for diagnosis and therapy [12, 13] In the earliest study of ... electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and fluorescence spectroscopy The generation of singlet oxygen was monitored by RNO bleaching assay, and the photodynamic ... 40 kV and 100 mA Transmission electron microscopy (TEM) was employed to determine the morphology and size of the aqueous dispersion of nanocarriers, using a HITACHIH-800 electron microscope,...
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Báo cáo hóa học: " Fabrication of Highly Ordered Polymeric Nanodot and Nanowire Arrays Templated by Supramolecular Assembly " pot
... assemblies (SMA) of low molecular amphiphiles and block copolymers [20, 21] The amphiphiles can be physically bonded to homopolymers and block copolymers using noncovalent interactions, this complexation ... microscopy (AFM) imaging was performed using a Dimension 3100 scanning force microscope (Digital Instruments, Inc.,) in the tapping mode Analysis of the AFM images (fast Fourier transform) was performed ... dichloromethanes were purchased from Acros Organics and used as supplied Fabrication of Ordered Nanodots and Nanowire Arrays PS-PVP and HABA (1 mol of HABA and mol of 4vinylpyridine monomer unit) were dissolved...
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Báo cáo lâm nghiệp: "Strength properties of thermally modified softwoods and its relation to polymeric structural wood constituents" pot
... 2.2 Heat treatment For each timber species at least 10 boards were treated for each set of process conditions The heat treatment was performed in two separate heat treatment stages and a drying ... 100% RH Conditioning Figure Effects of conditioning on the bending strength (a) and Modulus of Elasticity (b) of heat treated and untreated radiata pine specimens (defect free) Treatment conditions: ... involves cleavage of the sidechain constituents (arabinose and galactose), followed by degradation of the main chain constituents (mannose, glucose and xylose) The corresponding pentoses and hexoses...
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Báo cáo khoa hoc:" Evaluation of triblock copolymeric micelles of δvalerolactone and poly (ethylene glycol) as a competent vector for doxorubicin delivery against cancer" doc
... characterization and in vitro antitumor evaluation of δ-valerolactone and PEG based triblock copolymeric micelles for the delivery of anticancer agent, doxorubicin Effective ring opening polymerization using ... http://www.jnanobiotechnology.com/content/9/1/42 Page of 14 Figure 10 Cell viability assay Comparison of the cell viabilities of MCF7 and U87MG cells on treatment with free DOX and equivalent concentrations of VEVDMs ... need the evaluation of these micelles in animal models, sustained drug release from VEVDMs supports the idea of using VEV copolymer based micelles for controlled delivery of anticancer agents Enhanced...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25