susceptibility modifier genes rnai in hf

Báo cáo y học: " Modifier genes and variation in cystic fibrosis" pot

Ngày tải lên : 12/08/2014, 18:20

... reasoned that genes involved in innate defense against bacteria outside CF might also be relevant in the context of CF They examined CF patients for alleles of the mannose-binding lectin (MBL) gene ... expression, protein processing, protein turnover or CFTR activity could all impact on disease In the airway, genes modifying the downstream effects of CFTR mutations, such as infection susceptibility, ... and basic research regarding CF is consequently focusing on the airways, but identifying effective sites for intervention remains elusive (see [3]) Searching for modifier genes of pulmonary disease...

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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"

Ngày tải lên : 31/10/2012, 15:28

... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray ... ethanol-induced expression and activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal ... Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma derived...

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Tài liệu Báo cáo Y học: Identiﬁcation of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf

Ngày tải lên : 21/02/2014, 01:21

... transcription terminator The resulting fragment only contains the initial 67 bp and the ﬁnal 68 bp of the pur4 coding sequence It was inserted in plasmid pGM9 The resulting construct was introduced, ... Chemical structure of A201A and puromycin In actinomycetes, it is well established that genes implicated in antibiotic biosynthesis, including those encoding self-resistance, are clustered [10,11] ... Possible ribosomal binding sites are indicated by dotted lines Putative translation initiation and termination codons are in bold letters The start and direction of each ORF are indicated by horizontal...

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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several speciﬁc biological processes through GCN2-dependent and GCN2-independent pathways ppt

Ngày tải lên : 07/03/2014, 03:20

... described for the amino acid-dependent regulation of several genes, including Chop, Atf3, Cat-1 and insulinlike growth factor binding protein (Igfbp1), making it possible that amino acid availability ... regulated in wild-type cells For example, the genes involved in amino acid metabolism were not regulated by amino acid starvation in GCN2) ⁄ ) cells, whereas enrichment for the genes involved in cholesterol ... is directly involved in the regulation of amino acid and protein metabolism, as many of the genes involved in these processes are not regulated in GCN2) ⁄ ) cells These results are in good agreement...

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Báo cáo khoa học: Functional expression of the quinoline 2-oxidoreductase genes (qorMSL) in Pseudomonas putida KT2440 pUF1 and in P. putida 86-1 Dqor pUF1 and analysis of the Qor proteins doc

Ngày tải lên : 17/03/2014, 10:20

... to integrate the Mo-MCD cofactor into the corresponding apoprotein In a ﬁrst attempt to functionally express genes coding for a Mo-MCD-containing hydroxylase in heterologous hosts, the iorAB genes ... Brevundimonas diminuta 7, coding for isoquinoline 1-oxidoreductase, were cloned in P putida KT2440 and in the quinoline degrading strain, P putida 86 However, the level of Ior synthesis was very low in both ... FAD) GMP was not present in any Qor extract, indicating that the host strains did not incorporate Mo-MGD, or free GMP, into the cofactor binding domain of the Qor protein Similar amounts of CMP...

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Cytokines Genes Polymorphisms in Iranian Patients with Pulmonary Tuberculosis doc

Ngày tải lên : 22/03/2014, 18:20

... homozygous individuals in CTB affected subject group In the present study the genotype frequencies of a number of polymorphic genes coding for cytokines or for cytokine receptors have been investigated ... production in response to culture filtrate proteins in comparison with endemic healthy controls (3) In a TNF-¿ (-238 and -308) gene polymorphism analysis that was carried out by Selvaraj et al in an Indian ... 3.75 fold increased risk of developing tuberculosis, in contrast IL-10 polymorphism did not affect susceptibility to tuberculosis (5) Bellawy et al have investigated IL-1 cluster gene in a group...

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báo cáo hóa học: " Robustness of digitally modulated signal features against variation in HF noise model" pdf

Ngày tải lên : 21/06/2014, 02:20

... details Electrical Engineering Department, College of Engineering, King Saud University, Riyadh, Saudi Arabia 2Prince Sultan Advanced Technologies Research Institute/STC-Chair, King Saud University, ... against the change in noise model Note that the contribution of this article is pertaining to the features extraction stage; hence the results obtained are independent of the classifier being ... applications in Proceedings of ICACT 2007, Gangwon-Do, 1, 9–12, February 2007 K Maliatsos, S Vassaki, Ph Constantinou, Interclass and intraclass modulation recognition using the wavelet transformation in...

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Báo cáo hóa học: " Research Article Identifying Genes Involved in Cyclic Processes by Combining Gene Expression Analysis and Prior Knowledge" pot

Ngày tải lên : 22/06/2014, 00:20

... sets, that is, the set of genes involved in a cyclic process and the set of noncycle-involved genes recognized in biological experiments The cycle-involved genes are used to initialize the proposed ... proteins or are involved in ribosome biogenesis It has been veriﬁed that ribosome biogenesis consumes up to 80% of proliferating energy, and it is linked to cell cycle in metazoan cells However, in ... as Algorithm Lines to accept inputs and initialize the target cyclic gene set with the spectral analysis results and the prior cycle-involved genes Inside them lines to exclude genes whose peak...

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Báo cáo khoa học: "Drought susceptibility and xylem dysfunction in seedlings of 4 European oak species" pdf

Ngày tải lên : 08/08/2014, 19:21

... be increased beyond 20%, possibly affecting growth and causing leaves to fall If vulnerability in seedling stems is similar to that in petioles, then winter freezing and thawing will further increase ... were germinated in November 1990 to provide seedlings for use in 1992 and 1993 In addition, plants of Q robur, Q petraea and Q cerris, purchased in root trainers, were potted for use in 1992 and ... to a general weakening of trees (OEPP/EPPO, 1990) An increased incidence in eastern Europe in the 1980s has been of concern following the 1976 drought, affecting Quercus robur in particular Although...

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Báo cáo y học: "Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish wome" pdf

Ngày tải lên : 09/08/2014, 07:20

... reading of grade 2–4 in at least three joints of the fingers OA was defined to be symmetrical if at least two symmetrical pairs of joints (the same joint in both hands) were affected Our findings ... hand OA In addition, our findings suggest a detrimental effect of low dietary calcium intake on OA The findings remain to be weighted in future studies Further studies into mechanisms underlying ... consequences, however, since it is located in intron and is not affecting any splicing site or transcription factor binding site Moreover, although the TaqI polymorphism is located in the coding sequence...

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Báo cáo y học: "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians" potx

Ngày tải lên : 09/08/2014, 07:20

... modulator in OA by fine-tuning transforming growth factor beta in the repair of damaged cartilage, this effect will be limited to some ethnic groups or environmental settings Competing interests ... aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis Nat Genet 2005, 37:138-144 Loughlin J: Polymorphism in signal transduction is a major ... asporin a newly discovered member of the leucine-rich repeat protein family J Biol Chem 2001, 276:12212-12221 Mustafa Z, Dowling B, Chapman K, Sinsheimer JS, Carr A, Loughlin J: Investigating...

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Báo cáo y học: "SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis" docx

Ngày tải lên : 09/08/2014, 10:21

... following SOX9 transduction Interestingly, SPINT1 was also significantly upregulated in the chondrocytes (2.1-fold), which differed from the finding in the SW1353 cells APOD was Available online ... calcium-binding protein A1 (S100A1) NM_006271 8.84 NA Sushi-repeat-containing protein X chromosome (SRPX) NM_006307 3.47 NA Cytokine receptor-like factor (CRLF1) NM_004750 3.31 NA Cartilage linking ... protein component of low density lipoprotein in human plasma [34], and is reported to be a transit protein in the skin [35] It may therefore have some function in cartilage ECM The finding that...

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Báo cáo y học: "The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets" pptx

Ngày tải lên : 09/08/2014, 14:22

... major role in RA angiogenesis Angiogenesis is stimulated in RA by the increased metabolic demand of the pathologically active synovial tissues [1,14-16] Potentially, inhibition of this angiogenesis ... supported by studies in animal models in which injection of ανβ3 antagonists has shown inhibition of neovascularisation and attenuation of joint inflammation [18] A previous genome-wide linkage scan suggested ... minor allele under-represented in the case groups in all three cohorts (Table 1) However, the allele distribution in the Oxford RA cohort differs in that the minor allele is over-represented in...

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Báo cáo y học: "Tandem repeats modify the structure of human genes hosted in segmental duplications" docx

Ngày tải lên : 09/08/2014, 20:21

... ITRs modify protein sequences In agreement with an active role in modifying protein sequences, we found that 50% of the detected ITRs occur in the coding sequence of genes lying in SDs (Table 2) ... proteins, the VCX/Y proteins, the nuclear pore interacting proteins, and the prostateovary-testis-endometrium proteins In this latter case, the formation of an amino acid repeat is involved in ... represent an innovation in terms of amino acid composition within the primate lineage In all seven cases ITR modifications occur in the last coding exon, thus producing an accretion of the protein sequences...

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báo cáo khoa học: "Prospecting for Genes involved in transcriptional regulation of plant defenses, a bioinformatics approach" pdf

Ngày tải lên : 11/08/2014, 11:20

... of SA and induction of JA defense genes; yellow boxes, genes involved in JA biosynthesis; light blue boxes, genes involved in ET biosynthesis; pink boxes, genes involved in ET signaling van Verk ... the pink and green dot almost in the middle of the network), are in between the super cluster with the genes encoding proteins involved in SA signaling (red dots), Flg22-initiated MAPK kinase ... colored components of the signaling pathways indicated in Figure The genes in white boxes indicate co-expressed genes with at least one edge to the kinase genes in the colored boxes Exploration...

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báo cáo khoa học: "A microarray approach to identify genes involved in seed-pericarp cross-talk and development in peach" ppt

Ngày tải lên : 11/08/2014, 11:21

... other signaling molecules, playing either direct or indirect roles Concerning hormones, parthenocarpic fruit development in some species is induced by applications of auxin or cytokinins (CKs), ... expression, being induced in LS and repressed in LM (group H) In addition to the 108 genes more abundantly transcribed in ES (group B), 22 were also expressed in EM (group G), while were abundant in ES ... transfer protein (LTP), ctg1026, coding for a pathogenesis related (PR) protein, ctg1540, coding for a prunin, and ctg3563, coding for a late embryogenesis abundant (LEA) protein, have been chosen...

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báo cáo khoa học: "SND2, a NAC transcription factor gene, regulates genes involved in secondary cell wall development in Arabidopsis fibres and increases fibre cell area in Eucalyptus" doc

Ngày tải lên : 11/08/2014, 11:21

... protein 2) Protein kinase family protein IQD10 (IQ-domain 10); calmodulin binding RIC2 (ROP-INTERACTIVE CRIB MOTIF-CONTAINING PROTEIN 2) Protein kinase family protein Rho GTPase activating protein, ... domain-containing protein / MATH domain-containing protein Nodulin MtN3 family protein GCN5-related N-acetyltransferase (GNAT) family protein Hydroxyproline-rich glycoprotein family protein Unknown ... Glycine-rich protein GLP10 (GERMIN-LIKE PROTEIN 10); manganese ion binding / metal ion binding / nutrient reservoir AGP4 (ARABINOGALACTAN-PROTEIN 4) FLA15 (FASCICLIN-LIKE ARABINOGALACTAN PROTEIN...

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báo cáo khoa học: " High levels of nucleotide diversity and fast decline of linkage disequilibrium in rye (Secale cereale L.) genes involved in frost response" doc

Ngày tải lên : 11/08/2014, 11:21

... lines differed from gene to gene ranging from 128 lines (64%) in ScCbf11 to 198 (98%) in ScVrn1 Missing amplification products in individual lines were most likely the result of SNPs/Indels in ... are significantly higher in lines harbouring the vrn1 winter allele than in lines harbouring the Vrn1 spring allele [19] It remains unknown how the Cbf family members interact with Vrn1 under ... Responsive (COR) genes through binding to cis-elements in the promoters of COR genes under cold stress in Arabidopsis [12] More than 70 proteins encoded by COR genes are involved in direct response...

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Báo cáo y học: " An RNAi in silico approach to find an optimal shRNA cocktail against HIV-1" potx

Ngày tải lên : 11/08/2014, 21:21

... multiple alignment In bold, residues directly involved in enzyme activity DBS, DNA binding site dBS, dNTP binding site NNBS, non-nucleoside reverse transcriptase inhibitor binding site AS, active ... against the reference HIV-1 POL protein in the NCBI Conserved Domain Database (CDD) with a cut-off of 1e-85 Within this domain, nine subregions were mapped that were associated with DNA binding ... targeting a single region resulted in rapid emergence of resistance by means of selecting subdominant variants -those that remained untargeted [28] Achieving a higher silencing could be obtained...

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báo cáo khoa học: " Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca) BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into a conifer genome" pdf

Ngày tải lên : 12/08/2014, 03:21

... containing genes of interest involved in conifer defence First, many conifer defence genes exist as closely related members of large families For example, genes encoding the oleoresin producing ... binding site analysis In addition, several cis-acting elements previously identified in other plant species to be involved in responses to giberellin (GARE, TAACAGA; Pbox; GCCTTTTGAGT), auxin ... loblolly pine CYP720B1 in diterpene resin acid formation [20,21] Primers used for gene-specific screening for TPS (3CAR)or P450 (CYP720B4)-containing BAC clones were assessed in silico against other...

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