surface modification of polymeric micelle particles for enhancement of cancer targeting and penetrating ability
Development of multi functionalized polymeric carriers for delivery of anticancer drug combinations
... 2.6.4 Determination of combined chemotherapeutic effect 41 CHAPTER Surface modification of polymeric micelle particles for enhancement of cancer targeting and penetrating ability 44 ... micelles: non-modified micelles, FOL(10)-micelles, FOL(20)-micelles, and FOL(30)-micelles for days 63 Figure 3.6 Effect of FOL concentration of the TAT(10)/FOL-micelles on the viability of ... Cytotoxicity enhancement of drug-loaded micelles with the addition of TAT on the micelle surface 86 4.3.6 Synergistic effect of the co-delivery of DOX- loaded micelles and PTX-loaded micelles...
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Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers
... Advantages and challenges of the spray-drying technology for the PT production of pure drug particles and drug-loaded polymeric carriers SC RI Alejandro Sosnik1* and Katia P Seremeta2,3,4 Laboratory of ... challenges of the spray-drying method for the production of pure drug particles and drug-loaded polymeric particles and discusses the potential of this technique and the more advanced equipment to ... RI consists of four fundamental steps: (i) atomization of the liquid feed, (ii) drying of spray into drying gas, (iii) formation of dry particles and (iv) separation and collection of the dry...
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analysis and deformulation of polymeric materials paints, plastics, adhesives, and inks
... Scheme for preparation of solid ink specimen for deformulation Scheme for deformulation of a solid ink specimen SEM micrographs of washable black writing pen ink Scheme for preparation of liquid ... in paint chips Scheme for preparation of liquid paint specimen for deformulation Scheme for deformulation of liquid paint specimen Distillation apparatus for separation of solvents from liquid ... spectrogram of right side of laminated film IR spectrum of left side of laminated film IR spectrum of right side of laminated film DSC thermogram of laminated film Scheme for preparation of liquid...
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design, synthesis, and characterization of polymeric materials for uses in energy storage applications
... result of a specific grouping of various minerals that form soft thread-like fibers For example white asbestos, or Chrysotile, has a chemical formula of Na2Fe2+3Fe3+2Si8O22(OH)2 Polysilicates and ... adapted for publication in Chemistry of Materials and was coauthored by H.R Allcock and D.A Stone Chapter has been adapted for publication in Solid State Ionics and was coauthored by H.R Allcock and ... adapted for publication in Solid State Ionics and was coauthored by H.R Allcock, R.M Morford, C.E Kellam III, and M.A Hoffmann The appendix was adapted for publication in Advanced Materials and was...
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A mechanism based approach void growth and coalescence in polymeric adhesive joints
... high stress and temperature (Evans and Hutchinson, 1995; Strohband and Dauskardt, 2003) An important example is the failure of polymeric die-attach layers during the surface mounting of electronic ... triaxiality also consists of dimple surfaces and traces of voids (Fig 1.1) Away from the center of the crack-tip, void growth is suppressed In view of this, the applicability of the cell element approach ... 2.4: One-half of a craze in homopolystyrene, with centre of the craze at left-hand edge of top micrograph, and the right-hand craze tip at right side of bottom micrograph (Kambour and Russell,...
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Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery
... of polymeric micelles 106 There are many advantages of using of polymeric micelles as a delivery vehicle Similar to liposomes, the stability and subsequent circulating time of the polymeric micelles ... Micelles size and size distribution of (a) TPGS micelles and (b) mixed micelles with 10% TPGS 112 Figure 6.2 Drug release profiles of DOX-loaded PLGA-PEG-FOL micelles and mixed micelles ... Chapter 2.3.2 Polymeric microparticles/nanoparticles Microparticles (inclusive of submicron particles of 100-500 nm) are delivery vehicles that allow for a local and controlled release of both hydrophilic...
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Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres
... of the flexibility of the polymer chain and may be an indication of the ease of hydrolysis of the ester bonds [Baker, 1992]; (2) DSC/DTA are useful in evaluating the form of the drug in the polymeric ... liposomes, and the interior of (B) blank microspheres and (C) LIMs Figure 5.12 Surface morphology of blank microspheres and LIMs Figure 5.13 In vitro release of liposomes from LIMs xiii LIST OF TABLES ... composition and the mechanical and degradation properties of the materials For example, a copolymer of 50% glycolide and 50% dl-lactide degrades faster than either homopolymer [Stallforthe and Revell,...
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Design of functional polymeric micelles as a carrier for anticancer drug delivery
... mixed micelles systems for targeting To verify the formation of uniform mixed micelles, a number of methods have been reported For example, in the mixed micelles made from Pluronic F127 and PPS20-b-PEO44 ... studies of blank and DOX-loaded 1b micelles 83 4.3.7 Biodistribution of DOX-loaded 1b micelles 84 4.4 Conclusion 85 Chapter Effect of kinetic stability of polycarbonate micelles ... interaction; and characterize the drug-loading capability and in vitro anticancer efficacy of the DOX-loaded mixed micelles The mixed micelles exhibited superior kinetic stability compared to micelles...
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Báo cáo y học: "Pravastatin Provides Antioxidant Activity and Protection of Erythrocytes Loaded Primaqe"
... hemolysis of 94.8% for control erythrocytes, 98.4% for pravastatin, 99.5% for primaquine and 95.2% for the combination between pravastatin and primaquine was occurred at NaCl concentration of 0.1% ... the volume of ml After boiling for h, the mixture was cooled, and ml of n-butanol and pyridine (15:1) solution was added to it This mixture was then centrifuged at 5000 rpm for 15 and the absorbance ... fragility and oxidative damage of erythrocytes of zinc-deficient rats J Nutr 1997; 127: 1290–1296 Lajos N, Miki N, Sandor S Protein and non-protein sulfhydryls and disulfides in gastric mucosa and...
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Báo cáo khóa học: Conformational changes of b-lactoglobulin in sodium bis(2-ethylhexyl) sulfosuccinate reverse micelles A fluorescence and CD study docx
... range of water-pool sizes The study of the interaction between bLG and AOT RM was carried out using CD, and steady-state and timeresolved fluorescence techniques In spite of the widespread use of ... 30; and 6, GdnHCl (6 M) (B) CD spectra of bLG in AOT (1–4) and SDS (5 and 6) aqueous solutions at different surfactant concentrations Inset: % of a-helix obtained with SELCON for SDS (d) and AOT ... a medium for ion diffusion and ion pair formation, which leads to the movement of the charged groups of the protein in order to keep themselves neutral As a means of testing the role of the surfactant...
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Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... bonds of D92 and H110 with carboxyl group of the OA molecule, specific for this particular ligand conformation Whether this form of OA binding is enhanced further by the more stable conformation of ... lack of a hydroxyl group of Ser146 diminishes the role of this residue in the stabilization of the substrate– ligand molecule, leading to the ÔconfusionÕ of the enzyme in the process of the ligand ... the destabilization of the closed (low activity or activated form [15]) forms of Tl lipase, facilitating faster opening of the lid and its transformation into the fully active form It is also likely,...
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inorganic polymeric nanocomposites and membranes (advances in polymer science) (advances in polymer science)
... A comparative study of the thermal properties and of the glass transition temperatures of the (A)n and (B)n homopolymers and of the (AB)n random and alternated copolymers and (BAB)n alternated ... 86 ◦ C) and exhibited the highest degree of thermal and oxidation stability that has been observed so far for any elastomers” Additionally they were supposed to be promising candidates for potential ... terms of thermal stability They generally present rather low Tg s and good stability at high temperature and may thus be used over a wide range of temperature Furthermore, in the search for new...
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buchmeiser - polymeric materials in organic synthesis and catalysis (wiley, 2003)
... 1.4.2.2 Models for Calculation of Surface Area and Pore Sizes BET Theory for the determination of surface area This acronym is derived from the names of its originators Brunauer, Emmett and Teller ... Physical Formats and Characterization of Polymer Supports Yolanda de Miguel, Thomas Rohr and David C Sherrington 1.1 Synthesis and Molecular Structure of Polymer Supports The overwhelming majority of ... shrinkage of the matrix and the introduction of considerable strain The latter is relieved even on wetting with water and this is the driving force for imbibition of the latter With such very high surface...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
... Stability of mixed micelles in bovine serum albumin solution The stability of mixed micelles in bovine serum albumin (BSA) solution was assessed from the change of particle size of micelles and ... (sometimes below the CMC) Therefore, the in vitro and in vivo stabilities of micelles depend upon CMC values of micelle- forming materials, and the CMC is an effective parameter of micelle preparation Table ... the content of mPEGPLA in the prepared mixed micelles was almost mg/mL Optimization of micelle composition and characterization of mixed micelles Drug-free plain and mixed micelles of mPEG-PLA/Solutol...
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Báo cáo hóa học: " Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules" ppt
... (CoQ10 and GTCC), and the amount of lipid (CoQ10 and GTCC) was kept at a fixed concentration of 12.5% (w/w) with regard to the total mass of 100 g Briefly, CoQ10 and GTCC were mixed at 60°C, and then ... magnification of 10,000–50,000 and at a defocus of 3–5.46 lm 1563 by Image-pro plus software (Media Cybernetics, USA) The excitation and emission wavelengths were 549 and 628 nm for NR We selected ... about repulsive forces between particles or droplets and makes a prediction about the stability of colloid dispersions An absolute value above 30 mV usually indicates good stability of the colloid...
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Báo cáo hóa học: " Facile Preparation of Crosslinked Polymeric Nanocapsules via Combination of Surface-Initiated Atom Transfer Radical Polymerization and Ultraviolet Irradiated " docx
... CaH2 and distilled under reduced pressure Triethylamine (TEA) and tetrahydrofuran (THF) were dried by CaH2 overnight, and then distilled under reduced pressure before use Toluene, dimethylformamide ... Results and Discussion Wavenumber(cm ) The bromo-acetyl modified silica nanoparticles (BrA-SNs), by the bromoacetylation of the surface amino groups of the aminopropyl modified silica nanoparticles ... centrifugation and subjected to intense washing by toluene, and to remove soluble ungrafted polymers The percentage of grafting (PG, mass ratio of the grafted polymer to silica nanoparticles) of the...
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Báo cáo hóa học: " Studies on Preparation of Photosensitizer Loaded Magnetic Silica Nanoparticles and Their Anti-Tumor Effects for Targeting Photodynamic Therap" ppt
... with the values of standard pattern In addition to the dispersed and well-separated features, the formed Fe3O4 nanoparticles also exhibited some degree of aggregated morphology The particles show ... depicting the synthesis and purification of (PHPP-Fe3O4/OA)/SiO2 Fig TEM image (a) and XRD pattern (b) of PHPPSMNPs suspension of particles These aggregates were not stable and could be easily redispersed ... shift of the special absorption peak of PHPP from 399 to 409 nm (c) Spectrum (d) indicated absorptions of SMNPs and HCl at 240, 314, and 364 nm, demonstrating that the 240, 314, and 364 nm peak of...
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Báo cáo hóa học: " Fabrication of Highly Ordered Polymeric Nanodot and Nanowire Arrays Templated by Supramolecular Assembly " pot
... dichloromethanes were purchased from Acros Organics and used as supplied Fabrication of Ordered Nanodots and Nanowire Arrays PS-PVP and HABA (1 mol of HABA and mol of 4vinylpyridine monomer unit) were dissolved ... order of nanodomains Alternatively, the samples were treated in vapors of chloroform to arrange parallel alignment of the nanodomains Nanoporous thin film was fabricated by selective extraction of ... h and keep h), to remove the PS-PVP and resulted ordered nanodots arrays (Fig 1) Nanoscale Res Lett (2009) 4:459–464 461 Fig Scheme of the fabrication of highly ordered polymeric nanodot and...
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Báo cáo lâm nghiệp: "Strength properties of thermally modified softwoods and its relation to polymeric structural wood constituents" pot
... treated The standard cross section of the boards had a thickness of 25–44 mm and a width of 150 mm The length of the boards was approximately 3.0–5.1 m The moisture content of the boards before treatment ... treatment is the weight of the boards and thus the density of wood (Tabs I and II) The main reasons for the decrease of the density of wood after heat treatment are: degradation of wood components ... effect of degradation and modification of hemicelluloses, degradation and/ or crystallization of amorphous cellulose, and polycondensation reactions of lignin on the mechanical properties of heat...
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Báo cáo khoa hoc:" Evaluation of triblock copolymeric micelles of δvalerolactone and poly (ethylene glycol) as a competent vector for doxorubicin delivery against cancer" doc
... concentrations of VEV, free DOX and VEVDMs as indicated and incubated for 24, 48 and 72 h, respectively Following treatment the amount of formazan crystals formed was measured after h of MTT addition ... http://www.jnanobiotechnology.com/content/9/1/42 Page of 14 Figure Sub-cellular internalization of DOX entrapped VEV micelles (VEVDMs) MCF7 and U87MG cells were treated with μM DOX formulations Micelle uptake of VEVDMs by MCF7 and U87MG ... diagram showing the structure of micelles formed on DOX entrapment in VEV copolymeric micelles The micelle is represented by a hydrophobic PVL core and hydrophilic PEG on the surface with the drug entrapped...
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