... speaking, two distinct kinds of money award in English law, which, in different ways, seek to uphold the aim of putting the innocent party into the position as if the contract had been performed The ... against maintaining the distinction this book proposes is that ultimately both substitutionary and compensatory awards are grounded inthe same underlying objective of putting the innocent party ... Awards Inconsistent with the Law’s Orthodox Understanding 51 A SubstantialMoneyAwardsinthe Three- PartyContext 52 Specific Exceptions to the General Exclusionary Rule .52 Extending...
... ligaments especially near their insertions, in bone, in muscle, and inthe outer third of the meniscus inthe knee In an unusual study in which the lead investigator became the study subject and ... knee pain Buckling inthe knee may reflect weakness of muscles such as the quadriceps, which stabilize the joint during activities like stair climbing Strengthening exercises and balance training ... Since cartilage is aneural, other structures within the joint must be the source of pain in OA Historical and anatomical studies suggested that pain fibers can be identified inthe synovium, in...
... improvement These and other insights mandate a change in clinical trial reporting by requesting the provision of information on categories of disease activity attained inthe course of a trial and at the ... dared to entertain just few years ago – a novel reality challenging us to aim for more One of the most surprising findings inthe decade since the introduction of TNF inhibitors was the observation ... most if not all of the total phenotypic expression of RA, including joint destruction The fact that CRP is induced by the proinflammatory cytokine interleukin-6 (IL-6) and the observation that...
... for the strikingly increased risk of atherosclerosis seen in premenopausal women with SLE These findings suggest that features of the disease itself drive this process Even inthe absence of clinical ... proteins [11,12] Within thecontext of SLE, these findings suggest that molecules inducing autoimmunity have intrinsic immunologic activity and may serve as adjuvants for their own responses as ... with the changes in these molecules during apoptosis enhancing immunogenicity Furthermore, because cell death probably leads to the release of other immune mediators known as alarmins, the immune...
... chondrocytes Further work is needed to determine whether leptin or other adipokines are important systemic or local factors inthe link between obesity and OA Joint malalignment Whether joint malalignment ... into the basal layers of degenerating cartilage, or as a result of abnormal healing of stress fractures inthe subchondral trabeculae near the joint margins [63] TGF-β, when introduced into the ... result in increased joint reactive forces inthe medial compartment of the knee, thereby accelerating the degenerative process [23] Emerging data implicate a crucial role for adipocytes in regulation...
... deterioration inthe joints These studies suggest that the Wnt signaling pathway, which is important in joint development, is also important in diseases of the joint Further understanding of the Wnt ... receiving serotonin re-uptake inhibitors have low bone mass compared with age-matched control individuals, suggesting that if circulating levels of serotonin are increased in these patients then they ... and the involvement of the Wnt signaling pathway in inflammatory bone destruction RA is characterized as an inflammatory arthritis in which joint inflammation results in bone deterioration In...
... defect in post-translational modification but a defect in inducing or maintaining peripheral tolerance, which is very much in line with the global changes inthe T-cell compartment observed in patients ... engineered mice that expressed an influenza hemagglutinin antigen in combination with a transgene for hemagglutinin-reactive TCR Different strains were constructed carrying TCR with varying affinity ... proteins including fillaggrin, keratin, fibrinogen, and vimentin [73,105] These antibodies can be measured through their recognition of cyclic citrullinated peptides, now commonly used in clinical...
... presenting cells, CTLA4-Ig (abatacept), improves joint pain and swelling in RA However, the controlled trials of abatacept in SLE have not yet met their defined endpoints In data presented at the ... debate inthe clinical research community has included the possibility that prednisone, administered early inthe trial and then tapered, might have blunted differences inthe responses of the rituximab ... I IFN inthe premature atherosclerosis of lupus patients is an attractive concept in light of the growing literature implicating this cytokine in many aspects of altered immune function in SLE...
... Money Market Fund / HSBC Funds ING Money Market Fund / ING Series Fund, Inc ING Money Market Fund / ING Series Fund, Inc ING Money Market Fund / ING Series Fund, Inc ING Money Market Fund / ING ... the highest of the beginning, semiannual, or ending AUM figures for the year when the support occurred, as disclosed inthe SEC filings For the remaining instances and funds, the AUM amount reported ... use of ending AUM is deemed appropriate given that even if a fund shrank during the year, all losses incurred during the year would remain inthe fund and be shared by the remaining investors...
... just plain silliness An all too common complaint that's heard with regard to making money on the internet is "I can't it" in one form or another So the first thing I'm going to here is explain just ... pages to the rest of your site with at least one incoming link and one outgoing link Also, when linking from other pages on your site, try to incorporate the primary keyword of the 'receiving page' ... 'reciprocal linking' Three- Way linking is now a favoured way of exchanging links This is where your site links to another site, which then links to a third site, which in turn links back to your...
... are inthe blooming years of their life, look like the walking dead Their deathly pale appearance sets them apart from all the other inhabitants inthe most depressing way.” Later, after the ... inthe autumn and the spring which had been held inthe town since the Middle Ages And because of the enormous variety of coinage circulating in Europe up until the late nineteenth century, the ... gentlemen when they were inthe West End or the country But inthe “counting house” they were unalloyed capitalists, applying rules and precepts of business which had their origins inthe Frankfurt...
... had taken the employee route instead of the business building and real estate investing route that I had The first step for them, determining their starting point, was the hardest one They had ... LIVING OPERATIONS +/– +/– FINANCING FINANCING +/– +/– INVESTING INVESTING +/– +/– = MORE OR LESS CASH = MORE OR LESS CASH STARTING POINT—UNDERSTANDING YOUR FINANCIAL STORY 11 Income Statement In ... box, and they’re all in it together They pull others back into the box because they don’t want them to leave Part of the desire to pull the others back is because they are afraid for them And...
... men inthe same business are inthe same neighborhood, and one gets rich while the other fails, it indicates that getting rich is the result of doing things in a Certain Way And further, the ... world's becoming rich Think of the riches the world is coming into, instead of the poverty it is growing out of; and bear in mind that the only way in which you can assist the world in growing rich ... become the master class whenever they will begin to things in a Certain Way; the law of wealth is the same for them as it is for all others This they must learn; and they will remain where they...
... the patient's participation inthe decision-making process and the ultimate decision regarding care must be voluntary The usual definition of voluntariness inthecontext of consent is that the ... has increased dramatically since the beginning of the 20th century People are living longer due, for example, to the decline in deaths from infectious diseases Beyond that, more people are living ... education, kinship support, and use of leisure time It is worth keeping this in rnind inthe following discussion of the demography and epidemiology of aging THE GRAYING OF AMERICA There are some...