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structure of citratoperoxotitanium complex

Báo cáo khoa học: Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain doc

Báo cáo khoa học: Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain doc

Báo cáo khoa học

... and discussion Description of the structures There is one molecule in the asymmetric unit of both structures composed of a single domain consisting of 14 helices, 12 of them forming an (a ⁄ a6) ... side-chains The structure of the starch binding domain of A niger glucoamylase was solved by NMR in its native state [10] and in a complex with b-cyclodextrin [11] Crystal structures of an intact ... suspension of 37.5 mg of starch in 1.25 mL of 1.5 m TrisHCl buffer, pH 8.8, and mL of water was boiled for and after cooling to room temperature, 1.65 mL of acrylamide solution (30%), 60 lL of 10%...
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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

Báo cáo khoa học

... assist the structure- based rational design of enzyme inhibitors with potential medical interest Crystal structure of human ACMSD C-ter N-ter Results and Discussion Overall quality of the model ... three-dimensional structure of hACMSD in complex with DHAP was solved by molecular replacement ˚ and refined at a resolution of 2.0 A The monomer present in the asymmetric unit contains 332 residues out of 336, ... other members of the amidohydrolase superfamily [24,25] However, as no structure of complexes with either the substrate, product or inhibitors had been reported, precise identification of the protein...
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Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx

Báo cáo khoa học

... core of the protein Mononucleotides binding into the active site of RNase Sa2 not affect the overall fold of the protein Superposition of 88 corresponding CA atoms of all 16 molecules (structures ... Bauerova-Hlinkova et al Structures of RNase Sa2–mononucleotide complexes A B Fig Stereoview of the A ⁄ C crystallographic dimer (A, green; C, pink) in structures 3D5G, 3GDY, 3D5I, and 3D4A (A), and in structure ... et al Structures of RNase Sa2–mononucleotide complexes molecules A and B of 3DH2) Unlike the anti-conformation found in the complex with RNase Sa [24], exo2¢,3¢-GCPT in the active site of RNase...
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Tài liệu Báo cáo khoa học: Spectroscopic characterization of a higher plant heme oxygenase isoform-1 from Glycine max (soybean) ) coordination structure of the heme complex and catabolism of heme docx

Tài liệu Báo cáo khoa học: Spectroscopic characterization of a higher plant heme oxygenase isoform-1 from Glycine max (soybean) ) coordination structure of the heme complex and catabolism of heme docx

Báo cáo khoa học

... complex of GmHO-1 at pH 7.0 (0.1 M, KPB) a-1, Expansion of the gxy region of (A) (solid line) and of the corresponding part of the spectrum of ferric heme–rHO-1 (dotted line) a-2, Expansion of ... pocket structure As shown in Table 2, the hyperfine splitting constants of the 15N nucleus of the distal NO and of the 14N nucleus of the proximal His of the GmHO-1 complex are closer to those of ... that, in spite of the low homology of the amino acid sequence with those of known HOs, the heme– GmHO-1 complex has similar spectroscopic characteristics to those of the heme complexes of cyanobacterial,...
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Tài liệu Báo cáo khoa học: Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid Selective inhibition by structure-based design docx

Tài liệu Báo cáo khoa học: Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid Selective inhibition by structure-based design docx

Báo cáo khoa học

... deviation of ± 4% T brucei T cruzi 2000 2000 350 800 65 2000 150 900 200 700 HOP Inhibition and site-directed mutagenesis of T brucei gGAPDH In the absence of a 3D structure of a complex of T brucei ... brucei gGAPDH modelling studies Results 3D structure of the T cruzi gGAPDH–HOP complex Quality of the structure (RCSB PDB accession No 1QXS) Despite the lack of NCS restraints during the refinement ... that improved activity of this compound may be a result of hydrogen bonding between the hydroxyl of Thr167 of the protein and the amino group of compound No other inhibitor offered such an interaction...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

Báo cáo khoa học

... inhibitors of PETN reductase (Fig 6) ˚ The overall structure of the 1.05 A reduced PETNprogesterone complex is virtually identical to the oxidized complex (PDB code 1H60) Two molecules of isopropanol ... form of the enzyme-steroid complex We conjectured that the reduced form of the enzyme might direct binding of the steroid in the flipped conformation, thus facilitating catalysis Our structure of ... between the postulated structure of the catalytically active reduced enzyme-substrate complex and the observed crystallographic structures of the oxidized enzyme-substrate complex However, in some...
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Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx

Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx

Báo cáo khoa học

... a dimer of the abc heterotrimer There is a noncrystallographic twofold axis around the center of Fig 3A The structure of an abc heterotrimer unit is shown in Fig 3B The central region of the a ... 24 25 26 27 28 29 Structure of B12-dependent glycerol dehydratase (Eur J Biochem 269) 4493 coenzyme B12: X-ray structure of diol dehydratase-adeninylpentylcobalamin complex Structure 8, 775–788 ... crystal structure of glycerol dehydratase in complex with cobalamin and propane-1,2-diol was determined at ˚ 2.1 A resolution by the molecular replacement method The schematic view of the overall structure...
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Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain

Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain

Sinh học

... loop of helix 22 and to the tetraloop of helix 23a stabilize the tertiary fold of the upper three-helix junction The tertiary structure of the upper three-helix junction forms Fig Details of S15–Tth ... Trp; and Y, Tyr (B) Sequence of the Tth T4 RNA from the central domain of T thermophilus 16S rRNA The secondary structure and the general topology of the tertiary structure are shown Helical domains ... magnetic resonance structure of the free protein (19) but unlike the crystal structure of the free protein (20), in which ␣1 lies distal to the core (21) There are three principal regions of S15 that...
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Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases pptx

Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases pptx

Báo cáo khoa học

... loop L6 of chagasin and S21e of Chagasin–papain complex structure papain providing an illustrative example A comparison of the present chagasin–papain complex with the structure of papain in complex ... superposition of the Ca atoms of papain from the crystal structures of its complexes with cystatin B (PDB code 1STF) and chagasin (this work) The upper panel emphasizes the different angle of approach of ... the interactions of papain with loop L6 of chagasin and loop L2 of cystatin B (C) Zoom-in view of the interactions of papain with loop L4 of chagasin and the N-terminal segment of cystatin B (D)...
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Báo cáo khoa học: Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex doc

Báo cáo khoa học: Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex doc

Báo cáo khoa học

... nicotinamide ring of NAD Based on the structure of citrate, we modeled the l-aspartate molecule into the active site of A fulgidus l-aspDH (Fig 4B) and then minimized the energy of the complex using ... bonds Fig Comparison of the structures of A fulgidus L-aspDH and T maritima L-aspDHs (A) The superimposed Ca-traces of A fulgidus L-aspDH and T maritima L-aspDH; the structures of the two enzymes ... structure [22,23] A pair of aromatic Ion-pair interaction Recent studies of the structures of hyperthermophilic proteins have shown that the number of ion pairs and the formation of ion networks contribute...
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Báo cáo khóa học: Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex doc

Báo cáo khóa học: Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex doc

Báo cáo khoa học

... observation) Maintenance of the open C-shape of the base of the clamp-loader complex is also consistent with crystal structures determined recently in our group, of a nucleotide-loaded c complex (S L Kazmirski, ... determined the 3D structure of a : complex of the E coli v and w subunits in order to explore the function of these two proteins Subunits v and w interact to form an elongated heterodimer, of comparable ... of the replication factor C (RFC) clamp-loader subunits of eukaryotes and archaebacteria [16] Crystal structures of a functional E coli clamp-loader complex, cdd¢ (stoichiometry : : 1), and of...
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Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx

Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx

Báo cáo khoa học

... for this residue in the crystal structure of Anx24(Ca32) In the current structure, the conformation of the AB loop in the first domain differs from that of molecule of Anx24(Ca32) only around residues ... crystal structure of Anx(Gh1) from cotton emphasizes the high conservation of the unique annexin fold even among the members of the plant subfamily of annexin proteins The fold is comprised of the ... side of the plant proteins, which is not observed with non-plant annexins since the modules are packed much tighter A comparison of the current structure of Anx(Gh1) with the structures of Anx24(Ca32)...
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Báo cáo khoa học: Crystal structure of the halotolerant c-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket docx

Báo cáo khoa học: Crystal structure of the halotolerant c-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket docx

Báo cáo khoa học

... FEBS 1003 Structure of B subtilis c-glutamyltranspeptidase A K Wada et al B C Fig Comparison of the structures of GGTs from (A) B subtilis, (B) E coli and (C) H pylori The structure of each GGT ... Elucidation of the structural factors related to the salt tolerance of B subtilis GGT may help in the development of better-engineered GGT Here, we report the crystal structure of B subtilis GGT in complex ... envelope [20] When the structure of CapD in complex with di-a-l-glutamate peptide, a nonhydrolyzable analog of the substrate, is compared with that of the B subtilis GGT–glutamate complex, it is apparent...
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Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf

Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf

Báo cáo khoa học

... Least-squares superimposition of domain of all of the GBP structures is shown in Fig 5B, illustrating the ‘fan’ of A B related conformations observed The GGal complex is the most closed structure found to ... importance of GGal as a bacterial carbon source Results and Discussion Overall structure The structure of GBP in complex with GGal was determined by molecular replacement using the Salmonella GBP–Gal structure ... because of the significantly larger number of hydrogen bonds compared with the structures with simple sugars The other structures represent a series of conformations that ‘link’ the GGal complex...
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Báo cáo khoa học: The crystal structure of Thermoactinomyces vulgaris R-47 a-amylase II (TVA II) complexed with transglycosylated product potx

Báo cáo khoa học: The crystal structure of Thermoactinomyces vulgaris R-47 a-amylase II (TVA II) complexed with transglycosylated product potx

Báo cáo khoa học

... method of Somogyi-Nelson [26] was followed Ó FEBS 2004 Structure of T vulgaris a-amylase II complex (Eur J Biochem 271) 2533 Results Carbohydrate in the catalytic site The structure of the complex ... Ó FEBS 2004 Structure of T vulgaris a-amylase II complex (Eur J Biochem 271) 2531 Fig Ribbon representation of the fold of TVA II in complex with 42-P2 (A) Dimeric form ... 42-P2 binding The complexed structure enables a detailed analysis of the interactions of the active site with 42-P2 To facilitate description of these interactions, the active cleft of TVA II is separated...
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Báo cáo khoa học: Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme pot

Báo cáo khoa học: Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme pot

Báo cáo khoa học

... (2003) Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate: conformational change of Ó FEBS 2004 39 40 41 42 43 44 Structure of cyanobacterium heme–HO complex (Eur ... S.Y., Shiro, Y & Ikeda-Saito, M (2004) The crystal structures of the ferric and ferrous forms of the heme complex of Hmu O, a heme oxygenase of Corynebacterium diphtheriae J Biol Chem 279, 11937–11947 ... bond partner of the carbonyl group of Gly139 is the amide group of Gly144, and the amide group of Gly143 is hydrogen-bonded to the distal ligand of the heme iron (the residue numbers of the three...
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Báo cáo khoa học: Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand pot

Báo cáo khoa học: Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand pot

Báo cáo khoa học

... differences between the two structures Structure of individual CTPR390 molecules Considering the individual 3-TPR units, the structure of CTPR390 is almost identical to the structure of the parent protein, ... Cortajarena et al A C Structure of designed TPR module–ligand complex B D CTPR390–peptide complex CTPR390 binds specifically and with moderate affinity (Kd of 200 lm) to the C-terminal peptide of Hsp90 [5] ... and Structure of designed TPR module–ligand complex a = b = 90°, c = 120° The CTPR390 structure was solved by molecular replacement using molrep [16] in the ccp4i suite [17] The structure of the...
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Báo cáo khoa học: Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide ppt

Báo cáo khoa học: Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide ppt

Báo cáo khoa học

... unliganded PDZ domain structures Figure shows a superposition of SAP97PDZ2 C378S structure with the NMR structure of PSD-95PDZ2 and the crystal structure of SAP102 The backbone structures are highly ... The structure of the C378G variant of SAP97PDZ2 was practically identical to that of C378S variant, except for the mutated residue, and because of its better resolution, only the structure of ... related PDZ domain structures The solution structure of the second PDZ domain of PSD-95 has been determined by NMR [21], and, quite recently, coordinates of the PDZ2 domain of SAP102 crystallized...
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Báo cáo khoa học: Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme pdf

Báo cáo khoa học: Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme pdf

Báo cáo khoa học

... analogues Fig (A) The structure of one subunit of Uu-TK (yellow) with conformations of the flexible loop as found in Uu-TK in complex with dT in subunit A (orange, A), Uu-TK in complex with dTTP (green, ... determined the first structure of a member of the TK1 family in complex with the substrate dT The possibilities for drug design have been investigated by enzyme kinetics and analyzed in view of substrate ... further advances Results and discussion Overall structure The overall tetrameric structure of Uu-TK in the substrate complex is very similar to that in the complex with the feedback inhibitor dTTP Each...
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Báo cáo y học:

Báo cáo y học: " Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3" docx

Báo cáo khoa học

... University on behalf of the U.S Department of Energy, Office of Basic Energy Sciences The SSRL Structural Molecular Biology Program is supported by the Department of Energy, Office of Biological and ... (Table 1) As a result, the structure of the complex is an average of the two half-sites Similarly, TL3 was bound in the active site of the 12X FIV PR with its C2 axis of symmetry coincident with ... Schiffer CA: "Substrate Shape Determines Specificity of Recognition for HIV-1 Protease: Analysis of Crystal Structures of Six Substrate Complexex" Structure 2002, 10:369-381 Ozer N, Haliloglu T, Schiffer...
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