structure function correlations in asthma
Báo cáo khóa học: The structure–function relationship in the clostripain family of peptidases potx
Ngày tải lên :
23/03/2014, 12:20
... clostripain The molecular modelling, in conjunction with sequence analysis studies, indicates the P1 specicity determining residue as Asp229 and locates possible calciumbinding sites involved in the ... Enzyme inactivation studies Inactivation of clostripain was performed in an incubation mixture containing, in a total volume of mL at 25 C, ChC (100 lg) in 100 mM Hepes/NaOH buffer pH 7.6 was inactivated ... clostripain homologues but it is interesting to note that both forkhead and NHL domains are implicated in proteinprotein interactions [48,49] Similarly, both bacterial immunoglobulin-like domains...
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Atomic structure and composition structure properties correlations in metallic glasses
Ngày tải lên :
11/09/2015, 09:17
... over the years, introducing indicators that presumably can serve as a measure of the role glass structure plays in controlling properties [47-50] These indicators mainly fall into two categories ... as a function of composition And the composition -structure- properties (including GFA and mechanical behavior) correlations in the Cu-Zr MGs were established The atomic-level origin of these correlations ... [23] Chapter Introduction 1.2 The structure and structure- properties relations of MGs It is of vital importance to investigate the atomic structure of MGs, since structure determines the properties...
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Tài liệu Cognitive function and brain structure correlations in healthy elderly East Asians doc
Ngày tải lên :
14/02/2014, 06:20
... class East Asian individual could benchmark against Finally, we correlated measures of cognitive performance and brain structure In view of the increasing automation in brain structure measurement, ... valuable starting point from which to base future studies concerning brain aging in Asians Methods Participants The volunteers were members of the Singapore Longitudinal Aging Brain Study, a community-based ... cognitive function and dementia in the Sacramento Area Latino Study on Aging Am J Clin Nutr 82, 1346–1352 Raz, N., 2005 The aging brain observed in vivo: differential changes and their modifiers In: ...
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Báo cáo y học: "TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway" pps
Ngày tải lên :
08/08/2014, 21:20
... for intracellular cytokine staining or in the absence of Brefeldin A for ELISA Staining for membrane-bound TGF-b was performed with standard surface staining protocols For intracellular cytokine ... was observed only in response to IL-7 [21-23] Thus, signaling events triggered by binding of IL7 to IL-7Ra (the only signaling component in IL-7 receptor complex), but not binding of TSLP to TSLP-R ... role for TSLP in the development of inflammation in an asthma model J Exp Med 2005, 202:829-839 Zhang Z, et al: Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates...
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Báo cáo y học: " Inhaled salmeterol and/or fluticasone alters structure/function in a murine model of allergic airways disease" potx
Ngày tải lên :
12/08/2014, 11:20
... statistically insignificant increases in inflammation (Figure 2), epithelial damage (Figure 4), or mucus production (Figure 7), we think that an increase in mucus containing cells or mucus within the ... thickening, was essentially abrogated (Figures 4, 6, and 7) and correspondingly, methacholine responsiveness was returned to (or remained at) baseline levels (Figure 5) These findings are in keeping ... effect on mucin containing cells that is independent of any effects on the inflammatory response We base these conclusions on a number of interrelated findings and deductions First, using computational...
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Báo cáo y học: " In vivo imaging of the airway wall in asthma: fibered confocal fluorescence microscopy in relation to histology and lung function" potx
Ngày tải lên :
12/08/2014, 13:22
... been observed in the superficial elastin network of central airways in fatal asthma [12] The presence and extent of airway remodelling in asthma can be visualized by histology in endobronchial ... specimens Asthmatic subjects had controlled disease according to GINA guidelines [1] Furthermore, they met all of the following criteria: aged 18 to 50 years; non-smoking or having stopped smoking ... some indefinite and thin lines without a specific orientation could be identified In contrast, a linearly orientated pattern composed of clearly discernible light-coloured and thick individual lines...
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Báo cáo y học: " Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma" ppsx
Ngày tải lên :
12/08/2014, 16:20
... competing interests LB declare no competing interests SR declare no competing interests MM declare no competing interests EC declare no competing interests VB received a research grant in 2004 ... β2-AR agonists in bronchial asthma Competing interests GER received a research grant in 2005 from Merck, Sharpe & Dohme for in vitro studies on montelukast MB declare no competing interests SC ... human bronchial rings Salbutamol concentrations inhibiting 50% of active force in Salbutamol concentrations inhibiting 50% of active force in carbachol-contracted human bronchial rings Effects of...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
Ngày tải lên :
16/02/2014, 14:20
... involved in zinc coordination results in protein unfolding [22] The structure contains a positively charged surface groove containing a number of residues that were shown using chemicalshift mapping ... the KIX domain of the cAMP response element-binding (CREB) binding protein 2879 3762 -3969 3770 MLL1 TAD domain MLL1 Win motif c-Myb WDR5 CBP-KIX domain (CBP) [23], a peptide from the Win motif ... protooncoproteins including the multiple endocrine neoplasia type (Men1) [60] or the integrase interactor (Ini ⁄ hSNF5) [61] tumor suppressor proteins An additional challenge is in understanding the...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships docx
Ngày tải lên :
16/02/2014, 15:20
... identified to be involved in the interdomain interaction [16] However, no further conclusions could be made on the interdomain interaction by NMR unless structure of the b-domain of hGIF could ... devoted towards determining the structure of GIF During the past 15 years or so, the crystal structure of rat liver MT2 (rlMT2) has been the only crystal structure obtained of MT binding to divalent ... was suggested to provide an interacting interface for protein–protein interactions [12–14] The other structural feature found in the predicted structure of the b-domain of hGIF was the hydrogenbond...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc
Ngày tải lên :
19/02/2014, 16:20
... converted into rates Kinetic parameters were obtained from nonlinear ts of initial rate data to Eqn (1) using the SIGMAPLOT program (SPSS Inc., Chicago, IL, USA), 1ị where v is the initial rate, ... This nding is interesting because the packing of hydrophobic residues dispersed over the main part of the dimer interface is highly conserved among known a-glucan phosphorylases [22] including EcMalP ... K.R (1996) Activator anion binding site in pyridoxal phosphorylase b: The binding of phosphite, phosphate, and uorophosphate in the crystal Protein Sci 5, 24162428 Schinzel, R., Palm, D & Schnackerz,...
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Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in Hierarchical Phrase-based Translation" pdf
Ngày tải lên :
20/02/2014, 07:20
... pre- cal structure) , while rightFirst indicates that dominates for Y = Y subcategorization information Y in (indicated parentheses (3) by the following the nonterminal) propagates the function ... two rules by maintaining the ordering of the func- additional relationships: dontCare indicates that tion words according to their appearance in the topological ordering of the function words ... relation- Y ship using this alignment information will be d( ڔand) d (are) d (are) dሇ (of) discussed in detail in the next section Again taking Xb in Fig as a case in point, the dont- nei-...
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
Ngày tải lên :
20/02/2014, 23:20
... (5.1)° in aqueous solution The Asp1 side chain carboxylic group was suggested to be involved in hydrogen-bonding interaction with either the N-terminal amino group or the Arg2 side chain amino group, ... chain NH of the preceding arginine, forming a stable heptamer ring, both in the X-ray structure and the solution structure of AII (Fig 8) Indeed, aspartate residues at the N-termini of short polypeptides ... distance of the Asp1 side chain (OD1) to the main chain NH of the proceeding Arg2 is ˚ 2.9 A, underlying the possibility of the formation of a side chain–main chain hydrogen bond This distance...
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Báo cáo khoa học: New insights into structure–function relationships of oxalyl CoA decarboxylase fromEscherichia coli pptx
Ngày tải lên :
06/03/2014, 11:20
... the crystal structures, indicating that binding of acetyl CoA may induce changes in the protein conformation in solution Berthold et al [4] published crystal structures of OfODC in complex with ... the functional dimer The main chain oxygen of G421 and the side-chain carboxyl oxygen of E54 interact with the amino pyrimidine moiety of ThDP (Fig 3); these are highly conserved interactions in ... C-terminus were pinpointed in the presence of the activator ADP that are not defined in the absence of this ligand The EcODC monomer displays the typical binding fold of ThDP enzymes, comprising...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure–function relationships ppt
Ngày tải lên :
07/03/2014, 00:20
... N-terminus and the in uences of this change on binding to TH and on the functions of transthyretin, including that of proteolysis Structure of transthyretin 3D structure of human transthyretin The ... and retinol-binding protein Science 268, 1039–1041 65 Naylor HM & Newcomer ME (1999) The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction ... transthyretin tetramer, in the same or opposite dimers, were demonstrated [59,63,64] In the binding interaction, RBP and transthyretin each contribute 21 amino acids to the protein–protein recognition interface...
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Báo cáo khoa học: Structure ⁄function analysis of spinalin, a spine protein of Hydra nematocysts doc
Ngày tải lên :
07/03/2014, 12:20
... localization of spinalin predominantly on the spines of the desmoneme tubule (Fig 1C) Interestingly, the tubule surface showed some staining also This may indicate that spinalin is integrated here in the ... spinalin in M guanidine hydrochloride (s) were used at protein concentrations of 15 and lM, respectively region, a lysine-rich region, and an acid tail at the C-terminus Spinalin in m guanidine ... structures [3] Spinalin is not homologous to any protein in the databases, but has regions with partial homology to loricrins and keratins [3], which are also involved in forming structures with...
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Báo cáo khoa học: Studies on structure–function relationships of indolepyruvate decarboxylase from Enterobacter cloacae, a key enzyme of the indole acetic acid pathway ppt
Ngày tải lên :
08/03/2014, 02:20
... suggesting a similar catalytic mechanism Differences in tetramer packing, several amino acid exchanges in the substrate binding pocket and the diverse constitution of the C-terminal helix covering ... quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 14 Hallmann, G & Hagle, H (1963) Benzofuranderivate: Trypta¨ min-, Serotonin- und Melatonin-Analoga Liebigs ... calculated from the corresponding progress curves, on the concentration of ThDP (Fig inset) is indicative of a two-step mechanism of cofactor binding as Ó FEBS 2003 Structure function studies of E cloacae...
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Báo cáo khoa học: "LANGUAGE SYNTHESIS GENERATION OF GERMAN FROM CONCEPTUAL STRUCTURE: MT PROJECT IN A JAPANESE/GERMAN" pot
Ngày tải lên :
08/03/2014, 18:20
... labelled arcs are used in two ways: a) Binary arcs either express case relations between connected symbols or combine substructures b) Unary arcs serve as modifying tags of various kinds (logical junctors, ... is a structure which identifies a syntactic category (e.g CLAUSE, NP) and describes its functional roles (e.g HEAD, MODIFIER, ) We employ Winograd's terminology for functional gran~nar (Winograd, ... CONCEPTS TO LANGUAGE In the target language oriented stage the following decisions have to be made: REFERENCING AND FOCUSSING 2, For referencing and other phenomena like focussing, the simple approach...
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Báo cáo khoa học: "STRUCTURE AND INTONATION IN SPOKEN LANGUAGE UNDERSTANDING*" pptx
Ngày tải lên :
08/03/2014, 18:20
... category to combine with anything but a complete rheme In particular, it must not combine with a function into the category Rheme by functional composition Accordingly we give it a non-functional ... that particular surface structures that are induced by the specific combinatory grammar that are postulated to explain coordination in English subsume the intonational structures that are postulated ... rightward- looking) 14 functions into S al The rule is nondeterministic, so it correctly continues to allow a further analysis of the entire sentence as a single Intonational Phrase conveying the Rheme...
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RNA Structure Function
Ngày tải lên :
13/03/2014, 16:56
... Binding sites (BS) for specific TFs often variable Binding sites are short (typically 5-15 bp) Interactions between TFs (& other proteins) influence affinity & specificity of TF binding One binding ... in Pre-mRNA Splicing • Formation of exon-spanning complex hnRNP proteins • Subsequent rearrangement to form intron-spanning spliceosomes which catalyze intron excision and exon ligation Matlin, ... Announcements Seminar (Mon Oct 31) 12:10 PM IG Faculty Seminar in 101 Ind Ed II Plant Steroid Hormone Signal Transduction Yanhai Yin, GDCB • BCB Link for Seminar Schedules (updated) http://www.bcb.iastate.edu/seminars/index.html...
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RNA Structure Function bio( tiếp)
Ngày tải lên :
13/03/2014, 17:32
... Binding sites (BS) for specific TFs often variable Binding sites are short (typically 5-15 bp) Interactions between TFs (& other proteins) influence affinity & specificity of TF binding One binding ... in Pre-mRNA Splicing • Formation of exon-spanning complex hnRNP proteins • Subsequent rearrangement to form intron-spanning spliceosomes which catalyze intron excision and exon ligation Matlin, ... Announcements Seminar (Mon Oct 31) 12:10 PM IG Faculty Seminar in 101 Ind Ed II Plant Steroid Hormone Signal Transduction Yanhai Yin, GDCB • BCB Link for Seminar Schedules (updated) http://www.bcb.iastate.edu/seminars/index.html...
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