structural molecular relationships interactions among lipids and proteins in the myelin membrane
Báo cáo y học: " Molecular analysis of HBV genotypes and subgenotypes in the Central-East region of Tunisia" potx
Ngày tải lên :
12/08/2014, 02:20
... NH and OB conceived of the study, participated in its design, and in drafting the manuscript HT and JB participated in the study design and coordination and in discussing manuscript NH, NBF and ... and drafted the manuscript JG and AF participated in the sequence analysis All authors read and approved the final manuscript Competing interests The authors declare that they have no competing ... using the Neighbor-Joining method The evolutionary distances were computed using the Maximum Composite Likelihood method and are in the units of the number of base substitutions per site There...
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Báo cáo y học: "Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo" doc
Ngày tải lên :
09/08/2014, 07:20
... p38MAPKα and ERK in the synovial membrane, indicating that the intracellular effects of TNF can be inhibited This suggests that anti-TNF therapy reduces key signalling pathways in the synovial membrane, ... p38MAPKα and ERK in the synovial membrane in vivo Inference with the activation of these two MAPKs may therefore be an interesting goal for current and future drug development aimed at inhibiting ... protein kinase (MAPK)α, (b,e,h) extracellular signal-regulated kinase (ERK), and (c,f,i) c-Jun amino-terminal kinase (JNK) were stained in both the synovial pannus (panels a–c) and the synovial lining...
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Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx
Ngày tải lên :
07/03/2014, 21:20
... underlined, and the cysteine knot is boxed Also boxed are the transmembrane domain, the ATP binding site, the L45 loop and the serine ⁄ threonine kinase domain (B) The implied amino acid sequence ... receptors These are in bold and underlined, and the cysteine knot is boxed The second extracellular domain (C2) also contained 10 cysteines and these are also shown in bold and the cysteine knot ... contains two extracellular domains that we have named C1 and C2 C1 defines the domain closest to the amino terminal end and C2 defines the domain closest to the cell membrane A comparison of the inferred...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... in SLE Interactions between IFN and one of TNF, IFN, or E2 had a suggested involvement in the pathogenesis of SLE Competing interests 10 11 The authors declare that they have no competing interests ... cytokines and E2 This encouraged us to further examine the effects of interactions between IFN and one of TNF, IFN, or E2 on IFI gene expression Gathering the above results, TNF, IFN, and E2 ... subtracting the Ct value of GAPDH (generating a Ct value) The response to the cytokines or E2 was determined by subtracting the Ct value for the time-matched control from the Ct value for the...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 13:22
... in SLE Interactions between IFN and one of TNF, IFN, or E2 had a suggested involvement in the pathogenesis of SLE Competing interests 10 11 The authors declare that they have no competing interests ... cytokines and E2 This encouraged us to further examine the effects of interactions between IFN and one of TNF, IFN, or E2 on IFI gene expression Gathering the above results, TNF, IFN, and E2 ... subtracting the Ct value of GAPDH (generating a Ct value) The response to the cytokines or E2 was determined by subtracting the Ct value for the time-matched control from the Ct value for the...
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Tài liệu Báo cáo khoa học: Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane pptx
Ngày tải lên :
19/02/2014, 06:20
... The Alr1 and Alr2 fusion proteins carried either the N-terminal NubG ubiquitin part at their N-terminus or the C-terminal Cub ubiquitin part at their C-terminus Interaction of membrane protein ... of the pMetY-Cgate vector in the presence of methionine is low The C-terminus is important for protein–protein interaction Discussion Using the split-ubiquitin system, we investigated the interaction ... split-ubiquitin system, designed to assay interactions of membrane proteins in vivo [16,17] Alr1p and Alr2p fusions were constructed by in vivo cloning the PCR fragments comprising genes ALR1 and ALR2 into...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ()) Cross-linking ... ABPs in transcription regulation B Zheng et al Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding ... occurring C-terminal 100 kDa fragment of filamin, interacting with the motor protein dynein, may exert its inhibitory effect by interfering with interactions between the N- and C-terminal domains, and...
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Báo cáo khoa học: Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions docx
Ngày tải lên :
16/03/2014, 13:20
... at the 26 ⁄ 35% sucrose interphase and the LD-caveolae at the ⁄ 26% sucrose interphase caveolin-1 in the different caveolae (Fig 4A) The protein profile mirrored the caveolin profile (Figs 2A and ... (Fig 2G), but increased in response to insulin in both the LD-caveolae and HD-caveolae, with the increase being particularly pronounced in the LD-caveolae (Fig 4C) The presence of the triacylglycerol-hydrolysing ... that these VHDcaveolae membranes originate intracellularly TGN38 was found in the fractions corresponding to the closed VHD-caveolae, and this protein is found in highest amount in Golgi and is involved...
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Báo cáo khóa học: Acharan sulfate, the new glycosaminoglycan fromAchatina fulica Bowdich 1822 Structural heterogeneity, metabolic labeling and localization in the body, mucus and the organic shell matrix docx
Ngày tải lên :
16/03/2014, 16:20
... sulfate in the snail body by alcian blue staining and showed that it is mainly secreted into the outer surface of the body as a mucous material from internal granules [11] The mucus secreted on the ... acetate buffer (pH 5.5) containing 40 mg papain in the presence of mM EDTA and mM cysteine, and incubated at 60 °C for 24 h GAGs were isolated and purified from the papain-digested mucus by sequential ... was cut into very small pieces that were suspended in sodium acetate buffer (pH 5.5) containing 40 mg papain in the presence of mM EDTA and mM cysteine, and incubated at 60 °C for 24 h The suspension...
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Báo cáo khoa học: Role of the surface charges D72 and K8 in the function and structural stability of the cytochrome c6 from Nostoc sp. PCC 7119 potx
Ngày tải lên :
30/03/2014, 20:20
... kU0 and the Gibbs energy of unfolding at [urea] (DGU0) In the mutant series, the overall height of the energy barrier for the rate-determining step of the folding ⁄ unfolding transition is mainly ... on the structural model from [35] along the N-terminal a helix involving the amino acids V4 ⁄ N5, and S11 ⁄ A12 The side chain of D72 is part of an acidic patch, together with the residues D2 and ... stabilizing functional protein–protein interactions [6], as well as in the structural stability of proteins [23–25] Inspection of a preliminary structural model of cyt c6, based on the known structure...
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![Báo cáo khoa học: Accessory proteins functioning selectively and pleiotropically in the biosynthesis of [NiFe] hydrogenases in Thiocapsa roseopersicina docx](https://media.store123doc.com/images/document/14/rc/tv/medium_tvi1396203611.jpg)
Báo cáo khoa học: Accessory proteins functioning selectively and pleiotropically in the biosynthesis of [NiFe] hydrogenases in Thiocapsa roseopersicina docx
Ngày tải lên :
31/03/2014, 01:20
... HupK protein Thirty one amino acid residues in the truncated HupK originated from the N-terminus, 37 aa from the C-terminus of the protein and 13 aa came from the multiple cloning site of the pK18mobsacB ... each other in the hupK gene and its regulatory region One of them contained the hupK-hypC1DE genes (pBRKCDE), and the other one contained only the hypC1DE genes (pBRCDE) The presence of the pleiotropic ... roseopersicina and to understand their physiological roles The determination of the specificity of the accessory proteins is a challenging exercise in this microorganism because of the presumed...
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amino acids, peptides and proteins in organic chemistry
Ngày tải lên :
02/04/2014, 15:59
... enzymes and nucleic acids, and functioning based on precise molecular interactions and thermodynamic control Thousands of proteins/ peptides are assembled through the combination of only 20 amino ... on factors such as the intrinsic basicity of the deblocking amine For instance, amines such as piperidine, morpholine, and piperazine form adducts, while DEA does not Further, the adduct formation ... deblocking by sterically crowded amines is sluggish and often incomplete The possibility of premature deblocking of the group during coupling due to the basicity of the free amino group of amino...
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Báo cáo lâm nghiệp: "Interactions of ozone and pathogens on the surface structure of Norway spruce needle" potx
Ngày tải lên :
09/08/2014, 04:20
... 1986), the fact that areas (UBA, 1985; ozone can cause sur- face erosion in the needles is interesting at least as an intensifying factor in the erosion caused by other air pollutants In the current ... study, the surface in the needles infection in ambient air fumigation The fumigation with higher ozone concentrations could be sterilizing The effect of the ozone fumigation and fungal infection ... significant surface erosion in the material analyzed in our study Ozone concentrations higher than 200 pg/m increased the surface erosion in the material analyzed in our study Magel and Ziegler (1986)...
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Barriers to research utilization and research use among registered nurses working in the care of older people: Does the BARRIERS Scale discriminate between research users and non-research users on perceptions of barriers? potx
Ngày tải lên :
11/08/2014, 05:21
... Innovations theory [8] The items in the instrument cover four domains of barriers: the nurse, the setting, the research, and the presentation In a review including 39 published articles and six theses ... understand the presentation of research findings in research reports, they will not use research findings in practice Being aware of relevant research is the first stage in implementing findings ... through visiting the clients/patients in their home, making assessments, planning care, and evaluating provided care The RNs instruct ENs and NAs on how to carry out the planned care of the clients/patients...
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báo cáo khoa học: " Barriers to research utilization and research use among registered nurses working in the care of older people: Does the BARRIERS Scale discriminate between research users and non-research users on perceptions of barriers?" pptx
Ngày tải lên :
11/08/2014, 16:21
... Innovations theory [8] The items in the instrument cover four domains of barriers: the nurse, the setting, the research, and the presentation In a review including 39 published articles and six theses ... understand the presentation of research findings in research reports, they will not use research findings in practice Being aware of relevant research is the first stage in implementing findings ... through visiting the clients/patients in their home, making assessments, planning care, and evaluating provided care The RNs instruct ENs and NAs on how to carry out the planned care of the clients/patients...
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báo cáo khoa học: " Seroprevalence of select bloodborne pathogens and associated risk behaviors among injection drug users in the Paso del Norte region of the United States – Mexico border" ppt
Ngày tải lên :
11/08/2014, 18:20
... 3) Heroin alone was the drug injected most often in the past six months in New Mexico (69.0%) and Texas (66.5%), whereas in Mexico the 'speedball' or combination of heroin and cocaine was the most ... HBV and HCV than Mexico and slightly lower rates than New Mexico, they had higher rates of HIV and syphilis The common and site-specific findings in this study will enable those working in the ... are seen in the study findings, there are also distinctions between the three states and the two countries that could benefit from further analysis and study It will be important to continue to...
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Báo cáo y học: "The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis" pps
Ngày tải lên :
12/08/2014, 11:22
... to stain western blots containing different citrullinated proteins, such as fibrinogen, histones or vimentin The eluted antibodies react with all of these citrullinated proteins, indicating broad ... of the Committee for the Standardization of Autoantibodies in Rheumatic and Related Diseases, using the same substrate and using kits commercially available in Europe, and is now available at the ... directed to the vimentin protein or to the citrulline moiety of mutated vimentin [9,35] Only the CCP3 test appears in some studies to be comparable with the CCP2 test [36-38], although in the majority...
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Báo cáo y học: " Economic burden and comorbidities of attention-deficit/hyperactivity disorder among pediatric patients hospitalized in the United States" ppsx
Ngày tải lên :
13/08/2014, 18:21
... additional 0.55 inpatient days and an additional US $1,805 in costs [23] In a study looking at LOS and costs among patients with invasive fungal infections versus matched controls, Menzin and colleagues ... NIS is the largest all-payer inpatient care database in the United States and contains data from Page of approximately million hospital stays each year The data set contains clinical and resource ... estimated model included a dichotomous indicator variable, equal to if the patient was in the ADHD cohort and equal to if the patient was not in the ADHD cohort, as well as a vector of underlying patient...
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Báo cáo sinh học: "Cytogenetic and molecular characterization of eight new reciprocal translocations in the pig species. Estimation of their incidence in French populations" pot
Ngày tải lên :
14/08/2014, 13:21
... for the previous case, the reciprocity of the exchange was very difficult to prove using the banding techniques, but, once again, the demonstration could be done using chromosome painting In Figure ... chromosome pair involved in the rearrangement (pair 8) was much more difficult The hypothesis of breakpoints located in the 7q24 and 8p21 bands, as well as the reciprocity of the chromosomal exchange, ... left, the rearranged chromosomes on the right; the locations of the breakpoints are indicated by arrows the presence of chromosome 17 material and helped to demonstrate the origin of the unstained...
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Báo cáo y học: "Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors" pot
Ngày tải lên :
14/08/2014, 17:22
... 82 proteins involved in these processes (only 26 were described previously) These proteins may play crucial roles in maintaining the eye in a healthy condition Perturbation of these proteins in ... as the nucleus (20 proteins) , the Golgi apparatus (12 proteins) and the lysosome (11 proteins) On the other hand, only 68 proteins were classified as extracellular proteins, in addition to that ... staining kit (NuPAGE, Invitrogen), as instructed by the manufacturer After staining, two lanes of the gel were combined and then sliced in 13 pieces as indicated in Figure The pieces were then...
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