stromal androgen receptor in prostate cancer
The androgen receptor centric transcriptional network in prostate cancer
... distinct functional domains, namely, a N-terminal domain (NTD) containing transcriptional activation units (AF-1 and AF-5), a DNA binding domain (DBD) where four-cysteine zinc-binding domains ... Defined Role of ETS proteins in Prostate Cancers (Kumar-Sinha et al., 2008) 28 1.9 Reduced Androgen Signaling in Advanced Metastatic Prostate Cancers A partial attenuation of androgen signaling ... 1.7.2 The Androgen Response Elements and other Motifs in ARBS Like other DNA binding transcription factors, the AR DNA binding domain is mainly responsible for determining its DNA binding specificity...
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Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... cannula with saline-diluted Gd-DTPA (Magnevist ® , Schering, Berlin, Germany) was inserted into the tail vein Dynamic T1-weighted (T1W) imaging was acquired by performing 20 minutes of dynamic...
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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES
... Tower Block, Main Auditorium, Singapore.) xxvii Chapter Introduction 1.1 Common Occurrence of Prostate Cancer (PCa) in Men Prostate cancer (PCa) is the most widely diagnosed cancer in men worldwide ... Based on the Singapore Cancer Registry, PCa is ranked as the third most commonly diagnosed cancers in men but ranked sixth in cancer- causing deaths in Singapore between 2008 to 2012 In addition, ... PSA levels exceeding ng/mL is associated with increased risk of having prostate cancer (Aslan et al., 2011; Prostate cancer , 2012; Huang et al., 2014) However, since an increase in PSA levels...
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ADVANCES IN PROSTATE CANCER docx
... Activation in Prostate Cancer 589 Luis A Espinoza VII VIII Contents Section Cell Adhesion Proteins in Prostate Cancer 617 Chapter 25 Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin ... of all prostate cancer cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ ... of Prostate Cancer 331 Chapter 14 Stem Cells and Prostate Cancer 333 Vildan Bozok Çetintaş, Bur in Tezcanlı Kaymaz and Buket Kosova Chapter 15 Salinomycin-Induced Apoptosis in Human Prostate Cancer...
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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt
... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU145), as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for ... of urine (for at least 18 hours at 37°C) (Figure 6c) Discussion We present the findings of a pilot study, investigating urinary exosomes in prostate cancer patients We had two main aims in the ... loading Bands for prostate- derived proteins PSA or PSMA were evident in patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... Against HLA-A24-positive AMACR-positive Prostate Cancer Cell Lines To confirm that CTLs induced with AMACR peptides could exert cytotoxicity against AMACR-expressing prostate cancer cell lines in ... immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific expression ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue...
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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx
... replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines We demonstrate the presence of A3G in prostate ... cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line 22Rv1 has been shown to be chronically infected with XMRV and produces highly infectious virus [19] Since ... media containing FBS were added After 1–2 weeks, XMRV infection was confirmed by detecting XMRV p30 protein by using goat polyclonal anti-Rauscher MLV p30 Gag in uninfected (−) and XMRV infected...
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Báo cáo sinh học: " Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx
... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we identified a small panel of proteins that interacted with TGase-4, including RON (the HGF-like protein receptor) ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the...
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báo cáo hóa học:" Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx
... MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus areas ... interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we identified a small panel of proteins that interacted with TGase-4, including RON (the HGF-like protein receptor) ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the...
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Báo cáo khoa học: "Choline PET based dose-painting in prostate cancer - Modelling of dose effects" potx
... value concerning the primary detection and the staging of prostate cancer [27] In principle, signal-generation is based on an increased choline metabolism in prostate cancer leading to an increased ... planning in prostate cancer Q J Nucl Med Mol Imag 2009, 53(2):245-268 28 Reske SN, Blumstein NM, Glatting G: [C-11]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy ... [39] In such a geometrical setting it is defined as: TCP e n i SFi i SF i is the surviving fraction within the single subvolume with the running index i (ranging from to m = V/vi) Using the...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... lost or inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) ... paradigmatic intravenously applicable alkylphosphocholine ErPC3 potently induces apoptosis in prostate cancer cells in vitro These findings corroborate earlier reports on high efficacy of ErPC3 in human...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... participating in the non-self recognition of prostate cancer cells Thus we can hypothesize, according to results of Hurwitz et al [12] that the enhanced immune function, involving resting and terminally ... with a Becton Dickinson LSRII instrument (BD Biosciences) We included single-stain controls for further offline compensation Measurement and subsequent analysis was performed using FACSDiva (BD...
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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot
... FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression ... Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways Int ... anti -prostate cancer activity in vitro and in vivo Clin Cancer Res 2004, 10:5282-5292 Ouchi H, Ishiguro H, Ikeda N, Hori M, Kubota Y, Uemura H: Genistein induces cell growth inhibition in prostate...
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Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps
... Kemmerling L, Born EJ, Mini R, Greiner RH, Aebersold DM: Daily organ tracking in intensitymodulated radiotherapy of prostate cancer using an electronic portal imaging device with a dose saving acquisition ... always during RT Twenty-six patients received combined androgen blockade (CAB) consisting of antiandrogen and gonadotropin releasing hormone analogue (GnRH) Three patients received antiandrogen ... summarized in Table Incidence of single symptoms (dysuria, incontinence, retention, frequency/urgency, hematuria) as well as the highest toxicity occurred in a given patient concluding all single...
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Báo cáo khoa học: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy" docx
... performed on-line by repositioning the target according to the internal markers, moving the treatment couch manually To calculate the minimum required margin width around the clinical target ... 90%inthe median values (lines percentile 75% values10%variability, prostate line), format, Measured deviations in and Measured deviations in LR, SI and AP directions in a box plot format, showing ... the interobserver variability is low Therefore implanted markers and EPID based methods are used for targeting in radiotherapy of prostate cancer with increasing frequency Our results provide information...
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Báo cáo khoa học: " Consistency in electronic portal imaging registration in prostate cancer radiation treatment verification" pptx
... participated in study design, data interpretation, manuscript drafting and revising for intellectual content SZ participated in study design, data interpretation and manuscript revising for intellectual ... Bolognesi A, Cattaneo GM, Calandrino R: Intraand inter-observer variability in contouring prostate and seminal vesicles: implications for conformal treatment planning Radiother Oncol 1998, 47:285-292 ... Shinohara N, Harabayashi T, Miyasaka K: Threedimensional intrafractional movement of prostate measured during real-time tumor-tracking radiotherapy in supine and prone treatment positions Int...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... cell lines We found that somatostatin and Octreotide up-regulated XAF1 mRNA and protein expression in prostate cancer cell lines The enhanced XAF1 expression by somatostatin indicates a promising ... [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin and Octreotide on XAF1 expression in prostate cancer...
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báo cáo khoa học: "Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells" pps
... HM: IFNγ induction of p21waf1 in prostate cancer cells: Role in cell cycle, alteration of phenotype and invasive potential Int J Cancer 1998, 77:138-145 Sica G, Iacopino F, Recchia F: Interferon ... chemosensitizing effect of PDF has been postulated on conventional anticancer drugs being currently used [13] http://www.jhoonline.org/content/1/1/25 Accordingly, we are interested in investigating whether ... IFNs using both in vitro and in vivo cancer models [5] For instance, IFNs have been widely used as immunotherapy for urological malignancies including prostate, bladder, and renal carcinomas...
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