strategies for the discovery of new antiviral drugs
Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
Ngày tải lên :
12/08/2014, 23:22
... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... Nucleotide (nt1) is the start of U3 in the 5'LTR The transcription start site corresponds to the junction of U3 and R (C) Schematic representation of the nucleosomal organization of the HIV-1 genome ... In the next parts of this review, we draw the current portrait of the epigenetic control of HIV-1 transcription and we underline the potential of some new pharmacological agents to address the...
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Tài liệu Developing Culturally and Linguistically Competent Health Education Materials: A Guide for the State of New Jersey ppt
Ngày tải lên :
14/02/2014, 13:20
... prescriptions for improving the quality of life The differences are between perspectives: the individual and the societal; the negative and the positive; the curative and the preventive; the reductivist ... tremendous implications for material development 23.9% of the foreign-born population of New Jersey lives in linguistic isolation (About 19.5% of the population of New Jersey is foreign-born) A linguistically ... which the client/family is at the center and controls the flow of information The educator asks questions and listens thereby allowing the client/family to lead the discussion based on their...
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The importance of project management in small- and medium-sized enterprises (SMEs) for the development of new products through E-collaboration docx
Ngày tải lên :
07/03/2014, 00:20
... to h The participants were given an explanation regarding the purpose of the feedback, the purpose of the conceptual model, some background of the research that lead to the development of the ... concept (either for the company or for the customer) It includes all activities from the development of an idea or a concept for a product, to the realization of the product during the production ... collaboration, led by the project manager, the information for production of a new product will be integrated, and the project will be finished in real time Furthermore, the cost for production will...
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el-erian - when markets collide; investment strategies for the age of global economic change (2008)
Ngày tải lên :
03/11/2014, 18:46
... Times),3 and the “invasion of the sovereign wealth funds” (The Economist).4 To some of us, the financial market turmoil that started in the summer of 2007 reflects the secular transformation of the global ... This is true at the level of the individual firm, where the willingness of the portfolio managers to use new strategies is yet to be accompanied by the ability of the middle and back offices to adequately ... this time, the high-profile casualties were the CEOs of some of the most influential banks in the world and other senior corporate officials The list of aberrations goes on Interestingly, the numerous...
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Strategies for the conservation of two critically endangered, endemic primates in panama
Ngày tải lên :
04/09/2015, 08:01
... directors for the future management of the parks and reserves of the zones As we visit the remote areas of the peninsula, we inform the communities about what we are doing and also obtain information ... Forest Reserve in the north of the Herrera province, Cerro Hoya National Park at the southwestern part of the peninsula (eastern part of Veraguas province), and La Tronosa Forest Reserve at the ... obtain information about the history of the fauna, native plant knowledge, and the presence and problems related to the primates Training students from the Biology School of the University of Panama...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 1
Ngày tải lên :
10/09/2015, 09:08
... incidentally is the fourth, most common cancer in Singapore For the better understanding of the role of xenobiotics in the progression of ovarian cancer, it is necessary to monitor the levels of these ... the progress of disease or the effects of treatment 12 Chapter However, the final effect of xenobiotic exposure is not related to the action of a single chemical, but to the combined effect of ... widely used for the analysis of the pollutants It is routinely used not only in the analysis of thermally labile, non-volatile ionic compounds but for all types of molecules from the smallest...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 2
Ngày tải lên :
10/09/2015, 09:08
... of estrogens in these body fluids would be very important for the study of their roles in the carcinogenesis of ovarian and breast cancer The role of estrogen in the progression of gynaecological ... to the extraction from a limited amount of sample The judicious choice of sorbent materials, and therefore to some extent, the selectivity of µ-SPE can be fine-tuned With the protection afforded ... prepare the device, the longer edge of a polypropylene sheet was folded over to a width of ~2 cm The edge of the fold-over flap was then heat sealed using an electrical sealer to the main sheet The...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 3
Ngày tải lên :
10/09/2015, 09:09
... biplot, the observations are the samples and the variables are the chemicals present in those samples In a biplot, the length of the lines approximates the variances of the variables The longer the ... data The goodness of the biplot approximation depends on the axes and the points As for the points, the `quality' of the PCA approximation is found from the R program In this case, the quality 0.627 ... dimensions of the biplot Generally, for a good PCA approximation, the points and axes are always appears above the diagonal in the unit square The further to the right a point or axis appears, the better...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 4
Ngày tải lên :
10/09/2015, 09:09
... 320˚C (hold for 10 min) µL of the sample was injected into the GC-MS in splitless mode and the total GC-MS analysis time was 55.00 SIM mode employed for the set of target PCB compounds The method ... dynamic partitioning of the PCBs between the sorbent material and the sample solution, the extraction efficiency depends on the mass transfer of analyte from the aqueous sample to the solid sorbent ... ovarian tumor cyst fluid samples One of the strengths of the current study is the ability to measure the levels of many individual congeners Overall, sum of the 87 congeners were detected in all...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 5
Ngày tải lên :
10/09/2015, 09:09
... environmental exposure [1-3] The number of elements of interest has increased in the recent decade, not only the trace metals but the heavy metals as well The study of the role of the trace elements has ... emphasized in the search for the possible causes of cancer The International Agency for Research on Cancer has proposed trace elements for their carcinogenesis [4, 5] Some of them or their compounds ... in the benign possibly promote the malignant transformation of ovarian tumor The present findings in agreement with the results of earlier studies on tumor, irrespective of the nature of the...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 6
Ngày tải lên :
10/09/2015, 09:09
... into the GC syringe and the needle of the syringe was inserted into hollow fibre to about 0.2 cm of the tip of the syringe needle was covered by it The hollow fibre was then dipped into the organic ... that of human the prediction of rate of accumulation of estrogens in zebrafish can reveal the effects of xenobiotic estrogens on humans [12] There is a direct correlation between the rate of bioaccumulation ... a mL vial The organic solvent in the GC syringe was released into the channel of the hollow fibre after which the stir bar in the aqueous phase was activated and at the same time, the stopwatch...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 7
Ngày tải lên :
10/09/2015, 09:09
... molecular mass of polypeptides The speed of migration is dependent on the size of the ‘pores’ in the gel mesh which is in turn determined by the percentage of acrylamide present in the gel The polyacrylamide ... However, as of today, there is no known crystal structure of the protein available Therefore, in an attempt to further comprehend the molecular factors of the biological activity and the chemistry involved, ... Hence analysis of those body fluids by proteomic studies for quantification of endorepellin will lead to the clue about the state of the tumour cells Electrophoresis is the separation of macromolecules...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 8
Ngày tải lên :
10/09/2015, 09:09
... extraction conditions For all procedures, quality assurance was evaluated to ensure the reliability of the results For most of the analysis GC-MS was used for the detection of analytes GC-MS method ... effect on the malignant transformation and etiologic research of cancer Based on the conclusions drawn from the current work, the following implications are made for further studies: 1) For profiling ... Inclusion of more samples would enhance the reliability of the results 2) The association of chemical levels on the disease progress is greatly influenced by the characteristics of the sample,...
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Development of methods to improve sensitivity and portability of capillary electrophoresis for the analysis of stabilizers and drugs 1
Ngày tải lên :
14/09/2015, 10:36
... β-CD-NH2 and the backward movement of the neutral sample partitioned in the micelles of sodium dodecyl sulfate (SDS) Stability of the inclusion complexes formed between the carrier and the solute ... displacer plug was introduced before sample injection to reduce the length of the concentrated sample zone and increase the peak height by slowing down the forward movement of the neutral sample associated ... With the high separation efficiency, high resolution and portability, CE has been proven a powerful method for the studies of many groups of compounds The improvement of sensitivity and the miniaturization...
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Development of methods to improve sensitivity and portability of capillary electrophoresis for the analysis of stabilizers and drugs 2
Ngày tải lên :
14/09/2015, 10:37
... Where, Δp: the pressure difference; r: the inner diameter of the capillary; 20 t: the injection time; η: the viscosity of the buffer; L: the total length of the capillary In the case of all hydrodynamic ... macromolecules The transport of the solutes through the 15 capillary is based on the charge of the macromolecules, but the separation is dependent on the molecular size Besides the gel forming medium, other ... velocity of the leading anion The principle of separation is the variation of the electric field in each zone, which causes the self-adjustment of the field to maintain a constant velocity, with the...
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Tài liệu Một số thuốc mới chống rối loạn lipid máu (New drugs for the control of dyslipidemia) pdf
Ngày tải lên :
26/02/2014, 03:20
... tham khảo Tài liệu khoa học công ty dợc phẩm pfizer, MSD, Fourmier (1998 - 2004) Opie H.L: Drugs for the Heart; Edition (2001); W.B Samders Company, trang 323 350 Medline (2000 - 2004) ... ezetimibe với cholestyramin, cyclosporin Dùng riêng, rosuvastatin dễ dung nạp, kể phối hợp với fenofibrat, niacin, cholesteramin, dáng dấp an toàn tơng tự statin lu hành Chỉ định ezetimibe tăng ... "không sterol" có ích cho sức khoẻ nh dolichol, ubiliquinon (coenzym Q10) xin đọc sơ đồ Squalen synthetase xúc tác cho sinh tổng hợp cholesterol mắt xích gần cuối, chuyển farnesyl pyrophosphat sang...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
Ngày tải lên :
26/10/2012, 09:32
... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
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Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain
Ngày tải lên :
24/10/2013, 19:15
... the duration of the effect depends on the rate of enzyme resynthesis Furthermore, salicylate may contribute to the effect ASA irritates the gastric mucosa (direct acid effect and inhibition of ... secretion PG promote the production of gastric mucus and reduce the formation of gastric acid (p 160) Menstruation PGF2! is believed to be responsible for the ischemic necrosis of the endometrium ... subscripts refer to the number of double bonds, and the Greek letter designates the position of the hydroxyl group at C9 (the substance shown is PGF2!) PG are primarily inactivated by the enzyme 15hydroxyprostaglandindehydrogenase...
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Tài liệu Response statistics for ''''New Legislative Framework for the marketing of products: proposal to align 10 product harmonisation directives to Decision 768/2008.'''' pdf
Ngày tải lên :
19/02/2014, 03:20
... (2.6%) B11 How you evaluate the impact of the four elements of Action recalled below on the level of compliance, safety of products and functioning of the internal market for the product categories ... 95/16/EC of 29 June 1995 on the approximation of the laws of the Member States relating to lifts Pressure Equipment Directive: Directive 97/23/EC of the 25 European Parliament and of the Council on the ... Alignment of modules: The existing text of the modules in the directives is aligned to the standard modules set out in Annex II of Decision 768/2008 D33.1 Are you notified for more than one of the...
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