steroid thyroid hormone receptor superfamily
Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx
... high-affinity receptor for thyroid hormone Nature 324, 635–640 Weinberger, C., Thompson, C.C., Ong, E.S., Lebo, R., Gruol, D.J & Evans, R.M (1986) The c-erb-A gene encodes a thyroid hormone receptor ... M.A (1993) Thyroid hormone receptors: multiple forms, multiple possibilities Endcr Rev 14, 184–193 Glass, C.K (1996) Some new twists in the regulation of gene expression by thyroid hormone and ... expression by thyroid hormone and retinoic acid receptors J Endocrinol 150, 349–357 Sharma, D & Fondell, J.D (2000) Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa...
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Báo cáo khoa học: Proper targeting and activity of a nonfunctioning thyroid-stimulating hormone receptor (TSHr) combining an inactivating and activating TSHr mutation in one receptor pptx
... been described for glycoprotein hormone receptors [25–27] The T477I has been described as an inactivating mutation in a patient with congenital hypothyroidism and thyroid hypoplasia [16] Similarly, ... construct harboring the single mutated receptors (T477I, I486M, P639S) or double mutant receptors (T477I/ P639S; I486M/P639S) and WT-TSHr The Bmax, total receptor amount (binding capacity; expressed ... cooperate to potentiate the activity of the receptor The increase of basal activity by combining activating mutations is well known for glycoprotein hormone receptors [23,24] No further increase of...
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Tài liệu Báo cáo khoa học: Characterization and functional expression of cDNAs encoding thyrotropin-releasing hormone receptor from Xenopus laevis Identification of a novel subtype of thyrotropin-releasing hormone receptor ppt
... thyrotropin-releasing hormone receptor Proc Natl Acad Sci USA 87, 9514–9518 19 De La Pena, P., Delgado, L.M., Del Camino, D & Barros, F (1992) Cloning and expression of the thyrotropin-releasing hormone receptor ... acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene Biochem Biophys Res Commun ... thyrotropinreleasing hormone receptor Endocrinology 139, 3390–3398 28 Harder, S., Dammann, O., Buck, F., Zwiers, H., Lederis, K., Richter, D & Bruhn, T.O (2001) Cloning of two thyrotropinreleasing hormone receptor...
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Báo cáo khoa học: A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbb and removes Rev-erbb-induced inhibition of apoCIII transcription potx
... tissue specificity of selective receptor modulators Endocr Rev 25, 45–71 Lazar MA, Hodin RA, Darling DS & Chin WW (1989) A novel member of the thyroid ⁄ steroid hormone receptor family is encoded ... M, Escriva Garcia H & Laudet V (2003) The nuclear receptor superfamily J Cell 116, 585–586 Rosen J, Marschke K & Rungta D (2003) Nuclear hormone receptor assays for drug discovery Curr Opin Drug ... and Reverbb, two orphan members of the superfamily of nuclear hormone receptors Mol Cell Biol 17, 1860– 1867 Yin L & Lazar MA (2005) The orphan nuclear receptor Rev-erbalpha recruits the N-CoR...
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Thyroid hormone metabolism in poultry ppt
... the actions of THs seem to be dependent on the binding to a nuclear thyroid hormone receptor (TR) Two major isoforms of these receptors are known (TRα and TRβ) and both of them preferentially bind ... TH deiodination (review by Visser, 1990) THYROID HORMONE DEIODINATION 2.1 Characterisation of deiodinases The enzymes catalysing deiodination of thyroid hormones have first been described in mammals, ... growth hormone (GH) in poultry BASE (Special issue), abstract G2, p 16 Visser TJ (1990) Importance of deiodination and conjugation in the hepatic metabolism of thyroid hormone In Greer MA The Thyroid...
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Báo cáo khoa học: Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition potx
... luteinizing hormone receptor mRNA in the ovary J Biol Chem 280, 42809–42816 Wang L, Nair AK & Menon KMJ (2007) Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor ... Menon KMJ (1994) In situ hybridization of luteinizing hormone ⁄ human chorionic gonadotropin receptor messenger ribonucleic acid during hormone- induced down-regulation and the subsequent recovery ... Identification of a hormonally regulated luteinizing hormone ⁄ human chorionic gonadotropin receptor mRNA binding protein Increased mRNA binding during receptor down-regulation J Biol Chem 273, 10658–10664...
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Thyroid Hormone by Neeraj Kumar Agrawal ppt
... secondary thyroid hormone transporters Thyroid Res 4: S7 [27] Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors ... TSH receptor (TSHR) [36], iodothyronine deiodinases (DIO1, DIO2, and DIO3) [36,37], thyroid hormone transporter and thyroid hormone receptor genes accounted for variation in serum TSH and thyroid ... Maternal-Fetal Thyroid Interactions R.G Ahmed Section Thyroid Hormone Excess Chapter Thyroid Hormone Excess: Graves’ Disease 159 N.K Agrawal, Ved Prakash and Manuj Sharma 125 157 VI Contents Section Thyroid...
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Báo cáo khoa học: Identification of a novel thyroid hormone-sulfating cytosolic sulfotransferase, SULT1 ST5, from zebrafish Molecular cloning, expression, characterization and ontogenic study ppt
... homeostasis of thyroid hormones, remain to be clarified Developmental stage-dependent expression of zebrafish thyroid hormone- sulfating cytosolic SULT1 ST5 In view of its thyroid hormone- sulfating ... exclusively for thyroid hormones and their metabolites It will be interesting to investigate whether SULT1 ST5 plays a unique and important role in the metabolism and homeostasis of thyroid hormones ... constants determined for the sulfation of thyroid hormones and their metabolites, as well as b-naphthol It appeared that the Km values for the thyroid hormone ⁄ metabolites, except l-Thyronine,...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... cytosolic thyroid- hormone- binding protein (CTBP) in Xenopus liver Eur J Biochem 225, 1105–1112 10 Yamauchi, K., Nakajima, J., Hayashi, H., Horiuchi, R & Tata, J.R (1999) Xenopus cytosolic thyroid hormone- binding ... temporal regulation of amphibian matamorphosis: roles of thyroid hormone and its receptors Bioessays 18, 391–399 13 Maxwell, E.S & Topper, Y.J (1961) Steroid- sensitive aldehyde dehydrogenase from rabbit ... for thyroid hormone as the coenzyme-binding domains within dehydrogenases have a relatively conserved ternary structure [42] when compared to their catalytic domains However, Ki values for thyroid...
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thyroid hormone receptors
... Introduction 1 Introduction to Thyroid Hormone Receptors Aria Baniahmad Biology of Thyroid Hormone Receptors Thyroid hormone receptors (TRs) play a major role in animal physiology ... nuclear hormone receptors (NHR) These receptors represent hormone- regulated transcription factors Members of NHR include receptors for lipophilic hormones, such as steroids, receptor for nonsteroids, ... activation Thyroid Hormone Thyroid hormone, isolated by Kendall in 1915, is one of the first hormones identified in the early last century Its chemical structure has been known since 1925 Thyroid hormone...
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báo cáo hóa học:" Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter" pptx
... factor Gonadotropin releasing hormone receptor 14179 14715 MR -4.8 MA -2.5, MR -3.3 Gucy1b3 Guanylate cyclase 1, soluble, beta 54195 MR -2.7 Irak1 Interleukin-1 receptor associated kinase 16179 ... and FSH receptors, steroidogenic enzymes, and inhibin alpha [8] The KGN cell line was derived from a 73 year old woman in which granulosa cell carcinoma had recurred [23] The KGN cells had steroidogenic ... involved in steroidogenesis StAR encodes the steroidogenic acute regulatory protein, which transfers cholesterol from the outer to the inner mitochondrial membrane, the rate limiting step in steroidogenesis...
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THYROID HORMONE docx
... secondary thyroid hormone transporters Thyroid Res 4: S7 [27] Constantinou C, Margarity M, Valcana T (2005) Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors ... TSH receptor (TSHR) [36], iodothyronine deiodinases (DIO1, DIO2, and DIO3) [36,37], thyroid hormone transporter and thyroid hormone receptor genes accounted for variation in serum TSH and thyroid ... Maternal-Fetal Thyroid Interactions R.G Ahmed Section Thyroid Hormone Excess Chapter Thyroid Hormone Excess: Graves’ Disease 159 N.K Agrawal, Ved Prakash and Manuj Sharma 125 157 VI Contents Section Thyroid...
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Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance docx
... K, Samarut J, Xu J, O'Malley BW, Weiss RE: Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone reviews creatine kinase, muscle forward primer 5'-TTCCTTGTGTGGGTGAACGA-3'; ... CB, Williams GR: Mechanism of thyroid hormone action Thyroid 2002, 12:441-446 O'Shea PJ, Williams GR: Insight into the physiological actions of thyroid hormone receptors from genetically modified ... include transthyretin (Ttr), a high-affinity serum thyroid- hormone- binding protein that transports thyroid hormone to target tissues, thus facilitating thyroid Cerebellum reports Differentially expressed...
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Báo cáo khoa học: "The role of thyroid hormone therapy in acutely ill cardiac patients" pot
... experience and review of the literature Eur J Heart Fail 2002, 4:577582 Klemperer JD: Thyroid hormone and cardiac surgery Thyroid 2002, 12:517-521 Rosendale JD, Kauffman HM, McBride MA, Chabalewski FL, ... of activated NF-κB in the pathogenesis of euthyroid sick syndrome J Clin Invest 2000, 106:393-402 De Groot LJ: Dangerous dogmas in medicine: the nonthyroidal illness syndrome J Clin Endocrinol ... competing interests References 334 Wartofsky L, Burman KD: Alterations in thyroid function in patients with systemic illness: the ‘euthyroid sick syndrome’ Endocr Rev 1982, 3:164-217 Bianco AC, Salvatore...
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Bóa cáo y học: "Clinical review: Thyroid hormone replacement in children after cardiac surgery – is it worth a try" docx
... thyroid dysfunction, including SES Thyroid hormone replacement after cardiac surgery The rationale of thyroid hormone replacement/ treatment A vast literature is available on the changes of thyroid ... children with thyroid hormones after cardiac surgery Based on the findings after cardiac surgery and the pharmacological profile of thyroid hormones, it has been postulated that thyroid hormone replacement ... also structurally similar to the thyroid hormones [90] The incidence of thyroid dysfunction in children is well reported [91] and hypothyroidisms as well as hyperthyroidism are reported with varying...
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Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis" pps
... mone receptor PCR measurements of insulin-like growth factor-1 and the growth hormone receptor Bars represent the mean expression of mRNA of insulin-like growth factor-1 (IGF-I) and growth hormone ... anti-inflammatory (IL-10) cytokine and the expression of mRNA of SOCS proteins, of IGF-I and of the growth hormone receptor (GHR) in hepatic tissue from these animals These results are reported in the present ... Behncken SN, Tam SP, Li H, Shen B, Lobie PE: Growth hormone as a cytokine Clin Exp Pharmacol Physiol 1999, 26:760-764 Gibson FA, Hinds CJ: Growth hormone and insulin-like growth factors in critical...
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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES
... Prostate Cancer 1.4.1 Hormone or Androgen Deprivation Therapy (ADT) for Prostate Cancer 3-6 7 1.4.1.1 Orchiectomy or Surgical Castration 1.4.1.2 Luteinizing Hormone- releasing Hormone (LHRH) Agonists ... Hormone- releasing Hormone (LHRH) Agonists 1.4.1.3 Luteinizing Hormone- releasing Hormone (LHRH) Antagonists 1.4.1.4 Anti-androgens 1.4.1.5 Recently Developed Hormone Therapy 10 1.5 Occurrence of Castration ... Estrone E2 Estradiol or 17β-estradiol EGF Epidermal Growth Factor ER Estrogen Receptor ERα Estrogen Receptor α ERβ Estrogen Receptor β ESI Electrospray Ionisation FBS Fetal Bovine Serum FDA Federal...
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Gene expression of thyroid hormone receptors TR alpha and TR beta during early development in tilapia, oreochromis mossambicus
... INTRODUCTION The thyroid hormone receptors (TRs) belong to a family of hormoneactivated nuclear receptors which includes the receptors for retinoids, vitamin D3 and steroid hormones Thyroid hormones ... PROFILES OF THYROID HORMONE RECEPTORS TRα1 AND TRβ1 DURING EARLY DEVELOPMENT IN TILAPIA, OREOCHROMIS MOSSAMBICUS 3.1 INTRODUCTION Thyroid hormones act by interacting with thyroid hormone receptors ... addition, thyroid hormones also play important roles during embryogenesis and organogenesis (Sachs et al., 2000) Thyroid hormones exert their effect by binding to multiple thyroid hormone receptors...
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Báo cáo khoa học: Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy ppt
... Natriuretic peptide receptor signaling mechanism H Ogawa et al surface receptor for ANP, which possesses intrinsic guanylate cyclase (GCase) activity The ANP receptor occurs as a homodimer ... structures both occur, and represent the inactive and the hormone- activated states of the receptor, respectively [13,14] It is hypothesized that a hormone- induced rearrangement of the ECD from the hh ... natriuretic peptide receptors [15,16], and been suggested to be similar to those of the G-protein-coupled metabotropic glutamamate receptor [15–17] and the erythropoietin receptor [18,19] In...
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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... activity affect hormone- induced steroidogenesis [17–19,25] Those studies have raised the possibility that PLA2 could be involved in the mechanism of action of hormones that control steroid production ... Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis Science 267, 1828–1830 Stocco, D.M & Clark, B.J (1996) Regulation of the acute production of steroids in steroidogenic ... inhibitor receptor: biological role in steroidogenic cell function Endocr Rev 14, 222–240 54 Papadopoulos, V (1998) Structure and function of the peripheraltype benzodiazepine receptor in steroidogenic...
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