steroid sensitive nephrotic syndrome in children
GENETICS OF NEPHROTIC SYNDROME IN SINGAPORE PAEDIATRICS PATIENTS
... resulted in a gain of function. Mutations in WT1 affect the DNA‐binding affinity of WT1 to the target gene. Heterozygous de novo mutations in WT1 resulting in the inability of zinc fingers to bind to DNA, are seen in Denys‐Drash syndrome, a condition associated ... Title: Multiple Rare Alleles in Nephrin and Podocin Contribute to Poor Prognosis in Childhood Nephrotic Syndrome in Singapore. Nominated for Young Investigator Award xiv Introduction 1.1 Nephrotic syndrome Nephrotic syndrome (NS) is a common ... High resolution melting IP3 Inositol 1,4,5‐triphosphate xi IQGAP‐1 IQ motif–containing GTPase‐activating protein 1 ISKDC International Study of Kidney Diseases in Children MCNS Minimal change nephrotic syndrome ...
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GENETICS OF NEPHROTIC SYNDROME IN SINGAPORE PAEDIATRICS PATIENTS 2
... glomerulonephritis.GN: Glomerulonephritis. MCNS: Minimal change nephrotic syndrome. *Patient progressed to end‐stage renal disease. **Patient is resistant to calcineurin inhibitor. 151 Table 2: Genotyping profile of the significant SNPs for the patients. ... FSGS with a cellular crescent MCNS FGS FGS Not performed Glomerular minor abnormalities MCNS IgM nephropathy, MCNS Minimal change. Findings Poor Prognosis No No Steroid Resistant No No On CNI therapy ... pT (p.Ala22Val) ...
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Báo cáo y học: "Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus" pps
... cytokine secretion in Dex and PHA, n = cytokine secretion in RPMI alone, y = cytokine secretion in PHA alone By using this calculation, the variations for cytokine secretion among and within individuals ... the GR expression or binding in individual cell types Because GR expression and binding are different in respect to blood cell type, the variation in cell type percentages in different patients ... than those in both SS and control groups However, there was no difference in the expression and binding of GRs in SS patients compared with those in controls except for the binding of GR in T lymphocytes...
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Báo cáo y học: "Asthma is a risk factor for acute chest syndrome and cerebral vascular accidents in children with sickle cell disease" ppt
... http://www.clinicalmolecularallergy.com/content/3/1/2 Vaso-occlusive pain was defined as pain that could not be explained by injury or infection requiring hospital admission and treatment with intravenous ... treatment with intravenous steroids may have been due to aggressive treatment of underlying asthma Limitations of our study include those inherent in a retrospective analysis including selection ... Competing interests A randomized, placebo-controlled trial of 43 episodes of acute chest syndrome in 38 children revealed that intravenous dexamethasone prevented clinical deterioration in mild...
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Báo cáo y học: "Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthm" pptx
... be operative in mold-induced asthma involves chitin, a major structural protein of the outer coating of fungi [31] Chitin polarizes immune Th1 responses by suppressing Th2 responses In humans, ... atopy and a gain-of-function in the IL-4R as measured by increased CD23 expression in patients with 576arg This was also observed in the present study in children with Alternaria -sensitive moderate-severe ... significantly increased in Alternaria -sensitive moderate-severe asthmatics compared to Alternaria -sensitive mild asthmatics (p < 0.04 and p, 0.04, respectively) Cytokine synthesis In Alternaria-sensitive...
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Báo cáo y học: "Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome (HUS) in children" ppt
... in four children, in three cases based on the severity of abdominal pain and activity of enterocolitis and in one case due to recent abdominal surgery Peritoneal dialysis was chosen in four children ... read and approved the final manuscript LK contributed during all steps in designing and producing this report, coordinated the author team, been involved in the treatment in most of the patients, ... Antibiotics is contraindicated in the treatment of possible STEC infections, due to increased toxin-release from bacterial lysis [24] or increased production of toxin due to induction of bacteriophages...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"
... or in combination in the following order: fludrocortisone 0.1mg po bid, midodrine 5-10 mg po tid, propanolol10 mg po tid, pyrodostigmine 60 mg po bid, serotonin reuptake inhibitor or modafinil ... the medulla In addition there can be interference with the descending autonomic nervous system pathways during their course in the brainstem or spinal cord (6) Although orthostatic dizziness has ... episodic blurring of vision were seen in 4/9(44%) patients Sensory disturbances including numbness, tingling, pins and needles sensation in extremities were seen in 4/9(44%) patients Gait problems...
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Management of spasticity in children
... lacking in co-operation for instrumented gait analysis using current techniques Managing spasticity in children In our preliminary open label study into the use of BoNT-A in the lower limbs of children ... tissue to stretching forces Many clinicians combine casting with intramuscular injections of botulinum toxin It is still unclear as to whether the combined effect of injection and casting may be better ... Care must be taken in following the dosage guidelines of clinical papers We follow empirical guidelines established by trial and error in toxin administration including the following: Maximum dose...
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Tài liệu Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom pdf
... weaning the enteral feed 10 Néstle Clinical Nutrition SHS International Ltd Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom 3.1.2 Corticosteroids ... Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom 3.2 Refractory or non-responsive CD [51-78] Patients in whom standard induction therapy including ... specific indications Infliximab if fails, Adalimumab, cyclosporine, thalidomide 13 Guidelines for the Management of Inflammatory Bowel Disease (IBD) in Children in the United Kingdom 3.4 Maintenance...
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Tài liệu Preventing Dental Caries in Children at High Caries Risk doc
... national guideline in individual practices, clinics and hospitals and for securing compliance with them This may be done by a variety of means including patient-specific reminders, continuing education ... and training, and clinical audit SIGN consents to the copying of this guideline for the purpose of producing local guidelines for use in Scotland STATEMENT OF INTENT This report is not intended ... in this guideline, as studies have shown this to be a factor.115 Some sugar-free medicines cost more than those containing sugar Increased prescribing of sugar-free medicines will initially increase...
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Tài liệu Seropositivity for celiac disease in children and adolescents with short stature doc
... Occasional abdominal pain, difficulty gaining weight and height Prior history of anemia Difficulty gaining weight and height Prior history of anemia Frequent abdominal pain, difficulty gaining weight ... covering socioeconomic and demographic aspects as well as complaints related to celiac disease (abnormal intestinal rhythm, abdominal pains, flatulence, recurrent aphthous ulcers, difficulty gaining ... by permanent gluten intolerance in people who are genetically susceptible Gluten provokes an inflammatory reaction that damages the villi in the small intestine, causing an inadequate absorption...
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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx
... rash and itching may occur; the skin may become scaly; the skin may heal by scarring; hair loss may accompany the skin injury Look for dry eyes: no tears, constant rubbing and blinking; sensitivity ... produce additional proinflammatory cytokines, including tumor necrosis fac tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract more T-cells to continue the cycle of tissue ... Consensus recom mends a system for scoring chronic GVHD manifestations in organs and sites, including the skin, mouth, eyes, gastro intestinal tract, liver, lungs, joints and fascia, genital tract,...
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Tài liệu Nutrition in Children with Chronic Kidney Disease pptx
... 27 grams of protein a day before starting dialysis 60 × 0.45 = 27 Limiting a child to this amount may be difficult because some foods contain that much protein in a single serving You may need ... discuss any changing needs with your child’s health care team Protein Protein is an essential part of any diet It helps build and maintain muscle, bone, skin, organs, and blood Some proteins help fight ... content of potatoes and beans by soaking them in water for several hours before cooking Phosphorus is a mineral found in many foods, particularly those high in protein When your child’s blood phosphorus...
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Tài liệu Chronic interstitial lung disease in children doc
... Mini-symposium: interstitial lung diseases in children Paediatr Respir Rev 2004;5:93 20 Dinwiddie R, Sharief N, Crawford O Idiopathic interstitial pneumonitis in children: a national survey in ... choose an invasive examination method, we fundamental when dealing with chronic patients indicated lung biopsy, since it offers more objective informa- Epidemiological research into interstitial ... patients Wheezing is less common but of ILD in children and, in our hospital, became available only it was observed in 11 patients in 1997 As a result, in five cases HRCT scans were not In the 13...
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Tài liệu Sport and Physical Activity in Children with Congenital Heart Disease ppt
... surgery/interventions (including ablations) Group Patients after cardiac surgery/interventions (including ablations) 1.1 Without remaining findings (complete correction) 1.2 With minimal findings ... hemodynamic findings Exercise echocardiography Cardiac function and hemodynamic findings under exertion BOX Findings after cardiac surgery and/or interventions Minor remaining findings (1.2) – ... defects requiring surgery No sports A No (remaining) cardiac defects 1.1 Unlimited B Mild (remaining) findings 1.2; 2.1; 2.2; 2.3; 2.4; 4.2 Unlimited C Clinically significant (remaining findings) 1.3;...
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Tài liệu Understanding Growth Failure in Children With Homozygous Sickle-Cell Disease doc
... reduced in 64% of the children with SCD-SS (Lal, Fung, Pakbaz, Hackney-Stephens, & Vichinsky, 2006) This finding was associated with deficient calcium intake and low serum vitamin D levels in children ... study examining vitamin A status in children with SCD-SS revealed that the mean serum retinol level was suboptimal in 66% of the children (Schall, Zemel, Kawchak, Ohene-Frempong, & Stallings, 2004) ... studies examining vitamin D, vitamin A, and zinc status suggest that increased nutritional demands are likely contributing factors to the micronutrient deficiencies seen in SCD-SS Affected children...
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Tài liệu Acute Respiratory Infections in Children ppt
... vaccines on LRIs Hib Vaccine Currently three Hib conjugate vaccines are available for use in infants and young children The efficacy of Hib vaccine in preventing invasive disease (mainly meningitis, ... of vaccine Consequently, all industrialized countries include Hib vaccine in their national immunization programs, resulting in the virtual elimination of Acute Respiratory Infections in Children ... others 2003) In the United States, the 7-PCV was included in routine vaccinations of infants and children under two in 2000 By 2001 the incidence of all invasive pneumococcal disease in this age...
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Tài liệu Review of essential medicine priorities in ear, nose and throat conditions in children doc
... The Royal Children s Hospital Clinical Practice Guidelines combines advice for “rhinosinusitis”, defined as “inflammation of the epithelial lining in the paranasal sinuses” and noting that this ... Guidelines Clearinghouse Cincinnati Children' s Hospital Medical Center Evidence-based care guideline for management of acute bacterial sinusitis in children 1-18 years of age Cincinnati (OH): Cincinnati ... Management of rhinosinusitis in children Int J Pediatr Otorhinolaryngol 1999 Oct 5;49 Suppl 1:S95-100) The role of rhinitis in asthma has also been the subject of intense scrutiny.43 In terms of...
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Musculoskeletal Complications of Neuromuscular Disease in Children pot
... and clinical examination) using botulinum toxin injections have been reported, but evidence is limited regarding the effect of botulinum toxin treatment on the development of bony deformity In a ... interventions, including sitting supports and custom seating, spinal orthoses, and functional strengthening programs may be useful to improve sitting balance and functional independence [47–50] In myelodysplasia, ... decreased internal hip rotation at initial contact, toe-off, and mid-swing in children who had undergone multilevel botulinum A treatments Botulinum injections were started at a young age and combined...
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