step function of acceleration
A three phase voltage type PWM rectifier with the function of an active power filter
... AC-side phase voltage vi, ( vi, , vi, ) of the PWM rectifier is obtained, that is, voltage of s, when s,, = when SI,= S3 is ON and S, is OFF when Generation of PWM Signals respect to Using the PWM ... and s, s, is ON when is ON and S, is OFF when is OFF and s is ON when s, = s, = s, s, =1 =0 DETECTION OF HARMONICS As a method to detect harmonic components of a distorted current, we employ in ... which is shown in part D, ofFig This part represents the harmonic detector for phase U in Fig The upper part of D, detects the sine term of the n -th harmonic component of the U- phase load current...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... borders of active genes within polytene chromosome puffs [78] One of the proposed mechanisms of BE function involves the recruitment of chromatin modifying complexes that create islands of active ... recruitment of MOF to recently transcribed regions, especially at the 3¢ ends of genes where H3-K36me3 is enriched [128] In mammalian cells MOF also exists as part of a separate MOF–MSLv1 complex ... formation of a highly disorganized nucleosome array incapable of conforming to any of the current models of the higher order chromatin fibre It is even possible that this highly disorganized form of...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... family of cytoplasmic enzymes that are important for several aspects of leukocyte biology Both loss- and gain -of -function mutations in humans have been instrumental in our understanding of their ... T cells, the expression of ITK is extremely low and often undetectable in immunoblot analysis The activation of CD4+ cells, however, dramatically induces transcription of the ITK gene and is key ... the hallmark of which is unspecified peripheral T-cell lymphoma [69] Consequently, the PH–TH domain doublet of ITK fuses directly with the linker B kinase region of SYK The PH domain of TFKs usually...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... KIND2-binding specificity of residues 702–744 of MAP2, we performed a pulldown assay of combinations of EGFP-fused KIND1 or KIND2 of v-KIND with GST-fused CD2-1-6-1 or CD2-1-6-2 of MAP2 We successfully ... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the ... full-length v-KIND; DKIND1, deletion of KIND1; DKIND2, deletion of KIND2; DKIND1 + 2, deletion of both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2,...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... Potential role of metal-binding/exchange properties of GIF in AD One of the primary pathological hallmarks of AD is the formation of b-amyloid (Ab) plaques, composed primarily of Ab(1–40) and ... nucleophil, because of its high cysteine content, enabling it to efficiently bind reactive ROS [29] Function of GIF in injured and degenerative brain MT can function as a potent scavenger of hydrogen ... survival of cultured cortical neurons [31] The neuroinhibitory action of GIF is very specific to this MT isoform and can be attributed to the small differences in the protein sequence of this isoform...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... G H I L D R E W is Professor of Ecology in the School of Biological and Chemical Sciences at Queen Mary, University of London D A V I D G R A F F A E L L I is Professor of Environmental Science ... roles of different kinds of organisms in the flux and storage of elements in ecosystems The total biomass per unit area, W, is simply the sum of the body mass of all individuals For organisms of ... evaluated some of these predictions, using data compiled from the literature for a wide variety of ecological phenomena, taxonomic and functional groups of organisms, and types of ecosystems Here...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... point of support, needed for the hinging of the C-terminal part of helix III This relative rigidity of residue 50 is also relevant to biological function, and has been long recognized as one of ... analysis of the spectral density functions can be performed using the bar charts of Fig to obtain the individual dynamic properties of each 15 N–1H vector It can be seen that the 15N–1H vectors of ... contribution of each component Lorentzian function to the specific spectral density of each experimental point Therefore, according to the RSDM analysis [21], most of the 15N–1H vectors of the TTF-1...
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Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
... clear demonstrations of the utility of linear ligation assembly, a convergent chemoselective approach can offer the key advantages of more ready and flexible modification of a well-defined protein ... functionality or PTM For instance, a library of ‘catalytic antagonists’ was engineered for affinity proteolysis by incorporation of a variety of ligands onto protease SBL, including examples of ... glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin Chem Biol 8, 133–145 Mullegger J, Chen HM, Warren RAJ & Withers SG (2006) Glycosylation of a...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... capable of enhancing the superoxide production by Nox3 via the interaction of their SH3 domains with p22phox [25– 27] Although the SH3 domain of Noxo1 participates in regulation of Nox3, the role of ... fraction (Fig 4B) As the extent of the membrane localization of Noxo1 correlated well with that of the superoxide-producing activity of Nox1 (Fig 4C), a weaker activity of Noxo1c to support Nox1 activity ... Phosphoinositide-binding activity of the PX domains of Noxo1b and Noxo1c The membrane localization of Noxo1b is mediated in part by binding of the PX domain to membrane phospholipids [19] Less association of Noxo1c...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... form of cyprosin was processed in different isoforms by the excision of the prosegment and of most of the PSI [21] Conversely to what has been found in vivo [31], heavy and light chains of the ... two-chain form of the enzymes Proteolytic processing of plant APs starts with removal of the signal sequence upon translocation to the ER lumen The following conversion steps include cleavage of the ... by the prosegment, but also by the 13 residues of the N-terminal of the mature enzyme and by the ÔflapÕ The anchorage of the prosegment and of part of the N-terminus in the active site cleft is...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... Crystal structure of participate in the formation of EpI-resistant a7 receptors, or an ACh-binding protein reveals the ligand-binding domain of that the functional properties of the nAChR are ... form functional channels in any pairwise combination [13–15] From analysis of single channel conductances obtained upon coinjection of wild-type and mutant subunits, and from quantification of radiolabelled ... channel function and/or influence membrane transport and targeting of nAChRs [9] The subunit composition of different nAChRs determines the pharmacological and physiological properties of the channel...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... Letters denote the five residues of one of the three sides of sbwAFP or six residues of one of two sides of TmAFP The strands that make up the three, parallel b-sheets of the protein are designated ... structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and residues Thr54fiMet121 in CfAFP-501 (B) Overlap of isoforms 337 and 501 using the main chain of ... addition of an additional one, two or three b-helical coils compared to the shorter isoforms In the case of one sbwAFP isoform, named CfAFP-501, a detailed examination of the structure and function...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function to activate plasma proteins that perform immune functions ... Easter [31] Injection of either of these M sexta proteinases into larvae stimulated the expression of antimicrobial peptide genes, suggesting that they might function in activation of a Toll pathway ... identification of plasma proteins induced after Spatzle-C108 injection ¨ Fig S1 Sequence of the region of the M sexta proSpatzle gene encompassing the ORF ¨ Fig S2 Alignment of amino acid sequences of insect...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... structure and function of the eRF1 C-domain A B C E D Fig The solution structure of the C-domain (A) Stereo view of the ensemble of the final 48 calculated structures Twenty-four structures of the closed ... 1H,15N-HSQC spectrum of the C-terminal domain of human eRF1 illustrating the presence of two conformational states of the protein Fig S2 Plot of the number and distribution of the NOEs versus the ... the open and closed conformers of the C-terminal domain of human eRF1 Fig S3 NOE map of the minidomain (residues 329– 372) of human eRF1 NMR structure and function of the eRF1 C-domain Fig S4 Representative...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... resulted in the functional transition of the enzyme into a transport protein Comparison of structures of TLPs from various organisms A comparison of the TLP from three species of bacteria with ... duplication of the TLP gene in early vertebrate evolution, substitution of a small number of residues in the active site of TLP appears to have been sufficient for the acquisition of new functional ... Remarkably, the structures of these proteins, all tetrameric, showed significant similarity to the published structures of transthyretin By way of example, a comparison of the structure of S dublin TLP with...
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Báo cáo khoa học: Synthesis and function of ribosomal proteins – fading models and new perspectives pptx
... different steps of ribosome biogenesis and ⁄ or ribosome function Indeed, a systematic study of the incorporation of RPs into preribosomes led to the identification of the in vivo assembly pathway of ... activity of RP mRNA for adjustment of the biosynthesis of ribosomes to the requirements of cell growth and differentiation In addition, a relevant contribution of protein turnover to the regulation of ... of an RP in mice was an inducible deletion of both copies of the RPS6 gene in the liver of adult mice [77] In this study, the altered response to partial hepatectomy suggested the existence of...
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Báo cáo khoa học: Structure and function of KH domains docx
... structure of Nova-2 KH3 plus SELEX RNA Fig Solution structure of the KH3 domain of hnRNP K bound to ssDNA The third KH domain of hnRNP K (Protein Data Bank entry 1J5K) recognizes a tetrad of sequence ... Valverde et al Structure and function of KH domains A B C Fig 10 Crystal structure of tandem type II KH domains of NusA in complex with RNA The tandem KH1–KH2 domains of NusA recognize RNA ligand ... in the absence of the crosslinking agent, association of the KH domains was only observed in the presence of RNA Chen et al [47] investigated the possibility of selfassociation of the protein...
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Báo cáo khoa học: The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor pot
... terms of low background levels of reporter gene activity in the absence of a ligand and high levels of reporter gene activity in the presence of a ligand [23] However, the ligand sensitivity of ... after addition of ligand (Fig 11A) The turn off of reporter activity after withdrawal of ligand is also fast More than 50% of reporter activity was reduced by 12 h after withdrawal of ligand and ... switches developed to date One of the major limitations of current versions of EcR gene switches is the requirement of micromolar concentrations of ligand for induction of gene expression In phylogenetic...
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![Báo cáo khóa học: Selective release and function of one of the two FMN groups in the cytoplasmic NAD + -reducing [NiFe]-hydrogenase from Ralstonia eutropha pptx](https://media.store123doc.com/images/document/14/rc/gg/small_ggg1394180403.jpg)
Báo cáo khóa học: Selective release and function of one of the two FMN groups in the cytoplasmic NAD + -reducing [NiFe]-hydrogenase from Ralstonia eutropha pptx
... effect of FMN, but not of FAD or riboflavin, has been noticed earlier [36,37] Figure shows the effect of the FMN concentration on the reconstitution of the activity of the reduced SH Addition of about ... part that holds two of the Fe-S clusters in the small subunit of the D gigas enzyme is missing in HoxY of the SH, suggesting an exposure of part of the hydrophobic surface of the HoxH subunit ... resulted in the total loss of this activity when assayed in the usual way, i.e after addition of H2, a catalytic amount of NADH and the subsequent addition of BV Restoration of this activity (to 88%)...
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Báo cáo khoa học: Uptake of bilirubin into HepG2 cells assayed by thermal lens spectroscopy Function of bilitranslocase doc
... regulation of this step is probably achieved through the expression of more than one type of bilirubin carrier, as originally inferred from in vivo observations in the rat [8] A major property of rat ... effects of the addition of nicotinic acid, taurocholate and digoxin Monolayers of HepG2 cells grown in 25-cm2 flasks were preincubated for h in the presence of mM lactate After removal of the culture ... indicate that the functional features of bilirubin uptake in HepG2 5529 Bilirubin uptake into HepG2 cells cells, shown in this study, closely match some of the functional features of electrogenic...
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