stem cells to stimulate hepatic regeneration
báo cáo hóa học:" Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor" docx
... of CX3CL1 to multiple lung tumors by mesenchymal stem cells Stem Cells 2007, 25(7):1618-26 12 Komarova S, Kawakami Y, Stoff-Khalili MA, Curiel DT, Pereboeva L: Mesenchymal progenitor cells as ... in different experimental systems [2,12] Other cell types, such as umbilical cord matrix stem cells (UCMS) [14], neural stem cells [15,16] and endothelial progenitor cells [17,18] have also demonstrated ... Circulating endothelial cells, bone marrowderived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: From biology to therapy Crit Rev Oncol Hematol 2009, 69(2):108-24...
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Báo cáo y học: "Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration" potx
... cytokinecytokine receptor interaction, transforming growth factor-beta/ Toll-like receptor/Jak-STAT (signal transducer and activator of transcription) signalling and extracellular matrix receptor ... Pathways to stimulate chondrocyte regeneration The KEGG database was retrieved for the pathways to which the 110 RA-related genes belong These pathways comprised cytokine-cytokine receptor interaction, ... inflammatory cytokines (for example, tumour necrosis factor [TNF] inhibitor etanercept) or receptors [2,3] Despite recent progress in controlling inflammation, little cartilage repair has yet to be...
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Recruitment of mesenchymal stem cells to injury sites
... Factor GVHD Graft-Versus-Host Disease HaMSC Human Adult Mesenchymal Stem Cells HfMSC Human Fetal Mesenchymal Stem Cells HSC Hematopoietic stem cells HUVEC Human Umbilical Vein Endothelial Cells ... immunomodulatory ability of MSC has been shown to alleviate many autoimmune disorders (van Laar and Tyndall, 2006) In a recent study, MSC was observed to home to the spleen of mice with experimental autoimmune ... production of inflammatory cytokines In addition, the study also showed the presence of antigen specific regulatory T cells which were activated by MSC MSC have been shown to home to tumour sites (Spaeth...
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báo cáo hóa học:" Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice" docx
... suggest that vascular cells derived from human ES cells may have a potential to be a source for therapeutic vascular regeneration after stroke Abbreviations ES cells: Embryonic stem cells; VEGF-R2: ... human ES cells could serve as a source for vasculogenesis in order to contribute to therapeutic neovascularization and to neuroprotection in the ischemic brain human embryonic stem cells diferentiationon ... factor receptor type β (PDGFR-β) [10], and expanded these cells for induction to MC in the presence of PDGF-BB and 1% FCS At passage 5, all of the expanded cells effectively differentiated into...
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Báo cáo y học: "ntravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head"
... mesenchymal stem cells: feasibility and safety from monkey to human Stem Cells Dev,2006,15(3):349-357 Devine SM, Bartholomew AM, Mahmud N, et al Mesenchymal stem cells are capable of homing to the ... Autologous hematopoietic stem cell transplantation in autoimmune diseases Expert Rev Hematol,2009 Dec;2(6):699-715 12 Rosato E, Pisarri S, Salsano F Current strategies for the treatment of autoimmune ... transplantation of stem cells, it is very important to observe the survival and curative effects of transplanted stem cells Traditional immunohistochemical method can easily identify the transplanted cells...
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Báo cáo khoa học: Recruitment of transcription complexes to the b-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells docx
... these genes in progenitor cells or cells that have yet to express the genes at physiologically relevant levels [11] Chromatin structure modifications in uncommitted progenitor cells have also been ... The commitment of pluripotent stem cells to successively less plastic progenitors and, finally, differentiated cells exhibiting stable expression patterns is thought to involve the reorganization ... of hematopoietic stem cells to erythroid cells Transcription of HS3 could be important in maintaining this accessible structure, particularly in light of the fact that RNA Pol II is known to associate...
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Báo cáo khoa học: A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells doc
... Yamamoto et al Seo et al were the first to show that human adipose tissue-derived mesenchymal stem cells (AT-MSCs) differentiate into hepatocyte-like cells upon treatment with hepatocyte growth factor ... fibroblast growth factors and (FGF1 and FGF4)] to induce mouse ES cells to develop into functional hepatocytes These factors, named HIFC (hepatic induction factor cocktail), showed clearly up-regulated ... mechanisms underlying hepatic differentiation from stem cells For microarray analysis, we confirmed the hepatic differentiation of AT-MSC into hepatocyte-like cells using the original protocol (Fig 1A)...
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báo cáo hóa học:" Implantation of neural stem cells embedded in hyaluronic acid and collagen composite conduit promotes regeneration in a rabbit facial nerve injury model" doc
... it is requisite to nerve regeneration, but also it is vital to accommodate effecter molecules and cells Various signals and neural factors were incorporated into the conduit to minimize infiltration ... and stained with haematoxylin and eosin for histological examination Toluidine blue staining was performed to assess regeneration [18] Morphometric analyses were conducted to enumerate the fiber ... cultured Schwann cells Plast Reconstr Surg 2001, 107:485-494 Fong SP, Tsang KS, Chan AB, Lu G, Poon WS, Li K, Baum LW, Ng HK: Trophism of neural progenitor cells to embryonic stem cells: neural...
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EMBRYONIC STEM CELLS – BASIC BIOLOGY TO BIOENGINEERING doc
... of primary beta cells Most importantly, these cells can reverse hyperglycemia when grafted into streptozotocin-treated mice Relative to their progenitor E-RoSH cells, ERoSHK cells also exhibit ... Embryonic Stem Cells: Introducing Exogenous Regulators into Embryonic Stem Cells 123 Yong-Pil Cheon Chapter Functional Control of Target Single Cells in ES Cell Clusters and Their Differentiated Cells ... immune system could be manipulated to induce tolerance to foreign tissues by ablation of donor-reactive T cell in the thymus, generation of tolerogenic dendritic cells and induction of Treg cells...
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Báo cáo khoa học: " Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress" pdf
... dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress 255 10, 423-426 12 Brook FA, Gardner RL The origin and efficient derivation of embryonic stem cells in ... sodium bicarbonate, 1% penicillin and streptomycin, 1.7 mM L-glutamine, 0.1 mM β-mercaptoethanol, ng/ml mouse leukemia inhibitory factor and 15% FBS The cells were grown on either gelatinized 12-well ... experiments Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress 251 Fig Effect of hydrogen peroxide (H2O2)-induced p38 mitogen activated protein kinase...
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Báo cáo y học: "Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix" ppsx
... practical approach to autologous disc regeneration and repair Lu et al used micromass co-culture to show nucleus pulposus cells could secret soluble factors to direct stem cells towards the nucleus ... or the annulus cells Growth factor release in situ has been shown to have an effect on mesenchymal stem cells When the ratio of AD-MSC to annulus cells was increased from 1:1 to 2:1 or 3:1, no ... disc cells with BM-MSC [20] Stimulation of disc cells with stem cells or CM could enhance the success of autologous implantation of disc cells In the present study we use two approaches to investigate...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... in ectopic sites Such ectopic regeneration capacity has been proven to retain even after the transformation of normal prostate stem cells into PCSCs For example, AR- P63-CD44+Nestin+ HPET-5 cells ... basal /stem cells and to examine whether these cancer cells can maintain stem cell characteristics after metastasis More importantly, we intended to elucidate whether P63 + basal /stem cells can...
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Báo cáo khoa học: "Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series" docx
... The mechanism of regeneration is not yet clear It could be through direct differentiation of stem cells that were introduced to the diseased joints Alternatively, it could be due to the tropic effects ... then instructed to remain still with her leg elevated for 30 minutes to allow for cell attachment On discharge home, she was instructed to maintain activity as tolerated She returned to the clinic ... analysis according to the risk factor J Orthor Res 2006, 24:604-609 Nuttelman CR, Tripodi MC, Anseth KS: In vitro osteogenic differentiation of human mesenchymal stem cells photoencapsulated in...
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Báo cáo khoa hoc:" Human spongiosa mesenchymal stem cells fail to generate cardiomyocytes in vitro" doc
... confluence (about 10,000 cells/ cm2), stem cells were trypsinized with stem cell trypsin (CellSystems, St Katharinen, Germany) and re-plated at a density of 1000/cm2 to expand cell culture (cell ... the activity of a broad range of immune cells, including N -cells, Bcells, natural killer cells and antigen presenting cells Transplantation of MSCs into the periinfarct area decreases both production ... promoting of endothelial progenitor cells homing to the site of injury) [32], FGF (angiogenic, antifibrotic, antiapoptotic effect), HGF (angiogenic, antiapoptotic, mitogenic, antifibrotic activities),...
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Báo cáo khoa hoc:" Human haematopoietic stem cells express Oct4 pseudogenes and lack the ability to initiate Oct4 promoter-driven gene expression" ppt
... c-kit+ haematopoietic cells (T0) and following culture (T3–T10); EC 2102Ep cells (+ control); water (- control); normal hepatocytes (NL); diseased hepatocytes (DL); HepG2 cells; Hek293T cells (Hek); ... for adult stem cells The focus of this work was to ascertain whether human adult stem cells, specifically c-kit isolated cells from UCB were capable of expressing transcription factors described ... an alternative means to determine whether c-kit+ progenitor cells expressed the transcription factors necessary to activate Oct4 gene expression Freshly isolated c-kit+ cells were rested overnight...
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Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells" potx
... phagocytic cells such as neutrophils and macrophages In addition, several non-phagocytotic cell types such as hepatocytes [2] and hepatic stellate cells (HSCs) [3] have also been shown to express ... well as plateletderived growth factor (PDGF) receptors α and β are shown to be regulated which points to their regulatory functions in establishing resistance to oxidative stress Results and discussion ... reduces radical accumulation in myofibroblastoid cells These defense mechanisms are suggested to be particularly relevant in order to protect myofibroblastoid cells from harmful consequences caused...
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Characterization of the secretion of mesenchymal stem cells and its relevance to cardioprotection
... to pharmaceutical interventions28 Mesenchymal Stem Cells In The Treatment Of Acute Myocardial Infarction With the emergence of stem cells as potential regenerative medicine, attempts to use stem ... rationale for the use of stem cells to repair cardiac tissues was based on the hypothesis that these cells could differentiate into cardiomyocytes and supporting cell types to replace cells lost during ... Cardiovascular System Development and Function Nervous System Development and Function Ophthalmic Disease Neurological Disease Hepatology Dermatology Respiratory Disease Drug Metabolism Hepatic System Development...
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Applying macromolecular crowding to promote the expansion and adipogenic differentiation of human mesenchymal stem cells in vitro; an effect of matrix reciprocity
... and the haemopoietic stem cell Blood Cells (12):7-25 32 Moore KA, Lemischka IR 2006 ;Stem cells and their niches Science (5769):1880-1885 33 Lemischka IR, Moore KA 2003 ;Stem cells: interactive niches ... factor to its high affinity receptor Cell (4):841-848 68 Dombrowski C, Song SJ, Chuan P, et al 2009;Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells Stem ... relationship to the stromal system In ed Bone and MineralAmsterdam Elsevier pp :1-25 122 Owen M 1988;Marrow stromal stem cells J Cell Sci Suppl :63-76 123 Beresford JN 1989;Osteogenic stem cells and...
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Differentiation and derivation of lineage committed chondroprogenitors and chondrogenic cells from human embryonic stem cells for cartilage tissue engineering and regeneration
... embryonic-like stem cells, also known as induced pluripotent stem cells (iPSCs), as a potential autologous pluripotent stem cell source that can be generated from a patient’s own skin or blood cells (Takahashi ... the high-density pellet system and the adherent micromass system, where the latter system is able to mediate a better loss of discordant cells through apoptosis and to induce a rapid onset of ... chondrogenic cells Fig 24 Response of hESC-derived chondrogenic cells to anabolic growth factors of matrix synthesis Fig 25 Comparison of 3D HA hydrogel system with the pellet system Fig 26 Cartilage...
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Báo cáo y học: "Low temperature tolerance of human embryonic stem cells"
... enable some of the cells to undergo mitosis Mitotic hESC were then arrested at metaphase by colcemid treatment (0.1 μg/ml) for 16-18 h Subsequently, the cells were subjected to hypotonic treatment ... exposed to low temperature There were altogether four experimental groups in this study: (1) exposure to 4oC for 24h, (2) exposure to 4oC for 48h, (3) exposure to 25oC for 24h, and (2) exposure to ... correlated to loss of cell viability upon exposure to low temperature It was observed that some cells detached after exposure to low temperature Virtually all of the detached cells were determined to...
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