spr or nk1 receptor
Báo cáo y học: " Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation" docx
... tachykinin NK1, NK2 and NK3 receptors [13] NK1 receptors are mainly involved in neurogenic inflammation (microvascular leakage and mucus secretion) while NK2 receptors are considered to be important ... for citation purposes) Respiratory Research 2009, 10:37 http://respiratory-research.com/content/10/1/37 matory response may be of importance, as we did demonstrate an effect of the NK1 receptor ... the tachykinin NK1 receptor The interaction of MIP-3α/CCL20 with its receptor CCR6 has been described as one of the most potent mechanisms for recruitment of immature DCs [41,42] Moreover, we recently...
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Tài liệu Báo cáo Y học: A pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balance pot
... sevenfold receptors such as the thrombin receptor [26], the a2adrenergic receptor reserve (60–70% of all sites [27]), and the 5-HT1B receptor reserve (up to 90% of the total receptor [28]) The ... environment of the receptor, as there are no vicinal cysteines in the molecule of the rodent Y2 [17] Unlike the metabotropic glutamate receptors or the adrenergic receptors, the Y receptors, except ... via thioreductase could also be sensitive to PAO [42], and the loss of disulfide dynamics could be partly responsible for the observed Y2 accumulation Stretch receptors and mechanoreceptors could...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... in receptor affinity for the corresponding peptide [21,41] Indeed, the backbone conformation, the aromatic ring and the orientation (v1 and v2) of this phenylalanine have to be conserved for full ... those obtained with CHARMm 23.1 force field [12]: six- and eight-hydrogen-bonded conformations with the methyl group in axial or equatorial orientations (conformers C6eq, C6ax, C8eq and C8ax), ... as Ki for NK-1M (major site) and NK-1m (minor site), and EC50 values for the cAMP pathway and for the inositol phosphates pathway SP, [Ala9]SP and [Pro9]SP are almost equipotent at the major binding...
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Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
... Determinants on the Pore Forming Subunit J Biol Chem 274, 22652–22659 Harlow, E & Lane, D.P (1988) Antibodies A Laboratory Manual Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY Cui, ... 4.0 for line C2 (n ¼ 6) and 6.2 ± 2.8 lM, h ¼ 1.43 ± 0.33 and a ¼ 33.0 ± 4.2 for line E (n ¼ 8) (for Ki P ¼ 0.09 after log transformation for all comparisons, one way ANOVA with Bonferronni correction) ... phenylmethanesulfonyl fluoride and the protease inhibitor cocktail Lysates were then incubated on ice for h before being briefly sonicated (2 s using an MSE Soniprep 150 probe sonicator at half power)...
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Báo cáo y học: "A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer." pps
... Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis Arthritis ... competitive inhibitor, preincubation of the HSF with IL-1Ra for 24 hours before IL-1β stimulation significantly reduced the 50% inhibition level for each source of IL-1Ra For the recombinant ... performed in triplicate, and each data point repesents the mean value ± SD *P < 0.05 versus corresponding IL-1Ra source at 24 hours ELISA, enzyme-linked immunosorbent assay; IL-1Ra, IL-1 receptor...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... activities specific for endothelial cells It interacts with two receptor tyrosine kinases, VEGFR-1 (flt) and VEGFR-2 (flk) A defect in VEGF receptors could account for VEGF signalling abnormalities in ... abnormalities in SSc The human VEGFR-1 gene produces two major transcripts, corresponding to the full-length receptor and a soluble receptor (sVEGFR-1) with biological activities [12] Oxidative stress ... growth factor, or transforming growth factor Inter- and intra-assay variances for VEGF, sVEGFR-1, and sVCAM-1 were lower than 10% The minimum detectable concentration was less than pg/ml for VEGF,...
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DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and a2-adrenergic receptors potx
... electrical or formalin stimulations Both noxious stimuli at the hindlimb can excite projection neurons in the corresponding spinal dorsal horn (DH) to activate descending inhibitory systems (e.g noradrenergic ... opposing forces Unfortunately, many other factors, such as noxious qualities (e.g., inflammatory vs neuropathic), can bias this tug-of-war Therefore, more studies are necessary before introducing ... a2-recptor mediated (Fig 7) Descending inhibitory modulation mediated through spinal a2 receptor activation has been largely reported Electrical stimulating peripheral Aδ and C fibers [52,53] or central...
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Báo cáo y học: "Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice" pps
... homozygotes on uniform congenic or hybrid backgrounds for locomotor activity and masking ability The current results conclusively demonstrate that EGFR is not an essential mediator of locomotor or masking ... uniform congenic lines indicate that EGFR is not a required mediator of the locomotor or masking behaviors, though it may modulate the activity of other pathways involved in control of locomotor ... neomorphic in nature rather than being representative of normal biology [7] Thus, the suggestion that locomotor activity is strongly dependent on normal levels of EGFR signaling is not supported,...
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Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf
... signalling receptor function as well as avoid scavenger receptor clearance, a mechanism that potentiates its own activity on signalling receptors There are three 'atypical' or scavenger chemokine receptors ... model system to compare to regulatory receptors In order to investigate U83A activities on regulatory receptors and to compare them to those on signalling receptors, U83A binding competition was ... chemokines receptors and possible displacement by the viral chemokines U83A does not displace human chemokines from DARC and D6 regulatory receptors U83A binding to regulatory chemokines receptors D6...
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Báo cáo khoa học: "To be or not to be protease activated receptor-1 in activated protein C-initiated endothelial barrier protection" potx
... Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1phosphate receptor- 1 crossactivation Blood 2005, 105: 3178-3184 Finigan JH, Dudek SM, Singleton PA, Chiang ET, ... protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation J Biol Chem 2005, 280:17286-17293 Cheng T, Liu D, Griffin JH, Fernandez JA, ... Critical Care Vol 11 No Li Competing interests The authors declare that they have no competing interests References Looney MR, Matthay MA: Bench-to-bedside...
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When the Discussion Gets Stalled or Heated
... Keep power in your pocket (e.g. attorney, credible reference) Keep the door open Conflict as a Choice Point Explore whether conflict is a signal for a change View the disagreement as a choice point and explore options for moving ... Pause when formulating judgment Understand what was meant by actions or words Reflect on information and ask for additional information Reinterpret by applying an alternate explanation Redirect conversation toward ... Dismissive – interrupting, talking over, ignoring {men engage more frequently than women} • Exclusionary – leaving someone out of the meeting, discussion or social gathering • Undermining – going behind the back of others or using insults to discredit arguments...
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Quagmire or Gold Mine?
... make digital/hard copy of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage, the ... navigation In Working Notes of the AAAI Spring Symposium: Information gathering from Heterogeneous, Distributed Enviornments, 1995, AAAI Press, Stanford University, pp 69–73, To order a copy, ... in Information Retrieval (Copenhagen, Denmark), June 12, 1992, pp 318–329 Doorenbos, R.B Etzioni, O and Weld, D.S A scalable comparison-shopping agent for the world-wide web Technical Report 96–01–03,...
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Ship or Sheep Third Edition
... lunch for for '-9 {6} 16 untr /ieiman pair Minimal words a A27a Listen and repeat the words azzub You will hear five words from each minimal pair For each word write l for /e/ (sound 1) or for lal ... in th Thiscordwas in the sea short He wa 4/ I_ I ti He was short lt'sasmall H -z!rt It'sa small port fox forks Lookfor the fox -tA \-/' Port *-Z-=jy4:="a Lookfor the forks spot sPort I don'tliketnesespots ... sound Sports reportfrom Radio Station ANNOUNCER: morning Roarers This the football team arrived backfrom yorr LauraShortis our sportsreporter, she was at the airport and LAURA sHoRT:cood morning,...
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Example about Project or Plan in Writing Task 1
... in order to reach the two viewing platforms There are now plans to build below the foundations of the tower These plans include the development of five underground levels that will incorporate ... facilities, a cinema and museum and two floors of underground parking Although details have yet to be finalised, the principle is that the five floors will be connected by two vertical passenger ... tower In addition, the floor immediately below the tower, which is planned to house the ticket office, will also consist of a large atrium with a glass ceiling so that visitors can look directly...
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