... arise from the slightly broader active site in MtRpiBas a result of the switch of the catalytic base. Accord-ingly, the longer linear inhibitors can bind slightlymore deeply in the MtRpiB active ... found in the Pro-tein Data Bank (PDB) (including three that are unpub-lished) in Table 2 and Fig. 4. The majority of Caatoms match within a 2 A˚cut-off when the dimers arecompared. As in TcRpiB, ... EcRpiB(magenta) in (A) and SpRpiB (blue) in (B).The N- and C-termini are labelled in mole-cule A of TcRpiB. In the same molecule,two segments that make contacts in thetetramer interface are...
... antigen.IntroductionImmunoglobulins are multi-chain proteins usually con-sisting of two pairs oflight chains and two pairs of heavy chains (with the remarkable exception of ‘heavychain antibodies’, ... found in camelids [1] and in a number of fishes [2,3], and are devoid of light chains). In higher vertebrates, there are two types of light chain – j and k – whereas heavy chains can be of fivetypes: ... onaverage, the binding site of the type A immunoglobu-lins is wider than that of the type B immunoglobulins. In 71 cases in our dataset, the structure of theimmunoglobulin has been determined in a complexwith...
... different than in the inheritance case in that no sharing map isinvolved; an attempt to vm_write one mapping of the memory object would merely replace that mapping, rather thanreflecting it in other ... version of Mach is in use onover 200 workstations and large timesharing systems within the CMU Department of Computer Science. It is alsobeing used on dozens of machines outside the Department, including ... be described in more detail in a later section.6When shadowing, the data is instead copied from the original.11. Introduction In late 1984, we began implementation of an operating system called...
... introductory information about the Internet 94Introduction 94Introduction 94Internet Services offered 94Internet Services offered 94Appendix 3 - Internet Growth Figures 97Intelligent Software ... functions"The fall in the cost of gathering and transmitting information will boost productivity in the economy as a whole, pushing wages up and thus making people's time increasingly valuable. ... users of an information service for each piece of information they download) will be a big incentive to make use of electronic intermediaries (and agents in general too) as searching for information...
... Nicolas-Chanoin MH, Wolff M, Spencer RC, Hemmer M: The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care ... ultimate clinicalutility of a biomarker is defined by the degree it improvesclinical decision making and adds timely informationbeyond that of readily available information from clinicalexamination. ... Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections. Eur J Clin Invest 2007, 37:145-152.22. Christ-Crain M, Muller B: Biomarkers in respiratory tract infections:...
... The use of antidepressants varies byphysician specialty depending on the setting and type of insurance. In year 2000, the prevalence of prescribed stim-ulant medication for 0–4 year-olds in Western ... prevalence of antipsychotics in youth aged 0–4 ranged from 0.13% in Italy [24] to 0.5% in the Netherlands [29]. Generally, these antipsychoticprevalence findings closely matched those of this study,indicating ... ErbenCM, Matthiessen PF: The use of methylphenidate in children:analysis of prescription usage based in routine data of thestatutory health insurance bodies concerning drug prescrip-tions. Gesundheitswesen...
... higherthan routine incident-reporting systems, but without requiringsubstantial investments of additional resources. Academic centersare increasingly recognizing engagement in quality improvement ... distinct career pathway. Involving such physicians in medicalemergency teams will likely facilitate the dual roles of these as aclinical outreach arm of the intensive care unit and in identifyingproblems ... forms of surveillance have yielded higher rates of adverse events [4,5]. All of these detection methodsrequire substantial investments of time and money. Moreover,especially in the case of chart...
... Care Resources(ARCCCR) maintains a database recording information oncritical care resources, including the timing of introduction of METs. In addition, ANZICS maintains an Adult Patient Data-base ... projects to be undertaken using theinformation contained within the database.Assessment on timing of introduction of MET serviceWe obtained information from a database maintained by theANZICS ARCCCR ... surveys of ICU resourcesand activity. The information related to the timing of com-mencement of an MET into hospitals in ANZ which were notinvolved in the MERIT study [10]. Hospitals in this...
... [3]. Of 538routine CXRs, 8% presented new ‘major’ findings; however,58% of these were anticipated by the clinical examination, andonly 3.4% of all routine CXRs presented findings not clinicallyanticipated. ... clear whether the performance of routine CXRs altersmanagement in patients admitted to the ICU. Studiesevaluating the use of routine CXRs have mainly been in theform of prospective observational ... devices are in the correct posi-tion, clinical evaluation including ETT position at the lipscould potentially eliminate a large number of CXRs, resulting in significant cost savings.ConclusionThe...
... pneumatization results in the indi-vidual size and shape of the frontal sinus. An absence of pneumatization in the frontal bone results in frontal sinus aplasia [1]. This kind of variation should ... Italy) scanning was performed on patients who were resting in supine positions. Positioning of the patients’ heads was performed using two light- beam markers. The vertical positioning light was ... This study investigated the prevalence of agenesis of the frontal sinuses using dental volumetric tomography (DVT) in Turkish individuals. The frontal sinuses of 410 patients were examined by...