specific mechanism of action
Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... major role in the pathogenesis of both types of diabetes mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, ... effects on diabetes, hypertension and wound healing Presumably, one of mechanisms of action is its antioxidant activity The action of EPRT is to produce electrical pressure rather than an electrical ... development of the oxidative stress (68) If our findings are proven by further studies involving a larger number of patients, ultra-low microcurrent therapy might change the concept of management of chronic...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... generation of H2O2 in spores [9,15–18] In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, by examining the interaction of VtA3 with ... isoform, VtA3, with biological membranes and obtain information on its mechanism of action, we have applied different techniques as shown below The exact composition of the lipid membranes of ... any of the voltages assayed in the pulse protocol In the 0.1–1 lm range of added VtA3 (n ¼ 12; 44% of the active patches), we found ion-channel-like activity in the form of square pulses of current...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... combined action of propionyl- Ó FEBS 2004 CoA and acetyl-CoA In the presence of both thioesters one might expect an accumulation of succinyl-CoA in the cell and a deadlock of further reactions of the ... by the action of cycloheximide Cycloheximide binds to the 80S-subunit of eukaryotic ribosomes and prevents the initiation and elongation reaction of protein biosynthesis The mycelium of pregrown ... extract and water to a final volume of 980 lL The reaction was started by the addition of 20 lL of a 100 mM ATP solution (final concentration mM) and the reduction of NAD was monitored at 340 nm The...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
... Scheme shows the reactions of the two-step mechanism of action of TFPI It is shown in the Appendix that Scheme is equivalent to Scheme I of [8] within the area of the applicability of the latter In ... significant amount of the Xa–VIIa–TF complex The mathematical model has shown that the analysis of the inhibition curves of the Scheme A development of Scheme by addition of the reaction of the enzyme–substrate ... and found the values of the hypothetical reactions separately The model of the inhibitory action of the Xa–TFPI complex on the enzyme–substrate complex (model 3) The reaction of X–VIIa–TF inhibition...
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báo cáo khoa học: "Mechanism of action of lenalidomide in hematological malignancies" pptx
... before treatment showed decreased expression of the set of the genes Figure Mechanism of action of lenalidomide Mechanism of action of lenalidomide Various mechanisms by which lenalidomide achieves ... transduction or a combination of all of these Figure summarizes the mechanism of action of lenalidomide as we know so far Future studies will assess these mechanisms as well as direct actions on the malignant ... consists of the chemical structures and names of these three compounds and Table illustrates the differences amongst them http://www.jhoonline.org/content/2/1/36 Mechanism of action of Lenalidomide...
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Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt
... Federal University of Ceará, Brazil 2Department of Pharmacy, Federal University of Ceará, Brazil Department of Morphology, Federal University of Ceará, Brazil 4Faculty of Medicine of Juazeiro Norte, ... Faculty of Medicine of the Federal University of Ceará Lucetti et al Journal of Inflammation 2010, 7:60 http://www.journal-inflammation.com/content/7/1/60 Formalin test in mice Twenty microliters of ... mechanism of action, we studied the participation of pentoxifylline, a PDE5 and TNF-alpha inhibitor, and morphine, a mu and kappa agonist, on inflammatory processes, and their possible interaction...
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Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf
... presence of the FTC-TP or EFV, and by FTC-MP-terminated DNA and HIV-1 RT in the presence of EFV This study furthers our understanding of the mechanism of action for anti-HIV drug interactions ... between the mathematic models of Bliss Independence and Loewe Additivity contribute to this discrepancy is beyond the scope of this study The molecular mechanism of action for the synergistic effects ... with HIV-1 RT could be augmented in the presence of EFV, which could play an important role in the mechanism of action for the synergistic effects of TFV+EFV and FTC+EFV combinations observed in...
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Discovery and mechanism of action study of anti viral compounds for dengue virus
... 68 3.2.4 Anti-viral activity of compound NITD448 73 3.3 DISCUSSION 75 A STUDY OF THE MODE OF ACTION OF NITD770, A SMALL MOLECULE INHIBITOR OF DENGUE VIRUS 79 4.1 INTRODUCTION ... was a need to determine its mode of mechanism During the studies to determine the mode of mechanism of NITD770, host lipid rafts (as suggested by chemogenomic profiling data) and cholesterol were ... POCKET NEAR TO THE HINGE REGION OF DENV E PROTEIN 120 6.2 NITD770, AN ANTI-VIRAL SMALL MOLECULE WITH UNKNOWN MECHANISM OF ACTION 122 6.3 THE DEPENDENCE OF HOST CHOLESTEROL BY DENGUE...
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Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
... 2.3.7 SPS-S6P complex 2.3.8 Putative ADP / UDP binding pocket 2.3.9 Mechanism of action Chapter 3: Mechanism of Action and Structure of Fructokinase from Halothermothrix orenii 24 24 24 25 25 26 26 ... diagram of the reaction involving FRK and Fructose Top a) SDS-GEL image of purified FRK Bottom b) Gel filtration profile of FRK Crystal of SeMet FRK 3.4 Sample diffraction pattern of SeMet FRK crystal ... structure of HoFRK 85 3.6 Structure based sequence alignment of HoFRK 90 3.7 Stereo diagram of the conserved, binding residues of RK (magenta; PDB code 1RKD) interacting with both of its ligands...
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques
... 1.4.4 Mechanism of action of rapa Rapamycin is a known inhibitor of the mammalian Target Of Rapamycin (mTOR) pathway The mechanism of this inhibition has been well established 1.4.4.1 Structure of ... comparison of transcriptome profiles of MV411 and THP-1 75 Figure 4.3 Hierarchical clustering of transcriptomic profiles of microarray data 78 Figure 4.4 Linear regression analysis of fold-changes of ... prospect of using GEN as a therapy for AML is highly promising Yet, unravelling the proteomic aspects of the dynamics of GEN action on AML is necessary for complete cognizance of its mechanism of action...
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The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta
... localization 28 1.6.5 Inhibition of the Ras-ERK signaling pathway by Spry 29 1.6.6 Points of action of Spry 30 1.6.6.1 Upstream of Ras 30 1.6.6.2 Upstream of Raf 32 1.6.7 Regulation of receptor ubiquitination ... interaction specificity of Spry2 and PKCδ 150 4.2 Spry2 doesnot inhibit the phosphorylation of PKCδ by an upstream kinase 150 4.3 Implications of PLCγ1-Spry interaction 151 4.4 Formation of a ... representation of the primary structure of Raf 15 1.6.2 The structure and isoforms of Spry 27 1.7 Schematic representation of PLCγ signaling 39 1.7.1 Schematic representation of the primary structure of...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... the absence of 10 or 50 mM ể FEBS 2003 Disuldes and antitumor action of BS-RNase (Eur J Biochem 270) 1985 Fig Autoradiography of SDS/PAGE runs of the labelled monomeric derivative of BS-RNase ... dimerization reaction of BS-RNase M(SSR)2 monomers However, we did not detect any effects of 110 mM concentrations of bacitracin (Sigma), a known inhibitor of PDI [21], on the dimerization reaction Likewise, ... and is ể FEBS 2003 Disuldes and antitumor action of BS-RNase (Eur J Biochem 270) 1983 Fig Time-course of dimerization of the labelled monomeric derivative of BS-RNase 125I-labelled MSSAE added to...
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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
... tissue -specific and inflammation -specific regulation of fibroblast function Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol No Hardy et al Figure Expression of ... using Microsoft Excel Page of 10 (page number not for citation purposes) Arthritis Research & Therapy Vol No Hardy et al Figure Tissue -specific fibroblasts cortisol levels inexpression of 11β-HSD1 ... Willebrand factor staining) Page of 10 (page number not for citation purposes) Figure Autocrine activation of cortisol and the regulation of fibroblast function of fibroblast function Bone marrow,...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... of top hole of the arm_asm sub-assembly with the axis A_2 of post – see figure below 40 For Translation constraint, 41 Pick the circular face in the back of arm as shown Pick the front face of ... axis A_4 of the right hole of the link, and then pick the axis A_4 of the pin at eccentric For Translation constraint, select the back face of the link, and then pick the front large face of the ... of the link As Axis alignment constraint, select the axis A_3 of the left hole of the link, and then pick the axis A_12 of the pin at arm 45 For Translation constraint, select the back face of...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
... referring to the mechanism of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... actual choices and independently of their perceptions of available choices In our study, we also assessed women's understanding about the mechanisms of action of specific FP methods, and we also...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... depth of 160m in the central part of basin This is a product of tectonic activities of the Dien Bien - Lai Chau fault zone in Pliocene-Quaternary time and is one of the bases for determining age of ... formation of the Dien Bien basin The geological structure of the Dien Bien basin is composed of main parts: the basement consists of Triassic sedimentary bedrock and the cover consists of NeogeneQuaternary ... thesis, Institute of Geology, VAST, Hanoi, 2002 (in Vietnamese) [2] Ministry of Heavy Industry, Ministry of Construction, General Department of Geology, Report on investigation of the geological...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... effects of one of the substrates, i.e pantoate [8,9] One of the interesting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9] This sequence of amino ... we report the results of the structural studies of the pantoate-bound form of the N-terminal domain of E coli PS (nPS) The structure and substrate-binding interactions of E coli nPS have been ... deletion of this stretch of residues at the dimer interface are known to affect the catalytic properties of A thaliana PS [9], as a consequence of disruption of long-range allosteric interactions...
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