sp1 and huntington s disease
báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... SOD1 G93A and wild-type control mice at age ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson 's disease, Huntington' s disease, and amyotrophic ... image analyses The treadmill belt was wiped clean between studies if necessary Statistics Data are presented as means ± SE ANOVA was used to test for statistical differences among saline-treated, ... Parkinson 's disease and Huntington' s disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... position of the introns in the mouse and human genes are identical and the sequences at the 5¢- and 3¢-splice site junctions are conserved and correspond to splice junction consensus sequences ... was one predominant transcription start site and several other transcription start sites in the mouse CB1 gene that were used to express the CB1 gene in striatal and cortical neurons We consistently ... progression and severity of symptoms in HD patients and HD transgenic mice [3,10] The R6/1 mice have a later age of motor symptom onset and cognitive decline and slower disease progression than...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... promoters of caspase-1, caspase-8 and caspase-10, and increase their expressions In turn, increased pro-caspase-8 is recruited to HIPPI–HIP-1 heterodimer and increases apoptosis The role of caspase-1 ... the observations that caspase-1, caspase-3, caspase-7, caspase-8 and caspase-10 expression is increased in cells expressing exogenous FEBS Journal 275 (2008) 4271–4279 ª 2008 The Authors Journal ... transcription of caspase-1, and this warrants further studies A summary of the findings that HIPPI increases apoptosis and alters gene expression is shown in Fig Hi Pro-caspase-1 45 kDa Caspase-1 20 kDa...
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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf
... Huntington s and Parkinson s diseases Neurology 50, 1033–1040 Ma Y & Eidelberg D (2007) Functional imaging of cerebral blood flow and glucose metabolism in Parkinson s disease and Huntington s ... extensively studied neurological disorders, is representative of a number of inherited diseases The initiation of the disease process depends on the size of polyglutamine tails [32] The cognitive and psychiatric ... tissues as established by ourselves (Table 2) and others (Doc S4 ) The rate equations of the individual enzyme reactions were also taken from previous publications by ourselves and others (Doc S4 )...
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Huntington’s Disease – Core Concepts and Current Advances Edited by Nagehan Ersoy Tunali potx
... (1995) Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer 's disease, Lewy body dementia, Parkinson 's disease and Huntington' s disease Journal ... HD, disease progression is slow (Hodgson et al., 1996) 20 Huntington s Disease — Core Concepts and Current Advances All these models share some features with human HD However some of them present ... Huntington s Disease — A Computational Perspective Giulia Rossetti and Alessandra Magistrato Part 67 Neuropathological Mechanisms and Biomarkers in Huntington' s Disease 99 Chapter Biomarkers for Huntington s...
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Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps
... Huntington s Disease W.B Saunders London, 1996 Ross CA: Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington s disease and related disorders Neuron 2002, 35(5):819-822 Behrens PF, ... (P < 0.01) and striatum (P < 0.03) Despite the loss of GLT1 in older R6/ 2s, these animals showed the same response to ceftriaxone as the younger R6/ 2s and both WT age groups Thus, WT and R6/2 mice ... HD models even at ages when the behavioral phenotype is severe [6] Post-mortem analysis of HD patients, moreover, shows a selective decline in GLT1 mRNA expression [22] as well as a loss of glutamate...
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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... 2007 The Authors Journal compilation ª 2007 FEBS 3785 Therapy for prion disease and AD T Wisniewski and E M Sigurdsson species Transmissibility of prionoses between different species is generally ... Whether similar approaches can be used for prion disease remains to be determined Prion disease Interest in prion disease has greatly increased subsequent to the emergence of BSE in England and the ... chronic wasting disease Acta Neuropathol 102, 496– 500 Marsh RF, Kincaid AE, Bessen RA & Bartz JC (2005) Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)...
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Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx
... universality of the amyloid hypothesis in those diseases as well In Alzheimer s disease, genetic mutations in familial Alzheimer s disease reveal that Alzheimer s disease in those cases may be caused ... transmitted spongiform encephalopathies, Parkinson s Revisiting the aggregation hypothesis disease, and Alzheimer s disease [15] Polyglutamine diseases have often been historically considered as ... polyglutamine diseases and the struggle to understand what is cause and what is effect in these diseases Hunting the elusive toxic polyglutamine conformer A thorough search of crystallographic databases...
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Báo cáo khoa học: Huntington’s disease: degradation of mutant huntingtin by autophagy doc
... disease- causing proteins associated with various neurodegenerative disorders, such as mutant huntingtin [causing Huntington s disease (HD)], ataxin-3 (causing spinocerebellar ataxia 3), forms ... (causing frontotemporal dementias), the A53T and A30P a-synuclein mutants (causing familial Parkinson s disease) , and mutant forms of superoxide dismutase [causing familial amyotrophic lateral sclerosis ... features have been seen in brains from HD patients and transgenic mice, where there are excessive endosomal–lysosomal-like organelles, tubulovesicular structures, and multiple vesicular bodies [36,37]...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
... Statistically significant differences were examined using a t-test or analysis of variance (ANOVA) and Tukey s multiple comparisons post-test (a P value of less than 0.05 was considered significant) Results ... chimeric virus: (A) Schematic presentation of the rescue strategy of WSN-Ab1-10 chimeric virus (B) SDS-PAGE and coomassie staining of purified chimeric (WSN-Ab1-10) and wild-type (WT) viruses (C) WB ... alone Statistical Analysis Statistical parameters (mean, standard deviation (SD), significant difference, etc.) were calculated using Prism 3.03 software (GraphPad Software, Inc., CA) Statistically...
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Báo cáo khoa hoc:" Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison''''s disease in girls and women with Turner syndrome" docx
... biosynthesis Rate limiting enzyme in the synthesis of serotonin APS II 21-Hydroxylase (21-OH) Steroid hormone synthesis Description of important autoantigens in Addison 's disease, Addison 's disease ... conclusion the autoimmune disorders sometimes associated with Turner syndrome not seem to be of the same origin as Addison 's disease, APS I or APS II Methods Subjects Blood samples from patients ... history was attained, focusing on autoimmune diseases, previous and current ear diseases, ear operations and hearing problems A clinical investigation of the EarNose and Throat area was also...
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Báo cáo y học: " Synchronously diagnosed eosinophilic granuloma and Hodgkin''''s disease in a 12-year-old boy: a case report" pptx
... of simultaneous occurrences of these two pathologic processes in a patient can prevent us from erroneous misdiagnoses of organ involvement by LCH In such cases the diagnosis of synchronous HD and ... events Langerhans cell histiocytosis (LCH) and Hodgkin 's disease (HD) has been reported previously as metachronously diagnosed tumors in the literature with LCH mostly developing as a subsequent cancer ... initial symptom In 5– 10% of patients, general symptoms such as fever, malaise and peripheral eosinophilia may be present Microscopic findings of Langerhans cell histiocytosis include eosinophils and...
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Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx
... genomic and proteomic strategies such as gene-expression and protein profiling and genetic screens in model systems - to other human diseases will provide a wealth of new candidate targets for ... large size of Htt and its apparent role in several cellular processes has raised the possibility that Htt serves as a scaffold that arranges protein complexes by modulating the binding of accessory ... repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions Genome Res 2000, 10:1445-1452 Cha JH: Transcriptional dysregulation in Huntington s disease...
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Báo cáo y học: "Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer''''s disease" pot
... This work has, for the first time, established specific diseaseassociated alternative splicing events across a broad category of genes in two neurological diseases With the generation of these ... Capacity cDNA Synthesis Kit (Applied Biosystems, Foster City, CA, USA) according to product instructions Taqman® assays and custom-designed primer/probe sets that were used in rtPCR studies to confirm ... file custom-designed primer/probe sequences used in rtPCR fileand discussion the brain tissue samples used in studies methods, to confirm the presence of the splice variants 20 Acknowledgements 21...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... Parkinson s Disease Parkinson s disease (also known as Parkinson disease or PD) is a degenerative disorder of the central nervous system that often impairs the sufferer s motor skills and speech ... functions, neurotransmitter levels, emotional stress, and progression of neurodegenerative conditions such as Parkinson s and Alzheimer s diseases (Rahman et al., 2008) 11.4 Heart Disease 11.4.1 Case ... flesh, including essential fatty acids from seeds and seed oils, and fibers, such as microcrystalline cellulose, pectins, lignins, cutin-like polymers, and condensed tannins, have been suggested...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons, Ltd ISBN: ... degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES TOXIN Autosomal Recessive AGING PARKIN DJ-1 Protein O abnormal autophagy UPS ... Parkinson (French for Parkinson s disease) T-sub-type PD patients have a better prognosis and slower disease progression than AR-sub-type patients (Jankovic et al., 1990) Interestingly, most forms...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... congress site and was often seen discussing topics of mutual interest with congress participant s There was an interesting new study presented by Professor Deuschl, Kiel, in which he demonstrates ... Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview Arnulf, I.: Sleep and wakefulness disturbances in Parkinson s disease ... outstanding scientists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders), Saskia Biskup, Germany and Andrew B Singleton,...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression ... feelings, vision problems, etc Degenerative diseases like Huntington s disease or other rare, usually genetically transmitted diseases may also cause dementia in adolescents This illness destroys ... blood vessels that supply the heart muscle with oxygen and nutrients narrow These diseases can cause strokes and heart disease (heart attacks) in the elderly The most common causes of illness and...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... and synaptic plasticity, such as profilin [30], stathmin [31] and lamin A ⁄ C [32] Lamin levels could also change in response to oxidative stress conditions [33] GSTp, whose levels are increased ... represent a valuable starting-point for focused investigations aiming to better understand the key issues of PD pathogenesis Materials and methods Cells Human neuroblastoma SH-SY5Y cells were cultured ... network, as well as statistically significant functional association with GO classifications [16] Western blotting Expression of a-synuclein and HSP70 was determined by western blotting Proteins (80...
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