socialization in the family
BRCA1 mutations in the family history clinic 2
... Devilee P BRCA1 and BRCA2 testing: weighing the demand against the benefits [editorial] Am J Hum Genet 1999, 64, 943-8 32 Foulkes WD BRCA1 and BRCA2: penetrating the clinical arena [commentary] Lancet ... Cancer Inst 1999, 91, 1310-6 72 Goggins M, Hruban RH, Kern SE BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia Am J Pathol 2000, 156, 1767-71 73 Goggins M, ... Lancet 1998, 351, 1487 102 Eisinger F, Nogues C, Guinebretiere JM, et al Novel indications for BRCA1 screening using individual clinical and morphological features Int J Cancer 1999, 84, 263-7...
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BRCA1 mutations in the family history clinic
... cancers had chain terminating mutations occurring in the 5’ half of the BRCA1 gene In 10 BRCA1 mutations detected in Finland, Vehmanen et al80 found that in families with mutations in exon 11, breast ... families having one of nine different BRCA2 mutations Four of these mutations were within the OCCR with the other five were outside of the OCCR Of the 82 families with mutations within the OCCR, the ... cases The presence of LOH in the markers in this region suggests the presence of a tumour suppressor gene in the vicinity of but possibly not at the AT locus Using the same mutation screening methods,...
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60733 roles in the family idioms and conversation
... for each other The sins of the father shall be visited upon the son You have to accept the family that you have.A close knit familyTo become independent from your mother.a match made in heavenChildren ... because of their parents’ mistakes When you think you’ll tie the knot? Who wears the trousers in your house? Are your family very close knit? Are your parents a match made in heaven? Who’s the black ... you left home? The Battle of the Sexes Look at the two adverts • Who are they targeted at? • What message are they trying to convey? • Is it wrong for women to embrace their masculine side or for...
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Cambridge.University.Press.Allegories.of.Union.in.Irish.and.English.Writing.1790-1870.Politics.History.and.the.Family.from.Edgeworth.to.Arnold.Oct.2000.pdf
... becoming good members of the Empire that they should not remain in the anomalous position they are in, but since they absolutely refuse to become the one thing, that they become the other; ... aim in this chapter is to examine the place that the family occupies in Burke’s thinking on Jacobinism and Ireland, analyzing the gendered rhetoric of the prophylactic against rebellion which the ... to the interests of patriarchal authority, in the family and in the state Unsurprisingly, Burke is also especially concerned in the ‘‘Tracts’’ about keeping unruly wives in check and indicts the...
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Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx
... the results obtained in the crayfish Orconectes limosus, showing that l-isomer of CHH is always present in the different parts of the d-CHH cells, in decreasing amounts from the cell body to the ... immunocytochemical results obtained in the present study invalidate our starting hypothesis proposing that the cells coexpressing VIH and CHH in the lobster X organ, as observed in previous studies [26,42], ... microscopy study of the neuronal endings in the sinus gland to determine the subcellular localization of the different epimers Taken together, these results allow a discussion of the existence of...
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Tài liệu Property and the Family in Biblical Law ppt
... and thus bring back ('redeem') their blood into the family And again, the outer limit of the right of inheritance is the mSphh While in theory the mSphh replcaes the old byt 'b of the deceased ... radical in its conservative tendency The law of redemption only aims at maintaining the unity of the family; if the family is not strong enough to maintain the property, then it must go down The ... within the confines of the mSphh On the other hand, the theoretical legal validity of the tribe in the context of inheritance can be accepted for the presettlement narratives precisely because the...
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Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
... the need of other proteins to stabilize the proteins in the membrane The interaction of Ga subunits with Gbc could be a stabilizing factor Mutations on Gaq residues which locate in the Gbc binding ... enhancement in the rate of degradation compared with the wild-type protein Our data is more consistent with an increased destabilization of the protein in the cytoplasm, a process that, in the case of the ... experiments the turnover rate of the proteins, thus excluding their involvement in protein breakdown On the contrary, treatment with the proteasome inhibitors MG132 5368 (50 lm) and the highly...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... The introduction of mutation into one of the putative Etsbinding sequences suppressed the promoter activity In addition, the specific binding of a nuclear protein to the oligonucleotide containing ... assay (EMSA) using the Ets consensus site at )133 As the involvement of the Ets consensus binding site at )133 in the promoter activity of the mouse a3 integrin gene was suggested by the luciferase ... a3b1 integrin plays essential roles in multiple processes during embryogenesis The promoter should thus contain elements directing the expression of this integrin in the kidney, lung, and skin...
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Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
... position 366 while all other proteins of the CYP11B family including CYP11B2 of the guinea pig have a basic residue (arginine or lysine, respectively) at the corresponding position These two basic residues ... 6) for the remaining introns Finally, the 3¢ UTRs of the guinea pig CYP11B genes show only 42% similarity whereas the 3¢UTR of the guinea pig CYP11B2 gene shares up to 72% identity with the corresponding ... abrogated almost completely These results indicate clear structural differences on the surface of these proteins involved either in glucocorticoid or in mineralocorticoid biosynthesis despite a high...
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Báo cáo khoa học: Starch-binding domains in the CBM45 family – low-affinity domains from glucan, water dikinase and a-amylase involved in plastidial starch metabolism pptx
... b-cyclodextrin injection, and the bottom panel depicts the binding isotherm; open circles represent the integrated binding heat of the data in the top panel, and the full line is the fit of a one-site binding ... showed no binding to maltoheptaose Taken together, the data presented here show that the binding affinity of the 1180 The full-length AtAMY3 offered an advantage when examining the binding affinity ... the starch-binding ability of AtAMY3 in vitro It cannot be precluded that some binding may involve secondary binding sites in the catalytic domain, but the demonstrated starchbinding ability...
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Báo cáo khoa học: Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family pdf
... cells expressing lamprey PQRFamide peptide mRNA in the brain must be taken into account when studying the neuropeptide action We therefore characterized the regions in the brain showing the expression ... system [40] These mammalian results indicate that NPFF may be involved in sensory transmission in the spinal cord, including pain systems, autonomic regulation in the medulla, and neuroendocrine regulation ... in the olfactory bulb and the nucleus olfactoretinalis in the Novel lamprey RFamide peptides telencephalon, but is absent in more caudal regions, including the hypothalamus, brainstem and spinal...
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Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx
... 1), thereby confirming the crucial role of Asp142 Catalysis in family 18 chitinases (Eur J Biochem 271) 259 In most ChiB structures, Asp142 is clearly defined, being either in the ÔdownÕ or in the ... that the carboxylic groups in the Asp140-Asp142-Glu144 triad contain two protons at the pH where the enzyme is most active The basic arm of the pH-activity profile must be determined by the loss ... for the wildtype enzyme, Glu144 is the only relevant titratable residue in the pH 6–12 range and the pKa of this residue is affected by substratebinding Therefore, it is surprising that the pH-kcat...
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Báo cáo khoa học: O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner doc
... activity like other MACS family proteins The recombinant plasmid carrying either the rat o-macs or the murine MACS1 cDNA was transfected into HEK293T cells The recombinant proteins contained the c-Myc ... to the murine acetyl-CoA synthetase (AceCS) family was much less (20–30%) These observations indicate that the O-MACS protein is a novel member of the acyl-CoA synthetase family, belonging to the ... like Rat IGF binding protein Rat FGF receptor activating protein Rat PKC delta-binding protein Rat cellular retinoyl-binding protein Mouse rho (NET1A) like Rat RYF3 (vomeromodulin) Rat RYA3 potential...
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Báo cáo khoa học: Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family ppt
... stages in the biological cycle of the parasite (i.e the epimastigote and the metacyclic trypomastigote in the insect vector, and the intracellular amastigote and the bloodstream trypomastigote in the ... Arg141¢ The other end of the substrate points into a deep pocket in the enzyme Moving along the ligand from the phosphate, O4 interacts with His102¢ and a water molecule that is in turn within hydrogen-bonding ... contacts with their equivalents in the other subunit of the second dimer (Fig 4A) In the case of P21212 (TcRpiB-R5P), the four molecules in the asymmetric unit represent the tetramer The two active...
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Fertility of Men and Women Aged 15–44 Years in the United States: National Survey of Family Growth, 2006–2010 docx
... 12, 2012 required from the minor: If either the parent or the minor declined to give written consent, the minor did not participate in the survey The response rate for the 2006–2010 NSFG was ... from the NSFG, because mothers report information for the birth registration system Not all mothers report information about the fathers of their babies, and if they do, their reports of the father’s ... living arrangements at age 14 The definition of Hispanic origin and race used in this report takes into account the reporting of more than one race, in accordance with the 1997 guidelines from the...
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Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
... different trypsins in the digestive gland of the spiny lobster Panulirus argus EF1-a was used as the housekeeping gene The same results were obtained when using b-actin as the housekeeping gene (not ... at the junction of the two barrels Another conserved characteristic of lobster trypsins is the presence of calcium-binding sites (Fig 3C) The calcium-binding motif does not occur in many invertebrate ... despite the presence of calcium-binding sites, Ca2+ affected neither the activity nor the stability of crab trypsin because there are no accessible autolysis sites in the N-terminal domain, which...
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Báo cáo khoa học: Genomic structure and expression analysis of the RNase j family ortholog gene in the insect Ceratitis capitata pptx
... represent the exons and the horizontal bold lines the introns The black parts of the rectangles show the protein-coding region, the white parts represent the non-coding regions and the gray parts ... (NW_001834409:c1450413–1449631) The numbers above the boxes indicate the size of the exons, and those below the lines indicate the size of the introns (B) Multiple amino acid sequence alignment of the RNase j family ... differences in the size of their respective introns Furthermore, there is a strong conservation of exon organization The exon size and the intronic positions are identical within mammals In the insect...
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Báo cáo khóa học: The structure–function relationship in the clostripain family of peptidases potx
... domain preceding the peptidase C11 domain and a bronectin type domain lying between the two The picture that emerges is one in which clostripain itself, the only member of the peptidase C11 family ... mechanisms [42,44] The study of the effect of pH on enzyme inactivation allows the calculation of the pKa of the His176 side chain involved in the inactivation reaction The rate of inactivation exhibited ... and, since our interest lay principally in understanding peptidase activity in the clostripain family, was not studied further The appearance of inactivated copies of related peptidases in various...
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Job Family Position Classification Standard for Professional Work in the Physical Science Group, GS-1300 docx
... mathematics, and engineering to the study of metals Metallurgy is the art and science of extracting metals from their ores, refining them, alloying them and preparing them for use, and studying their properties ... series includes all positions involving work that requires full professional education and training in the field of chemistry This work includes the investigation, analysis, and interpretation of the ... definitions in the law alone The language in the title definitions is to be interpreted within the context of all the applicable grading criteria in this standard In grading a position, users should...
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