sleep apoptosis and neurogenesis
Báo cáo y học: "1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss"
... 1,25-(OH)2D3 on podocyte apoptosis and podocytopenia The present study aimed to investigate the effects of 1,25-(OH)2D3 on podocyte apoptosis and podocytopenia induced by adriamycin (ADR) and the potential ... Bax/Bcl-2 ratio and finally limiting glomerular cell apoptosis Our study demonstrates the protective effect of 1,25-(OH)2D3 on podocyte apoptosis by down-regulating Fas, FADD and Bax and up-regulating ... collagenase and culture Early cellular outgrowths at 5-7 days were selectively removed by a cylinder cloning technique Cells were replated, and plates growing pure colonies were then expanded and identified...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... of TJ proteins such as claudin-1 and claudin-4 induces apoptosis and suppresses metastatic potencies [10,11] Occludin has also been reported to induce apoptosis and apoptotic sensitization, which ... occludin (OccWT) and variant occludin in apoptosis and invasion, as determined by assay, we revealed that exon played a major role in the induction of mitochondria-mediated apoptosis and the reduction ... concentration increases apoptosis and decreases invasiveness On the basis of the differences between OccWT and OccDE9 with regard to mitochondria-dependent apoptosis and reduction of invasion,...
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Sleep Disorders and Neurologic Diseases potx
... NORMAL AND ABNORMAL DEVELOPMENTAL AND ANATOMICAL CORRELATES OF THE CENTRAL NERVOUS SYSTEM AND SLEEP The CNS is the predominant organ system governing sleep, sleep s components, and the sleep –wake ... patients with sleep disorders, the advancement of sleep research, and public and professional education In 2005, AASM listed 2993 diplomates in Sleep Medicine (Fig 1) and 550 accredited sleep centers ... Egatz 13 Sleep in Parkinson’s Disease Robert L Rodnitzky 205 PART VI: EPILEPSY AND PARASOMNIAS 14 Epilepsy and Sleep 229 Bradley V Vaughn and O’Neill F D’Cruz 15 Somnambulism, Somniloquy, and Sleep...
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Báo cáo khoa học: Programmed cell death Apoptosis and alternative deathstyles pot
... microvilli and junctional complexes, and blebbing can occur In several cases, an intense endocytosis is observed, and this probably Fig Multiple pathways to apoptosis, both dependent and independent ... activation (GluRd2-Lc) Yue and collaborators [113] showed that GluRd2, nPIST and beclin-1 interact, and that autophagy can be induced by nPIST and beclin-1 synergy and by the mutated GluRd2-Lc, ... section will examine its relationship with apoptosis Apoptosis vs autophagy Notwithstanding the abundant evidence for a role for both autophagy and apoptosis in various diseases, their interplay...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... reduced tumour proliferation, and tumour regression, accompanied by apoptosis [40] An understanding of how and under what circumstances MEK inhibition can promote apoptosis may permit a more targeted ... variants, BIMS, BIML and BIMEL (BIM-short, BIM-long and BIM-extra long, respectively), are all cytotoxic and subject to different modes of regulation by various prodeath and prosurvival signalling ... loss of ERK1 ⁄ and ⁄ or PKB signalling and, as a consequence, promote increased expression of BIM and BIM-dependent cell death in tumour cells Here we review recent advances in understanding BIM...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... kinases ATM and ATR ATR and ATM in turn phosphorylation-dependently activate the downstream checkpoint kinases Chk1 and Chk2, respectively, and the tumour suppressor p53 Furthermore, ATM and ATR ... we focus on the apoptotic p53, p73 and HIPK2 in apoptosis signalling routes of the DDR regulated mainly from the cell nucleus and the key molecules p53, p73 and homeodomain-interacting protein ... cisplatin) and has been shown to drive the expression of apoptotic p53 target genes, such as p53-upregulated modulator of apoptosis (Puma), p53 regulated apoptosis- inducing protein (p53AIP1) and breakpoint...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
... caspase-1, caspase-9 ⁄ HIP-1 & HIPPI mediated apoptosis and transcription caspase-6, and caspase-3 Cleavage of Bid and release of cytochrome c and apoptosis- inducing factors from the mitochondria ... apoptosis and transcription Hippi Also, expression of the mitochondrial-coded genes ND1 and ND4, the nuclear genome-coded mitochondrial genes SDHA and SDHB and the antiapoptotic genes BCL-2 and ... in the regulation of cytoskeletal and endocytic processes HIP-1 and its interacting partners – roles in apoptosis and survival Various pathways followed during apoptosis have been reviewed recently...
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Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx
... the androgen receptor to control cellular processes such as proliferation, apoptosis and other metabolic events in prostate cancer [14] Taken together, a combination of gene amplification and androgen ... 24 h and (D) 48 h (D) Overlay of (A) and (C) TPD52 downregulation activates caspase activity and increases the loss of mitochondrial membrane potential (E, F) Showing the relative caspase-3 and ... as TPD52 and its locus has been mapped on chromosome 8q21 [4,5] Its encoding gene is also referred to as PrLZ and is a member of the tumor protein D52 (TPD52) gene ⁄ protein family and is designated...
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apoptosis and cell proliferation
... – Apoptosis and Necrosis Cell Death – Apoptosis and Necrosis Apoptosis Assay Methods Apoptosis Assay Methods Cell Death – Apoptosis and Necrosis Apoptosis Assay Methods Methods for studying apoptosis ... studying apoptosis in individual cells 38 39 Cell Death – Apoptosis and Necrosis Cell Death – Apoptosis and Necrosis Apoptosis Assay Methods Apoptosis Assay Methods Cell Death – Apoptosis and Necrosis ... ̆ Table 1: Differential features and significance of necrosis and apoptosis Cell Death – Apoptosis and Necrosis Introduction Differences between necrosis and apoptosis b Prelytic DNA fragmentation...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... necrosis and natriuretic peptides are well known indicators of cardiac dysfunction and filling pressures In addition, certain other biomarkers are known to be indicators of inflammation and apoptosis, ... Fas/Fas ligand system, shows increased activity in HF patients and correlates to disease severity [6,7] To briefly summarize, soluble Fas-Ligand (sFas-L) binding to membrane-bound Fas triggers apoptosis, ... manufacturer protocol and using standard curves and software The kits for NTproBNP (fmol/ml) were purchased from ALPCO Diagnostics, Salem, New Hampshire; for IL-6 (pg/ml) and TNFα (pg/ ml) from...
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Báo cáo y học: "Residual sleep disturbance and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine" docx
... established a positive correlation between the presence of sleep disturbance, including hypersomnia and insomnia, and a greater severity of depressive and anxiety symptoms [8,9], as well as increased suicide ... participants who underwent random assignment were a mean age of 38.2 years (SD = 10.9), and 55.3% were female Their mean HDRS score was 17.1 (SD = 4.1) at baseline and 4.9 (SD = 3.1) at randomization; 22.7% ... original study, and helped interpret the data for the current study AC and LB conducted the statistical analysis PJM and MF were the principal investigators of the original study and provided critical...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
... degenerative disorders [8,9] Apoptosis is a physiological process and is a highly selective way to eliminate aged and injured cells In addition to internal pathways that trigger apoptosis mainly in response ... of the apoptosis- inducing receptor Fas in periarticular tenocytes of patients with OA and studied their susceptibility to apoptosis in the presence or absence of recombinant human FasL and TNF-α ... Germany) and reverse transcribed using random hexamer primers Primers and FAM-TAMRA-labelled probes for the real-time PCR were purchased as a predeveloped assay from Applied Biosystems and used...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
... contributions YZ and AY are researchers working in cancer biology and carried the study QL and YB undertook the Statistical analysis QZ along with MZ designed the work and interpreted the results QZ and MZ ... western blot and stained by both anti-Bcl-2 (BH3) and anti-Bax (6A7) antibodies, express conformational change of Bcl-2, which may play a role in arsenic trioxide-induced apoptosis and Bax activation ... arsenic trioxide on early and late apoptosis/ necrosis of SGC7901 cell (* represents p < 0.05 compared to the black control group and arsenic trioxide treated groups) at 24 hours and the difference compared...
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Báo cáo y học: "ragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis" ppt
... the cleavage of proteins during apoptosis and necrosis because its cleavage products in Jurkat cells undergoing apoptosis (89 kDa) and undergoing necrosis (60 and 50 kDa) are well established ... nuclear proteins in apoptosis and necrosis revealed by autoantibody probes Cell Death Differ 1998, 5:183-190 Utz PJ, Anderson P: Posttranslational protein modifications, apoptosis, and the bypass ... in apoptosis and in necrosis, prompting us to examine whether specific Golgi proteins are targeted for proteolysis in these modes of cell death Golgi autoantigens are cleaved during apoptosis and...
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Báo cáo y học: "Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthri" pdf
... generated and provided the recombinant chimeric TRAIL protein PDR conceived of the study and participated in its design and coordination and helped to edit the manuscript All authors have read and ... USA) plasmid, and expressed protein was purified using the His-band Resin and Buffer Kit (Novagen) [13] Analysis of the purified rTRAIL protein demonstrated that both trimeric and dimeric TRAIL ... expression of TRAIL/Apo-2 ligand in activated mouse T and B cells Eur J Immunol 1998, 28:1492-1498 Jeremias I, Herr I, Boehler T, Debatin KM: Trail/Apo-2-ligandinduced apoptosis in human T cells...
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Báo cáo y học: "CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase" ppsx
... rejection level of 5% Data are expressed as mean ± standard deviation Results Expression of CD95 and CD95 ligand To determine whether CD95 and its ligand were involved in induction of cell death in ... of apoptosis and that of necrosis were increased by antiCD95 treatment, and these increases were diminished by inhibition of p38 MAPK (Figure 3b) Thus, both CD95 induced chondrocyte apoptosis and ... [lower right] and panel c [lower right]); and y axis is FL2-H (log), and fluorchrome is red for PI (panel b [upper left] and panel c [upper left]) Living cells are shown to the lower left and double...
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Báo cáo y học: "CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase" pps
... anterior and posterior commissure and covered the whole brain in all sequences Conventional T1-weighted spin-echo, fluid-attenuated inversion recovery and dual (fast spin-echo proton density and T2-weighted) ... MTR, peak height and peak location Nonparametric Mann–Whitney tests were performed to compare clinical and grey and white matter MTR histogram parameters between patients with and without IgM ... aCLs and 13 for Lac, yielding a comparison of nine versus nine patients for IgM aCL, nine versus nine patients for IgG aCL, and 13 versus five patients for Lac For anti-dsDNA and anti-ENA, four and...
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Báo cáo khoa học: "Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients" ppt
... tables and figures and has been involved in type of packaging likewise in the submission process PCL has been involved in conception and design of the study and in drafting the manuscript and has ... are 1) non-homologous end joining (NHEJ) and homologous recombination repair (HRR) [29,30], and 2) cell-cycle checkpoints that provide time for repair and apoptosis [31] Depending on the severity ... spontaneous apoptosis) ; and the coefficient b defining the slope of the curve a and b followed a normal distribution (Kolmogorov-Smirnov test, p > 0.05) Mean of b was 7.93 ± 2.68 standard deviation...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... eagle medium (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained ... the expression of b1- and b2-ARs was determined at both the mRNA and protein level in SGC-7901 and BGC-823 cells by RT-PCR and western blot Our results showed that b1- and b2-adrenergic receptors ... the data and plotting of the figures were performed with the aid of software (Origin Version 7.5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic receptors in SGC7901 and BGC-823...
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Báo cáo y học: "Sleep structure and sleepiness in chronic fatigue syndrome with or without coexisting fibromyalgia" pdf
... their self-reported sleepiness before and after sleep We labeled those with more sleepiness in the morning than on the night before as 'a.m sleepier' and those with less sleepiness in the morning ... curves of every episode of sleep (that is, a bout of sleep preceded and followed by periods of wakefulness) for controls and patients in the a.m less sleepy and a.m sleepier groups for whole-night ... after a night's sleep than before sleep and a group that felt less sleepy after a night's sleep reduced the variability of the sleep records considerably Those patients reporting less sleepiness after...
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