sites multiple targets dna looping
Tài liệu Bioregulatory Properties of Medications Aiming at Multiple Targets Open New Therapeutic Perspectives doc
... Assumptive (light green) Targets for Traumeels Action in Inflammation Traumeel acts on multiple cellular targets during tissue injury and local acute inflammation These targets include tissue and ... networks, as well as using multicomponent medicines to manipulate networks and multiple organ systems rather than single targets. 12 In this supplement, some exemplified principles of bioregulatory ... medicine is one of such approaches The multifactorial origin of many chronic diseases suggests multiple targets to be addressed when successful treatment is the goal This also applies to most diseases...
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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
... defensive compound may have multiple molecular sites of action and may well have synergistic effects with other such compounds This book is concerned with the biochemical targets of plant defensive ... specific targets or groups of targets of plant defensive compounds Target-related tables are grouped into specific chapters that are prefaced by succinct summaries of the biochemistry of the targets ... macrocyclic alkaloids including the DNA- binding RNA- and DNA- polymerase inhibitor pithecolobine from Pithecolobium Plant defensiue compounds and their molecular targets 19 sanzan (Fabaceae) and...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... RNasefree DNase treatment to remove baculoviral DNA as described by the manufacturer Completeness of removal of baculoviral DNA was monitored by including control samples spiked with plasmid DNA (either ... were generously provided by D Kelly (Washington University Medical School) Vectors pcDNA1.1, pEF1/myc-His and pcDNA 3.1/mycHis/lacZ were purchased from Invitrogen (Carlsbad, CA, USA) Vectors pEGFP-N3 ... iPLA2 activities we identified in multiple membrane compartments were resistant to our attempts at their purification In the postgenome era it became apparent that multiple different gene products...
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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot
... precise location and the relative orientation of the binding sites in decorin and collagen are not yet known Our findings on multiple binding sites in collagen and on the relevance of Lys/Hyl residues ... decorin reveal the following (a) Type I and probably also type II collagen appear to have multiple binding sites for decorin, because several CNBr peptides are able to interact with this small proteoglycan ... tendon and its core as well as a recombinant decorin preparation The results suggest that multiple binding sites for decorin are present in these collagens We have also tested the influence on decorin...
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Báo cáo khoa học: Analysis of DNA-binding sites on Mhr1, a yeast mitochondrial ATP-independent homologous pairing protein potx
... interacts with DNA They also suggested the presence of multiple DNA- binding sites (at least two sites near Trp71 and Trp165) on Mhr1 These may explain our difficulty in obtaining a DNA- bindingdeficient ... single-strand DNA (ssDNA) and assimilation of ssDNA into homologous super-coiled duplex DNA J Biol Chem 276, 41906–41912 13 Li X & Heyer WD (2008) Homologous recombination in DNA repair and DNA damage ... 2010 FEBS T Masuda et al DNA- binding sites of Mhr1 Table DNA- binding activity of the Mhr1 variants N, DNA- binding activity is comparable to that of the wild type; +, DNA- binding activity is slightly...
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Báo cáo khoa học: Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA pptx
... strand scission at dL sites to the regular (aldehyde) AP sites shows that cleavage at dL sites is 12- to 55-fold faster than at AP sites [27] However, the immediate breakage of DNA at the dL lesion ... reactive oxygen species, produces structurally distinct abasic sites, known as oxidized abasic sites Oxidized abasic sites include lesions at DNA strand breaks, such as 3¢-phosphoglycolate esters and ... Combined with the AP sites produced by DNA glycosylases, the daily burden of AP sites is probably much higher One estimate yielded steady-state levels of 50 000–200 000 AP sites per cell in various...
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Báo cáo khoa học: CmtR, a cadmium-sensing ArsR–SmtB repressor, cooperatively interacts with multiple operator sites to autorepress its transcription in Mycobacterium tuberculosis pptx
... binding sites in the 90 bp protected region, which corresponds fairly well to four predicted binding sites in this region To establish that the predicted sites are genuine CmtR binding sites, ... position of free DNA, and the arrows indicate the DNA protein complexes The arrow within the gel indicates the position of DNA protein complex (C) The fraction of bound F-1 DNA (estimated by ... not have visualized the multiple DNA protein complexes observed in the present study In addition, DNase I footprinting experiments show that CmtR binds to an extended 90 bp DNA sequence compared...
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Báo cáo khoa học: End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx
... damaged and undamaged DNA Biochemistry 43, 16505–16514 Parsons JL, Dianova II, Allinson SL & Dianov GL (2005) DNA polymerase b promotes recruitment of DNA ligase IIIa–XRCC1 to sites of base excision ... dissociating from the DNA Therefore, cross-linking of Pol b and the XRCC1 DNA ligase IIIa heterodimer correlates well with the kinetics of repair We next immunodepleted the XRCC1 DNA ligase IIIa heterodimer ... absence of XRCC1 DNA ligase IIIa (Fig 3C), suggesting that Pol b probably binds first, processes the gapped DNA to the ligatable stage by filling the gap, and then recruits XRCC1 DNA ligase IIIa...
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Báo cáo Y học: Molecular interactions between nuclear factor kB (NF-kB) transcription factors and a PNA– DNA chimera mimicking NF-kB binding sites doc
... DNA DNA target molecule Protein DNA complexes are indicated by an arrow Asterisks indicate the free 32 P-labelled NF-kB DNA DNA Control DNA DNA competitors carrying binding sites for GATA-1 and NF-IL2A ... 32P-labelled DNA DNA target molecules Protein– DNA complexes are marked with an arrow Asterisks indicate the 32P-labelled NF-IL2, STAT-1 and GATA-1mers Control DNA DNA competitors carrying binding sites ... DNA DNA molecules Fig CD spectra of NF-kB PDP–PDP (- - -) and of DNA DNA (– – –) duplexes In order to determine the activity of the double stranded PDP –PDP chimera carrying NF-kB binding sites...
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báo cáo hóa học: " Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis" pot
... Weinshenker BY, Wolinsky JS: Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis Ann Neurol 2001, 50:121-127 Menge et ... predict multiple sclerosis? N Engl J Med 2003, 349:107-109 doi:10.1186/1742-2094-8-161 Cite this article as: Menge et al.: Conformational epitopes of myelin oligodendrocyte glycoprotein are targets ... progressive MS Acknowledgements T.M and P.H.L were postdoctoral research fellows of the National Multiple Sclerosis Society We are indebted to Ishita Barman for recombinant MOG preparation and...
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Báo cáo sinh học: " Research Article Real-Time Multiple Moving Targets Detection from Airborne IR Imagery by Dynamic Gabor Filter and Dynamic Gaussian Detector" doc
... hit rate for the datasets Dataset 381 326 55 85.6% 14.4% 85.9% Total number of targets Detected targets Missed targets Correct detection rate Miss detection rate Hit rate (a) (b) Dataset 266 ... contains 100 frames, and each frame contains two to four moving targets The ground truth targets are labelled manually The total number of targets in these datasets is 1231 We examined the correct ... detection Outliers clustering Target localization Figure 2: Processing flow of the proposed multiple moving IR targets detection algorithm video, the background is moving over time due to the moving...
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Báo cáo hóa học: " Research Article Detecting and Georegistering Moving Ground Targets in Airborne QuickSAR via Keystoning and Multiple-Phase Center Interferometry" doc
... cancellation technique for detecting weaker moving targets GEOREGISTRATION OF DETECTED MOVING TARGETS IN QUICKSAR The “apparent” locations of the moving targets detected in the SAR image are not their ... these detections are likely to be false alarms, most of them are possibly multiple detections from “extended,” that is, large targets 3.4 Clustering of the detections An observer can readily group ... pixels corresponding to the moving targets, we expect to detect, should be of sufficient strength as well as deviate significantly from the phase plane Thus, the moving targets have to meet the dual...
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Báo cáo hóa học: "Research Article Detecting and Georegistering Moving Ground Targets in Airborne QuickSAR via Keystoning and Multiple-Phase Center Interferometry" pdf
... cancellation technique for detecting weaker moving targets GEOREGISTRATION OF DETECTED MOVING TARGETS IN QUICKSAR The “apparent” locations of the moving targets detected in the SAR image are not their ... these detections are likely to be false alarms, most of them are possibly multiple detections from “extended,” that is, large targets 3.4 Clustering of the detections An observer can readily group ... pixels corresponding to the moving targets, we expect to detect, should be of sufficient strength as well as deviate significantly from the phase plane Thus, the moving targets have to meet the dual...
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Báo cáo y học: "Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites" potx
... canonical targets, ii) only non-canonical targets and iii) all target sites True positives for all sets are defined as targets with a log expression change (Zscore) ≤-1 and false predictions are targets ... target sites are generally more effective sites than non-canonical sites as shown by their more negative mirSVR scores and corresponding log expression change Where scores for non-canonical sites ... noncanonical sites are bona fide microRNA target sites that contribute, either in addition to canonical sites or independently, to gene silencing and that careful inclusion of such sites in the...
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báo cáo khoa học: "Split-Inteins for Simultaneous, site-specific conjugation of Quantum Dots to multiple protein targets In vivo" pptx
... Uninjected ii) DnaE IC-QDot585 ii) Paxillin-EGFP-DnaE IN RNA iii) DnaE IC-QDot585 + Paxillin-EGFP-DnaE IN RNA, D: i) Uninjected ii) QDot585-DnaB IN iii) DnaB IC-memEGFP RNA iv) QDot585-DnaB IN + DnaB IC-memEGFP ... corresponding RNAs encoding DnaB IC-memEGFP and Akt-EGFP-DnaE IN, (B) the probe QDot655-DnaB IN and RNA encoding Akt-EGFP-DnaE IN or the probe DnaE IC-QDot655 and RNA encoding DnaB IC-memEGFP Both QDot585 ... C-terminus DnaE intein peptide (DnaE IC-Biotin) and biotinylated N-terminus DnaB mini-intein peptide (Biotin-DnaB IN) The 47 amino acid peptide sequence of the C-terminus DnaE intein peptide (DnaE...
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Báo cáo y học: "Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-B-dependent transcription of TNF-a and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA" ppsx
... according to the manufacturer’s specifications Residual genomic DNA was eliminated using oncolumn DNase digestion with the RNase-free DNase set (Qiagen) and resulting extracts were resuspended in ... antibodies were used to precipitate RelA :DNA complexes DNA was subsequently purified and analyzed by quantitative RT-PCR using primers specific for the NF-B binding sites on the TNF-a, MCP-1/CCL2, and ... and its cognate sites on the DNA TMP could be acting on RelA itself, binding to conserved motifs present in the amino terminus RHD thereby preventing RelA from recognizing its DNA binding site...
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Báo cáo y học: " Measurement of Epstein-Barr virus DNA load using a novel quantification standard containing two EBV DNA targets and SYBR Green I dye" pps
... EBV Targets DNA load EBV EBNA-1 DNA load (copies/ml) 24 (11.0%) 2.0 × 102 - 9.1 × 104 1.00 EBV BHRF-1 DNA load (copies/ml) 47 (21.6%) 2.0 × 102 - 3.3 × 104 0.63 p < 0.001 1.00 Combined EBV targets ... EBV DNA targets, EBNA-1 or BHRF-1 (Table 3) EBV DNA was detected in 100%, 85.7%, 100% and 33.3% of patients with PTLD, IM, EBVAHS and HIV-infected individuals (Groups to 4), respectively EBV DNA ... positive samples, 91.7% were also BHRF-1 DNA positive, and of the 47 BHRF-1 DNA positive samples, 46.8% were also EBNA-1 DNA positive Viral loads (combined targets) were detectable between 2.0 ×...
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Báo cáo y học: "DNA double strand break repair enzymes function at multiple steps in retroviral infection" pptx
... to the host DNA (strand transfer) [1] Since the two ends attack the target DNA in a 5'-staggered fashion, single strand gaps between viral DNA and the target DNA are generated Host DNA repair ... non-homologous end joining (NHEJ) [10] In the NHEJ pathway, DNA- dependent protein kinase (DNA- PK), which consists of DNA- PK catalytic subunit (DNA- PKcs) and Ku, binds and holds the two ends of the ... unintegrated viral DNA is circularized to form two kinds of circular viral DNAs, 2-LTR circles and 1-LTR circles Formation of these circular DNAs is also catalyzed by host DNA repair enzymes...
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Báo cáo y học: "Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5a-mediated restriction" docx
... CM SPRY (-) TRIM5a, thus, we were unable to evaluate the effect of these sites Taken together, we conclude that multiple sites in the N-terminal half of SIVmac239 CA (N-S, CypS (L4/5), and the ... by site-directed mutagenesis Restriction enzyme sites NgoM IV and Xho I, located in the LTR and p6 cording region, respectively, were used for DNA recombination To obtain the NgoM IV-Xho I fragment ... though the 179th amino acid of the C-terminal half possessed a slight effect of restriction Multiple sites in the N-terminal half of SIVmac239 CA contribute to evasion from restriction by Rh TRIM5a...
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