... distinct monoclonals, two of them preventing, the third one accelerating the development ofthe disease [40] The effect of each reagent on the signaling activated by CD4 via the p56lck interacting ... pocket, a discontinuous region at the interface between the inner and the outer domain of gp120 [52] On the other hand, the lateral face ofthe D1 CD4 domain is implicated in MHC-class II interaction, ... depletion ofthe CD4 T lymphocytes is the hallmark ofthe progression of HIV infection and, inthe absence of antiviral treatment, the main contributor to the development of opportunistic infections...
... Most ofthe increase in CO2 emissions from gas-fired plants was offset by the decline in CO2 emissions from petroleumand coal-fired plants The amount of CO2 emissions fromthe combustion of fossil ... Emissions fromthe Generation of Electric Power inthe United States increased in 1999 in these States, reducing the need for fossil-fueled generation and contributed to keeping CO2 emissions low inthe ... electricity varies according to the quality ofthe fuels, defined by their carbon content and the associated heating value (Btu).15 The Btu content of fuels is a determinant ofthe number of kilowatthours...
... differences between domains γ1 of AAG and abrin-a occurred in N-terminal The Nterminal ofthe AAG A-chain is one residue shorter than that ofthe abrin-a A-chain and the first five terminal residues are ... also minimizes energy based scores [42] Parameters used in DOCK were modified fromthe paper of protein docking and complementary principle [43] The atomic coordinates ofthe refined agglutinin ... studying the structure and function of these RIPs [21,23,24] And the results showed that Pro199 in A- (or C-) chain of AAG impair the activity of protein synthesis inhibition because of steric hindrance...
... promote the migration and invasion capacity of these cells [14] These effects were inhibited when cells were treated with TWEAK inthe presence ofthe NF-κB inhibitor pyrro lidine dithiocarbamate In ... Research inthe past years has unraveled the multiple mechanisms that enable NF-κB to support ovarian carcinogenesis, including that this pathway confers some ofthe properties of OCSCs These findings ... A2780 cells In addition, they showed that blocking IKKβ activity through either small-molecule inhibition or siRNA can inhibit anchorage-independent growth and the capacity ofthe cells to invade...
... REVIEW The Development of Auditing Profession in China Shortly after the founding ofthe People’s Republic of China in 1949, the auditing profession in China disappeared entirely due to the public ... THE DETERMINANTS OF AUDITOR SWITCHING FROMTHE PERSPECTIVE OF CORPORATE GOVERNANCE IN CHINA costs of raising capital and hiring a low-quality auditor to maintain the gains fromthe opaqueness ... expropriation of minority shareholders’ interests thereafter As a result, the auditing profession and the stock market may be able to develop smoothly in China In line with the continuing progress of the...
... the purpose of “opinion shopping” in order to mitigate the negative impact ofthe unclean audit report on the firm's stock price inthe market, and on the self-interests ofthe management or the ... act inthe best interest ofthe owners One ofthe binding mechanisms is the auditing function performed by independent professionals over the operations and information disclosures provided by the ... auditors during the period fromthe beginning of 2001 to the end of 2004.4 There are two main reasons to limit the sample firms that made auditor switches in this time period The first one is the availability...
... housing census of Vietnam in 2009 (UNFPA), indicating the alarming status of growing gender imbalance in Vietnam; Gender issues in migration (IOM) pointing out the differences inthe amount of ... be seen inthe continuous practice of wedding challenge, demonstrating the inferior position of women inthe family and inthe community, as well as the importance of having sons.” Being fully ... Thus, in reality, rather than believing that the division of labor has shed the burden on the women’s shoulders, fromthe point of view of EM people, the issue of “who does what” originates from the...
... asked to indicate how distressed they were by feelings of hopelessness, lack of interest, worrying, feeling blue, feeling lonely, blaming themselves, feeling trapped, crying easily, having a poor ... criteria of physical functioning and two criteria of cognitive functioning to identify those functioning inthe top third ofthe age group The selection criteria included the following: (a) no ... living spouses at both time points were included, yielding a sample of 439.1 Table summarizes the sociodemographic and psychological characteristics ofthe sample at the time ofthe first interview...
... Side-chain packing inthe regions responsible for the stability of HT c-552, and the corresponding regions inthe wild-type PA c-551 and its quintuple mutant The mutated residues inthe quintuple ... determining the structural origin of protein stability Experimental data on the stability and 3D structure of these proteins in addition to their amino-acid sequences will provide valuable information ... to the polypeptide chain [5] The amino-acid sequence (Fig 1) and main chain folding (Fig 2) of HT c-552 from this thermophile closely resemble those ofthe 82-amino-acid cytochrome c-551 from...
... elements, including early administration of mitomycin-C, inclusion of cisplatin and prolonged doxifluridine administration besides the intraperitoneal therapy Thus, it remains to be proven if the survival ... the OFF arm The median OS inthe OFF arm was 28 weeks, and that ofthe FF arm was 13 weeks, thereby fulfilling the study hypothesis There was also a significant prolongation of PFS inthe treatment ... examined intermittent administration of oxaliplatin in minimizing neurotoxicity from oxaliplatin The Combined Oxaliplatin Neurotoxicity Prevention Trial (CONcePT) randomized patients receiving...
... trial of gemcitabine and oxaliplatin alone or in combination with biweekly cetuximab inthe first-line treatment of advanced biliary cancer: Interim analysis ofthe BINGO trial J Clin Oncol (Meeting ... presentations in gastrointestinal oncology from 2009 annual meeting of ASCO The key findings are summarized as the followings, and will lead to paradigm change in clinical practice Adding trastuzumab ... Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation inthe definitive nonsurgical treatment of epidermoid carcinoma ofthe anal canal: results of...
... inthe ZEAL study The large sample size in ZODIAC may explain the significant improvement in PFS even though the PFS was almost the same in both studies Evaluation of secondary endpoints inthe ... testing for making decisions inthe firstline treatment setting cannot be recommended at this time Lastly, there is hope for improving outcomes inthe Page of 11 second-line setting given the ... positive data fromthe ZODIAC trial The important finding in this trial has demonstrated the improvement of PFS and RR from vandetanib translated into the clinically meaningful delay in symptom...
... MRI ofthe affected region, together with whole skeleton bone scintigraphy and CT ofthe chest MRI is essential inthe determination ofthe true extent ofthe tumor It is important to bear in mind ... predominantly affecting young patients ofthe ages five to 20 years It involves the diaphyses of long bones and occurs Figure CT image ofthe patient’s foot, revealing a soft-tissue mass originating ... Reinus WR, Wilson AJ: Quantitative analysis ofthe plain radiographic appearance of Ewing’s sarcoma of bone Invest Radiol 1997, 32:59-65 10 Reinus WR, Gilula LA: Radiology of Ewing’s sarcoma: Intergroup...
... The SNR increase is firstly explained in theory with the conclusion that SNR can be increased by increasing the number of coils inthe array provided that the mutual coupling can be removed Then ... Therefore the heating effect is not very sensitive to the radius ofthe needle In a practical invasive treatment, the radius ofthe needle can be determined by the requirement ofthe needle insertion ... Figure 2.3: The YOZ cutting plane ofthe model in FEKO 18 Figure 2.4: The incident directions ofthe plane wave inthe two cases The blue arrow represents the incident direction while the red...
... 1.2.3 Innate immunity 1.2.3.1 The iron-withholding strategy as a component of innate immunity 1.3 The iron-binding proteins involved during infection and inflammation 1.3.1 The transferrin family ... Fe2+ enters the core ofthe apoferritin, after which it is oxidized to Fe3+ by the catalytic action ofthe amino acid side-chains ofthe H-chain 1.3.2.2 Secreted ferritins Ferritin was demonstrated ... growth in media containing these iron-binding proteins or human serum (Takase et al., 2000) However, whether or not other iron-binding proteins in human serum are also targets of siderophores remains...
... activity of ODC gene [29], which is involved in polyamine synthesis It is likely that the cell cyclearresting action of CY inthe stomach in this study was due to the activation of p53 and therefore ... therefore leading to the suppression ofthe c-Myc/ODC pathway All these findings could explain the mechanism of CY on repression of cell proliferation inthe gastroduodenal mucosae In general, ... was therefore not surprising that CY administration resulted in a decrease inthe proliferating cell number in both the gastric and duodenal tissues Indeed the decrease in cell proliferation in...
... bird, still he was soaring through the air, gleefully riding the wind currents down the side ofthe mountain When they reached the valley floor and neared the shoreline ofthe lake, a giant clamor ... pyramid shaped mountains flanked the opposite side ofthe incredible fissure Feeling compulsively drawn to the edge ofthe chasm, she gazed into the absorbing darkness The billowing blue smoke was ... have arrived at the most opportune moment! We are about to witness the fall of Tenochtitlan and the beginning of a new epoch inthe history ofthe world!" The wanderer felt a tug of apprehension...
... also inconsistent with their understanding of language teaching Inthe case ofthe activity Reading and reporting from website, only 14% ofthe teachers said they 'use it regularly' when 50% of them ... analysis and the major findings ofthe study Fromthe findings ofthe two survey questionnaires, it appears that: Unlike the teachers reported inthe previous related studies, HaUI EFL teachers in this ... think the researcher wants to read rather than their real feelings Moreover, the number ofthe subjects is small which may influence the implications ofthe thesis to some extent The results of...
... about the human who took the photo ofthe toilet Having each of these fields remain separate fromthe others means the content can be sorted according to any of these fields; also, each ofthe fields ... Drupal Fromthe Library of Athicom Parinayakosol This page intentionally left blank Fromthe Library of Athicom Parinayakosol Front End Drupal Designing, Theming, Scripting Emma Jane Hogbin Konstantin ... create the page you see—one of which might be content The flow chart in Figure 1.2 shows the same information that is displayed inthe Web site in Figure 1.1, but in terms ofthe hierarchy of each...