signal transduction via the b cell antigen receptor a crucial regulator of b cell biology
báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
Ngày tải lên :
11/08/2014, 12:20
... genomics analysis of these functional RNAi datasets in breast and ovarian cancer, we have identified regulators of mitotic arrest and ceramide metabolism as mediators of taxane resistance and confirmed ... complex relationship Nat Rev Cancer 2006, 6:729-734 36 Abraham RT, Gibbons JJ: The < /b> mammalian target of rapamycin signaling pathway: twists and turns in the < /b> road to cancer therapy Clin Cancer Res ... for the < /b> most active therapeutic compounds targeting the < /b> mammalian target of rapamycin (mTOR) and vascular endothelial growth factor (VEGF) pathways About 90% of kidney tumors arise in the < /b> renal...
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The integration of lean man and 6 sigma
Ngày tải lên :
23/11/2013, 14:22
... warranty claims for automatic transmissions The < /b> transmissions were made at both the < /b> Ford Batavia (Ohio, USA) facility and at a Mazda facility in Japan Data showed that customer satisfaction was ... total quality management (TQM) and the < /b> Six-Sigma statistical metric originating at Motorola Corporation Today, Six Sigma is a broad long-term decision-making business strategy rather than a narrowly ... in a single-piece flow through a U-shaped machining cell, but then accumulate into a large batch at the < /b> end of the < /b> cell before being moved to a chrome plating station In fact, very few lean manufacturers...
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Báo cáo khoa học: "Diagram Understanding Using Integration of Layout Information and Textual Information" ppt
Ngày tải lên :
17/03/2014, 07:20
... Word04 meshibe Word05 mebana Word06 oshibe Word07 obana name name type name type name type of plant of plant of plant of plant of plant of plant of plant parts parts parts parts parts parts parts Rule ... structure of diagrams as the < /b> extension of diagram analysis But they analyzed diagrams by using knowledge about diagrams which is quite separate from natural language information On the < /b> contrary, (Nakamura ... (Nakamura 93) analyzed diagrams in the < /b> encyclopedia dictionary by using its explanation texts and the < /b> thesaurus information But it is difficult to analyze the < /b> PBF diagrams in the < /b> same way as (Nakamura...
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Báo cáo hóa học: " Research Article Binocular Image Sequence Analysis: Integration of Stereo Disparity and Optic Flow for Improved Obstacle Detection and Tracking" pptx
Ngày tải lên :
21/06/2014, 22:20
... m ahead of the < /b> equipped car at a relative speed of zero in both longitudinal and lateral directions Thus, the < /b> longitudinal and lateral distances between the < /b> two cars are kept constant The < /b> tracking ... gives the < /b> tracking results for the < /b> longitudinal distance and speed The < /b> other two groups of state variables, the < /b> lateral and vertical movements, have the < /b> same iteration equations with a small change ... analysis can be fused by a Kalman filter for object tracking Stereomotion integration has been studied in a theoretical manner for extracting the < /b> relationship between them Waxman and Duncan [9] claimed...
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INTERNATIONAL ASSIGNMENTS An Integration of Strategy, Research, and Practice ppt
Ngày tải lên :
28/06/2014, 09:20
... consults and trains in the < /b> areas of global leadership and cross-cultural management Some of the < /b> companies he has worked with include IBM-Asia Pacific, IBM-Japan, National Aeronautic and Space Administration ... Stroh was honored at the < /b> 2000 Academy of Management Meeting with the < /b> Sage publications research scholar award She was also named the < /b> Graduate Faculty Member of the < /b> Year at Loyola University Chicago ... husband, Greg, have married children: Angie and Joe Gittleman and Brad and Brandy Stroh They are awaiting their first grandchild in July J Stewart Black is the < /b> Managing Director of the < /b> Global...
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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx
Ngày tải lên :
06/08/2014, 18:21
... 2.2 Journal of Biology 2005, Volume 4, Article Habas and Dawid (a) Canonical pathway http://jbiol.com/content/4/1/2 (b) Non-canonical or planar (c) Wnt-Ca2+ pathway cell polarity pathway Wnt Wnt ... activate both canonical and non-canonical pathways such as Wnt 3a, whereas others such as Wnt 5a appear to be specific to non-canonical signaling Equally elusive is the < /b> understanding of how the < /b> signal < /b> ... significance of nuclear/perinuclear localization remained unclear, but it is noteworthy that a number of components of the < /b> canonical signaling pathway, such as APC, Axin, and GSK3, appear to traffic between...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
Ngày tải lên :
10/08/2014, 10:21
... Correa AM, Wu TT, Malhotra U, Chao CKS, Luthra R, Ensor J, Dekovich A, Liao ZX, Hittelman WN, Aggarwal BB, Ajani JA: Pretherapy nuclear factor- B status, chemoradiation resistance, and metastatic ... esophageal squamous cell carcinoma Oncol Rep 2003, 10:1747-1751 Ishikawa M, Kitayama J, Kazama S, Nagawa H: The < /b> expression pattern of vascular endothelial growth factor C and D in human esophageal ... transcription factor that responds to cellular signaling pathways involved in cell survival and resistance to chemotherapy; notably, aberrant NF- B activation has been associated with some malignancies...
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Báo cáo y học: " Bringing metabolic networks to life: integration of kinetic, metabolic, and proteomic data" pptx
Ngày tải lên :
13/08/2014, 16:21
... relative data are available, appropriate scaling factors have to be estimated along with the < /b> other model parameters Instead of steady state data, metabolic time series may also be used in the < /b> ... to sparse and unreliable data, the < /b> parameters will be poorly determined, and the < /b> remaining uncertainty can be read from the < /b> parameter distribution If new data become available, the < /b> model parameters ... metabolite and enzyme concentrations basic parameter θ Figure Bayesian2parameter estimation Bayesian parameter estimation Left: a kinetic parameter θ (abscissa) determines an observed parameter...
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integration of fracture, reservoir and geomechanic Modeling for shale gas reservoir development
Ngày tải lên :
04/10/2014, 22:11
... Modeling and Analysis Production Data Analysis & Flowing Material Balance Geomechanic Output Obtain initial estimates of permeability, drainage area, fracture height and length to reasonably constrain ... estimated from the < /b> drainage area calculations discussed above The < /b> history matching variables were the < /b> permeability and the < /b> number of fractures The < /b> history match of the < /b> production data of Well is ... these results lies in the < /b> utilization of all of the < /b> available data and reasonably constraining the < /b> models parameters The < /b> product of this approach is obtaining more reliable and customized predictions...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
Ngày tải lên :
14/09/2015, 14:25
... develop small chemicals or monoclonal antibodies (mAbs) that target the < /b> extracellular domain (ectodomain) of the < /b> receptor As the < /b> structure of the < /b> extracellular domain of the < /b> receptor has already been ... process signal < /b> transduction < /b> As more and more cellular signaling pathways have been identified, it becomes clear that signaling pathways not exist as linear pathways, but are organized as complex signaling ... biophysical approaches 1.2 Cell signal < /b> input by ErbB receptor tyrosine kinases 1.2.1 Signal < /b> initiation: activation of the < /b> ErbB receptor tyrosine kinases 1.2.2 Activation mechanisms of the < /b> ErbB receptors...
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The convergence challenge global survey into the integration of governance, risk and compliance
Ngày tải lên :
06/12/2015, 23:16
... company law structures, to being a term that covers all the < /b> moving parts in an organization,” says Brian Harte, Group Head of Compliance, Europe and Asia, at the < /b> Royal Bank of Canada And a clearer ... running their organizations, and external regulators are doing the < /b> same Lord Adair Turner, chairman of the < /b> UK Financial Services Authority (FSA), told City bankers last year that the < /b> days of soft-touch ... Switzerland Turkey Czech Republic Finland Indonesia Iran Japan New Zealand Pakistan Spain United Arab Emirates Brazil Ireland Lithuania Mexico Netherlands Norway Russia South Korea Thailand 9%...
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The convergence evolution global survey into the integration of governance, risk and compliance
Ngày tải lên :
06/12/2015, 23:16
... reaping the < /b> rewards from this rapid growth Already the < /b> largest bank in its domestic market, Maybank has ambitious plans for the < /b> future It is expanding across South-East Asia, and has made several acquisitions ... scenarios are chosen, there is often limited analytical data on which to base them In the < /b> absence of historical data, Mr Ivantsov suggests that banks should instead rely on a more qualitative approach ... understand the < /b> risks and manage them appropriately,” says Ms Tate have realized that they have greater responsibility to understand what’s happening in the < /b> business,” says Mr Harris “As a result, they...
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Tài liệu Transformation through Integration An Activity Theoretical Analysis of School Development as Integration of Child Care Institutions and the Elementary School ppt
Ngày tải lên :
16/01/2014, 16:33
... school I have kept the < /b> narratives and the < /b> overt analysis of them separate Consequently Chapter is the < /b> narrative about the < /b> VT, which I analyze in Chapter 5; Chapter is the < /b> narrative about the < /b> 5thD, ... responsible for their servants’ reading skills The < /b> object of the < /b> study was the < /b> Christian creed and particularly the < /b> Lutheran Catechism The < /b> ultimate goal was a deeper understanding of and an ability ... fought for a six-year-long public elementary school (bottenskola) as a base for all further education At the < /b> time of the < /b> two world wars the < /b> debate about the < /b> school took place as a fight about when,...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
Ngày tải lên :
08/03/2014, 08:20
... linearized pCRII vector, were vacuum transferred onto a Zeta-probe nylon membrane using a slot blot apparatus (Biorad) The < /b> membrane was UV-irradiated and prehybridized as described above for Northern ... peaks at and 15 of incubation and a progressive decrease thereafter The < /b> phosphorylation of both MSK1 and CREB was blocked by SB-203580 and Y-27632 that inhibit p38 and RhoA kinase activation, ... the < /b> indicated vectors and incubated with S1P as described in (A) Cell lysates were prepared and analyzed by Western blotting Immunodetection of A- fos and A- ATF-2 was achieved by probing the < /b> blots...
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Báo cáo sinh học: "Wnt signaling and the developmental fate of lung cells" ppsx
Ngày tải lên :
06/08/2014, 18:21
... have upon binding to receptors at the < /b> cell surface What they found was that high levels of Wnt signaling at the < /b> wrong time can dramatically alter the < /b> developmental pathway a cell takes Metaplasia ... microarray, transcripts from all expressed genes can be assayed simultaneously • Metaplasia is the < /b> transformation of tissue from one type to another In an adult, metaplasia can be a pre-cancerous ... pulmonary fibrosis, a severe form of lung metaplasia, cells resembling those of the < /b> bronchioles - cuboidal in shape and with a secretory or ciliated appearance - arise in the < /b> distal airways that...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
Ngày tải lên :
08/08/2014, 21:20
... 4, and 6), based on an average of three areas per slide The < /b> antibody was not guaranteed to be isoform-specific Discussion Our data indicate that fibroblast growth factor is among a set of factors ... lymphoma protein (Bcl-2), and normalized to the < /b> b- 2-microglobulin gene Statistics Statistical analysis was performed with the < /b> GraphPad Prism software (GraphPad Software, La Jolla, CA) Huang et al Allergy, ... Glostrup, Denmark) and was double-stained with mouse anti-human EG2 primary antibody (gift of Dr Reinhard B Raggam) A MACH Double Stain HRP-AP secondary antibody (Biocare Medical, Concord, CA) was used...
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Báo cáo y học: " Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method" pdf
Ngày tải lên :
13/08/2014, 16:21
... pathways [2,10-13] The < /b> wnt pathway is one of the < /b> computationally best-studied signaling pathways [14-16] The < /b> kinetics of β-catenin, axin, and other proteins have been examined in the < /b> well-established ... estimated [2] Effects of wnt signaling and changes of activity of some components on the < /b> kinetics of the < /b> pathway can be investigated by solving kinetic rate law equations [2] A number of the < /b> effects ... examine the < /b> effect of Apc mutations on the < /b> wnt signaling pathway [10], cross-talk with the < /b> ERK pathway [11], and the < /b> interaction of axin2 proteins with the < /b> wnt pathway [12] While many characteristics...
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