... shown in Fig 1B, the distance between the two termini ofthe inserted Ca2+-binding sites inthe model structure ofthe EF-hand of STIM1 is within ˚ 15 A Accordingly, a total of six glycine linkers ... Ca2+-coordinating loop positions and was introduced to perturb the Ca2+-binding ability ofthe grafted EF-hand of STIM1 (B) Modelled structure ofthe engineered protein with the grafted EF-hand Ca2+-binding ... it retains its native structure after the insertion of foreign sequences and inthe presence and absence of Ca2+ ions, so that thein uence fromthe host protein to the inserted sites is minimized...
... rearrangement ofthe interdomain interaction affects the electronic condition ofthe Fe-S cluster through the protein scaffold, resulting in an alteration ofthe signal rhombicity ofthe EPR spectrum The ... to NifA; the binding ofthe ATP analog induces the rearrangement ofthe GAF and possible AAA+ (the central domain) domains in VnfA Indeed, the limited protease assays confirmed that the conformational ... is the purification of an AnfA variant reported by Austin et al [22] In their study, the N-terminal domain of AnfA was truncated to prevent the intrinsic aggregation ofthe intact form during...
... catalytic residues, indicating a role in binding the nucleotide into the active site [15,16] The crystal structure of CNS from Neisseria meningitidis crystallized inthe presence ofthe substrate analogue ... concentrations inthe presence or absence of 0.2 mm dithiothreitol Effect of Mg2+ concentration The effect of an increase inthe concentration of Mg2+ was determined by measuring the rate ofthe reaction in ... Neu5Ac from other sugars, or that they are residues proposed to form the binding site ofthe catalytic Mg2+ ion We have determined the kinetic parameters ofthe wild-type enzyme from N meningitidis...
... trainees [8] Apparently, the third period of Title VII support induced a sustained growth of PA workforce, especially the expansion between 2000 and 2005 The findings of increased percentage of ... a reflection of similar trends in other professions and inthe nation's population in general To keep up with the PA profession's original goals of meeting the aging population's primary care ... practice in rural areas if they are recruited and receive training there [32] Therefore, recruiting younger PA students locally would help to meet the original Title VII goals of filling the existing...
... argue that the building ofthe LUT using the considered steps requires a lot of time and an accurate resolution ofthe integral in (5) However, the LUT is computed once for all off-line and would ... (31) ˆ The selected angular distribution, γf , is the one associated with the minimum ofthe sum (24) (using the standard deviations ofthe AS estimates of distant eleˆ ments) The final mean ... eigenvalues, but by the product ofthe characteristic matrix and the eigenvectors En The estimated AoAs are then the arguments ofthe complex roots ofthe obtained pseudospectrum One drawback ofthe extended...
... reversed inthe banking industry The same is true ofthe reasons for saving the biggest clods from their self-caused wounds Inthe wake ofthe financial flap, the deadbeats balked at fulfilling their ... and Spain To put things in proper context, the loss of confidence in financial backing fromthe European Union was not the cause ofthe contagion inthe first place For one thing, any sane investor ... inthe financial sector had caused the fiasco to begin with, and were now dying of their self-inflicted wounds Instead of clearing out the rot, the politicos rushed in to prop up the blight The...
... suggest that the rate of virus evolution is greater in this group than in other volunteers Differences in immune response to HIV-1 infection have been pointed out by the rgp120 HIV Vaccine Study ... priority Indeed, our results highlight the need for selecting a broader representation of volunteers, based on ethnicity, inthe design of future HIV-1 vaccine studies and trials [19] Competing interests ... responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase HIV-1 preventive vaccine trial J Infect Dis 2005, 191:666-677 Pérez-Losada M, Jobes DV, Sinangil F, Crandall...
... the challenge virus The diversity of FIV is likely to result from a combination ofthe infidelity of reverse transcriptase, inter-variant recombination and the cytidine deaminase activities of ... evolution ofthe virus-receptor interaction may not simply be a modulation of binding affinity, rather it could represent a shift inthe way the Env and receptor interact The two modes of interaction ... examined The mutated GL8 clone ABSN retained the neutralisation sensitivity ofthe parent clone to the A613 plasma, confirming the integrity ofthe amino acid sequence post-mutagenesis (Fig 6) In...
... values of orbital angularmomentumThe torsion ofthe fibre sustaining the lenses can be predicted in terms ofthe intensity ofthe light and the orbital angularmomentumThe quantum state of a ... can be interpreted as a measurement ofthe component ofthe spin angularmomentuminthe direction ofthe wave vector [45] Inthe experiment, the amplitude and phase spatial distribution ofthe ... emerging fromtheangularmomentumofthe photon Spin is however only one component ofthe total angularmomentumof light Beyond polarization, the correspondence principle suggests that other...
... protected Rise ofthe machines Introduction The disruptive potential of a connected world Since its inception, the notion of connecting the physical world to the online one via some kind of wireless ... continue Rise ofthe machines M2M drivers for the next decade Approaching the tipping point? For M2M advocates, the dawn of 2012 offers much hope, as many ofthe vital building blocks for the ... part ofthe growing pains of a burgeoning industry Rise ofthe machines Sector in focus: Energy Share of M2M market (in terms of total connections): 12% in 2010 Key subsectors: Smart metering,...
... recession, i.e the position ofthe gingival margin with respect to the cement enamel junction (CEJ); • CAL (clinical attachment level): i.e the position ofthe attachment in relationship to the CEJ; ... Considering that no previous report exist reporting on the use of EHA combined with autologous bone but without the application of a membrane inthe treatment of infra bone defects, our clinical ... encouraging considering that in a similar study a mean value ofthe increase ofthe bone height of 0.5 mm was obtain with membrane application [31] CONCLUSIONS All these properties make HA useful in...
... task, then it is not only confined to the Ministry of Labour or Ministry of Education and Training, it is also concerned with human resource planning inthe Ministry of Planning or Ministry of Finance ... and teaching has helped Vietnam inthe new era of integration On the other hand, the learning and teaching of English at the expense of other languages is posing serious issues We should first ... what are their education and training levels etc It is largely concerned in determining what training needs there are so that the labour supply can be shaped to meet the demands ofthe economy...
... Town (located inthe south-west of Hanoi) deserves one ofthe new urban models, dealing with the high-density development inthe south-west of Hanoi By learning fromthe planning of Linh Dam New ... components: Bac Linh Dam (North of Linh Dam), Linh Dam peninsula inthe middle and Linh Dam expansion (South of Linh Dam) The success ofthe project has set the stage for a series of New Towns that ... tropical climate Among these, the outstanding point is the area of highstorey apartments and office buildings inthe center of Linh Dam peninsula, surrounding by low-storey buildings, parks, open...
... nặng nhọc với mức thu nhập thấp, kéo theo điều kiện sống mức tối thiểu, tạm bợ khu nhà trọ rẻ tiền với điều kiện sinh hoạt an ninh không đảm bảo Đời sống tinh thần lao động hạn chế Họ thấy cô ... làm việc chợ lao động thuê trọ theo ngày (đêm), lại thuê nhà theo tháng Có khoảng 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt không đảm bảo, vệ sinh; 40,95% không sử dụng nước ... vật chất, tinh thần lao động nghèo nàn Họ thường tiêu tiết kiệm cho khoản chi phí sinh hoạt thiết yếu Có 22,86% nữ lao động tự phải sống nơi có điều kiện sinh hoạt thiếu thốn, vệ sinh Họ thường...
... that The prevailing direction of wind fall is fromthe north-west (NW) i.e (315°-00) which is more than 70 % of all the time The frequencies of wind coming fromthe remaining sectors are insignificant ... average value of wind speed inthe North zone of Iraq during any calendar year A histogram ofthe wind direction measurements for the site of Tuz during this windy month is shown in Figure From this ... preparation The northern area of Iraq (the area selected in this study) is considered transition zone because it located between mountain inthe extreme north east and the opening plains inthe south,...
... five definitions, in spite of slight differences inthe expressions, share common features that they all emphasize the importance of finding the closest equivalence in meaning by the choice of appropriate ... inthe translation of exhibit labels inthe Vietnam Museum of Ethnography (VME)? II SCOPE OFTHE STUDY There are several types of exhibit labels in a museum: title or headline labels giving the ... not reflect the role ofthe speaker ofthe House of Commons as an independent person who maintains authority and order in Parliament (b) The SL concept is not lexicalised inthe TL The SL word...
... AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OFTHE USE OF THIS SOFTWARE, EVEN IF ADVISED OFTHE POSSIBILITY ... Before jumping into how Outlook uses these settings, a quick review of their use in Internet Explorer is in order • Local Intranet zone: This zone contains addresses that are typically behind the organization’s ... practically speaking, this means inthe context ofthe user launching the code Good practices include making certain that administrative accounts are kept to a minimum, that administrators use...
... costs by reducing the volume of unneeded repairs Non-intrusive Testing and Monitoring for Proactive Maintenance Maintaining the health ofthe network is the prime responsibility of Operations ... causing an increased workload for reconfigurations and maintenance Meeting the challenge of increasing profits inthe face of fewer capital and operating resources to manage this steadily growing and ... is evident in fiber connector cleaning Dirty connectors are the leading cause of poor fiber performance and the most likely failure points inthe network, making periodic cleaning of connectors...
... regime ofthe South Chinese Sea Here, the tidal amplitude is approx 1.5 m The study site Hoa An is located in an area where an interaction ofthe tidal regimes ofthe South Chinese Sea and ofthe ... whereas the ground water use fromthe upper-middle Pleistocene aquifer is prevailing According to geological profiles ofthe study site An Binh and Hoa An (see figure 3) the thickness ofthe covering ... Hau Giang province in terms of quality and quantity ofthe available water resources Thus, the improvement ofthe rural drinking water supply requires investigations regarding the specific local...
... because of her insufficient investment in preparing the lessons In summary, we can see fromthe findings that the interview can really provide in depth the information about the reality of speaking ... of English speaking teaching and learning at Gia Phu High School summary ofthe findings According to the finding fromthe questionnaire, the realities ofthe students’ inhibition and unwillingness ... occurring in typical kinds of interactions These routines thus can be characterized in broad terms including the kinds of terms typically occurring in given situations, and the order in which the...