shd and flag rab proteins
Control of Cell Proliferation and Growth byMyc Proteins
... adhesion to the basal lamina and Myc disrupts this adhesion; therefore, keratinocytes respond to Myc with premature differentiation and arrest of proliferation (Gandarillas and Watt 1997) The frequent ... in cell proliferation and their proposed functions Control of Cell Proliferation and Growth by Myc Proteins 333 2003) There is clear evidence that this effect is direct and not mediated by activation ... and Myc may repress a common set of target genes (Phan et al 2005) Mechanistically, many questions remain open Myc proteins interact with a number of potential co-activator and co-repressor proteins...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... and hnRNP U Moreover, it has been shown that actin, hnRNP U and PCAF associate with the Ser2 ⁄ 5and Ser2-phosphorylated Pol II C-terminal domain hnRNP U and PCAF are present at the promoter and ... family, ABLIM-2 and -3, as STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin-binding in several proteins, such ... component of pre-mRNP particles, and is incorporated into pre-mRNAs by binding to a specific subset of RNA-binding proteins [4,22]; and (h) actin is a component of PICs and depletion of actin prevents...
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Báo cáo khoa học: Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control sidephore and antibiotic biosynthesis in Streptomyces coelicolor A3(2) pdf
... behaviour of TAadm and TAdmdR1 strains regarding production of antibiotic suggests interaction between the actions of the Adm and DmdR1 proteins (see below) Lack of both DmdR1 and Adm proteins prevents ... formation of desferrioxamines B and E (labelled as DesB and DesE) and complementation of desferrioxamine production (A) Cultures of S coelicolor A3(2) and the TAdmdR1, TAadm and DdmdR1 ⁄ adm mutants ... genes and iron regulation A B C Fig Immunodetection of DmdR1 and Adm proteins (A,B) Western blot reactions of wild-type S coelicolor A3(2) (lane 2) and the TAadm (lane 3), TAdmdR1 (lane 4) and...
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Báo cáo khoa học: Thermodynamic stability and folding of proteins from hyperthermophilic organisms doc
... (a) co-chaperonin proteins, (b) nonheme iron proteins, (c) DNA-binding proteins, as well as (d) a few other proteins Although the number of characterized hyperthermostable proteins is rather ... kinetic folding ⁄ unfolding parameters (kf and ku) for hyperthermostable proteins If not otherwise stated, TM and DGU refer to pH 7, and kf ⁄ ku to pH and 20–25 °C, conditions In the last column, ... hyperthermostable proteins were included Perhaps proteins from hyperthermophilic organisms most often use Models and 2, whereas thermostable proteins are more likely to use Models and It was recently...
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Aligning the Stars - Improvements to General and Flag Officer Management potx
... unified commands, and the defense agencies The principal investigators are Harry Thie and Margaret Harrell Comments are welcome and may be addressed to harry_thie@rand.org or margaret_harrell@rand.org ... general and rear admiral (lower half); for O-8, major general and rear admiral (upper half); for O-9, lieutenant general and vice admiral; and for O-10, general and admiral Aligning the Stars RANDMR1712-2.1 ... officer was assigned to and the Table 4.1 Categories of General and Flag Officer Positions Organization Type Operations Position Type Command Deputy Command Staff Training and Education Center All...
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Báo cáo khóa học: C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins docx
... template and the oligonucleotides FAD(CA)-1 and FAD(CA)-2 as primers (Table 1) The 1006-bp amplication product was digested with EcoRI and BamHI and ligated into the vector pMal-c2 (New England Biolabs) ... TARFH2 and FMNH2, are C(5a), C(7), C(9a) and C(10a), and as already mentioned above, C(2) (Fig 7B) With respect to the 13C chemical shifts of FMNH2, C(2), C(5a), C(9a) and C(10a) of wild-type and ... site disulde is close to and can oxidize the avin (FO), and the form in which the nascent dithiol is exposed to solvent and the pyridine nucleotide binding site is close to and can reduce the avin...
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Báo cáo khoa học: Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation pptx
... cycle, including positive-strand and minus-strand DNA synthesis, pre-genomic RNA packaging, and virion formation and release [17,18] This core protein is a phosphoprotein, and its function may be ... the interplay between viral proteins and cellular SR proteins (A) Viral SR proteins (rectangle) recruit cellular SR proteins (oval) to promote splicing efficiency and ⁄ or modulate alternative ... the interplay between host and virus via their RS domain-containing proteins Virus-encoded SR proteins cutaneous and mucosal lesions, ranging from warts to neoplasia and even cancer [14] A subset...
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Computer Simulation of General and Flag Officer Management - Model Description and Results ppt
... posting of R AND documents to a non-R AND Web site is prohibited R AND documents are protected under copyright law For information on reprint and linking permissions, please visit the RAND permissions ... and Margaret Harrell Comments are welcome and may be addressed to schirmer@rand.org or to margaret_harrell@rand.org For more information on RAND’s Forces and Resources Policy Center, contact the ... fields and assignment histories to identify those who are best suited for the positions and then ranks the officers by past job performance and seniority 12 Computer Simulation of General and Flag...
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Báo cáo khoa học: Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins Implications in mechanical stress-associated pathologies pptx
... chondrocyte proliferation and extracellular matrix production and turnover [18,19] In this review we describe in vivo and in vitro evidence relating CTGF and Cyr61 to mechanical stress and discuss the ... expression in vitro and in vivo Mechanical regulation in bone and cartilage Cartilage and bone provide ideal tissues for the study of the mechanical regulation and function of Cyr61 and CTGF, because ... multifunctional proteins The readers are referred to other reviews describing in detail the structural and biological activities of these proteins [8,9,11] Mechanical modulation of CTGF and Cyr61 gene...
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Báo cáo khoa học: Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins pdf
... in which proteins are expressed and post-translationally modified [8] Experimental procedures Baculoviral expression and purification of p53 proteins S37D S376A S376D S378A S378D Fig p53 proteins ... human and murine, and also on a dimeric mutant L J Warnock et al PAb240 Mouse WT S15P Dimer Fig Recombinant human and murine wild-type p53 proteins are phosphorylated at S15 and acetylated at ... K373Ac K373/K382Ac 10 11 12 13 Fig Phosphorylation status at S15 and acetylation status at K373 and K382 of murine wild-type p53 and p53 proteins mutated at specific phosphorylation sites expressed...
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![Báo cáo khoa học: A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins ppt](https://media.store123doc.com/images/document/14/rc/tl/small_tlm1396203606.jpg)
Báo cáo khoa học: A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins ppt
... acid and 25% acetonitrile was used as matrix Determination of sulfide and iron Determination of sulfide and iron were carried out as described by Siegel [30] and Fish [31] Gel electrophoresis and ... vinelandii IscA) T44283, A_vinOrf6 (Azotobacter vinelandii NifIscA) Q44540, Slr1565 (Synechocystis IscA2) NP_442892 present in two other proteins found in oxygenic photosynthetic organisms, Arabidopsis ... recombinant IscA1 and soluble protein extract from Synechocystis Lanes 1, and 3: 7.5, 15 and 30 ng purified recombinant IscA1, respectively; lane 4: 60 lg soluble Synechocystis proteins DNA sequence...
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Báo cáo sinh học: " Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus " docx
... Janus kinase (Jak-1) and tyrosine kinase (Tyk-2) and signal transducer and activator of transcription (STAT1 and STAT2) proteins The Jak1 and Tyk-2 phosphorylate the STAT proteins which either ... tyrosine kinase (TYK2) and signal transducer and activator of transcription (STAT1 and STAT2) proteins The JAKs phosphorylate STAT proteins that either homo-or heterodimerize and translocate to the ... of Stat and Stat proteins between sensitive and resistant cells Interferon treatment leads to tyrosine phosphorylation of Stat and Stat protein followed by heterodimerization of Stat1 and Stat...
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Báo cáo sinh học: " Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" pptx
... virus, rabbit calicivirus, and mammalian orthoreovirus [3-6] However, the diverse and complex functions and regulation of these enzymes, including their interactions with other viral proteins and ... particles6 SDS-PAGE and immunoblot analyses of virion and core SDS-PAGE and immunoblot analyses of virion and core particles Proteins from gradient-purified T1L (1), T2J (2), and T3D (3) particles ... near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates The start and stop codons...
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Báo cáo hóa học: " Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression" potx
... cotranslationally and posttranslationally processed to mature proteins in the ER membrane The core and envelope glycoproteins E1 and E2 form the structural proteins of the virion Non-structural (NS) proteins ... 0,1 0,3 1,0 g Flag- Cardif Flag- CardifΔTM NS3/4A-S139A NS3-wt NS2 Figure and NS3/4A inhibit RIG-I and Cardif-induced IFN promoter activity HCV NS2 HCV NS2 and NS3/4A inhibit RIG-I and Cardif-induced ... [8-11] TRIF and Cardif mediate the activation of IκB kinase (IKK)α/β/γ complex and IKK-like kinases, IKKε and TBK1 [7-10,12], which leads to activation and nuclear translocation of NF-κB and IRF3...
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báo cáo hóa học:" Comparisons of the M1 genome segments and encoded µ2 proteins of different reovirus isolates" doc
... virus, rabbit calicivirus, and mammalian orthoreovirus [3-6] However, the diverse and complex functions and regulation of these enzymes, including their interactions with other viral proteins and ... particles6 SDS-PAGE and immunoblot analyses of virion and core SDS-PAGE and immunoblot analyses of virion and core particles Proteins from gradient-purified T1L (1), T2J (2), and T3D (3) particles ... near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates Sequences near the 5' (A) and 3' (B) ends of the M1 plus strands of 14 reovirus isolates The start and stop codons...
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Báo cáo khoa học: " Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutinin- neuraminidase proteins" pdf
... HN glycoproteins Kamiya et al [8] also reported the protective effects and antibody response of rND F and rND HN derived from the virulent and avirulent NDV strains They used the D26 and Miyadera ... Discussion The protective effect of individual F and HN glycoproteins of the virulent and avirulent strains of NDV and the synergistic effect of the combined F and HN 306 Youn-Jeong Lee et al glycoprotein ... response and protective effect The protective efficacy of a single dose of each of the four recombinant glycoproteins, a half dose of the two recombinant glycoproteins derived from vvNDV and the...
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Báo cáo khoa học: "Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins" ppt
... standardized across all cases studied Cell cycle and apoptotic regulatory proteins were analyzed for statistical significance as possible prognostic indicators Two cell cycle proteins, Mcl-1 and ... cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components of uterine MMMT in relation to clinicopathological data including survival outcomes Materials and methods ... original slides and paraffin blocks were retrieved and reviewed to confirm the diagnosis as seen in Figures 1A and 1B A representative block was chosen for detailed histological and immunohistochemical...
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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc
... (CV) events [19] Most S100 proteins have a mass between and 14 kDa, and are characterized by two calcium binding sites of the EF-hand type (helix-loop-helix) [20] S100A8 and S100A9, generally functioning ... relationship to joint and vascular damage and risk factors in RA patients [19] We report associations of each protein with both joint and vascular disease and their risk factors Materials and methods Subjects ... design, acquisition, analysis and interpretation of data WY and CG carried out S100A8, S100A9 and S00A12 assays YC, CG, MB and RT wrote the manuscript All authors read and approved the final manuscript...
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Báo cáo y học: "Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution" ppt
... and data analysis, and contributed to writing and editing the manuscript JC designed the assay and performed some of the preliminary experiments GM conducted all of the optimization studies and ... developed a rapid, sensitive, and simplified fluorescence-based assay to study the joining activity of IN proteins in solution In this report we describe and validate the assay, and illustrate its utility ... Steps 1–2 Preincubation and reaction conditions The double stranded, 6-FAM-labeled viral oligodeoxynucleotide (donor substrate) was mixed with IN and the metal cofactor, and the mixture was left...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25