sct demonstration of t cell therapeutic activity
Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
... primary structure of the peptide To confirm our hypothesis that the b-turn structures are important for the inhibitory activities of the peptides, the structures of the cyclic peptides were determined ... inhibitory activity of the cEL peptide and the very low inhibitory activity of the cYT peptide compared to other peptides The flanking residue of the b-turn, i.e Tyr3 of the cVY peptide appears to ... patterns, indicative of a stable major conformer at the experimental temperature The structure of peptide cER NMR data of cER indicated the possibility of the b-turn structure in peptide cER The...
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Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... Pohlers et al interpretation that is supported by: i) the increase of T- cell reactivity in some patients successfully treated with antiCD4 mAbs [6], ii) an increased DTH to antigens like tetanus toxoid ... Film Co Ltd) stimulation with ConA were higher than those of PBStreated rats, while T cells of the RIB5/2-treated rats showed proliferation rates similar to those of T cells from PBS-treated animals ... (ConA) reactivity of total spleen T cells (day 13 of adjuvant arthritis) from rats preventively treated with anti-CD4 mAbs Proliferation data from two individual animals of each treatment group...
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báo cáo hóa học:" Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients" potx
... GCCAGCAGTTT TCT 40 GCCAGCAGTTTA B/22 GCCAGCAGT C A .ACAGGG TTTGGG 41 GCCAGCAG CCA .ACAGGGG CTCGG B/9 GCCAGCAGTTT TCA GGGAC TCGG aNucleotides 5' J region C GGG TTGGG CAGCCCCAGCA T .TATGGCTACACC ... Frequent contribution of T cell clonotypes with public TCR features to the chronic response against a dominant EBV-derived epitope: application to direct detection of their molecular imprint on the ... clonotypes of melanoma patients Further biases were the frequent association of this public motif with TRBV28 and TRBJ1-5 segments and the lack of rearrangement with members of TRBJ2 cluster The...
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Báo cáo hóa học: " Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients" docx
... study was the application of mathematical markers to describe the global restriction of the αβ TCR repertoire in the different compartments rather than the detection of single expanded T- cell clones ... were tested negative more often than others (negative correlation between average relative concentrations P j and the number of negative Table 1: Characteristics of patients and healthy controls ... two SD n(F) are indicated at the bottom (D) Ochsenreither et al Journal of Translational Medicine 2010, 8:35 http://www.translational-medicine.com/content/8/1/35 To accommodate the fact, that...
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Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
... reasonable Strategy Escalation increment to a starting test with 109 T cell engrafted is not preceded by a test of 109 T cells infused, but by a test of 1011 T cells infused In the latter case, ... of the potential to shut off growth factor on Tet withdrawal, thereby avoiding need for a prior Strategy trial for patient safety Endnotes This inference of toxicity manageability under Strategy ... death with the first patient to have engraftment of the same dose (0 → (3) → test) (3 in parentheses because it was not a full dose-escalation test.) Was this death due to on-target toxicity...
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Báo cáo y học: " Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses" pps
... pathology and that at least a part of the protective effect of CIN treatment can be attributed to a reduction in numbers of a specific CD8+ T- cell population Intranasal administration of antigen ... thus may participate in the protective effect of CIN therapy To determine whether CIN therapy affects the activity of lung dendritic cells, CD11c+ mononuclear cells were isolated from lungs of ... IFN-cmediated downregulation of IFN-c production by a specific subpopulation of lymphocytes These CIN-mediated alterations in T- cell populations support the hypothesis that CD8+ T cells are important...
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Báo cáo y học: "T-cell senescence and contraction of T-cell repertoire diversity – catalysts of autoimmunity and chronic inflammation" pdf
... compartment, which is the primary contributor to TCR diversity, was affected in addition to the memory T cells Contraction of diversity in the naive T- cell compartment could not be attributed to ... is, at most, 5% of the capacity that existed at the age of 20 years [5,26] Consequently, the need for the replenishment of naive T cells must come from the autoproliferation of existing T cells ... cells that would result in dilution of TREC+ T cells The time of increased turnover must have preceded the onset of RA By the time the patients have developed RA, they have reached a steady state...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
... suggesting that the gene transcription of activated T cells, rather than the regulation of proteins, is altered by CTLA-4 It is not yet clear whether CTLA-4 interferes with CD28 costimulation ... activation of target cells; on the other, blockade of CTLA-4 abrogates the inhibitory function of Treg cells [72] Interestingly, naive T cells, converted to Treg cells by retroviral transduction with the ... simultaneously (Fig 2) Multiple-function model for cytotoxic T- lymphocyte antigen-4 (CTLA-4) The traditional view of the function of CTLA-4 is that it is upregulated upon stimulation of the T cells...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... whether or not a patient will respond to anti-TNF and anti-IL-1 therapy AntiIL-17 cytokine therapy might be an interesting new antirheumatic approach that could contribute to the prevention of ... treatment of destructive arthritis Because it is known that this T cell factor can have synergistic effects with catabolic/inflammatory mediators, it is tempting to speculate that IL-17 levels ... considered an important target for the treatment of destructive arthritis The discovery of IL-17 family members may further extend the role of this cytokine family in arthritis pathology IL-17F showed...
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Báo cáo y học: "Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin" pptx
... presented herein suggest that the pathology of RA within the first few months after symptom onset is distinct from that of other early inflammatory arthritides and of established RA The nature of the ... put back into that tree to test the validity of the classification obtained from the bootstrap sample In this way, a test set classification is obtained for each case, in about one-third of the ... degree of uniformity between RA patients in this early phase of disease The concept that T cells play an important role in the initiation of RA, with antigen specific T cells mediating autoimmunity,...
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Báo cáo y học: "E3 ubiquitin ligases and their control of T cell autoreactivity" potx
... directly to the target protein, whereas HECT proteins themselves accept the ubiquitin polypeptide prior to its transfer to a target protein Specificity is achieved through the recognition of target ... suppresses the activation of CD25– T cells through an activation of a TGFβ receptor-Smad2 pathway [55] The activation of Smurf1 E3 ligase activity leads to a ubiquitination and degradation of both Smad ... synapse that forms between the T cell and the antigenpresenting cell during antigen recognition The end result of this strong costimulatory interaction is a maintenance of the high level of antigen...
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Báo cáo y học: "Characteristics of T-cell large granular lymphocyte proliferations associated with neutropenia and inflammatory arthropathy" ppt
... lymphocyte (T- LGL) lymphocytosis Histopathological features of bone marrow in patients with arthritis and T- cell large granular lymphocyte (T- LGL) lymphocytosis (a) Patient with rheumatoid arthritis ... recurrent infections as well as RA were controlled In all of the patients, arthritis responded well to the treatment Two patients with FS and polyclonal T- LGL lymphocytosis were treated with a combination ... was found Abundant interstitial infiltrates of T cells were observed in the bone marrow, but without intrasinusoidal localization This case seems to support the hypothesis that T- LGL leukemia may...
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Báo cáo y học: " Depletion of T-cell intracellular antigen proteins promotes cell proliferation" potx
... expression of TIA proteins deregulates the basal transcriptional activity of both promoters Taken together, these results could suggest that the gene expression patterns detected in TIA-1/TIARdepleted ... steady-state target mRNA levels in TIA-1/TIARdepleted HeLa cells, we decided to estimate the contribution of the TIA-1/TIAR-induced silencing on transcription activation of two target genes For this ... between pathways that account for the functional reprogramming of TIA-1/TIARdepleted HeLa cells Distinct and overlapping functions of TIA-1 and TIAR in the control of the transcriptome To determine...
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Báo cáo y học: " Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)" doc
... represent the official views of the Fogarty International Center or the National Institutes of Health We wish to thank all of the patients who agreed to participate in this study We thank the Johannesburg ... (10–32%) of patients initiating ART [2,4-7] It is speculated that IRIS results from the restoration of immunity to pathogen-specific antigens present at the time of ART initiation Following ART, a ... opinion that the manifestations of IRIS due to a variety of pathogens possess distinct immunopathological etiologies Examples include the role of cytotoxic CD8 T cells in cases of varicella zoster...
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báo cáo khoa học: "Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia" pot
... interesting to detect the evolution of T- cell clonality in the patient at different disease status The features of restrictive usage and absence of partial T cell clones could be found in patients ... different pattern between CT and ALL Vb13 or Vb9 and Vb17 were identified at the stage of CT and ALL respectively More oligoclonal TCR Vb T cells were detected after CT for ALL in the patient (Figure ... the present study, we characterized the T- cell repertoires between the stages of CML-CP and Ph- negative ALL Our previous studies showed that the clonally expanded T cells were associated with...
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Báo cáo y học: " Asthma and gender impact accumulation of T cell subtypes" doc
... accumulation of T cell subsets in asthmatics Conclusions In conclusion, our data demonstrate that both type and type T cell subsets increase to a greater extent in asthmatic than control subjects ... but also IFN-g+ T cells from asthmatic subjects in response to IL-2 suggest the importance of antigen-independent stimulation of T cells in asthma Cytokine-stimulated (bystander) accumulation of ... maintenance of T cell subset progenitors rather than enhanced proliferation Discussion Our study provides the first evidence to date that T cells from atopic asthmatic and nonasthmatic control...
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Báo cáo y học: "Altered expression of T cell Immunoglobulin-Mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis" docx
... expression of TIM-3, compared to healthy controls Both these factors may contribute to the characteristic Th1-type inflammation Differences in the exact type of antigen(s) presented in the respective ... functional role of these cells has not been determined Recent investigations of mechanisms that regulate activation and function of CD4+ T cells have shown that T cell immunoglobulin -mucin (TIM) ... Institutet, that were distributed to Johan Grunewald, Anders Eklund and Jan Wahlström and were important for the study design, data collection, analysis and interpretation of data Statement on...
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Báo cáo y học: " Abnormalities of T cell signaling in systemic lupus erythematosus" pdf
... component of the AP1 transcription factor mTOR Production of reactive oxygen intermediates and ATP synthesis are critical determinants of T cell activation, proliferation, cytokine production and cell ... the regulation of alternative splicing of these molecules in SLE T cells may lead to identification of potential therapeutic targets Epigenetics DNA methylation leads to chromatin inactivation and ... results and some biologics such as anti-Blys therapy have had mild effects This should direct our attention also to the development of therapeutic targets that correct T cell function A subset of...
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Báo cáo y học: " Alteration of T cell immunity by lentiviral transduction of human monocyte-derived dendritic cells" pdf
... oligonucleotides IL10i#1: sense 5'-GAT CCC CAG CCA TGA GTG AGT TTG ACT TCA AGA GAG TCA AAC TCA CTC ATG GCT TTT TTG GAA A-3' and antisense 5'-AGC TTT TCC AAA AAA GCC ATG AGT GAG TTT GAC TCT CTT GAA GTC ... TGT TCC ATG TTT CTT-3' and antisense 5'-TTC TCG AGT TAT CAG TGT TCT TTA GTG CCC ATC3' The LVs were produced and concentrated as described previously [20] Lentiviral siRNA vectors were generated ... AAA CTC ACT CAT GGC TGG G-3'; IL10i#2: sense 5'-GAT CCC CGG GTT ACC TGG GTT GCC AAT TCA AGA GAT TGG CAA CCC AGG TAA CCC TTT TTG GAA A-3' and antisense 5'-AGC TTT TCC AAA AAG GGT TAC CTG GGT TGC...
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Regulation of t cell clonal expansion
... differentiate into their effector cells – either into cytotoxic T lymphocytes (CTLs) for CD8+ T cells or T helper (TH) cells for CD4+ T cells The contraction phase of the T cell response begins after ... together with IL-2 to stimulate the T cells Their findings have important implications in the study of T cell clonal expansion It demonstrates that intrinsic control mechanisms that regulate T cell ... return to the basics of in vitro cell culture to set up a suitable T cells activation model that would allow us to map out the time course and kinetics of CD8+ and CD4+ T cells after TCR activation...
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