screening of prodrugs on cells grown from dupuytren s disease patients
báo cáo hóa học: " Serum antibodies from Parkinson''''s disease patients react with neuronal membrane proteins from a mouse " ppt
... Parkinson 's disease (Hoehn and Yahr, 1967) UPDRS is the unified Parkinson 's disease rating scale IPD patients' brains [6-8] and utilization of mouse models of parkinsonism [9-12] Specifically, roles for ... neuronal cells (4 × 104 cells/ ml) Black bars represent DA values upon exposure to a pool of control sera; gray bars represent values upon exposure to a pool of 19 sera from IPD patients Results ... scoreWestern analysis (Fig 2) Correlation analysis of clinical score (UPDRS – total) with the sum of the peak areas from the Western analysis (Fig 2) The r2 value was assessed by linear regression...
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Health related quality of life and pharmacoeconomics amongst asian parkinson¿s disease patients in singapore
... previously.64, 80, 81 Statistical analysis Responsiveness of PDQ-8SI scores was assessed using responsiveness indices including Cohen s effect size (ES)84, the standardized response mean (SRM)85 ... between HRQoL and its influencing factors as the disease progresses Second, we did not assess depression and its impact on patients HRQoL Depression has been found to be strongly associated with HRQoL ... national institute of neurological disorders and stroke PD - Parkinson s disease PDQ-8 - the 8-item Parkinson s disease questionnaire PDQ-8SI - the 8-item Parkinson s disease questionnaire summary...
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Effect of Nitrate on Phosphorus Mobilization from Bottom Sediment in Shallow Eutrophic Lakes
... the high phosphorous content of the sediments The DIP release fluxes at most sample sites increased under anaerobic conditions in response to increases in the DIP gradient across the sediment–water ... seasons from various sites in the shallow eutrophic waters of Lakes Nishiura and Kitaura The primary purposes of this study were to (i) examine the seasonal variation of phosphorus release potential ... 3, 2009 RESULTS AND DISCUSSION Seasonal changes in phosphorus concentration and release flux The seasonal changes in boundary-layer and pore-water DIP for each sampling site in Lakes Nishiura and...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... effect of c-secretase inhibitors on both substrates The effect of the L-685,458 and MW167 was less pronounced on cells expressing the Notch substrate than on the cells expressing the APP substrate ... DNA constructs into COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected...
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Báo cáo sinh học: " Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors" docx
... luciferase expression increased substantially (over 10-fold increase in undifferentiated cells) , confirming the strong epigenetic repression of transgene expression from our lentiviral vector in these ... transgene expression from three types of LV containing a luciferase expression cassette (see Additional File for vector design) Three types of cells (HEK293T, Hela and NIH-3T3) were transduced ... expression cassette also enhances transgene expression by several fold [12] S/ MAR (Scaffold/Matrix Attachment Region) and LCR (Locus Control Region) are insulators, and their contribution to...
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Identification of Publications on Disordered Proteins from PubMed
... chains of sentence tokens Some systems can also use small dictionaries to improve precision and recall Examples of Rule Based Systems are presented in: a Narayanaswamy et al [11] (precision 96%, ... sequences This dataset had the names and sequences of 100 completely structured proteins 18 3.3 Tests and Results Test1: To test the correctness of the thresholds used on PONDR score We have tested ... DisProt Dataset-2 consisted of 100 results from PubMed keyword search (keywords mentioned in section A1 in Appendix are used for this search) Dataset-3 consisted of 100 completely ordered sequences...
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![bauer et al - 2007 - the impact of cg on cp - evidence from japan [gmi]](https://media.store123doc.com/images/document/2015_01/06/small_tkx1420548520.jpg)
bauer et al - 2007 - the impact of cg on cp - evidence from japan [gmi]
... performance regressions for the global GMI index; Section presents the results for the various governance categories and their relationship to stock returns; and Section offers some conclusions Data GMI ... main issues: First, it considers the takeover defenses that a firm employs and measures the extent to which management restricts shareholders' decisions about these measures; and second, it measures ... ratings are relative (i.e., the inclusion or deletion of firms affects the rating of all firms in the sample), we focus only on the last rating.3 This construction of relative ratings contrasts the...
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báo cáo hóa học: " The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients" pptx
... all patients in this study were combined into one group for analysis regardless of medication type Because the focus of this study was not to evaluate the effects of one medication versus another, ... problems, were excluded Additional exclusion criteria for the PAD patients were severe congestive heart failure, severe hypertension (>180/110), severe lung disease, severe ischemic heart disease, severe ... collections because it represents the natural self-selected walking speed of the populations This decision is supported by research with elderly populations where it is common practice not to control...
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báo cáo hóa học: "Effect of gait speed on gait rhythmicity in Parkinson''''s disease: variability of stride time and swing time respond differently" docx
... force-sensitive system was used to quantify gait and stride-to-stride variability [22,39] The system measures the forces underneath the foot as a function of time The system consists of a pair of shoes ... dynamics in Parkinson 's disease: relationship to Parkinsonian features, falls and response to levodopa J Neurol Sci 2003, 212:47-53 Nakamura T, Meguro K, Sasaki H: Relationship between falls and stride ... most serious complications of the gait disturbance in Parkinson 's disease (PD) [1-7] Beyond the acute trauma that they may cause, falls may lead to fear of falling, self-imposed restrictions...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... statistically significant All p-values were two-tailed Statistical analyses were performed using The SAS System for Windows version 9.2 Power and sample size analyses All calculations were based on a significance ... samples in this study raised the issue of whether the two antibody measures may essentially be the same Depleting the samples of anti-monomer antibodies would not necessarily resolve this issue ... intervals [PMI]), and exact versions of Pearson s chi-square tests (for gender, apolipoprotein E [apoE] status, and use of anti-inflammatory medications) P-values ≤ 0.05 were considered statistically...
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báo cáo khoa học: "Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR" doc
... classification system determines stage of disease using tumour size, involvement of lymph nodes, and distant metastasis, the relationship of overall stage of disease and positive expression of markers ... samples would only be considered positive for circulating cells if TACSTD1 expression was positive along with expression of one of the other markers Using this panel of markers, 20/56 (36%) of ... because it was considered unlikely these results were due to disseminated disease (see Discussion) Blood samples from 10 normal donors were analysed in an identical manner to those blood samples...
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báo cáo khoa học: " Transcriptomic analysis of pluripotent stem cells: insights into health and disease" potx
... cells Characteristic Mouse iPSCs Human iPSCs mRNA expression Distinct from mESCs at lower passages, donor cell gene expression still present [62,69]; closely resemble mESCs at late passages [62] ... potential of disease- specific iPSCs in unlocking hidden pathways Additionally, the use of disease cell lines can facilitate drug design and screening under disease conditions (Figure 2) [6] One such ... Regulates the expression of pluripotency genes, and suppresses lineage-specific genes [23,24]; Sox2 is also an iPSC reprogramming factor [4] Mutation in SOX2 causes anophthalmia (congenital loss of...
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báo cáo khoa học:" Impact of dizziness on everyday life in older primary care patients: a cross-sectional study" potx
... (additional file 1) The DHI is a self-report questionnaire used to assess the degree of disability associated with dizziness regardless of its underlying cause (s) The questionnaire contains 25 items ... least 65 years who consulted for dizziness We ensured consecutiveness by checking GPs’ electronic medical records for missed inclusions each month Our definition of dizziness included patients ... falls Another strength of this study is our sampling procedure with which we ensured the inclusion of consecutive patients to rule out selection bias This study has several limitations First,...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... models of Alzheimer s disease dent differences in the speed of Ab accumulation Moreover, transgene expression can differ across generations and give rise to unstable Ab phenotypes because of loss ... relevance of cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of ... neocortical tissue extracts Ab42 could still have initiated deposition of Ab in vessels, because some focal lesions were only Ab42-immunoreactive [45] By contrast, brains from patients with the London mutation...
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Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... It is possible that RCAN1 may be protective when expressed transiently, but may be part of a maladaptive response if its expression fails to be turned off, resulting in disease conditions There ... of the isoforms in brainspecific cell types: neurons, microglia, and astrocytes Results RCAN1 isoform expression in human brain Previous work from our laboratory has shown that RCAN1 mRNA is significantly ... antisense RNA probe against exon Expression was examined in neurons, astrocytes and microglia, by labeling cells with antibodies against each of these specific cell types We first created a construct...
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báo cáo hóa học:" Functional bracing for delayed union of a femur fracture associated with Paget''''s disease of the bone in an Asian patient: a case report" pot
... complications associated with more commonly used techniques of internal fixation This unusual case of delayed union of the femur fracture associated with Paget 's disease of the bone for which functional ... Shapiro JR: Paget 's disease of bone (osteitis deformans) J Am Geriatr Soc 1998, 46:1025-1033 Thomas DW, Shepherd JP: Paget 's disease of bone: current concepts in pathogenesis and treatment J ... Kanis JA: Pathophysiology and treatment of Paget 's disease of bone 1st edition London: Martin Dunitz; 1992 Bradley CM, Nade S: Outcome after fractures of the femur in Paget 's disease Aust N Z J Surg...
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quality of life of alzheimer’s disease patients, caregivers and evaluating the effectiveness of thenonpharmacologicalinterventions
... Alzheimer’sdisease patients and being as basisfor more extensive studies The results of this thesis gave new contributions for studies in the elderly especially on dementia and Alzheimer s diseaseand contributed ... changes which were important clinical manifestations such asdenial this disease, apathy, psychosis (delusions, hallucinations), mood disorders (depression, anxiety), agitation activities, seriously ... Quality of life should be considered as an important outlet to assess for trials in Alzheimer 's disease There were many methods to assess the QOL of Alzheimer 's patients' : patients self-evaluation,...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
... rarely possible Also, the recognition of dementia in the individual subject rests on the use of criteria derived from unsatisfactory definitions and procedures Assessments such as the WAIS bring ... diseases, and others have given its name to diseases differing essentially from it" [1] For instance, dementia with Lewy bodies and Parkinson 's disease are one or two disorders? [37-39] This ... found in young patients and in patients with early onset of disease, demented patients are older; they may have a later age at onset of motor manifestations, longer duration of the disease, and a...
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Báo cáo khoa học: " 3-D reconstruction of anterior mantle-field techniques in Hodgkin''''s disease survivors: doses to cardiac structures" pptx
... boost (C) Reconstruction of dose distribution for typical cases of anteReconstruction of dose distribution for typical cases of anterior mantle field (A), monoaxial, bisegmental rotation boost ... equivalence [8] Despite these efforts to reduce radiation-induced late toxicity, of which heart disease is one aspect, oncologists and cardiologist are still seeing survivors of Hodgkin 's disease treated ... cardiac doses differed between survivors and non-survivors However, in preparation of a clinical investigation of long-term survivors, the dose reconstruction now presented was limited to this subgroup...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose