salinomycin induced apoptosis in human prostate cancer cells
Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... GTP-binding protein rab22b Minichromosome maintenance protein homolog Ribosomal L1 domain containing Hepatocellular carcinoma-associated protein HCA10 Chromosome 20 ORF 30 Splicing factor proline ... that prevents the apoptosis induced by cisplatin and doxorubicin [29,30] In addition, irinotecan -induced changes in MT expression correlated with clinical response in gastric cancer patients, ... protein), c11 Polyglutamine-binding protein FK506-binding protein Phosphoserine phosphatase-like Chromosome 15 ORF 24 Coiled-coil domain-containing protein 72 Dihydropyrimidinase-like ADP-ribosylation...
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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... for Zn -induced apoptosis in human Burkitt lymphoma B cells An increase in labile Zn in the cytoplasm may suppress apoptosis by inhibition of the action of caspase, cytoplasmic apoptosis inducer, ... protein)1, indicating that the ability of Zn to induce apoptosis is dependent on the intracellular Zn level In fact, it has been shown that treatment with Zn (80–200 lM) induced apoptosis in mouse ... aspects in the regulation of apoptosis is the involvement of mitogen-activated protein kinases (MAPKs), a family of serine/threonine kinases that mediate intracellular signal transduction in response...
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báo cáo khoa học: "Basic Mechanisms of Arsenic Trioxide (ATO)Induced Apoptosis in Human Leukemia (HL-60) Cells" potx
... result is in support of previous findings indicating that ATO induces clinical remission in a high proportion of patients with APL by inducing apoptosis [2,9] Conclusions We have demonstrated in the ... expression of annexin positive cells in ATO-treated cells compared to the control Annexin-V is a specific phosphatidylserine-binding protein used to detect apoptotic cells by providing an assessment ... granular contents into the surrounding extracellular space, with subsequent inflammation [30-32] To gain insight into the mechanism of arsenic trioxide (ATO) -induced apoptosis, we examined the modulation...
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Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
... phosphorylation of Bcl-2 following a variety of stimuli These include paclitaxel-activated Raf-1 [15], paclitexel- or vincristine -induced protein kinase A [16], bryostatin- 1induced mitochondrial localized ... Results To examine the kinetics of the apoptotic cell death induced by ionizing radiation in human cervical cancer cells, we treated HeLa cells with 10 Gy radiation, and analyzed induction of apoptotic ... radiation -induced mitochondrial cell death M.-J Kim et al Fig Ionizing radiation induces expression of Fas and activation of caspases in human cervical cancer cells (A) Ionizing radiation-induced...
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Báo cáo khoa học: "Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21" pdf
... protein in the human colon carcinoma cell line T-84, and in EMT6 mouse mammary carcinoma cells and Lewis Lung Carcinoma (LLC) cells [4,8] We also showed that DCQ inhibited cell proliferation and induced ... DCQ induces DNA damage and increases ATM expression in p53+/+ HCT116 cells SSB and DSB induced by DCQ in p53+/+ cell line (A) Examples of comets induced by DCQ in cells subjected to the alkaline ... treatments FHs74Int normal human intestinal cells were cultured in Hybri-Care medium supplemented with 30 ng/ml epidermal growth factor HCT116 (p53+/+) human colon cancer cells were maintained in RPMI...
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Báo cáo khoa học: " Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells" pdf
... radio-sensitizer in hypoxic cells DCQ radiosensitization in the FHs74Int normal intestinal cell line After establishing effects of DCQ and IR in cancer cells, we compared DCQ efficacy in normal cells For ... Cox-2 inhibitor, was shown to induce apoptosis in human prostate cancer cells by blocking Akt activation, independent of Bcl-2 signaling [27] Our results correlate with that of celecoxib, since ... Suppresses Hypoxia -induced Apoptosis via a Combination of Direct and Indirect Inhibition of p53 Activity in a Human Prostate Cancer Cell Line J Biol Chem 2005, 280:3817-3823 Kaanders J, Bussink J, van...
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báo cáo khoa học: "Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP" pptx
... Angiogenesis in Gastric Cancer Cancer Microenviron 2009 in press 14 Waugh DJ, Wilson C: The interleukin-8 pathway in cancer Clin Cancer Res 2008, 14(21):6735-41 15 Nishimoto N: Interleukin-6 in rheumatoid ... factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells Am J Physiol Cell Physiol 2009, 296(4):C821-7 13 Kitadai Y: Cancer- Stromal Cell Interaction ... angiogenesis in gastric cancer [13], and acquisition of chemotherapeutic resistance in androgenindependent proliferation of prostate cancer cells [14] Finally, there is extensive experimental and clinical...
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EXPRESSION ANALYSIS AND FUNCTIONAL STUDY OF HS3ST3B1 IN HUMAN PROSTATE CANCER
... prognostic indicator, seminal vesicle invasion, is defined as cancer invading into the muscular coat of the seminal vesicle (Ohori et al., 1993) In most cases, it occurs in glands with EPE (Epstein et ... preferentially inducing apoptosis of cancer cells Franzen et al.’s study has also revealed a potential dilemma in that CCN1 enhances TRAIL -induced apoptosis via interactions with integrins !vß3 and ... fibronectin 3.4 Immunohistochemical analysis of HS3ST3B1 in 77 prostate cancer 3.4.1 Clinicopathological parameters of prostate 77 cancer patients in study 3.4.2 Expression of HS3ST3B1 in prostate cancer...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
... PBS The cells were then permeabilized with 1% Triton X-100 in PBS for Fixed cells were preincubated for 45 in PBS containing 5% bovine serum albumin at room temperature, followed by incubation ... demonstrated that Bcl-2 could manifest opposing phenotypes, induced by interactions with proteins, such as Nur77, suggesting novel strategies for regulating apoptosis in cancers and other diseases [30] This ... trioxide -induced apoptosis rather than affecting total Bcl-2 expression in human gastric cancer SGC7901 cells Although the anti-apoptotic effect of Bcl-2 is well established, the role of Bcl-2 in cancer...
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Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf
... between polyamine analogue -induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines Cancer Res 51, ... extensively induce cell death in the human breast cancer cell line L56Br-C1 This cell line carries a germ-line mutation (1806 C fi T) in the BRCA1 tumour Fig Propidium iodide-stained nuclei of L56Br-C1 cells ... L56Br-C1 cells, DENSPM treatment induced an increase in SSAT activity, which resulted in a decrease in the polyamine pools The spermine analogue thus activated the catabolism of the natural polyamines...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... proteins involved in various cellular processes, including inhibition of apoptosis Hypoxia has been reported to inhibit apoptosis induced by tumor necrosis factor-related apoptosisinducing ligand ... hypoxia in MDA-MB-468 cells (Fig 2B), resulting in a 35% decrease in nuclear BRCA1 relative to the level in normoxic cells in the presence of 2E5 The decrease in C Fig Hypoxia -induced changes in BRCA1 ... the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells As...
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Báo cáo khoa học: " Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells" pot
... gamma-tocopherol quinone induced apoptosis in cancer cells through caspase activation and cytochrome c release [5] In FACS analysis, NNK induced significant apoptosis while live cells decreased in concentration-, ... Our findings of rapamycininduced caspase activation is coincident with Nottingham et al’s [28] result that rapamycin expressed activated caspase in spinal cord of rats Rapamycin-dependent increase ... causative factor in human lung cancer [15] In this study, the relative roles of cap-dependent and/or -independent protein translations in NNK -induced apoptosis have been evaluated using human bronchial...
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Báo cáo khoa học: " Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells" docx
... of ERK inhibition on tetrandrine -induced apoptosis in A549 human lung carcinoma cells 25 Fig Flowcytometric detection of apoptosis of A549 cells treated with tetrandrine (TET) Cells were incubated ... examined TET treatment induced apoptosis and resulted in a decrease in Akt and ERK expression PI3K inhibition had no clear synergistic effect on tetradrine -induced apoptosis, however, ERK inhibition ... 10-14% in the USA [11] Therefore, it is clear that Synergistic effect of ERK inhibition on tetrandrine -induced apoptosis in A549 human lung carcinoma cells Fig The effects of a PI3K/Akt inhibitor...
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báo cáo khoa học: "Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells" doc
... volume and shown in this table as folds of increase or decrease (-) Fusarium [38,39] In the present study, ZEA induced apoptosis in human leukemic HL-60 and U937 cell lines, but less in PBMCs, as ... performed in in vivo model before using ZEA as a therapeutic drug Taken together, the intrinsic (mitochondrial) and ER stress pathways cooperated in ZEA -induced human leukemic cell apoptosis ... 13:363-373 16 Yamaguchi H, Wang HG: CHOP is involved in endoplasmic reticulum stress -induced apoptosis by enhancing DR5 expression in human carcinoma cells J Biol Chem 2004, 279:45495-45502 17...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... global changes in the proteins related to apoptosis during hypoxia to clarify the mechanism of hypoxia -induced apoptosis, and to find out useful hypoxia-related markers of trophoblastic cells Materials ... and methods Cell line and cell cultures The human choricarcinoma cell line JAR was obtained from American Type Culture Collection (Manassas, VA, USA) Cells were maintained in RPMI 1640 medium ... analyzed forty proteins by using the PowerBlot (BD Bioscience Pharmingen, San Diego, CA, USA) system We selected 40 apoptosis- related proteins to examine the mechanism of hypoxia -induced apoptosis After...
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Tài liệu Báo cáo Y học: Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents pptx
... protects the cells from TNFa -induced U937 cell apoptosis by maintaining mitochondrial integrity and function [43], and ricin -induced apoptosis of U937 cells by maintaining an intracellular reducing condition ... Mn-SOD in human breast tumor MCF-7 cells suppressed apoptosis induced by ROS-generating agents [33], and that in cultured pheochromocytoma PC6 cells overexpression of Mn-SOD prevented apoptosis induced ... nitrogen intermediates, can induce apoptosis in various cells [25], if these oxidants can induce apoptosis, then antioxidants should be able to inhibit apoptosis Dithiocarbamates, including PDTC,...
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Báo cáo khoa học: MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells potx
... and ⁄ or escape from apoptosis In addition, miR-143 expression has been shown to increase after a-mangostin exposure in human colon cancer DLD-1 cells, resulting in increased apoptosis [31] Furthermore, ... expressed in a wide array of human cancers, including colorectal cancer [3,4] Nevertheless, the molecular signalling pathways modulated by miRNAs, which play a role in colorectal cancer, as well as cancer ... exposing cells to 5-FU The results obtained show that ERK5 silencing augmented apoptosis compared to mock-transfected cells, whereas increasing 5-FU -induced apoptosis (P < 0.05) (Fig 6D) Furthermore,...
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Báo cáo khoa học: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells docx
... washed in NaCl ⁄ Pi and resuspended in annexin-binding buffer Cells were collected, washed in NaCl ⁄ Pi and resuspended in binding buffer containing a final concentration of 0.5 lgÆmL)1 annexin V-FITC ... down-regulating vimentin in the absence and in the presence of MTX Targeting of vimentin was carried out by lipofecting aODN-VIM into parental HT29 cells causing a decrease of 60% in the expression ... during apoptosis [45] The proteolysis of vimentin promotes apoptosis by dismantling intermediate filaments and by generating a proapoptotic aminoterminal cleavage product that interferes with intermediate...
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Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt
... kinase activity is critical for C2- and C8-ceramideinduced apoptosis in PC12 cells DISCUSSION DAP kinase is a Ca2+/calmodulin-regulated serine/threonine kinase that participates in apoptosis induced ... calmodulin-binding domain In the K42A-DK mutant, a lysine residue at position 42 in the kinase domain (asterisk) is replaced by an alanine The DD-DK construct contains the death domain and the serine-rich ... mediator of apoptosis [1±3] As Western blotting showed that DAP kinase was endogenously expressed in PC12 cells (Fig 2, lane 1), we examined whether the ceramide -induced apoptosis in PC12 cells was...
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