... Properties ofthe iron-binding site ofthe N-terminal lobe of human and bovine lactotransferrins. Importance ofthe glycanmoiety andofthe non-covalent interactions between the N- and C-terminal ... Location of nucleolin-binding sites in both lobes, but not inthe basic N-terminus of lactoferrin. (A) Schematic linear representation of the human lactoferrin (hLf) derivatives used in binding competition ... nucleolinthat constitutes the binding site for ligands of nucleolin,such as HB-19 [26], midkine [19] and Lf (the resultsherein). In view of their efficient binding to surface nucleo-lin and to their...
... arole in managing chest pain from the point of entry, theymust acquire and demonstrate competence in diagnosing the complaint.Chest pain can have a multitude of etiologies, involves aninherently ... set of themes as reached via consensus.This process involved examining themes for commonal-ity, classifying them for uniformity, and then reachingagreement on the final list of six key themes. ... forchest pain will depend on the nature ofthe condition and the urgency ofthe situation, that the point of referral maydepend on the familiarity or relationship between the providers, and that the...
... phosphorylation of these sites are involved in the regulation of p130 specific functions and interactions. The difference in phosphorylation sites and kinases involved inthe phosophorylation of thesesites ... expression of anE2F variant containing the DNA binding motif but not the pRb-binding ortransactivation domain or introduction of a competitor plasmid containingmultiple E2F binding sites, preventing ... modifications of pRb, p107 and p130. Within the Rb proteinfamily p107 and p130 share the highest degree of homology (indicated by shaded areas).Within the pocket domain (pocket subdomains A and B and the...
... FrameworkConclusions, including the results of the November 2001 Workshop Management Framework - Introduced Marine PestsManagement capabilities and approaches APEC andthe MRCWG have a role in liaising ... PestsBackgroundWithin APEC little is known on the introduction of marine pestsLittle practical information on measures to prevent introductionsLack of knowledge in what individual countries are doingNeed ... NACA to enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most economies Baseline surveys to...
... v-KIND KIND2 binding resides withinresidues 702–744 of MAP2.Residues 456–487 inthe KIND2 domain of v-KINDcontain the core MAP2 binding moduleTo identify the core MAP2-binding site within the KIND2 ... specific MAP2 binding resideswithin the 32 residues (amino acids 456–487) of the v-KIND KIND2 domain.To examine whether the MAP2 binding core site of v-KIND binds to intact MAP2 protein, we coex-pressed ... under-stood, the data obtained inthe present study indicatethat the 43 residues (amino acids 702–744 in mice) thatreside inthe middle region ofthe CD act as the v-KIND binding core. The v-KIND-binding...
... ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration ofthe wide range of vaccine efficacies deter-mined by clinical trials and ... toexplore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site andthe data ... resurgence inthe incidence of TB occurred inthe UnitedStates and included increases inthe number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...
... retraining of health-care providers and laboratory technicians• producing and disseminating standards for performing N.gonorrhoeae culture and AMR testing• working with WHO collaborating ... facility needs clear information for preventing reinfection, and counselling on the risks of infection, ways of 1. Test -of- cure is the reculturing or isolation and identification ofthe pathogen, ... strengthen their channels of communication with each other, as well as engaging with international and national media to highlight the issue of STIs in general and AMR in particular. Some of the...
... hydrophobiccore (M88V) andthe other inthe protein–RNA interaction(T45S), decrease the stability ofthe capsid. Our findingsilluminate the role of packing inthe icosahedral lattice of the virus capsid.Experimental ... different from those of other simple icosahedralviruses [13]. The main chain ofthe protein subunit foldsinto a five stranded antiparallel b-sheet (strands bC–bG)facing the interior ofthe phage particle, ... assembly of anicosahedral virus is encoded inthe native conformation of the capsid protein andin its interaction with the nucleic acid.Here we investigated how the packing and stability of viruscapsids...
... points ofthe 11 basis-point decline in the average expense ratio of funds of funds over the period (labeled in Figure 13 as “Fall in expense ratios of individual funds”). By definition, the ... inflation by taking the fee breakpoints available in 2010 and multiplying by the Consumer Price Index in December 2000 and dividing by the Consumer Price Index in December 2010. 3 The front-end ... Trends inthe Fees and Expenses of Mutual Funds, 2010KEY FINDINGS »On average, fees and expenses incurred by investors in long-term mutual funds declined in 2010. Stock fund investors in 2010...
... percentage of the assets that the financial professional manages for an investor, rather than as a percent ofthe dollars initially invested. Over time, brokers and other financial professionals ... underlying funds in which it invests. Since 2005, the average expense ratio for investing in funds of funds has fallen 18 basis points. » The average expense ratio investors paid to hold either index ... including its investment objective, its level of assets, the average account balance of its investors, the range of services it offers, fees that investors may pay directly, and whether the...
... would b e interesting todetermine whether the insect AFPs Asn residues are alsosomehow involved in ice binding.Both sbwAFP and TmAFP have a capping structure atone terminus. Inthe case of sbwAFP, ... considerable number of questions remainbefore we can solve the interaction at the atomic level and understand t he role ofthe threonine side chains in icebinding. The contradiction between the higher ... he side-chain of residues on the s ides ofthe triangular cross-section of sbwAFP follow the similar alternate in/ out pattern of LpxA [where in refersto a side-chain pointing into the hydrophobic...