rs riggs ce jr bachur nr pharmacokinetics and metabolism of adriamycin in man clin pharmacol ther 1973 jul aug 14 4 592 600
Use of upconversion fluorescent nanoparticles for simultaneous imaging, detection and delivery of sirna
... Detection of cell and tissue surface 200 -40 0 nm antigens Cellular imaging Specific imaging of cancer cells In vivo Imaging Imaging in Caenorhabditis elegans 50 nm 50-200 nm Imaging tissues in small ... treatment effects in real time 1.3.1 Integration of imaging and therapy Fluorescent nanoparticles have shown a great promise for cellular labeling and in vivo imaging of cancer Monitoring of the biodistribution ... prostate cancer cells and sense the release of DOX by activating the fluorescence of QD, which concurrently images the cancer cells and inhibits the growth of specific prostate cancer cell lines However...
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In vitro and in vivo evaluation of transferrin conjugated lipid shell and polymer core nanoparticles for targeted delivery of docetaxel
... the targeting of cancer cell (Figure 7B.1) and (ii) the targeting of tumoral endothelium (Figure 7B.2) (i) The targeting of cancer cell The aim of targeting of cell-surface receptors, overexpressed ... Surface Morphology 60 4. 4 .4 Surface Charge 61 4. 4.5 Surface Chemistry 61 4. 4.6 Drug Encapsulation Efficiency 62 4. 4.7 In Vitro Drug Release 62 4. 5 Conclusions CHAPTER 5: IN VITRO CELLULAR STUDY OF ... LPNPs 56 56 4. 3 .4. 1 Particle Size Analysis 56 4. 3 .4. 2 Surface Morphology 56 4. 3 .4. 3 Surface Charge 56 4. 3 .4. 4 Surface Chemistry 57 4. 3 .4. 5 Drug Encapsulation Efficiency 57 4. 3 .4. 6 In Vitro Drug...
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báo cáo khoa học: " Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts" potx
... 10:291 http://www.biomedcentral.com / 147 1-2229/10/291 Page of 14 100.0 % Viability 80.0 48 hrs % Viable Protoplasts 24 hrs 16 hrs hrs 60.0 hrs hrs hrs 40 .0 20.0 0.0 -6 -5 -4 -3 Log [CPN](M) Figure ... were incubated with 10 μM of CPNs for 24 h followed by incubation with FM4- 64 for 10 -30 Green and red fluorescence co-localized in vesicles at the cell margin and internally There was a profusion ... http://www.biomedcentral.com / 147 1-2229/10/291 Page of 14 Typically, following preparation of BY-2 protoplasts from intact cells, we noted 90-96% viable protoplasts during the first h of culture This declines...
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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx
... receptor-mediated intracellular delivery process In vivo imaging of different kinds of NPs in animals Same as the cell tests, all kinds of the NPs were labeled by rhodamine B in advance; 0.2 ml suspension of ... the concentration of mg/ml was administrated by injection into the tail vein of nude mice, and the resulting images were shown in Figure 7A Immediately after tail vein injection, fluorescence emitted ... in animals and participated in its design and coordination All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received:...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
... Research Letters 2011, 6 :44 5 http://www.nanoscalereslett.com/content/6/1 /44 5 capable of inducing oxidative stress, which is of great concern in terms of the nanotoxicology of particles being pursued ... concentrations of A- and HA being 95% and 5% at pH and 15 and 85% at pH 4, respectively (pK a = 4. 75) Furthermore, even though the concentration of the anion changes in this case as well, and ... functionalizing the nanoparticle with carboxylate ligands to bind Cu 2+ ; however, other metal/ligand/polymer combinations could be synthesized including those employing other polymers routinely used in...
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Báo cáo hóa học: " Oral Delivery of DMAB-Modified DocetaxelLoaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy" potx
... CYP3A4, enhanced the anticancer effects of docetaxel in androgenindependent prostate cancer cells in vitro and in vivo Cancer Res 20 04, 64: 742 6- 743 1 Florence AT, Hussain N: Transcytosis of nanoparticle ... Scherman D: Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers Biochem Pharmacol 19 94, 48 :1528-1530 Marre F, Sanderink GJ, ... to induce apoptosis and not due to its increased cell uptake into cells [22- 24] Synergistic antitumor effects could be obtained by the use of combinations of vitamin E isomers or derivatives in...
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Báo cáo hóa học: " Fluorescence Modified Chitosan-Coated Magnetic Nanoparticles for High-Efficient Cellular Imaging" pdf
... histograms of fluorescence intensity of cells that were incubated with various concentrations of FITC-CS@MNPs for h were displayed, and data showed that the number of labeled cells and the mean value of ... The mean fluorescence intensity of FITCCS@MNPs labeled cells was noted below the line and the percentage of labeled cells was noted above the line The number of positively labeling cells (defined ... The mean fluorescence intensity of FITCCS@MNPs labeled cells was noted below the line and the percentage of labeled cells was noted above the line The number of positively labeling cells (defined...
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Magnetic chitosan nanoparticles for removal of Cr(VI) from aqueous solution
... 14 t/qt(min.g/mg) indicating the occurrence of monolayer adsorption process Thermodynamically, the adsorption of Cr(VI) is spontaneous (in term of ΔG) and exothermic (in term of ΔH) process Kinetically, ... Polym 83 (4) (2011) 144 6 145 6 [ 14] Feng-Chin Wu, Ru-Ling Tseng, Ruey-Shin Juang, J Environ Manage 91 (4) (2010) 798–806 [15] Choong Jeon, Wolfgang H Höll, Hydrometallurgy 71 (3 4) (20 04) 42 1 42 8 [16] ... initial concentrations: 40 , 80 and 180 mg·L−1; pH value: 3.0; temperature: 298 K) 1218 N.N Thinh et al / Materials Science and Engineering C 33 (2013) 1 2 14 1218 18 40 mg/L 80mg/L 180mg/L 16 14...
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báo cáo khoa học: "Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro" potx
... determining antifungal effect of cationic surfactants and lipids is not cell lysis but rather the reversal of cell surface charge from negative to positive [28] In this work, we combine the SLN and ... Interface Sci 2001, 244 :42 7-31 Pacheco LF, Carmona-Ribeiro AM: Effects of synthetic lipids on solubilization and colloid stability of hydrophobic drugs J Colloid Interface Sci 2003, 258 : 146 - 54 Lincopan ... ultrasound at a nominal output of 90 W (10 minutes, 70°C) to disperse 32 mg of DODAB powder in 25 mL water solution The dispersion was centrifuged (60 minutes, 10000 g, 4 C) in order to eliminate residual...
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ROMP based polymer nanoparticles for the targeted delivery of antitumor agents
... Tissue Ligand-Targeted Therapeutic • Many cancer cells overexpress receptors related to signaling pathways for cell growth (HER-2, ανβ3 integrin, folate receptor) • Ligand-targeted therapeutics ... combining a high-density of chemotherapeutics with Davis Bertin and antisense oligonucleotides in a tumor-targeting nanostructure Institute for BioNanotechnology in Medicine In vitro Cancer Cell ... Macromolecules 20 04, 37, 83 64- 8372 Bertin Institute for BioNanotechnology in Medicine In Vitro Drug Release Dialysis Experiment pH = 3.0 In vitro release of indomethacin from copolymer IND35-b-PEO7...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
... Preparation of FITC-loaded P(MDS-co-CES) nanoparticles 2.10.2 Preparation of fluorescence-labeled protein 2.10.3 Intracellular uptake and distribution of fluorescence- 38 40 41 42 43 44 46 47 49 49 51 ... uptake of Herceptin Co-delivery of Pac and Herceptin to human breast cancer cell lines Targeted delivery of drug-loaded nanoparticle/Herceptin complexes 6.3 Conclusion IN VIVO INVESTIGATION OF HERCEPTIN ... three days of incubation with nanoparticle/lectin A-chain nanocomplexes containing a fixed concentration of lectin A-chain and P(MDS-co-CES) of varying concentration Lectin A-chain concentrations...
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Carboxymethyl chitosan functionalized magnetic nanoparticles for disruption of biofilms of straphylococcus aureus and escherichia coli
... disrupting biofilms in recent years (Krespi et al., 2008) For instance, the combination of Q-switched Nd-YAGSW (SW) and NIR diode (NIR) lasers can result in a decrease of more than 43 % of methicillin-resistant ... considerable interest in recent years The carboxymethylation of chitosan increases its solubility in water, and the increase in −NH3+ groups, resulting from the intra- and intermolecular interaction ... my sincerest and deepest appreciation to my supervisors, Professor Neoh Koon-Gee and Professor Kang En-Tang, at National University of Singapore, for their invaluable guidance, instructions, and...
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Tài liệu KRONE - Catalogue - HighBand - For Broadband delivery - HK- Jun 2000 pdf
... Magazine Loaded 230V Profile Overvoltage Protection, can be used in DLC applications and in Category circuits and maintain performance Product Number: 646 2 1 04- 00 Pack Qty: Bag of HIGHBAND 10 ... an RJ45 interface Provides pair patching Product Number: 645 1 1 04- 10 1M 645 1 1 04- 20 2M 645 1 1 04- 30 3M Pack Qty: Bag of HIGHBAND 10, Pair to RJ45 Test Cord Used for testing HIGHBAND 10 circuits ... Number: 645 1 178- 04 Pack Qty: Bag of Patch Cord, to Pair For use on all HIGHBAND modules Provides one pair patching on HIGHBAND and 10 and two pair patching on HIGHBAND 16 and 20 Product Number: 645 1...
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Tài liệu KRONE AccessNET - Opens the Pipe for Broadband Delivery doc
... 2865 48 88 Fax : +852 2861 144 4 KRONE New Zealand Cnr The Esplanade and Nevis St Petone PO Box 36177 Wellington Mail Centre New Zealand Tel : + 64 576 9213 Fax : + 64 576 9 243 Also representative offices ... meet the demands of your business AccessNET: The building blocks of your Network In today’s fast evolving Access Networks the capability to deliver more and more bandwidth hungry services to the ... subscribers that solve issues around Network Termination Points, receiving and managing information via POTS, ISDN, xDSL, etc and the primary Distribution Point in the customer’s premises I N T E R G R...
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Báo cáo khoa học: NovelN,N¢-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids for gene delivery – synthesis,in vitro transfection activity, and physicochemical characterization docx
... as determined by nonlinear tting of TNS uorescence intensitypH plots Lipid pKa Ca Coefcient of determinationb 1,3lb1 1,3lb2 1,3lb3 1,3lb4 1,3lb5 7. 24 7.09 7.37 7.36 7 .42 0 .40 0.52 0 .40 0.58 0.53 ... hydrophobic interactions was measured by uorescence resonance energy transfer using the NBD-Rh FRET pair [26] Lipid mixing occurs in various cellular processes, including lipoplex internalization and ... solutions (40 mm Tris, 40 mm Mes) of varying pH containing TNS to give a lipid probe molar ratio of 100 : Samples were stirred for 30 before measurement of TNS uorescence intensity Nonlinear tting of...
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nanoparticle technology for drug delivery, 2006, p.427
... microconvection in the interstitium, and perforation of cancer cell membrane, and therefore provides enhanced delivery of drugs from the blood into cancer cells with minimal thermal and mechanical ... killing a cancer cell, repairing the cellular metabolism, or preventing wrinkles or other signs of aging One cannot use a human arm to massage the hurt leg of an ant Size matching is important in ... Osborne and Anton H Amann 43 Drug Stability: Principles and Practices, Jens T Carstensen 44 Pharmaceutical Statistics: Practical and Clinical Applications, Second Edition, Revised and Expanded,...
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Báo cáo hóa học: " Efficient data replication for the delivery of highquality video content over P2P VoD advertising networks" pdf
... search in Proceedings of BTW 125 144 (2005) 19 Mininova, http://www.mininova.org/ Accessed 20 Oct 2011 20 IJ Taylor, in From P2P to Web Services and Grids: Peers in a Client/Server World, Springer, ... Netw Service Manage 4( 2), 74 83 (2007) 51 HL Yu, DD Zheng, BY Zhao, W Zheng, Understanding user behavior in large-scale video-on-demand systems in Proceedings of EuroSys 40 (4) , 333– 344 (2006) ... the PING command; dotted line is the PONG command) to compute the RTT between a pair of peers Peer A1 sends a PING command to all of its Page of 18 neighbor-peers {B1, B2, B3, B4} with a pooling...
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Báo cáo hóa học: " Functionalized halloysite nanotube-based carrier for intracellular delivery of antisense oligonucleotides" pdf
... loading and intracellular tracking of ASODNs, f-HNTs were obtained by surface modification with g-aminopropyltriethoxysilane [APTES], and fluorescein [FAM] was used to bind to ASODNs as fluorescent ... Survivin, versatile modulation of cell division and apoptosis in cancer Oncogene 2003, 22:8581-8589 Altieri DC: Validating survivin as a cancer therapeutic target Nat Rev Cancer 2003, 3 :46 - 54 Rosi ... calculated as the percentage of fluorescent cells out of the total number of cells Fluorescence was detected from the FAM labeled on ASODNs at 48 8-nm excitation In vitro cell toxicity assay of the f-HNT-ASODN...
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Báo cáo hóa học: " Catalytic properties of Co3O4 nanoparticles for rechargeable Li/air battery" doc
... performance of the air electrode containing Co3O4 nanoparticles was examined using a modified Swagelok cell, consisting of a cathode, a metallic lithium anode, a glass fiber separator, and an ... because of vigorous mixing in making a slurry The crystallinity of the three types of Co3O4 nanoparticles was investigated by XRD As shown in Figure 2, all XRD peaks of the cube-type Co3O4 nanoparticles ... catalyst/carbon contact area, thereby preventing O2 intake and Li+ delivery to the active reaction site and terminating the discharge process According to previous reports [13, 14] , there was a strong correlation...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
... suggested that propofol-loaded mixed micelles might reduce the incidence and intensity of pain on injection of propofol as compared with CLE and therefore might have favorable compliance to the patients ... micelle size of about 101 nm and PDI of 0.12 as shown in Figure The LC of mixed micelles was about 32 .4% , and the content of propofol in the preparation was approximately 0.3% Determination of ... micelles led to the different LC of micelles [27] Noticeably, the LC of propofol in micelles increased with increase of Solutol HS15 content in mixed micelles (Table 2) When the molar ratio of...
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