roles of oxidative stress and redox regulation in atherosclerosis
Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... studies of inactive and active Src, the SH2 and SH3 domains are believed toform a ‘regulatory apparatus’. Binding of the phos-phorylated C-terminus to the SH2 domain and ⁄ orbinding of the SH2-kinase ... demonstrated that intra-domain interactions betweenSrc family kinases (SFKs), stabilized by binding of the phosphorylatedC-terminus to the SH2 domain and ⁄ or binding of the SH2 kinase linker tothe ... results in blocking of the binding of the SH2 domain to thesubstrate and thereby preventing interaction of the substrate with the kinase domain. For active n-Src in which the C-tail tyrosine was...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative ... development.HA-induced oxidative stress activates PARP within5 min (Fig. 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide. Preincubation of cells ... the response of this organism to oxidative stress and the role of PARP during development. We used hydroxylamine (HA)to induce in situ generation of H2O2 and monitored the effect of benzamide,...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... becoming involved in solving major operational problems, serving on the board of directors,finding and hiring managers, occasionally replacing poorly performing managers, and assisting the firm in forming ... important aspect of small business finance the financial intertwining of owners and their businesses (Ang 1992). Outsideinvestors and intermediaries often put considerable weight on the financial conditions ... is intermediated.lc Venture capitalists performthe quintessential functions of financial intermediaries, taking funds from one group of investors and redeploying those funds by investing in informationally...
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Báo cáo khoa học: Assimilation of excess ammonium into amino acids and nitrogen translocation in Arabidopsis thaliana – roles of glutamate synthases and carbamoylphosphate synthetase in leaves ppt
... composed of 33 exons coding fora protein of 165 kDa, containing a class II (purF)-typeglutaminase domain and short regions for binding toFMN and iron sulfur center. GLT is composed of 20Amino ... (ORN), citrulline (CIT) and arginine (ARG) contents in leaves of Arabidopsis plants cultured with 5 mM nitrate in air. (F) Ornithine, citrulline and arginine contents in leaves of Arabidopsis ... 5.8-fold increase in arginine relativeto the wild-type plants in air, whereas in high CO2,arginine remained at a wild-type level, indicating thatthe high level of photorespiratory ammonium was in part...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... significant insights into the roles and mechan-isms of PM2.5-associated physiology and pathology. In summary, our data demonstrate the importanteffects of PM2.5exposure on oxidative stress and ... lesions on a standard chow diet. It isused for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding themechanisms of lipoprotein metabolism and athero-sclerosis. ... blot.A.RepresentativebandsofFAandPM2.5onUCP1 protein level in iBAT by Western blotting. B. Quantitative results of Western blotting of UCP1. n = 8. *P<0.05 vs. FA.Xu et al. Particle and Fibre Toxicology...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... College, Beijing, China2 Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory AnimalScience, Chinese Academy of Medical ... overexpression of CYP2E1 both in vivo and in vitro is associated with several cellular markers of oxidative stress, including products of lipid peroxi-dation (e.g. 4-hydroxynonenal and malondialdehyde),as ... longitudinal sections are shown in (A) (magnifi-cation ·20; scale bars = 1 mm). The hemotoxylin and eosin-stained sections of the left ventricle are shown in (B) and Masson’s trichromestained sections...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... [41], and human U87-MGcell line, a kind gift of Professor C. Martini (Department of Psychiatry, Neurobiology, Pharmacology and Biotechnol-ogy, University of Pisa, Italy), were maintained under ... trypsin treatment and stained for 30 min at 37 °C in fresh medium containingJC1 (final concentration of 10 lgÆmL)1). Cells were thenwashed twice with PBS, suspended in 500 lL of PBS and analyzed ... expression of ANT isoforms in astrocytes and astrocytic tumors. Ithas been reported that ANT1 levels are increased in reactive astrocytes [28] and that ANT2 levels areincreased in glial cells and...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... determine theeffects of Hsp105a on JNK and p38 signalling pathways, weexamined the activation of JNK and p38 in F9 cells by oxidative stress. As shown in Fig. 6A, JNK was notactivated in control ... activation of p38 induced by oxidative stress, we further examined whether its activationis responsible for the induction of apoptosis in F9 cells usingSB202190, a potent inhibitor of p38. As shown in ... peroxide. In contrast, hydrogen peroxide-treat-ment induced marked activation of JNK within 30 min in S23 cells, but not in S3 cells. Therefore, the enhancement of the oxidative stress- induced...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... with NdeI and HindIII, and cloned between the NdeI and HindIII sites of pMV361e, apMV361 derivative containing the pblaF* promoter instead of the original phsp60 promoter and carrying a Km resis-tance ... becontrolled in vivo by specific interactions betweenFadD29 and PKS15 ⁄ 1 on the one hand, and FadD26 and the FasI system on the other hand. Further inves-tigations, including protein interaction ... progress in our knowledge of the bio-synthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to beestablished and ⁄ or completed. For instance, theinvolvement...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... activation of checkpoint kinases belonging to the family of phospha-tidylinositol-3-OH-kinase-like protein kinases. Thecurrently best studied phosphatidylinositol-3-OH-kinase-like protein kinase ... protein; Bcl-2, B-cell lymphoma 2; CtBP, C-terminal binding protein; DDR, DNA damage response; HDM2/MDM2, human double minute/murine double minute 2; HIPK2, homeodomain-interacting protein kinase ... Homeodomain-interacting proteinkinase-2 phosphorylates p53 at Ser 46 and mediatesapoptosis. Nat Cell Biol 4 , 11–19.23 Dauth I, Kruger J & Hofmann TG (2007) Homeodo-main-interacting protein kinase...
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Báo cáo khoa học: Roles of adenine anchoring and ion pairing at the coenzyme B12-binding site in diol dehydratase catalysis pptx
... pro-tein by hydrogen bonding of N3 with the side chainOH group of Sera224, of 6-NH2 and N7 with mainchain amide groups of other residues, and of N1 witha water molecule [21]. Cobalamin is ... structure of the diol dehydratase–adeninylpentylcobalamin com-plex revealed that the adenine moiety of adenosylcobalamin is anchored in the adenine-binding pocket of the enzyme by hydrogen bonding of ... spectrum obtained at 30 min of incubation. In the case of the Sa224A mutant, how-ever, the peak at 478 nm increased gradually uponprolonged incubation, and the spectrum obtained at30 min of incubation...
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Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
... of proteasomepreparations with cardiolipin and Grx2. The resultsobtained showed 25% and 65% increased chymotryp-sin-like activity and 61% and 100% increased post-acidic cleavage of n-PT and ... SpainOxidation of protein cysteine residues into sulfenicacid (Cys-SOH) and the subsequent S-glutathionyla-tion of these residues during enzyme catalysis and redox signaling have been increasingly ... observed in vivo that glutaredoxin 2 was ubiquitinated in cellular extracts of yeastcells grown in glucose-containing medium. Other cytoplasmic oxido-reduc-tases, namely thioredoxins 1 and 2,...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... point to the involve-ment of oxidative stress in the early stages of symbiosisbreakdown. In fact, several authors have suggested theinvolvement of ROS production in the zooxanthellaphotoinhibition ... under-standing of the mechanisms involved in coral bleachingevents in host cells of symbiotic cnidarians. Gastroder-mal cells appear to be the predominant location of thermal stress impact. In the ... bleaching of the experimental animals occurredas the heat stress incubation progressed. This resultsupports the induction of a bleaching event as a conse-quence of an oxidative stress period.In...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... complex leads to theinitiation of complex signaling events leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... [86,91-94]. Levels of both dityrosine and nitrotyrosine are elevated in brain regions specificallyaffected in AD [91]. Protein nitration is also increased in the hippocampus of AD patients compared ... the inducible nitric oxide synthase(iNOS) [75-77]. Fibrillar Aβ peptides stimulate the induc-tion of iNOS and NO production through an NADPH-dependent oxidative deamination of L-arginine[56,75,78,79]....
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Báo cáo hóa học: " An exploration of job stress and health in the Norwegian police service: a cross sectional study" docx
... acquisition,analysis and interpretation of data and drafting of themanuscript. EH was involved in design, interpretation of data, drafting of the manuscript and supervision. ØE wasinvolved in conception and ... Brown J, Fielding J, Grover J: Distinguishing traumatic, vicarious and routine operational stressor exposure and attendantadverse consequences in a sample of police officers. Work Stress 1999, ... wasinvolved in conception and design, interpretation of data,drafting of the manuscript and supervision. BL wasinvolved in analysis and interpretation of data. AMB is theguarantor for this...
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