roles of ontologies in cognitive radios
Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance pptx
... couplings from protons whose nuclear spins are interacting only very weakly with the unpaired electron spin, e.g protons from the protein backbone within the cofactor binding pocket, protons of ... modification of the cofactorbinding site at the 8a-methyl group and at the linkage of the ribityl side chain Hence, as a first result, structural information regarding the distance and location of the ... (Fig 8), the positions of the two histidines were assigned surprisingly accurately by ENDOR His365 (the analog amino acid of His354 in X laevis) is indeed located in the binding pocket nearby the...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... is in agreement with the domain organization in the first line The third line shows a summary of the identified linear motifs (after filtering processing taking in account the accessibility of the ... Lys4 of histone H3 tail polyamines polyamines aromatic amines aromatic amines aromatic amines L-amino acids glycine, sarcosine sarcosine gene expression regulation polyamines metabolism vitamin ... differences in the shape of the substratebinding site, the details of the active sites of flavin amine oxidases are strikingly conserved (Fig 3B) In all enzymes listed in Table (except for glycine oxidase),...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation pptx
... are involved in recognition of the polyubiquitinated protein substrates, unfolding of the condemned protein [24], removing ubiquitin chains for recycling [25,26] and opening an axial gate into ... presence of proteasome, supporting the direct or indirect involvement of the flavin cofactor in protein complex formation [34] Mdm2 dependent polyubiquitination Fig Proposed mechanisms of ubiquitindependent ... state of the flavin cofactor present in the active site of Lot6p Recruitment of the transcription factor occurs when the flavin is in its fully reduced form This process is independent of the mode of...
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Báo cáo y học: "γ Paradoxical roles of IFN-γ in models of Th1-mediated autoimmunity" potx
... demonstrated in the analysis of the role of IFN-γ in models of autoimmunity Early attempts to define the role of IFN-γ in autoimmunity by the administration of IFN-γ or neutralizing antibodies ... immunopathogenesis involves a complex pattern of Th1 and Th2 cytokines with elevated levels of PG-specific IgG1 dominating in comparison to IgG2a, yet a strong predominance of IFN-γ over IL-4 in inflamed ... heavily influenced by yet other cytokines Conclusion Animal models of autoimmune disease are providing a valuable means of analyzing the functional roles of cytokines in the pathogenesis of autoimmunity...
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Báo cáo y học: "cGlobal analysis of microRNA target gene expression reveals the potential roles of microRNAs in maintaining tissue identity" ppsx
... findings strongly suggest that miRNAs play a most important role in driving tissue terminal differentiation and particularly in maintaining tissue identity rather than in determining or regulating ... These findings strongly suggest that miRNAs play a most important role in driving tissue terminal differentiation and maintaining tissue identity rather than in determining or regulating tissue-specific ... functions of microRNAs are largely involved in driving tissue differentiation and maintaining tissue identity rather than in tissue-specific physiological functions In addition, these findings imply...
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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 1
... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL ... OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE 2011 ...
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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 2
... Polyubiquitin Chains 19 1.3.5 Ubiquitin-Proteosome Adaptors 23 1.4 The Non-proteolytic Roles of Ubiquitin 24 ii 1.4.1 An Introduction to the Role of Ubiquitin as a Signaling Molecule 24 1.4.2 Ubiquitin ... Ubiquitin in the Regulation of Endocytosis and Intercellular Trafficking 29 1.4.6 Ubiquitin’s Role in DNA Repair 33 1.4.7 Signaling by Ubiquitin-like Molecules 34 1.5 The Role of Mediator, Ubiquitin ... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B’ Through RNA interference of SKP1, a component of an ubiquitin ligase...
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Investigations on the roles of ubiquitin in the regulation of heat shock gene HSP70B 3
... isoleucine 44 in ubiquitin is the binding site of these ubiquitin binding domains (UBDs) despite the different structural folds in each UBD resulting in minor variations with their exact interaction ... certain ubiquitin-binding endocytotic regulators and adaptors The ubiquitin-binding domains have been implicated in the ubiquitination of their parent proteins as well Many proteins possessing ... Possessing the ability to bind polyubiquitin chains through an N-terminal ubiquitin binding domain, ZNF216 is known to aid in the efficiency of proteosomal degradation The deletion of this gene in...
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The roles of PIN1 in the pituitary ganadotropes
... N-terminal DNA binding domain (DBD) including two zinc fingers, a hinge region with an activation function domain (AF)-1 in its distal part, and a ligand binding domain with a conserved C-terminal ... in activating SF-1, in which the C-teminus of Pitx1 interacts with the putative ligand binding domain (LBD) of SF-1 to enhance transcriptional activity of SF-1 through an apparent unmasking of ... Inhibitor of differentiation IκB Inhibitor of NFκB IKK IκB kinase IL Interleukin INFβ Interferon β IRF3 Interferon-regulatory factor IRS2 Insulin receptor substrate ITCH Itchy E3 ubiquitin protein ligase...
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Zebrafish liver and pancreas development 1 roles of rbp4 in early liver formation 2 genetic ablation to deduce pancreas cell lineage
... Ablation of ins expressing β-cells 5.2.1 Specific ablation of ins expressing β-cells by transient expression of DTA under the ins promoter 5.2.2 Analysis of recovery of β-cells in pINS-DTA affected ... Summary of phenotypes of Tg(elaA:gfp) embryos after injection of pElaA-DTA at dpf Summary of phenotypes of Tg(ins:gfp) embryos at 26 hpf after injection of pINS-DTA Summary of phenotypes after injection ... specification in zebrafish Retinol binding protein (Rbp4) is the plasma transporter of retinol, the precursor of RA, and is mainly produced in the adult liver Except for delivering retinol from liver...
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Roles of BNIPXL in regulating cell growth and morphology
... immunofluorescence microscopy 115 Chapter Results 3.1 Investigating the roles of the BCH domain in novel proteins 3.1.1 In silico identification of a novel BCH-domain containing 118 118 protein ... Subsequently, an increasing number of Dbl homology (DH) domain-containing proteins were isolated In addition to the DH domain, these proteins also possessed a pleckstrin homology (PH) domain found in tandem ... acid DNA-BD DNA-binding domain Duo Huntingtin-associated protein-interacting protein Dvl Dishevelled ECM Extracellular matrix ER Endoplasmic recticulum ERM Ezrin-radixin-moesin EST Expressed...
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Expression and roles of microRNAs in cell cycle
... involved in the control of developmental timing in C elegans uncovered a ~22nucleotide single-stranded non-coding RNA as the product of the lin-4 gene Lin-4 RNA repressed the protein levels of ... Screening of predicted targets of miR-210 59 4.5 Screening of predicted targets of miR-193a 63 Discussion 67 5.1 Differential expression of miRNAs during cell cycle phases 67 5.2 Role of miR-210 in ... repression RISC consists mainly of the core protein Argonaute (Hammond et al, 2001; Liu et al, 2004) Argonaute proteins contain two RNA-binding domains: the Piwi domain, which binds the small RNA guide...
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Expression and roles of microRNAs in cell cycle
... involved in the control of developmental timing in C elegans uncovered a ~22nucleotide single-stranded non-coding RNA as the product of the lin-4 gene Lin-4 RNA repressed the protein levels of ... Screening of predicted targets of miR-210 59 4.5 Screening of predicted targets of miR-193a 63 Discussion 67 5.1 Differential expression of miRNAs during cell cycle phases 67 5.2 Role of miR-210 in ... repression RISC consists mainly of the core protein Argonaute (Hammond et al, 2001; Liu et al, 2004) Argonaute proteins contain two RNA-binding domains: the Piwi domain, which binds the small RNA guide...
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summary of doctoral thesis in economics the roles of government in social sercurity for farmer in vietnam
... households having information (Household) Total income of household having information (million/ year) Average income of a househould having information (million/ year) Number of people in a family ... and in three central provinces in particular, as well as analyzing and pointing out factors which affect sustainable development of the social welfare system for farmers, since then indicating ... challenges in achieving the objectives of social welfare implementing progress in incoming stages, then finding appropriate models to apply and expand social welfare system for farmers in Vietnam in...
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(1) how learners approach learning, both in and out of classrooms, and (2) the kinds of strategies and cognitive processing they use in second language acquisition
... purposes In the hope of finding a solution to this confusion, Ellis, R (1999) offers a new approach to defining learning strategies He characterizes the main characteristics of learning strategies in ... Creating mental linkages B Applying images and sounds C Reviewing well D Employing action II Cognitive A Practising B Receiving and sending messages strategies C Analysing and reasoning D Creating ... contribute indirectly to learning since they not lead directly to the obtaining, storing, retrieving, and using of language.” (Rubin & Wenden, 1987:23-27) 15 O’Malley and Chamot’s (1990) taxonomy Basing...
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Tài liệu THE ROLES OF AMINO ACID CHELATES IN ANIMAL NUTRITION pdf
... Adenylate kinase Creatin kinase Arginine kinase 1,3-Diphosphoglycerate -> ADP-Transphosphatase Pyruvate kinase Hexokinase 6-Phosphofructokinase Galactokinase Phosphoglucokinase Gluconokinase Ribokinase ... of soft tissue; fluorine, zinc, and silicon play roles in the formation of proteins and fats that compose the body (8) Minerals also preserve cellular integrity through their roles in maintaining ... net utilization of minerals Absorption of mineral ions is dependent upon numerous factors, including the levels of the elements ingested, the age of the animal, Ph of the intestinal contents and...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous limb) of the development of neural crest derivates, including ... forced expression of Runx2 in nonosteoblast cells is sufficient to induce the osteoblast-specific gene osteocalcin [60] The inactivation of both Runx2 alleles in mice results in a lack of osteoblasts ... the interaction of AP-2 and its binding partners in cartilage However, at least CBP ⁄ p300-interacting transactivator with ED-rich tail and protein poly(ADP-ribose) polymerase-1 are expressed in...
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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... basis of incorrect pairing of sister chromatids and of the lack of integrity of the synaptonemal complex in Hsf2) ⁄ ) spermatocytes is a pending question [62] Role of HSF1 in the quality control of ... section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the HSF2 ... played prominent roles in the maintenance of species during evolution through its differential effects in either protecting against cell death or, conversely, in promoting cell death in stage-specific...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... VH2-N) which we previously showed does contain an actinbinding domain (this actin-binding domain has not yet been mapped) [23] We name the actin-binding domain that we have identified VH2-C and VH2-N ... cluster interacts with G-actin, but not F-actin An alignment of the various known and putative actin-binding sequences in Vrp1p is shown in Fig 4A Vrp1p-WH2-1 is the WH2 domain at the N-terminus of ... Vrp1p domain structure Schematic of Vrp1p showing the Vrp1p truncations and mutant proteins used in this study and their various known domains: actin-binding domains, Hof one trap (HOT) domain, and...
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