roles of gnrh sex steroids and immunomediators
Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... unsaturated steroids with a double bond located between C1 and C2; the double bond between C4 and C5 is not susceptible to reduction, and thus progesterone and related steroids (e.g 4-androstene3,17-dione), ... architecture of OYE1 and PETN reductase, and (ii) geometry for the binding of steroid compounds and 2-cyclohexen-1-one [2,19] The structure of the Y186F enzyme is essentially identical to that of wild-type ... and Arabidopsis thaliana [9] These enzymes reduce a variety of cyclic enones, including 2-cyclohexen-1-one and steroids Some steroids act as substrates, whereas others are potent inhibitors of...
- 12
- 603
- 0
Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... letters (A and B), whereas the small t peptides are designated by lower case letters (a and b), so that the wild-type AChE and BChE are Aa and Bb, and the chimeras are Ab and Ba Comparisons of wild-type ... between human AChE and BChE The T variants of human AChE and human BChE are composed of a catalytic domain of approximately 500 residues, followed by small C-terminal t peptides of 40 and 41 residues, ... processing and the activity of AChE and BChE, notably those involving charged residues, the presence in peptide b of an additional tryptophan (W8) and the presence of six instead of five residues...
- 15
- 446
- 0
Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
... Y Takayanagi and T Onaka PrRP and RFRPs in metabolism and stress Table Summary of mammalian RFamide peptides and their receptors The effects of administration of RFamide peptides upon ... brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting in the termination of meals and the induction of energy ... the roles of PrRP in the control of stress responses may depend upon the nature of stressful stimuli used Stressful stimuli affect food intake and increase energy expenditure On the other hand,...
- 8
- 489
- 0
Báo cáo y học: "Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4" pot
... protective and pathogenic roles in CIA, depending on the stage of disease, location of IL-4 production and relative abundance of other cytokines This suggests that in vivo the balance of IFN-γ, IL-4 and ... complete filling of the joint space and extension to the soft tissue Cartilage is significantly destroyed and the bone shows a substantial amount of destruction and remodeling (hematoxylin and eosin, ... level of IL-4 in the arthritic joints (Figures 1d, 2c and 3c), in the absence of detectable amounts of IL-4 in the lymphoid organs and only small amounts of IL-4 in the serum (Figures 2b and 3b)...
- 15
- 388
- 0
báo cáo khoa học: " Roles of arabidopsis WRKY18, WRKY40 and WRKY60 transcription factors in plant responses to abscisic acid and abiotic stress" doc
... Laboratory of Biocontrol and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China 2Department of Botany and Plant ... isolation of total RNA and analysis of transcripts using qRT-PCR Expression level was defined as the ratio of qRT-PCR result of treated sample to its respective mock The means and standard errors ... B Ratio of GUS activities (+/- DEX) Transcription-regulating activity of WRKY18, WRKY40 and WRKY60 Page of 15 Figure The effect of ABA and SA on the transcriptionregulating activities of WRKY18,...
- 15
- 462
- 0
Báo cáo y học: "The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression" ppt
... miRNA targeted, and assigned the same number of random genes to that miRNA In the case that a miRNA belonged to a family of miRNAs, we assigned the same set of random genes to all of the miRNAs ... the number of binding sites and the degree of repression [43,44] Together, the observations that both 3' UTR length and number of binding sites affect repression show that the strength of repression ... out of the seven total pairs of extensively overlapping sites Given the large number of potential binding sites in a localized region of 3' UTR, the increased repression of multiple pairs of binding...
- 18
- 367
- 0
roles of fi nancial reporting and fi nancial statement analysis
... of audits of financial statements, the types of audit reports, and the importance of effective internal controls • Identify and explain information sources besides annual financial statements and ... Standards of Practice Handbook (SOPH) dictates standards that must be followed in communicating recommendations The SOPH provides, in part: Standard V(B) states the responsibility of members and ... the ability of a company to deliver goods and services at prices in excess of the costs of delivering the goods and services Profits also provide useful information about future (and past) cash...
- 24
- 291
- 0
INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS THE ROLES OF ANNEXIN a1 PROTEIN AND CLEC9A+ DENDRITIC CELLS
... Preparation and culture of BMMΦs 43 2.3.2 Preparation and culture of BMDCs 43 2.3.3 Isolation and culture of primary splenocytes 44 2.3.4 Infection of BMMΦs for quantification of ... profile in WT and ANXA1−/− mice Figure 3.3 Histological analysis of lungs and spleens from WT and ANXA1−/− M tuberculosis-infected mice Figure 3.4 Local cytokine profile in the BALF from WT and ... and injectable agents, and are so classified due to relative scarcity of clinical data, unfavourable or poorly characterised pharmacokinetic profile, and/ or increased incidence and severity of...
- 196
- 451
- 0
The roles of histone deacetylases 1 and 2 in hepatocellular carcinoma
... 4.1.5 Expressions of HDAC1 and in various colon and liver cancer cell lines 67 4.2 Verification of efficiency and specificity of siRNA against HDAC1 and 67 iii 4.3 Effects of HDAC1 and knockdown ... understand the functions of the HDAC isoforms and their mechanism of actions Numerous studies tried to test the effect of knocking down each individual isoform of HDAC on gene expressions and survival ... of HDAC1 and are dependent on their enzymatic activity Lastly, 31 we will study the gene targets of HDAC1 and and validate their roles in mediating the effects of HDAC1 and in cell survival and...
- 168
- 372
- 0
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... treatment of the chick face with RA, and this is accompanied by an increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits ... with craniofacial defects, thoracoabdominoschisis, and severe skeletal defects in the head and trunk region [17,18] Studies of earlier embryonic stages of these mice indicate a failure of cranial ... functions of AP-2s in physiological processes, they have also crucial roles in pathological processes such as tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the...
- 9
- 642
- 0
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... of modifier genes that would enhance or diminish the impact of HSF2 deficiency Pending questions for the roles of HSF1 and HSF2 in oogenesis and in early embryos The role of HSF2 in oogenesis and ... basis of incorrect pairing of sister chromatids and of the lack of integrity of the synaptonemal complex in Hsf2) ⁄ ) spermatocytes is a pending question [62] Role of HSF1 in the quality control of ... over-expression of Hsp60 and Hsp70 and exhibit abnormal morphology in correlation with increased proliferation, premature differentiation and elongation, inhibition of denucleation and of loss of organelles...
- 23
- 796
- 0
Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... physiological role of this interaction is conserved [30,52] Interactions of Vrp1p and Las17p in yeast and WIP and WASP-family proteins in mammalian cells are direct and result in constitutive and apparently ... localization of Hof1p to the bud neck at elevated temperature and this in turn is important for cytokinesis and cell growth under these conditions Interestingly, mutation of K485 and R486 in the ... with a role of F-actin and ⁄ or actin polymerization in the generation or maintenance of a polarized distribution of cortical patches Las17p and type I myosins promote the assembly of actin monomers...
- 23
- 679
- 0
Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... Roles of the HsRad51 L1 and L2 loops D231W (L1 loop) Table Changes in the fluorescence of tryptophan probes inserted in the L1 and L2 loop upon binding of nucleotides and DNA The fluorescence of ... Camerini-Otero DR & Takahashi M (1999) The L2 loop peptide of RecA stiffens and Roles of the HsRad51 L1 and L2 loops restricts base motions of single-stranded DNA similar to the intact protein FEBS Lett ... Alignment of the HsRad51 sequence to those of MvRadA, Pyrococcus furiosus Rad51 (PfRad51), and ScRad51 around the L1 and L2 loops The L1 and L2 loops, which are invisible in the crystal structure of...
- 12
- 662
- 0
Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... auto-oxidation rates and catalytic activities of Ec DOS Breakage of the salt bridge between Asp40 and Arg85, and the hydrogen bond network consisting of Asp40, two water molecules and His77, appear ... structure of the cyanide-bound complex of FixL is similar to that of its oxygen-bound complex [10], a cyanide binding study should facilitate elucidation of the structure and catalytic mechanism of ... Fig Soret and visible optical absorption spectra of Fe(III) (solid line), Fe(II) (broken line) and Fe(II)-CO (dotted line) complexes of the Asp40Ala (upper) and Asp40Asn (lower) mutants of Ec DOS...
- 6
- 423
- 0
Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
... equivalent volumes of M urea solution and then run on SDS ⁄ PAGE Lanes a and d, in the absence of both TnC and Ca2+; lanes b and e, in the presence of TnC and the absence of Ca2+; lanes c and f, in the ... presence (lanes m–q) of equimolar amounts of Akazara scallop TnC Lanes h and m, ATnI-52K; lanes i and n, ATnI-19K; lanes j and o, ATnI1)128; lanes k and p, ATnI130)252; lanes l and q, ATnI232)292; ... absence of both urea and KCl and the presence of 0.5 mm CaCl2, whereas ATnI130)252, RTnI1)116, and RTnI96)181 strongly bound to TnCs These results suggested that the inhibitory region and the...
- 12
- 514
- 0
Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... dysfunction SH3 and SH2 domain dysfunction Deletion of N-terminal, SH3 and SH2 domain of active n-Src Deletion of N-terminal, SH3 and SH2 domain of kinase-dead n-Src of PP3, the inactive form of PP2, ... ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21] After PP2 application, peak amplitudes of ... Institutes of Health (R01 NS053567) to X.-M.Y Plasmids of v-Src, and n-Src and its mutants were kindly provided by Dr T Pawson (Department of Molecular Genetics, University of Toronto, Canada) and Dr...
- 11
- 597
- 0
Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... diversification of different members of a gene family In previous studies, we examined the expression profiles of all the members of the GH3 and Aux ⁄ IAA gene families and a few members of the SAUR ... these probe sets in control and IAA-treated Results and Discussion Identification and overview of auxin-responsive genes Previously, we identified and characterized members of the early auxin-responsive ... (etiolated and green shoot, root, flower, and callus) by real-time PCR analysis, and showed their specific and overlapping expression patterns [7,18,19] The expression patterns of members of ARF gene...
- 15
- 430
- 0
Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... development of a new generation of effective and selective MMPIs is an emerging and promising area of research Acknowledgements We thank Professor G N Tzanakakis (University of Crete, Greece) and Dr ... of TGF-b Shedding of HB-EGF Proliferation Cleavage of Fas ligand Shedding of tumor associated major histocompatibility proteins complex class-I Indirect activation of Akt through activation of ... growth and invasion effects, interfering with the expression ratio and activity of several MMPs and TIMPs [77,78] Challenges and future prospects MMPs have well-established complex and key roles...
- 12
- 463
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008