roles in intestinal neurophysiology and neuroprotection
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the FYRC domain and the ... protein-binding platform for several other proteins to initiate a fundamental cellular process P-TEFb binds to the N-terminal portion of AF4, whereas the C-terminal portion of AF4 confers binding ... different signaling pathways, Role of MLL in human malignancies for example, protein kinase C, protein kinase A, RAS ⁄ RAF, WNT-, phosphatidylinositol 3-kinase and Hedgehog, and thus affects...
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Báo cáo y học: "Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthrits" pdf
... protective roles in vivo Interleukin-17 and interleukin-17 receptor signaling 244 The signaling mechanisms used by IL-17 to regulate its downstream targets are surprisingly poorly defined As indicated ... [50]) In particular, both T cells and inflammatory cytokines have been implicated in this process Interestingly, activated T cells inducibly express RANKL, and can thus bypass osteoblasts in triggering ... metabolism, and in the context of arthritis it appears to be a bone destructive cytokine Interleukin-17 in other diseases IL-17 has been implicated in numerous other disease settings Intriguingly,...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain The DNA-binding domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... domain involved in protein–protein interactions FYRC and FYRN domains are involved in heterodimerization between MLLN and MLLC terminal fragments High-mobility group (HMG) domains are involved in ... selective and independent roles within the hematopoietic system, maintaining quiescence in HSCs and promoting proliferation in progenitors [23] Similarly, in an independent study using a conditional...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... the kinase by preventing it from reverting to the auto-inhibitory state [33] In Src and Abl kinases, the SH2 domain can act in conjunction with an additional SH2 or SH3 domain to maintain an inactive ... Src (c-Src) and neuronal Src (n-Src), are found in neurons n-Src contains a six amino acid insertion in the SH3 domain, and is only expressed in neurons [3] The SH3 and SH2 domains in Src have...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... W8 and E9 together and separately; G13, N18, M22 and D23 together and separately; and N29 and D30 together, replacing these residues by the corresponding ones in a We also mutated KES to QDR, and ... protein–protein interactions [45], because their catalytic domain is homologous to adhesion proteins such as neuroligin [46,47] For example, AChE may be involved in neurite extension during brain ... anchoring of cholinesterases NeuroSignals 11, 130–143 ´ Massoulie J & Bon S (2006) The C-terminal T peptide of cholinesterases: structure, interactions, and in uence on protein folding and secretion...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development ... such as angiostatin, tumstatin, endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, respectively, affecting both cell phenotype ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... interactions between FadD29 and PKS15 ⁄ on the one hand, and FadD26 and the FasI system on the other hand Further investigations, including protein interaction studies and structural studies, will ... acyl-containing lipids, including DIMs Lipids were then extracted from the recombinant strain and analyzed by TLC These analyses revealed that the strain was still able to produce DIM A and DIM ... biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 in the biosynthesis...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... small business finance the financial intertwining investors and intermediaries of owners and their businesses (Ang 1992) Outside often put considerable weight on the financial conditions and reputations ... regarding institutional small firm finance in financial system architecture are just beginning to attract research attention The private markets that finance small businesses different investing in ... those funds by investing in informationally Venture capitalists perform taking funds from one group of investors and opaque issuers In addition to screening, contracting, and monitoring, venture...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... proteins, BjFixL and SmFxL, are Gly225 and Gly218, respectively (Fig 2) It is well known that CO-binding and O2-binding access channels of myoglobin and hemoglobin are composed of hydrophobic amino ... binding was monitored between and 500 ms Within this time scale, O2 binding curves for all proteins examined in this study were biphasic and fitted well to double-exponential functions O2 binding ... proteins, including myoglobin, hemoglobin, peroxidases, and cytochromes P450, have 6-coordinated NO–heme complexes [21–24 and references therein] The protein structures on the heme proximal side and...
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Báo cáo khoa học: Cytochrome P450 metabolizing fatty acids in plants: characterization and physiological roles pptx
... attract insect pollinators, giving CYP77A6 an indirect role in reproduction It is possible that the introduction of in- chain hydroxyl allows cross-linking of cutin, leading to reticulation and strengthening ... part overlapping Indeed, ectopic overexpression of CYP86A1 in Arabidopsis resulted in the production of C22–C24 x-hydroxy FA and diacids in stems cutin in addition to a major increase in C16–C18 ... x-hydroxylation x-hydroxylation in- chain hydroxylation in- chain hydroxylation x-hydroxylation x-hydroxylation in- chain hydroxylation Epoxidation Epoxidation in- chain hydroxylation in- chain hydroxylation x-hydroxylation...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... understanding pathogenic roles Z Yue function [5] LRRK2 also contains armadillo-like repeats, LRR, kinase and WD40 domains [6] In vitro biochemical analysis demonstrates that LRRK2 contains kinase and ... various model systems, including lower eukaryotes and invertebrates, in order to obtain clues for building important hypotheses The rapidity and efficiency of in vivo studies in many nonmammal models ... ROCO proteins in D discoideum indicate their roles in regulating cytoskeleton structures Interestingly, it was previously noted that human LRRK2 binds to cytoskeleton-related proteins [22], microtubules...
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Báo cáo khoa học: Roles of adenine anchoring and ion pairing at the coenzyme B12-binding site in diol dehydratase catalysis pptx
... (S)-1,2-propanediol in this drawing Pink and green colors indicate the a- and b-subunits, respectively, darkening continuously from the N-terminal to the C-terminal sides (B) Residues interacting with the adenine ... a cobalamin-binding site [18] and an adenine-binding pocket [21] for AdoCbl A modeling study using X-ray structures suggested that the tight binding of AdoCbl to both of these sites induces marked ... the adeninebinding pocket in the active site of the enzyme [21] (Fig 1A) The adenine ring of the bound AdePeCbl is nearly parallel to the corrin ring and faces pyrrole ring C It is trapped in the...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis Arthritis Rheum 43, 2501–2512 FLIP and MAPK in MLN51-mediated FLS ... activated in MH7A cells (Fig 5A), as reported previously [21], ERK inhibitor (PD98059) does not affect MLN51 and FLIP induction in MH7A cells (Fig 5B), indicating that ERK is unlikely to be involved in ... Firestein GS (1991) Cytokines in chronic in ammatory arthritis VI Analysis of the synovial cells involved in granulocyte–macrophage colony-stimulating factor production and gene expression in rheumatoid...
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Báo cáo khoa học: Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells doc
... in the apical membranes of intestinal (PEPT1) and renal (PEPT1 or PEPT2) epithelial cells Absorption of intact di- and tri-peptides and related mimetics at the intestinal epithelium or their reabsorption ... (1982) Activity of alafosfalin against bacterial pathogens of the gastrointestinal tract in vitro and in vivo Current chemotherapy and immunotherapy: Proceedings 12th Int Congr Chemother 1, 340–342 ... cells, 20 and 50 lM for SKPT cells) in the presence of increasing amounts of alafosfalin The linear, nonmediated transport components, i.e simple diffusion plus tracer binding, of 19.2% and 5.1%...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf
... proapoptotic proteins are divided into two distinct groups: the multidomain proteins, containing three BH domains (Bax, Bak and Bok); and the BH3-only proteins (Bad, Bid, Bim, Bmf, Bik, Hrk, Noxa and Puma) ... hVps34–Beclin interaction, suggesting that Bcl-2 ⁄ Bcl-xL inhibit autophagy by sequestering Beclin away from hVps34 [4] Beclin forms a dimer in solution via its coiled-coil domain both in vivo and in ... stimulates autophagy and involves an interaction with hVps34, and another that inhibits autophagy and involves an interaction with Bcl-2 and Bcl-xL Accordingly, overexpression of Bcl-2 and Bcl-xL disrupts...
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Báo cáo khoa học: Assimilation of excess ammonium into amino acids and nitrogen translocation in Arabidopsis thaliana – roles of glutamate synthases and carbamoylphosphate synthetase in leaves ppt
... Ornithine, citrulline and arginine contents in leaves of Arabidopsis plants cultured with mM ammonium in air (G) Ornithine, citrulline and arginine contents under high-CO2 conditions (H) Ornithine, ... arginine levels The levels of ornithine, citrulline and arginine remained low, at between 0.01 and 0.04 lmolặg)1 fresh weight (Fig 3E) However, arginine accumulated up to 70-fold and 80-fold in ... 5.8-fold increase in arginine relative to the wild-type plants in air, whereas in high CO2, arginine remained at a wild-type level, indicating that the high level of photorespiratory ammonium was in...
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Báo cáo khoa học: Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription ppt
... Champoux and S J Schultz Rausch JW & Le Grice SF (2004) ‘Binding, bending and bonding’: polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus Int J Biochem ... subunit, in addition to possessing both the polymerase and RNase H domains found in the a subunit, also contains a C-terminal region corresponding to the viral integrase The isolated RNase H domain ... genomes and template switching between genomes has been observed during reverse transcription, only a single genome strand is considered in the following discussion The key steps in M-MLV and HIV-1...
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Báo cáo khoa học: DNA-binding and transcription characteristics of three cloned sigma factors from mustard (Sinapis alba L.) suggest overlapping and distinct roles in plastid gene expression doc
... HTH-motif [20] in region 4.2 is involved in binding of the )35 promoter element [7] As shown in Fig 7A, two conserved amino acids, E13 and R16, can be identified in all three SASIG proteins within the ... using antisera against SASIG2 (lanes and 4) and SASIG3 (lanes and 7), or the corresponding preimmune sera (pi) (lanes and 5), respectively Lane shows the Coomassie-stained chloroplast protein ... the recombinant SASIG proteins confer promoter-specific binding and transcription initiation on the RNA polymerase, thus providing clues as to their functional roles as sigma factors [19] In the...
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Báo cáo sinh học: " Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse" pdf
... resistance against IAV infection, independent of the glycoprotein makeup of circulating IAV strains The ectodomain of matrix protein (M2e) is a promising candidate for a broadly protective IAV vaccine ... effective vaccine construct and/ or vaccine administration Of note in the latter context is the present finding that concomitant administration of M2e-MAP and a sublethal dose of infectious virus ... contrasting finding by Tompkins et al [9] that T cells contributed to protection against lethal IAV challenge in mice immunized by M2-DNA and M2recombinant adenovirus may be explained by induction...
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Báo cáo sinh học: " Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats" doc
... therapy induces beneficial effects including neuroprotection and hepatoprotection as well as a reduction of insulin resistance and lipid circulating levels increasing testosterone [4,5] In the ... decrease in some hormones in aging, such as estradiol and IGF-I, may have a negative impact on brain function since estradiol and IGF-I signaling interact to promote neuroprotection [35] Of interest, ... growth factor-2 in postnatal life? Mol Cell Endocrinol 1993, 92(1):C1-C3 Clemmons DR: Insulin-like Growth Factor Binding proteins and their role in controlling IGF actions Cytokine Growth Factor...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25