role of the wto imf and world bank
Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... its physiological role is uncertain In fact, the role and physiological advantages of the coexistence of several PPOs in the same micro-organism remain unknown The synthesis of melanin in micro-organisms ... to be part of the defense system against wounding and infection by the pathogen [16] Thus, the timing and location of melanization seems to be essential for the prevalence of one of these two ... but the differentiation between these two types of enzyme is not clear [4] Looking at the sequences of the two enzymes, both show absolute conservation of the histidine residues of the CuA and...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... of the effect of single point mutations on the solution structure of monomeric derivatives, we analysed the 2D NMR spectra of the different variants of mBS Figure shows the expanded regions of ... °C and 37 °C, and the extent of the swapping was assessed as previously described Figure shows the amount of the MxM form present as a function of incubation time P19A-BS-RNase behaves like the ... (D) The percentage of the MxM form as a function of the incubation time at °C (r) and 37 °C (d) is reported for each dimeric protein intrinsic flexibility of this tract of the protein Yet, in the...
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Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
... entirely to the catalytic role of these domains Rather, the advantage appears to depend on the ability of the lipoyl group to protrude from the inner core of the complex, indicative of the biological ... function of (a) concentrations of the reaction substrates and products, (b) kinetic properties of the component enzymes, E1, E2 and E3, and (c) their stoichiometry and interactions within the complex ... confirmed the inhibition of the overall reaction by the low molecular mass disulfides [41] The data pointed to the exchange of redox equivalents between the complexes and the medium, involving the dihydrolipoate...
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Explaining Bank Failures in the United States: The Role of Self-Fulfilling Prophecies, Systemic Risk, Banking Regulation, and Contagion pdf
... decrease at the beginning of the 1990s Table of the appendix provides further details about the distribution of the bankruptcies across US states ranked in the order of the total number of bank failures ... to the reaction of bankruptcies across different types of banks and thrifts to the history of recent failures across the entire industry Looking at the effect of contagion within each type of bank ... actual bank failures Based on the coefficients of the baseline model of column of table 1, the solid line of figure represents the predicted number of bank failures whilst the bars show the corresponding...
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Department of Reproductive Health and Research including the UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP) doc
... Foundation, the Government of Norway, Grand Challenges Canada, and the World Bank 3.1.2 The role of controlled cord traction in the active management of third stage of labour: A randomized non-inferiority ... transitioned into the recovery phase of the study The early termination of the regimen will compromise the precision of a final estimate of the contraceptive failure rate of this regimen The side-effects ... Director of the United Nations Population Fund (UNFPA); the US Surgeon General; the Director of the Office of Global Health Affairs in the US Department of Health and Human Services; the Secretary-General...
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RESPONSIBLE REFORM OF THE WORLD BANK - THE ROLE OF THE UNITED STATES IN IMPROVING THE DEVELOPMENT EFFECTIVENESS OF WORLD BANK OPERATIONS pptx
... and social assessment THE WORLD BANK AND THE POVERTY REDUCTION STRATEGY PAPER (PRSP) Oxfam America and Friends of the Earth In late 1999, the World Bank and the International Monetary Fund (IMF) ... Mining………………………………………….……… …17 10 The World Bank and the World Commission on Dams………………… …………….… …… 19 11 The World Bank and Pesticides…………………………………………………… ……… ………21 12 The World Bank and Gender……… …………………………….…………… ... World Bank Loans…………… ….… 11 The World Bank and Workers’ Rights…………………………………………………………… 13 The World Bank and Forest Protection……………………………………………………….… …15 The World Bank and Fossil Fuels and Mining………………………………………….………...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... independent of the thermodynamic and kinetic properties of the binding process and is solely based on the detectability of the peptides of interest We have used this method to show that binding of fosfomycin ... ligand binding The loop region of the upper domain moves towards the active site of the enzyme, thus shielding the substrates (and ligands) from bulk solvent A detailed thermodynamic study of ... the importance of R120 for the formation of the covalent fosfomycin adduct, we constructed the K22V/R120V and K22V/R120K double mutants (see Materials and methods) and repeated the analysis of...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... panel) The signal from the 18 kDa subunit of complex I (NDUFB6) served as another identification of the complex at the position of the histochemical stain in the left panel Antisera against the SDHC ... how the level of a complex of 46 subunits is determined The activities of complex II and the downstream complex III of the electron transport chain were measured and found to be near normal in the ... about the formation of supercomplexes and the effect of the absence of intact complex I, but the results are too preliminary in this regard Heterologous expression of the ESSS-HA subunit The localization...
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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... to the first site This is of particular interest as we, and others, have detected multiple forms of the cytoplasmic tail of MUC1, MUC1FDTR and its derivatives [9,13] Further, the migration of the ... cleavage Comparison of the relative intensity of the noncleaved and cleaved forms of the S ⁄ A, G ⁄ A and F ⁄ A mutants suggests that the S ⁄ A mutation has the most dramatic effect on the cleavage ... Ribbon representation of the modelled SEA domain of human MUC1 The model consists of three a-helices and six b-strands forming an a ⁄ b sandwich fold The FRPG ⁄ SVVV residues of the MUC1 cleavage...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... one of these studies collected data on the number of poultry kept by the sampled households in the study year and, in the case of Kenya, Nigeria, and Ghana, on the number of poultry sold and the ... income and wealth According to this method of matching, the two groups—which include the treatment group of households representing the result of the HPAI-induced supply -and- demand shocks and the ... on the type and quantity of assets owned by the households Therefore, these datasets allow us to investigate in detail the role of poultry (both as a source of income and as an asset) in the...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... activation of the glutaminase reaction and CTP synthesis was compared (Fig 5) In the absence of GTP, the rate of glutamine hydrolysis was signicantly higher than the rate of CTP synthesis so that the ... locks the enzyme in the active form for CTP synthesis and thereby stimulates the kcat of the reaction Since GTP actually will activate the uncoupled glutaminase reaction the structure of the monomer ... (Figs 4C and 5) One might have expected that if the role of GTP was solely to increase the rate of glutamine hydrolysis, there would have been no effect of adding GTP when the rate of CTP synthesis...
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The Role of the Media in Promoting and Reducing Tobacco Use doc
... explain the paradox of millions who successfully The influence of the media and their role in product marketing represent one of the key developments of modern society Effective advertising and ... tobacco the individual, organizational, and societal levels and how these levels affect the framing of research efforts and their findings This chapter lays the groundwork for understanding some of the ... product of the mass media era; the art and science of mass communications and mass marketing were critical to the growth of tobacco use in the past century At the same time, however, the media...
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Báo cáo khoa học: Role of the C-terminal extension in a bacterial tyrosinase Michael Fairhead and Linda Thony-Meyer doc
... been hypothesized to be a result of the presence of an amino acid that occludes the active site This idea has been proposed because of similarities in the structures of the C-terminals of the related ... tyrosinase denatured and, thus, the apparent shapes of the unfolding curves should not be over interpreted The use of the concentration of GdnCl at 50% unfolded as a simple measure of the change in ... increases the overall stability of the protein It was also apparent that the C-terminal extension of pro-tyrosinase reduces its overall stability in either the holo- or apo-forms of the enzyme The...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... determinants of the presence of Zn(II), and therefore of the Zn- or Cu-thionein character of the polypeptides Hence, the two full-length peptides, CeMT1 and CeMT2, give rise to mixtures of complexes, ... stoichiometry and the homogeneity of their preparations These differences are a result of the different coordination capacities of the respective C-terminal moieties and are attributable to the four ... reported for the native and recombinant Cd(II)–CeMT2 isoform [16,20] The slight blueshift of the spectrum of Cd6Zn1–CeMT1 in relation to that of Cd6–CeMT2 is attributable to the influence of the Zn(II)...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... where Ri and Gi are the red and green intensities of voxel I, respectively, and Rav and Gav the average values of Ri and Gi, respectively It is used for describing the correlation of the intensity ... of D2R Because this study used genetic variants of D2R that lacked either 2, or residues from the 217–222 motif of ic3, and the cellular localization of these mutants depended on the number of ... indicated basic region of ic3 of the D2 receptor and acidic region of the C-tail of the D1 receptor might be involved in the interactions between the two dopamine receptors In addition, the subcellular...
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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
... cleavage of the c-phosphate does occur in the NBD with the mutation at the IC [36,38,39] Moreover, these and other studies suggest that the IC residues are involved in the formation of the NBD ... contacts the c-phosphate of the bound nucleotide across the dimer [15] and the aromatic residue of the A-loop Abcb1a catalytic mechanism stacks against the adenine moiety of bound nucleotide and provides ... order to investigate further the role of the IC in the catalysis of ABC transporters, we created, in Abcb1a, six single-site mutants (E552D, N and A, and E1197D, N and A,) and three double-mutants...
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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
... ammonia-lyases Results and discussion Modeling the active conformation of the essential Tyr110-loop of parsley PAL Because of the uncertainty of the arrangement and the role of the essential Tyr110-loop ... putida [33] and Bacillus subtilis [34], respectively On the basis of the functional similarity of HAL and PAL, of the same electrophilic prosthetic group at the active sites, and of the sequence ... 17 A apart from the exocyclic methylene C-atom of the MIO prosthetic group On the basis of the experimental structures, hypotheses on the role of the Tyr110-loop have been put forward One group...
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Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt
... seen for the Phe triad in the structure of the mutant Exg:L3 complex Neither of the two sugar residues interacting with the Trp triad overlaps with the sugar seen in the Phe-Phe clamp of Exg Structural ... exoglucanase W M Patrick et al to help explain their importance to the specificity and catalytic efficiency of the enzyme The role of the Phe-Phe entranceway Fig Binding of laminaritriose (L3) to Exg double ... Rearrangement of the water molecules in and around the clamp region as seen in the crystal structure may be relevant The relative activities of the mutants tested showed the same trend for both the hydrolysis...
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Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf
... show the critical role of the last amino acids in the C-terminus of MaL Deletion of the four last amino acids strongly reduced the expression of the protein in T reesei and S cerevisiae Furthermore, ... 5B) Owing to the lower steric limitations of the side chain of the Ala than of the Leu, water may occupy the space Furthermore, the side chain of His140, which is coordinated to the T3 copper, ... loses its chloride ion and probably also the T2 copper, as the B-value of the T2 copper was rather high On the basis of the anomalous signal, the estimated occupancy of the T2 copper was about...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... in the range 15) 60 C The results of the analysis of these curves using the linear extrapolation model (LEM) are shown in Tables and and Fig 4AC There is a slight temperature dependence of the ... structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the major and minor conformations of holo-ACP bear close ... estimated on the basis of the linear regression of the fraction number of the molecular mass markers cytochrome c (CyC), carbonic anhydrase (CA), and BSA From the calibration curve of the sucrose...
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