... infection [30]. These data were alsosupported by several other research groups [15].However, theroleof CagA with respect to inducing the loss of cell polarity is much clearer. The kinasePar1b ... result ofthe lengthrestrictions of this minireview. The work of S.W. wassupported by the Deutsche Forschungsgemeinschaft(We2843 ⁄ 2-1) and BGAG-Stiftung Walter Hesselbach. The work of S.B. ... thatthere is a controversy in the literature about the impor-tance ofthe CagL RGD-motif in T4SS functions andhost cell signalling. Another unsolved question is the proposed structure of CagY...
... and Professor of Economics at the Wharton School ofthe University of PennsylvaniaThorsten Beck Professor of Economics and Chairman ofthe European Banking Center, Tilburg University, NetherlandsCharles ... transmission of information in the price, and greater effi-ciency ofthe market. In the bond market, the most commonly used variable is the tightness of the bid-ask spread (with the U.S. and ... from around the world.Two building blocks underlie the report’s view oftheroleofthe state in finance. First, there are sound economic reasons for the state to play an active role in financial...
... at pH 7. These preferred activities of the two PPOs of R. solanacearum are opposite to the names assigned to them when the genome of this bac-terium was sequenced and the function of these con-ceptual ... 1.10.3.1), but the differentiation between these two types of enzymeis not clear [4]. Looking at the sequences ofthe twoenzymes, both show absolute conservation ofthe histi-dine residues ofthe CuA ... itsphysiological role is uncertain. In fact, therole andphysiological advantages ofthe coexistence of severalPPOs in the same micro-organism remain unknown. The synthesis of melanin in micro-organisms...
... must still be determined whetherits absence in the V79-G18 mutant is the result ofthe missingESSS subunit alone, or whether the absence of ESSS causes the f ailure of other integral membrane subunits ... and the effect of the absence of intact complex I, but the results are toopreliminary in this regard.Heterologous expression ofthe ESSS-HA subunit The localization ofthe ESSS subunit in the ... as a nother identification of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex IIand against the Rieske protein of complex...
... required for efficientcleavage [11]. The solution structure ofthe SEA domain of the mouse homologue of MUC16 (which in the humanencodes the core protein ofthe ovarian cancer antigenCA125) was ... furtherinvestigate theroleofthe SEA domain in cleavage of membrane-tethered mucins we carried out site-directedmutagenesis ofthe FRPG ⁄ SVVV site and evaluatedhybrid mucins in which the ... ducts is of considerable significance in the pathology of a number of diseases including cystic fibrosis and cancer.Equally important is the fate ofthe cytoplasmic tail of the mucins once the extracellular...
... However, the 9-mer peptide B, CGGWHRLRC, corres-ponding to the sequence ofthe MGD1 loop 3 occurringbetween the two b-strands, had an MIC of 28 lM(i.e.about 2.5% ofthe activity ofthe synthetic ... is not possible to infer whether the key roleofthe b-hairpin loop of MGD1 (loop 3) inantimicrobial activity of MGD1 is of general value in the mechanism of action of defensins. However, our ... results obtained by other groupswho also point to theroleofthe connecting loop of the b-hairpin of defensins. A combination of mutationalanalysis [35] and structural analysis ofthe plant defensinRs-AFP1...
... locks the enzyme in the active form for CTP synthesis andthereby stimulates the kcat of the reaction. Since GTP actually willactivate the uncoupled glutaminase reaction the structure of the monomer ... wassimilar to that ofthe overall CTP synthesis reaction. Itwas concluded that the effect of GTP was mainly toenhance the rate of chemical steps ofthe glutaminasereaction. The finding that the kcatvalue ... as the displacement ofthe baseline. The peaksobserved at each injection time are derived from the heat of dilution of glutamine into the reaction cell. (B) The heat generated by hydrolysisof...
... sense of group identity, in the eyes of its members and those outside the group. What is theroleofthe facilitator? The roleofthe facilitator is to make it easier for groups to work together ... 1. TheRoleofthe Facilitator – page 6What is theroleofthe facilitator?How do facilitators help groups achieve their goals?They do it by ã Clarifying and reinforcing the purpose ofthe ... aware both ofthe communication styles ofthe individuals who make up the group, and ofthe way the group interacts as a whole. The way in which the group works together, and the way in which...
... examine the dynamics of tobacco-related media interventions at each of these levels, within a systemic framework. The relationships among these levels and stakeholders on either side ofthe tobacco ... product ofthe mass media era; the art and science of mass communications and mass marketing were critical to the growth of tobacco use in the past century. At the same time, however, the media ... underestimate the effectiveness ofthe campaign.n Last, the all-pervasive nature ofthe media environment includes both messages of interest as well as background “noise.”Given these challenges,...
... hypothe-sized to be a result ofthe presence of an amino acidthat occludes the active site. This idea has beenproposed because of similarities in the structures of the C-terminals ofthe related ... thus, the apparent shapes of the unfolding curves should not be over interpreted. The use ofthe concentration of GdnCl at 50% unfolded asa simple measure ofthe change in stability between the various ... further asses the functional importance of the C-terminal extension, we created a shortened form of the V. spinosum tyrosinase, using the presence of the conserved YX(Y ⁄ F) motif as a guide. The...
... Communications to the RegentsCommittee on Auditã Letter of Comments & Recommendations to the Regentsã Letter of Comments & Recommendations to the Chancellor– Reports to the Board of Regents ... respect the rights and dignity of othersUC Standards of Ethical Conduct1. Fair Dealingã No unlawful practice or a practice at odds with these standards can be justified on the basis of customary ... confidence in the financial markets in the wake of Enron, Tyco, Global Crossing, WorldCom, HealthSouth…– Created a new accounting oversight board to police the practices ofthe accounting profession–...
... analysis oftheroleofthe Healthy Waterways Partnership – Cottingham, Franz Delfau, Garde 25 as well as the risk to the assets under the current flow management strategies (Department ofthe ... increased by 71%, amounting to 23% ofthe State’s direct output from the industrial sector. Mining employed 3.2% ofthe local labour force during the period. The offices ofthe major mining companies ... what the key issues are in the region and how they have arisen. The second part ofthe report puts forward a critique of a program that targets one ofthe priority issues that emerged from the...
... possibleinterpretation ofthe data suggests that the indicatedbasic region of ic3 ofthe D2receptor and acidic region of the C-tail ofthe D1receptor might be involved in the interactions between the two ... on the number of Arg residues thatwere replaced by Ala in the Arg-rich region of ic3 (resi-dues 217–222) ofthe dopamine D2receptor. The effi-ciency of energy transfer in the wild-type ofthe ... localization of these proteins in the cell rather thanfrom the possible roleofthe D2R basic domain in the mechanism of D1–D2receptor heterodimerization. However, we find that the acidicepitope...
... cleavage ofthe c-phosphate does occur in the NBD with the mutation at the IC [36,38,39]. More-over, these and other studies suggest that the ICresidues are involved in the formation ofthe NBDdimer, ... sequence contacts the c-phosphate ofthe bound nucleotide across the dimer [15] and the aromatic residue ofthe A-loopstacks against the adenine moiety of boundnucleotide and provides further stabilization ... activates the attackingwater molecule that cleaves the terminal phosphate of bound ATP. In the latter model, the IC is part of acatalytic dyad, along with the histidine residue of the H-loop,...