... specific to the use of ICTs in the health sector in developing countries. A summary of these key lessons as they relate to intermediaries and beneficiaries, to improving the functioning of health ... understanding and the evidence base about the use of ICTs inthe health sector are: ã How to evaluate the impact ofthe use of ICTs on health? ã What can be done to strengthen theroleof and ... the emergence of new technologies include the advantages of integrating ICT activities into other programmes, the benefits and strengths of building on existing systems and structures and the...
... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs,thereby releasing the nucleocapsid into the lumen of these vesi-cles. Then, the capsid uses these intra-endosomal ... milddevelopmental delay. The protein defective in this disorder is alsoa NHEJ protein. The distinct clinical features ofthe patients willbe discussed inthe context ofthe protein function.3.4 Diabetes, ... Mutations in the ERCC1 gene induce a distinct set of accelerated ageing features,with a rate of onset depending on the severity ofthe mutation. The correlation between repair defect severity and clinical...
... which appear to be involved inthe finalresorption ofthe parental macronucleus during PND in T. thermophila, and suggested the involvement of mitochondria in this process [19]. In mammalian apop-tosis, ... key rolein PND in Tetrahymena. Unfortunately, the involvement of mito-chondria in PND has not been clarified fully. To eluci-date theroleofthe mitochondrion as a key effectorwe studied the ... directlyshow the localization of mitochondria inthe autophag-osome, as the red fluorescence corresponding to intactmitochondria was not observed inthe area. Therefore,to confirm further the localization,...
... go inthe same direction. The inverse isthecasefortheattractioninthecaseofAnabaena. Also, if the structure ofthe final complex in which electron transfertakes place remained unaltered with increasing ... character-ization ofthe plastocyanins has been described [1].Representations ofthe electrostatic surfaces showing the changes introduced by the mutations are displayed in Fig. 1. The decay ofthe flash-induced ... interaction.Electron-transfer chains like that of oxygenic photosyn-thesis impose special restraints on the proteins involved.Reactions must be fast to allow rapid turnover of the chain. Binding between the reaction...
... imaging of the brain was also performed in a subset of patients in this study.36 It was found that use of corticosteroidspossibly reduced the risk of developinghydrocephalus and vasculitic infarcts; ... of opportunistic infections in HIV-infected adults andadolescents: recommendations from CDC, the NationalInstitutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. ... Vietnam. Following the publication of this trial, Prasad and Singh12 updatedtheir Cochrane systematic review on the efficacy of corticosteroids in TBM.12 The combined mortality in the control...
... stomach, the presence of bile acids inthe intestines, and the competition against other micro-organisms inthe gastro-intestinal tract [91,92]. The tentative ways for selection of probiotics ... colonizing the intestine may secrete the enzyme, thus increasing the intestinal amylase activity [82,83]. It is well established that probiotics alter gastrointestinal pH and flora to favor an increased ... Interrelationship of Lactobacillus and zinc bacitracin in diets of turkey poults. Poult. Sci. 1978, 57, 1687-1689. 105. Fuller, R. The importance of lactobacilli in maintaining normal microbial balance in the...
... distribution of BsArb43B inthe proximity of the active site. Arabinotriose inthe binding cleft is representedusing sticks. (B) Detailed view ofthe binding cleft with arabinotri-ose. (C) Details ofthe ... witharabinohexose [15], this loop makes the reducing end of the carbohydrate chain bend towards the solvent,probably optimizing binding ofthe carbohydrate chain in the cleft, and resulting in trioses ... for the optimal activity of BsArb43B.Furthermore, to determine whether theroleof the calcium is structural, thermal shift assays were per-formed to determine the Tm of the protein in the...
... formation of MRNfoci [19–21]. The Mre11-binding domain of human Nbs1 hasbeen localized to amino acids 682–693 inthe COOH-terminal region ofthe protein. Deletion of this region of Nbs1 results in ... damage, thereby promotingATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with ... an NH2-terminally truncatedNbs1 protein that contains an intact Mre11-bindingdomain. Differences inthe nature ofthe Nbs1 muta-tion, as well as inthe dose of radiation administeredto...
... results in trimming the dry branches off the bush. And this is what the semantic type in (16) captures.3.3 Impingement Predicates In order to capture the semantic properties of the arguments ofthe ... (SOA [ch -of- loc-relFIG ElThat is, as (16) above captures, in German trim-ming necessarily results in trimming somethingoff something else; inthe case of example (9)above trimming the bush ... representative verb of the impingement predicates class in German, the verbschlagen (hit) in examples (10)-(12) above, wepropose the semantic types in (17) and (18), whichare inthe spirit ofthe MRS-based...
... also in His237 fi Ala the HS-CoM bindingresults in sulfur ligation to the active-site zinc.XANES spectra of wild-type and mutantsAs shown inthe following, the interpretation ofthe EXAFS of the ... Matthews, R.G. &Penner-Hahn, J.E. (1998) Characterization ofthe zinc binding site in methionine synthase enzymes of Escherichia coli – therole of zinc inthe methylation of homocysteine. ... unambiguouslyindicates that HS-CoM addition results in an increase in the number of sulfur atoms inthe first coordination sphere of zinc. This increase inthe number of sulfur ligands isaccompanied by the...
... Classification of Soils 204 Principle of Purpose 205 Principle of Domain 205 Principle of Identity 206 Principle of Differentiation 206 Principle of Prioritization 207 Principle of Diagnostics ... studying the passage of solutes through beds of clay.However unique in form and function, soil is not an isolated body. It is, rather, a central link inthe largerchain of interconnected domains ... through increasing use of agro-forestry techniques (e.g. inter-cropping cereals with leguminousnitrogen-fixingtrees) and increasing the efficientapplicationsof chemical fertilizers .In other impoverished,as...
... construction in China, Korea, Singapore and the Near East. The fast-developing nations in these regions place their expectations of economic growth and prosperity on the exhibition industry. Some ... Development The 21st century: Globalisation ofthe exhibition industry The framework conditions for today's development ofthe exhibition industry were established by the end of the last century. ... brought to their sites in return. The future will show which of these ways will be the most successful. back footnote go onUFI, The Global Association of the Exhibition IndustryUniversity of Cooperative...
... ester-induced disruption of the CD4–Lck complex occurs within a detergent-resistantmicrodomain ofthe plasma membrane. Involvement of the translocation of activated protein kinase C isoforms.J ... observed (Fig. 4C,Erespectively). These findings support the view thatGM3 is mainly involved in retaining ErbB2 in lipid-raft domains, but that it is not involved in ErbB2phosphorylation.EGFR ... 2006)doi:10.1111/j.1742-4658.2006.05203.xWe analyzed theroleof gangliosides inthe association ofthe ErbB2 recep-tor tyrosine-kinase (RTK) with lipid rafts in mammary epithelial HC11cells. Scanning confocal microscopy...
... both ofthe metal-binding sites(Table 3). Although the predominant effect is on the second metal-binding site, substitution of Asp97 byglutamate and asparagine makes the process of binding of the ... (Ka) for the binding of Co(II) wereobtained by fitting these data, after subtraction of the background heat of dilution, via an iterative processusing the origin software package. This software ... bidentate binding of Glu97 may pre-vent binding ofthe solvent ligand that appears to bepresent in other mono-cobalt(II) species of EcMetAP-I.Combination of these data suggests that mutatingthe...