role of oxidative stress in prostate cancer
The role of sentence stress in enhancing english speaking competence of HPU english majors
... to this kind of stress in referring, proclaiming, and reporting utterances Tonic stress is almost always found in a content word in utterance final position Consider the following, in which the ... clear to you The role of sentence stress in enhancing English speaking competence Sentence stress is the governing stress in connected speech All words have their individual stress in isolation When ... 34 8.1 Final intonation 36 8.1.1 Rising-falling intonation 36 8.1.2 Rising intonation 37 8.2 Non-final intonation 39 8.2.1 Rising-falling intonation...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110] Finally, ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an ... src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere ... Our findings clearly show the presence of oxidative stress in degenerating cartilage, and the resultant telomere erosion and dysfunction of chondrocytes in vitro and in vivo, suggesting a role ... and maintenance of GAG content in articular cartilage in tissue culture Interestingly, treatment of cultured cartilage with an antioxidative agent not only inhibited GAG loss but also maintained...
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Báo cáo khoa học: " The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise" doc
... combined with vitamin C (Vit C), on training -induced decrease of reduced Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training -induced decrease of reduced ... combined with vitamin C (Vit C), on training -induced increase of lipid Effect of methyl (LPO) levels Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training ... by increases in lipid peroxidation, glutathione oxidation, and oxidative protein damage [28] In our study exercise induced an increase in cellular oxidative stress (as shown by the increase in...
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functional characterisation of phosphodiesterase 4d7 in prostate cancer
... domain REC domains play a crucial role in bacterial signalling systems They may also be involved in protein-protein interactions (Galperin 2010) Phosphorylation of the REC domain may be involved ... and binds phosphatidic acid (PA) via a TAPAS domain in its unique N-terminal region An increase in intracellular CA2+ brings about binding of PDE4A1 to PA and insertion into lipid bilayers in an ... Signalling in the Prostate and Prostate Cancer 105 1.10.1 cAMP PDEs in Prostate Cancer 105 1.10.2 Protein Kinase A and Prostate Cancer 106 1.10.3 EPAC and Prostate Cancer 108...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... about 10% of all cancer incidence and mortality in 20132 Consistent with trends in developed countries, CRC is the most frequent cancer in Singapore, accounting for 14% to 18% of all cancer incidence ... 2005-20093 Colorectal cancers usually begin as non-cancerous polyps in the inner lining of the colon or rectum4 Over many years, adenomatous polyps in the dysplasic colon may develop into pre-neoplastic ... of kDa These cell line models are used in subsequent investigations to elucidate the functional role of STMN1 in colorectal cancer metastasis Expression of endogenous STMN1 and/or STMN1-DDK in...
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The role of prion protein in breast cancer cell metabolism
... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer ... respectively Breast cancer is the leading cause of cancer mortality in Singaporean females (MOH, 2012) Amongst all the different kinds of cancer, breast cancer is ranked fifth highest in terms of mortality ... (WHO, 2008), while according to the Singapore Cancer Registry, in 17 women will develop breast cancer in her lifetime in Singapore The risk of getting breast cancer increases with age, with the...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... apoptosis In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in the ... decreased protein levels of MKP1, one of MAP kinase phosphatases that inactivate JNK and p38 MAP kinases [2] Interestingly, NSC-741909 induced an increase of MKP1 mRNA expression in both time- ... several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor),...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... activation of p38 induced by oxidative stress, we further examined whether its activation is responsible for the induction of apoptosis in F9 cells using SB202190, a potent inhibitor of p38 As shown in ... determine the effects of Hsp105a on JNK and p38 signalling pathways, we examined the activation of JNK and p38 in F9 cells by oxidative stress As shown in Fig 6A, JNK was not activated in control ... hydrogen peroxide In contrast, hydrogen peroxide-treatment induced marked activation of JNK within 30 in S23 cells, but not in S3 cells Therefore, the enhancement of the oxidative stress- induced JNK-activation...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22]; ... element binding protein, isocitrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84] Mitochondria from different brain regions contain different ... buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca2+]c, probably coincides with the cleavage of the exchanger (but see [164]) Therefore, inhibition of the,...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... with larger fruits PARP involvement during oxidative stress- induced developmental changes in D discoideum To determine the role of PARP in oxidative stressinduced developmental changes, D discoideum ... important role under oxidative stress [21]; however, there is no report on the role of PARP in D discoideum development We have investigated the role of PARP in D discoideum development by inhibiting ... to investigate the long-term effects of PARP inhibitors for two successive generations n=3 Fig Effect of PARP inhibition during oxidative stress- induced growth changes in D discoideum Under oxidative...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... overexpressed in a variety of tumor tissues, including prostate cancer AMACR was identified as a tissue biomarker for prostate cancer by gene expression profiling of primary human prostate cancer and ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue ... with HLA-A24 binding motif (underlines) The predicted anchor residues to HLA-A24 are indicated in boldface within the amino acid sequences of the peptides B Binding affinities of AMACR-derived...
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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx
... of innate immunity for productive infection in humans XMRV replicates efficiently in prostate epithelial cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line ... source of infectious XMRV Virus infections were performed using cells plated day before infection Cells were at 50% confluency at the time of infection On the day of infection, fresh media containing ... replication in human peripheral blood mononuclear cells Interestingly, XMRV infects and replicates efficiently in prostate cancer cells of epithelial origin It has been proposed that due to lack off...
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Báo cáo sinh học: " Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx
... effect of MDA-7 on prostate cancer cells Studies of adenoviral vectorinduced expression of MDA-7 in human prostate cancer cells demonstrated varying degree of inhibition of growth and induction of ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we identified a small panel of proteins that interacted with TGase-4, including RON (the HGF-like protein receptor)...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16] This finding suggests that ... indomethacin plus vitamin Effect of1 brain oxidative stress E supplementation on Effect of indomethacin plus vitamin E supplementation on markers of brain oxidative stress Total cerebral cortex homogenates ... presence of vitamin E significantly reduced two independent markers of oxidative stress injury in both brain regions Thus, neocortex and hippocampus levels of iPF2α-VI (a reliable biomarker of lipid...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... organism to particle-induced oxidative stress The observed increase of reducing species in urine would mirror an increased level in blood originating from a response to oxidative stress in the body monitored ... to an increase in urinary 8OHdG levels during two consecutive days in non-smoking male bus mechanics This increase in oxidative stress markers was associated with increased urinary level of water ... concentration in the creatinine-corrected spot urine and the 24 hour urine [24] Thus, the creatinine correction may be applied in the present case Measurement of the reducing capacity in urine We used...
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báo cáo hóa học:" Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx
... effect of MDA-7 on prostate cancer cells Studies of adenoviral vectorinduced expression of MDA-7 in human prostate cancer cells demonstrated varying degree of inhibition of growth and induction of ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... interacting with TGase-4 using immunoprecipitation of proteins from the prostate gland, we identified a small panel of proteins that interacted with TGase-4, including RON (the HGF-like protein receptor)...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... PM10 to oxidative stress repair enzyme, we used RT-PCR analysis Figure shows the expression level of catalase mRNA induced by Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat ... suggesting that PM2.5 induced more oxidative stress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form Comparative study of PM2.5 ... molecular marker of oxidative stress in lung cancer cells EBS Letter 1998, 429, 17-20 16 Knaapen AM, Shi T, PJ, Schin R Soluble metals as well as the insoluble particle fraction are involved in cellular...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... significantly reduced (p ＜ 0.05) in all groups compared to the control group Similar finding have been reported in other study during oxidative stress [24] No significant changes in GST activity was seen ... resistant strain of insect [38] GST levels were also increased significantly after 30 days of exposure to protect RBCs from oxidative damage Further significant decreases in GSH levels in our study ... class of insecticide Chem Soc Rev 1978, 7, 473-505 Flodström S, Wärngård L, Ljungquist S, Ahlborg UG Inhibition of metabolic cooperation in vitro and enhancement of enzyme altered foci incidence in...
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