role of oxidative stress in cancer
The role of sentence stress in enhancing english speaking competence of HPU english majors
... you. 8. The role of sentence stress in enhancing English speaking competence. Sentence stress is the governing stress in connected speech. All words have their individual stress in isolation. ... 1997:190). 27 The pattern of stress in this sentence is stressed – unstressed – stressed – unstressed – stressed – unstressed, with equal number of alternating stressed and unstressed syllables. ... must distinguish between four levels of stress: major sentence stress, major word stress, minor word stress and unstressed. Thus, in the sentence: “I walked home in the rainstorm”. ‗I‘, in ,...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... use of vitamin E and vitamin C in combi-nation reduced the prevalence and incidence of AD in anelderly population; however, the use of either of thesevitamins alone had no effect [110]. Finally, ... complex leads to theinitiation of complex signaling events leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... inhibition of phosphati-dylinositol-3 kinase (PI3K) attenuates ROS production.These findings suggest that these kinases are involved in upstream signaling cascades responsible for activatingNADPH...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... cellactivity of several LOX inhibitors, including aesculetin (anonselective LOX inhibitor), MK886 (an inhibitor of the5-LOX-activating protein), zileuton (a 5-LOX inhibitor),baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of manyantineoplastic agents [13,14].To investigate whether oxidative stress is involved in the ... atthe National Cancer Institute. Using a reverse-phase pro-tein microarray assay, we determined molecular changes in 77 protein biomarkers in an oncrasin-sensitive lung cancer cell line after treatment...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... important role in protection of neuronal cellsagainst stress- induced apoptosis [26]. In accordance withthese findings, ischemia/reperfusion in the rat forebraininduces the expression of HSP105/110 ... activation of p38 induced by oxidative stress, we further examined whether its activationis responsible for the induction of apoptosis in F9 cells usingSB202190, a potent inhibitor of p38. As shown in ... mitogen-activated protein kinase(p38). Furthermore, oxidative stress- induced apoptosis wassuppressed by SB202190, a potent inhibitor of p38, in F9cells. These findings indicated that the activation of p38...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... depolarization of in situ mitochondria by oxidative stress parallels a decrease in NAD(P)H level in nerve terminals. Neurochem Int 36, 483–488.61 Chinopoulos C & Adam-Vizi V (1999) Depolarization of in ... imposing a continuous load of calcium to the neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease ... element binding protein, iso-citrate dehydrogenase is an RNA-binding protein, whilekgd2p is a mitochondrial DNA binding protein [81–84].Mitochondria from different brain regions containdifferent...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative stress- induced ... to oxidative stress and the role of PARP during development. We used hydroxylamine (HA)to induce in situ generation of H2O2and monitored the effect of benzamide, a PARP inhibitor, on oxidative ... animportant role under oxidative stress [21]; however,there is no report on the role of PARP in D. discoideumdevelopment. We have investigated the role of PARP in D. discoideum development by inhibiting...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug-gests ... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... brain sections from mice on placebo or receiving indomethacin plus vitamin EFigure 6Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E.IndomethacinVitamin...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... response of the organism to particle-induced oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative ... only 10% of urate is excreted in the urine (theremaining 90% being recirculated by the renal system[3]), an increase of this antioxidant in blood will alsolead to an increase in urine. The ... beenreported to increase the serum levels of uric acid in North Carolina police officers [4]. A similar increase of plasma antioxidants in response to an increased oxid a-tive stress was observed in newborns...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total plasmid DNA (formFig. 10. RT-PCR analysis of ... analysis of Nrf-2No remarkable change of expression level in Nrf-2,proteins related with many transcriptional and anti -oxidative stress enzyme, was observed in the groups of threeconcentration of ... Expression of Nrf2 protein in the PM2.5 - and PM10 -treated rat lung epithelial cell was determined by WesternBlotting. The lower shows the ratio of Nrf2/actin usingcalculatging by densitometor....
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... influx (41). The increased activity of NOS and the increased for-mation of NO in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of ... supply of oxygen in reperfusion group. The increased activity of arginase in reperfusion group may be beneficial by the way of competing NOS for arginine. In a recent study using GS inhibitor,...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44]. These factors are involved in ethanol-induced ... . Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma ... signaling. This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in HepG2 cells [19]. Int....
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