role of mechanical strain in promoting apoptosis and differentiation
ROLE OF THE ERP29 IN MIGRATION, APOPTOSIS AND PROLIFERATION IN BONE MARROW STEM CELLS
... protein 42 (Cdc42) and Par polarity complex protein, including Par3, Par6, and atypical protein kinase C (aPKC), may play crucial roles in the generation and controlling direction of polarity in ... filaments and induces growth of a new branch of actin filament at a unique 70 degree angle from the preexisting actin filament Proteins, such as profiling and ADF/cofilin, are also act as regulators in ... regulators in mediating actin polymerization by controling the availability of activated actin monomers, debranching and depolymerizing proteins and capping and severing proteins (Ridley et al.,...
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The Role of the Media in Promoting and Reducing Tobacco Use doc
... combining sponsorship, brand merchandising, brand stretching, packaging, point -of- sale promotions, and product placement, across a broad range of channels ranging from event marketing to the Internet.22,23 ... discounting, and brand marketing, in the context of the current regulatory and social environment Consumer marketing Consumer-product marketing efforts, including pricing, distribution, packaging, and ... taxonomy of past and present channels used in advertising and promoting tobacco products; emerging promotional channels such as packaging, viral marketing, and the Internet; and recent trends in tobacco...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving ... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered ... vaccination of adults and the type of vaccine strain administered precluded the inclusion of these factors as covariates in the random-effects regression model However, these researchers determined...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... consistent with loss of penicillin binding Arginines 306 and 307 Fig Proposed binding mode for penicillin N to the iron(II)-2-oxoglutarate complex of DAOCS, showing possible involvement of selected residues ... give support to the proposed mode of penicillin binding by DAOCS [1,12] a key feature of which is that arginines 160 and 162 bind to the carbonyl and/ or carboxylate of the bicyclic b-lactam nucleus, ... ferryl intermediate is important for optimum coupling between 2-oxoglutarate and penicillin conversion Recent studies have suggested that the C-terminus of DAOCS (including arginines 306 and 307)...
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The role of international agreements in environmental conservation and its implication to Vietnam
... became increasingly criticized by international activists as a source of poverty and environmental degradation in developing countries One of the most important turning point was the WTO Ministerial ... combining two types of sustainable management of natural resource in a single economic equation and also under a single diagram as represented by: C ≦ ΔOS*E + S therefore, E ≧ (C – S)/ΔOS1 (b) Introduction ... Original Sustainability, S for Sustainable Level for human activities ΔOS means the marginal increase of consumption against environmental amenity while original sustainability is maintained The degradation...
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Báo cáo khoa học: "Role of L2 cysteines in papillomavirus infection and neutralization" pptx
... of C22 or C28 affect either cell surface binding or appropriate trafficking of virions during infection Campos and Ozbun observed indistinguishable cell surface binding and uptake into Page of ... http://www.virologyj.com/content/6/1/176 Figure Impact of L2 C22A and C28A point mutations upon vaginal infection of mice by HPV16 pseudovirions Impact of L2 C22A and C28A point mutations upon vaginal infection of mice by HPV16 pseudovirions ... epitope [1,4] This process of revealing the 17-36 epitope Figure Binding of RG-1 antibody to disulphide hairpin of HPV16 L2 Binding of RG-1 antibody to disulphide hairpin of HPV16 L2 An HPV16 L2...
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Báo cáo y học: "Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis" pps
... mechanism involving COX2 and PGE2 expression in the resolution of inflammation Page of 11 Proinflammatory cytokines, including IL-17 and TNF-a, play a critical role in the progression of synovitis and ... cells in the presence of indomethacin Rheumatoid ST contains a number of proinflammatory cytokines that influence osteoclast formation and bone resorption Proinflammatory cytokines such as TNF-a and ... Effect of interleukin (IL)-17 on pannus-like tissue growth in the presence of indomethacin Synovial tissue (ST)-derived inflammatory cells (n = 7) were incubated with an incremental dose of IL-17 in...
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The role of international agreements in environmental conservation and its implication to Vietnam
... economic resource This thesis introduces a new concept of combining two types of sustainable management of natural resources in a single economic equation and also under a single diagram It has been ... degradation of the global environmental assets Many efforts are being made by individuals, governments, NGOs and international organizations including Green Peace and WWF International organizations and ... purpose of this thesis is to examine how International Agreements envisage to contributing to conservation of the global environmental assets that are diminishing rapidly at an increasing rate In...
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Role of phospholipase a2 in orofacial pain and synaptic transmission 4
... Depletion of cholesterol by pre-incubation of cells with MBCD and depletion of Ca2+ by thapsigargin and incubation in zero external Ca2+ resulted in attenuation of lysoPI induced exocytosis, indicating ... sustained increase in [Ca2+]i in PC-12 cells The lysoPI induced increase in [Ca2+]i was attenuated by pretreatment of cells with MBCD and by pre2+ incubation of cells with thapsigargin No change in ... transmission findings suggest that sPLA2 may have a role in exocytosis and neurotransmitter release in neuroendocrine cells and neurons In recent findings (in chapter 4), it showed high levels of sPLA2-IIA...
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Role of phospholipase a2 in orofacial pain and synaptic transmission 3
... immunolabeling of sPLA2-IIA in the spinal trigeminal nucleus of the brainstem and dorsal horn of the cervical spinal cord is consistent with previous findings of an important role of sPLA2 in nociceptive ... nicardipine (Arioka et al 2005) The contribution of sPLA2 in inflammation has been extensively studied Recent findings showed that sPLA2 induced expression of pro-inflammatory cytokines including ... showed bands at 14 kDa of sPLA2-IIA in homogenates from brainstem and spinal cord and a second band at approximately 30 kDa in the spinal cord The second band could be due to dimerization of sPLA2-IIA...
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Role of phospholipase a2 in orofacial pain and synaptic transmission 1
... region, indicating the nociceptive function of sPLA2-III The expression profile of sPLA2-III in CNS and its effects on exocytosis in rat PC-12 cells further illustrated the role of sPLA2-III in pain ... mRNA and protein expression were expressed at the highest levels in the brainstem and spinal segments The enzyme was localized to dendrites in spinal trigeminal nucleus, supporting its role in ... of sPLA2 isoforms mRNA and protein expression in rat CNS between previous reports and current findings ……………………… … 116 XI List of Figures LIST OF FIGURES SECTION I Figure.1.1 Site of action of...
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Role of phospholipase a2 in orofacial pain and synaptic transmission 2
... thapsigargin and recording in zero Ca2+ conditions, or treatment of cells with lanthanum chloride and recording in external solution containing Ca2+, resulted in attenuation of sPLA2-III induced ... anterior cingulate cortex which plays an important role in the affective dimension of pain (Gong et al 2010), indicating the important role of bee venom in nociceptive transmission The findings in this ... expression in the hindbrain Data represent the mean and standard deviation of four rats 115 Chapter Role of Group IIA sPLA2 in nociception Table 2.4.1 Comparison of sPLA2 isoforms mRNA and protein expression...
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A novel role of hydrogen sulfide in wound healing and a new approach to wound dressing in rat model
... similar role to NO in wound healing in the rat 1.3 Thesis Overview and Scope The aim of the work presented in this thesis is to determine the role of H2S in skin wound healing and the effect of PAG ... Chapter Introduction (2) Investigate the inflammation and wound recovery after PAG administration (3) Compare the H2S releasing profiles and outcomes of S-diclofenac administration and PAG incorporated ... system; inflammation in wound healing; DL-propargylglycine (PAG) and S-diclofenac (Ac-S)’s properties and effects as the inhibitor of H2S synthesizing and H2S donor; assembly of hydrogel in wound...
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THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION
... it consists of fibroin fiber proteins instead of keratin fiber proteins like that of fur bearing mammals.4 The most common mineral fibers are asbestos Examples of mineral fibers include chrysotile, ... baseline When a linearly sloping baseline is present, two or more points that only contain baseline information can be used to estimate a line.30 To remove the sloping baseline, the estimated line ... to PCA in that new axes called canonical variates (CVs) are created by taking linear combinations of the original variables Instead of determining directions of greatest variation like in PCA,...
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THE ROLE OF SWI/SNF IN REGULATING SMOOTH MUSCLE DIFFERENTIATION
... ability of myocardin to increase SRF binding to the promoters of smooth muscle-specific genes within chromatin 80 Figure 18 Myocardin, SRF and Brg1 form a complex in vivo and Brg1 binds directly ... structural domains and binding partners of the MRTF family A Structural domains of Myocardin, MRTFA and MRTFB The similarity percentage between each domain relative to myocardin is shown B Binding partners ... to be involved in gastric ulcer and esophageal ulcer healing in rats (21, 22) SRF is up-regulated in epithelial, myofibroblast and smooth muscle cells in gastric ulcers and local injection of an...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... analysis of the involvement of wild-type occludin (OccWT) and variant occludin in apoptosis and invasion, as determined by assay, we revealed that exon played a major role in the induction of mitochondria-mediated ... explain the induction of apoptosis and reduction of invasiveness mediated by occludin In previous reports, intracellular calcium concentrations were reported to in uence the onset of apoptosis and ... wild-type occludin were examined in Chang cells Furthermore, in a comparative analysis between OccWT and OccDE9, the exon region played a significant role in promoting apoptosis and inhibiting invasion...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray results ... and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced ... G-Protein-MAPK, NGF, and PDGF signaling This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... modification may in uence many of the physicochemical and biological properties of the proteins, such as protein folding, stability, targeting, dynamics and ligand binding, as well as cell-matrix and cell–cell ... side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal structures of the ... that of DDN, showing a value of only 5.5 h In contrast, the stability of NNN containing only mannosidic N-glycans after treatment with dMM 1629 Role of N-glycosylation and N-glycan trimming of...
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Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf
... generated in a model of soft budget constraint in Berglof and Roland (1994) 22 Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm's Qualitative Survey The main underlying ... remaining 11% An increase in indebtedness (of 80% in average) is associated with a 14% decrease in production, and with a 2% rise in inventories Conversely, enterprises with a decrease level of indebtedness ... equal to ô ằ (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of Expected-Debt to be equal to ô ằ (not indebted and not going to be) by 13 points (34 minus 21)...
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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
... advantage of the trypsin-sensitive region situated in the linker domain of Abcb1a Following trapping in the absence or presence of Vi and mild-trypsin treatment, the trypsin degradation products of ... conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette ... (length of the side chain maintained) and asparagine (shorter side chain) mutants, then trapping in the absence of Vi now occurs [39] (Fig 3); this is also the case when the side chain is almost...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25